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3. Live birth rate is higher in primary subfertile women undergoing ICSI with high normal compared to low normal range TSH levels

Author

Delprat, C., Van Dam, E., Van de Ven, P., Aissa, K., Ter Haar, M., Feenstra, Y., De Roos, A., Beelen, G., Schats, R., Lambalk, C., Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Internal medicine, APH - Methodology, Epidemiology and Data Science, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, ACS - Atherosclerosis & ischemic syndromes, and ACS - Heart failure & arrhythmias

Published
2019

5. Primary subfertility is significantly associated with higher levels of Thyroid Stimulating Hormone within the normal range preceding In Vitro Fertilization

Author

Delprat, C., Van Dam, E., Van de Ven, P., Aissa, K., Ter Haar, M., Feenstra, Y., De Roos, A., Beelen, G., Schats, R., Lambalk, C., Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Internal medicine, CCA - Cancer Treatment and quality of life, APH - Methodology, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, CCA - Imaging and biomarkers, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, and CCA - Cancer biology and immunology

Published
2018

7. A new polymer based integrated optic technology

Author

Beelen, G., Krijnen, G.J.M., Rikkers, E., Linders, P.W.C., Bulthuis, H.F., Bakker, A.F., Leijtens, X.J.M., Diemeer, M.B.J., Driessen, A., van den Heuvel, J., de Ridder, R.M., Demeester, Piet, and Baets, Roel

Published
1998

12. Nonlinear optics of chiral media

Author

Thierry Verbiest, Elshocht, S., Beelen, G., Boutton, C., Kauranen, M., and Persoons, A.

Abstract

Chiral media interact differently with left- and right-hand circularly-polarized light. In linear optics this gives rise to optical activity effects like circular dichroism, optical rotation and optical rotatory dispersion. Optical activity effects also occur in nonlinear optics. For example, second-harmonic generation from chiral surfaces is different for left- and right-hand circularly-polarized fundamental excitation.[1,2]

14. More Live Births in Primary Subfertile Intracytoplasmic Sperm Injection-Treated Women with High Normal TSH Levels.

Author

Repelaer van Driel-Delprat C, van Dam E, van de Ven P, Aissa K, Ter Haar M, Feenstra Y, de Roos A, Beelen G, Schats R, and Lambalk C

Subjects
Female, Fertilization in Vitro, Humans, Live Birth epidemiology, Male, Pregnancy, Pregnancy Rate, Retrospective Studies, Thyrotropin, Infertility, Male, Sperm Injections, Intracytoplasmic
Abstract

Objectives: The aim of this study was to analyze the fertility outcome in intracytoplasmic sperm injection (ICSI)-treated women across normal range thyroid-stimulating hormone (TSH) levels. Published results are inconclusive about optimal TSH levels and fertility., Design: This is a retrospective cohort study in 752 ICSI-treated women with predominantly severe male factor subfertility, starting treatment between the first of January 2008 and the first of March 2012 with a follow-up until 2014. Participants/Materials, Setting, Methods: Women aged 22-45 years with TSH 0.3-4.5 mIU/L without thyroid hormone substitution were included in Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands, an iodine-sufficient area. Demographic and baseline characteristics were compared between groups of patients based on TSH, using one-way ANOVA, Kruskal-Wallis ANOVA, and χ2 test. The patient was the unit of analysis: all cumulative cycles per patient were analyzed up to and including the first ongoing pregnancy. The primary outcome was a cumulative live birth rate. Clinical pregnancy rate, pregnancy loss, and ongoing pregnancy rate were secondary outcomes. The χ2 test and logistic regression were used to compare interquartile groups while adjusting for confounders. Logistic regression was used with the natural logarithm of TSH as a continuous predictor. Primary and secondary subfertile women were analyzed separately., Results: Analysis of the total cohort (n = 752) showed no difference in fertility outcomes across the normal TSH range. The cumulative live birth rate for the 4 groups of primary subfertile women (n = 455) was 76% in the upper TSH quartile compared to 56%, 60%, and 59% in the lower TSH quartiles., Limitations: Levels of thyroxine and presence of thyroid autoimmunity were not measured in this retrospective cohort study., Conclusions: The observation that a higher live birth rate was found in primary subfertile ICSI-treated women with high but allegedly normal TSH levels contributes to the hypothesis that in certain subfertile women in addition to a male factor, female factors such as subtle hypothyroidism and/or thyroid autoimmunity may play a role in keeping them from conception, which can be overcome by the process of ICSI., (© 2021 The Author(s). Published by S. Karger AG, Basel.)

Published
2021
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15. Determination of tranquillizers by GLC in biological fluids.

Author

van der Kleijn E, Beelen GC, and Frederick MA

Subjects
Animals, Autoradiography, Barbiturates analysis, Body Fluids analysis, Brain metabolism, Carbamates analysis, Carisoprodol analysis, Chemical Phenomena, Chemistry, Diazepam analysis, Diazepam blood, Diazepam metabolism, Dibenzazepines analysis, Forensic Medicine, Half-Life, Haplorhini, Hydroxyzine analysis, Hypnotics and Sedatives administration & dosage, Hypnotics and Sedatives blood, Hypnotics and Sedatives metabolism, Hypnotics and Sedatives poisoning, Hypnotics and Sedatives toxicity, Kinetics, Male, Meprobamate analysis, Methods, Oxazepam analysis, Structure-Activity Relationship, Tranquilizing Agents administration & dosage, Tranquilizing Agents blood, Tranquilizing Agents metabolism, Tranquilizing Agents poisoning, Tranquilizing Agents toxicity, Chromatography, Gas, Hypnotics and Sedatives analysis, Tranquilizing Agents analysis
Published
1971
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