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One critical step on the path from data taking to physics analysis is calibration. For many experiments this step is both time consuming and computationally expensive. The AI Experimental Calibration and Control project seeks to address these issues, starting first with the GlueX Central Drift Chamber (CDC). We demonstrate the ability of a Gaussian Process to estimate the gain correction factor (GCF) of the GlueX CDC accurately, and also the uncertainty of this estimate. Using the estimated GCF, the developed system infers a new high voltage (HV) setting that stabilizes the GCF in the face of changing environmental conditions. This happens in near real time during data taking and produces data which are already approximately gain-calibrated, eliminating the cost of performing those calibrations which vary ±15% with fixed HV. We also demonstrate an implementation of an uncertainty aware system which exploits a key feature of a Gaussian process.

The visual behavior under both static and dynamic viewing conditions was examined in a group of 13-year-old successful readers, compared with a group of the same age retarded in reading. Research supports the notion that problems of dynamic binocular vision and control while reading are important. (Author/KC)

Background:The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB) protocol is still to be clarified, while, for other group of patients, the presence of SCAs is associated with poor prognosis.Methods:To understand the role of SCAs we performed multilocus/pangenomic analysis of 98 tumour samples from patients enrolled in the EUNB protocol.Results:Age at diagnosis was categorised into two groups using 18 months as the age cutoff. Significant difference in the presence of SCAs was seen in tumours of patients between 12 and 18 months and over 18 months of age at diagnosis, respectively (P=0.04). A significant correlation (P=0.03) was observed between number of SCAs per tumour and age. Event-free (EFS) and overall survival (OS) were calculated in both age groups, according to both the presence and number of SCAs. In older patients, a poorer survival was associated with the presence of SCAs (EFS=46% vs 75%, P=0.023; OS=66.8% vs 100%, P=0.003). Moreover, OS of older patients inversely correlated with number of SCAs (P=0.002). Finally, SCAs provided additional prognostic information beyond histoprognosis, as their presence was associated with poorer OS in patients over 18 months with unfavourable International Neuroblastoma Pathology Classification (INPC) histopathology (P=0.018).Conclusions:The presence of SCAs is a negative prognostic marker that impairs outcome of patients over the age of 18 months with localised unresectable NB without MYCN amplification, especially when more than one SCA is present. Moreover, in older patients with unfavourable INPC tumour histoprognosis, the presence of SCAs significantly affects OS. [ABSTRACT FROM AUTHOR]