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To determine the long-term fetal cardiac effects of the SARS-CoV-2 infection in pregnant women recovered from moderate COVID-19 with fetal echocardiography (ECHO).Forty-five pregnant women that recovered from moderate COVID-19 (CRG) 4 weeks after the infection confirmation, were compared with 45 gestational and maternal age-matched control groups (CG) in terms of demographic features fetal cardiac morphological (sphericity index, cardiothoracic ratio), and functional (myocardial performance index, mitral E/A, tricuspid E/A, mitral and tricuspid annular plane systolic excursion) parameters.There was no difference in demographic features between the groups. Fetal cardiac morphologic parameters were found to be similar between the two groups. When the fetal cardiac functional assessment of the two groups was compared, only mitral E/A ratio results were found to be statistically significantly lower in the CRG than in the control group (p = 0.030).The fetal heart does not seem to be negatively affected by COVID-19 after recovery from moderate infection. These results about the fetal effect of SARS-CoV-2 may improve our limited knowledge of the utility of fetal ECHO in pregnant women who recovered from COVID-19.

Objective: We aimed to investigate the frequency of Postpartum Depression (PPD) and maternal attachment status in a region with a low socioeconomic level during the Covid-19 pandemic. Materials and Methods: Two hundred women who gave birth in our hospital were evaluated on postpartum 10th day with Edinburgh Postnatal Depression Scale (EPDS) and Maternal Attachment Inventory (MBI). Results: The mean EPDS in the group with Normal Body Mass Index (BMI) was lower than in the other two groups. Average EPDS was higher in the group with sleep problems than those without sleep problems. Women who received support from their spouses had lower EPDS scores and higher MBI scores. EPDS scores were lower in the group with a good income. MBI scores were found to be lower in people within the increased length of hospital stay. Conclusion: In the study, we conducted with a group with a low socioeconomic level during the pandemic. We determined that PPD rates increased considerably, and this situation

Aim: We aim to evaluate fetal cardiac output in intrahepatic cholestasis of pregnancy (ICP).Material and Method: Thirty-two patients with ICP and 42 healthy pregnant women were included in the study. The diagnosis of ICP was made by detecting fasting bile acid value >10 µmol/L in symptomatic pregnant women. Fetal echocardiographic evaluations were performed >34 weeks of gestation. Demographic data, fetal cardiac output, and perinatal outcomes of the patients were compared between the groups.Results: In the ICP group aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were higher than the control group (p, Amaç: Gebeliğin intrahepatik kolestazında (ICP) fetal kalp debisini değerlendirmeyi amaçlıyoruz.Gereçler ve yöntem: Çalışmaya 32 ICP izlenen hasta ve 42 sağlıklı gebe dahil edildi. Semptomatik gebelerde açlık safra asidi değeri >10 µmol/L saptanması ile ICP tanısı konuldu. Fetal ekokardiyografik değerlendirmeler >34 gebelik haftasında yapıldı. Gruplar arasında hastaların demografik verileri, fetal kalp debisi ve perinatal sonuçları karşılaştırıldı.Bulgular: ICP grubunda aspartat aminotransferaz (AST) ve alanin aminotransferaz (ALT) kontrol grubuna göre daha yüksekti (p

To evaluate the clinical significance of the systemic immune-inflammation index (SII) for patients who had miscarriages.The retrospective study included 709 pregnant women who had a miscarriage (nonviable intrauterine pregnancy up to 20 weeks of gestation) and 676 women who carried a viable intrauterine pregnancy up to 20 weeks of gestation-serving as the control group. The study and the control group were compared in terms of demographic characteristics, laboratory test results, and SII values. Furthermore, laboratory test results and SII values were compared between patients in the study group and the control group with a history of genital bleeding (threatened abortion).The mean gestational week of pregnancy was 9.5 ± 3 for the control group and 8.3 ± 2.5 for the study group (p = 0.150). The SII values were higher in the study group than in the control group (p = 0.030). In all participants with a clinical history of genital bleeding, the leukocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and SII values were higher in the miscarriage group than the group with viable fetus (p = 0.031, p = 0.003, p = 0.002, p 0.001). Based on a receiver operating characteristic (ROC) curve analysis, the SII cutoff value for miscarriage was 883.95 (10High SII values in early pregnancy may be used as an additional marker for the prediction of miscarriage, in pregnant women with threatened abortion. Further prediction models including maternal risk factors and multiple markers may be more valuable for clinical practice.

Objective: To compare the intra-abdominal and extra-abdominal techniques in the repair of uterine incision in cesarean delivery. Methods: In this study, we analyzed the data of patients that underwent a cesarean section in Viranşehir State Hospital, a secondary care center. The present retrospective study included a total of 589 patients, of whom 296 underwent intra-abdominal uterine repair and 293 underwent extra-abdominal uterine repair in cesarean delivery. The groups were compared in terms of clinical characteristics, operation time, blood loss, and length of hospital stay. Results: Operation time significantly shorter in patients who underwent extra-abdominal uterine repair (p

To investigate the association of systemic immune-inflammation index (SII) and systemic immune-response index (SIRI) with adverse perinatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19).The cases were divided into (1) the Mild-moderate COVID-19 group (n = 2437) and (2) the Severe-critical COVID-19 group (n = 212). Clinical characteristics, perinatal outcomes, SII (neutrophilXplatelet/lymphocyte), and SIRI (neutrophilXmonocyte/lymphocyte) were compared between the groups. Afterward, SII and SIRI values were compared between subgroups based on pregnancy complications, neonatal intensive care unit (NICU) admission, and maternal mortality. A receiver operator characteristic analysis was performed for the determination of optimal cutoff values for SII and SIRI in the prediction of COVID-19 severity, pregnancy complications, NICU admission, and maternal mortality.Both SII and SIRI were significantly higher in complicated cases (p 0.05). Cutoff values in the prediction of severe-critical COVID-19 were 1309.8 for SII, and 2.3 for SIRI. For pregnancy complications, optimal cutoff values were 973.2 and 1.6. Cutoff values of 1045.4 and 1.8 were calculated for the prediction of NICU admission. Finally, cut-off values of 1224.2 and 2.4 were found in the prediction of maternal mortality.SII and SIRI might be used in combination with other clinical findings in the prediction of poor perinatal outcomes.

Objective:This study aims to investigate the perinatal outcomes in COVID-19 pregnant women with intrahepatic cholestasis of pregnancy (ICP) and elevated liver enzymes.Methods: Present study was carried on pregnant women with COVID-19 between March 11, 2020 and August 11, 2021. Patients with liver enzyme levels higher than twice the upper limit of the reference range for Aspartate Aminotransferase (AST) and/or Alanine Transferase (ALT) were included. Cases with elevated Fasting Biliary Acid (FBA) levels were regarded as ICP. Remaining cases were used as the control group. A receiver operating characteristics (ROC) analysis was performed to assess the predictive value of ALT and AST for ICP.Results: There were a total of 1751 patients in the study period. Among them 126 had elevated liver enzymes. Nineteen of these cases had also ICP. AST and ALT values were statistically higher in the ICP group. Demographic features, clinical characteristics and perinatal outcomes were similar between the groups. The rate of ICP in pregnant women with COVID-19 was similar to the literature in this study. Although the rates of preterm delivery were higher than the current literature for both groups, study and control groups were comparable in terms of preterm delivery. The optimal cut-off values were 109.5 IU/L (specificity: 59.2%, sensitivity: 63.3%) and 89.5 IU/L (specificity: 68.4%, sensitivity: 67.3%) for ALT and AST ,respectively according to the results of the ROC analysis.Conclusion: Similar perinatal outcomes were observed between the ICP and control groups. However, relatively higher rates of maternal mortality, intensive care unit admission, neonatal intensive care unit admission, and preterm birth were observed for COVID-19 pregnant women with elevated liver enzymes compared to the previous literature. Thus, physicians dealing with pregnant women with COVID-19 should be cautious about the management of cases with elevated liver enzymes.

Background Chorioangioma is a vascular neoplasm of the placenta with the potential to cause heart failure, hydrops, and even death. Case A 30-year-old patient was referred owing to a large placental chorioangioma and fetal hydrops at 28 weeks of gestation. The patient underwent ultrasound-guided interstitial laser ablation. Ten days later, fetal blood transfusion was performed and at 31 weeks of gestation, and the patient delivered a female infant by cesarean section. The newborn was discharged from the neonatal intensive care unit without any complication. Conclusion According to our case, large placental chorioangioma may have a favorable outcome with interstitial laser ablation and fetal transfusion.

We aimed to examine fetal cardiac output (CO) in patients who recovered from severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection.This prospective study included 48 pregnant women recovered from SARS-CoV-2 infection and 50 control cases. SARS-CoV-2 infection was diagnosed by polymerase chain reaction (PCR) test in patients. Fetal echocardiographic evaluations were performed at 24-37 weeks of gestation in pregnant women who recovered from the infection and control group.The median value of ultrasound evaluation was 34 (2.6) weeks of gestation in the recovery from the SARS-CoV-2 infection (RSI) group, and 32 (7.6) weeks in the control group (p = .565). Left cardiac output (LCO) z score was significantly lower in the RSI group than the control group (p = .041). LCO and combine cardiac output (CCO) z score were significantly lower in the severe disease group than mild, moderate disease groups, and controls (p = .019 and p = .013). CCO (ml/min/kg) was decreased in the severe disease group when compared with control and mild disease groups (p = .044).In the present study, fetal cardiac output in pregnant women who recovered from SARS-CoV-2 infection was found to be significantly reduced in those with severe disease, while there was no significant difference in mild and moderate cases. Placental dysfunction and inflammatory cytokines might cause fetal cardiac changes. Further studies could be clarified on the impact of SARS-CoV-2 infection on fetal cardiac function.

Aim: We aimed to examine fetal cardiac output (CO) in patients who recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Materials: This prospective study included 48 pregnant women recovered from SARS-CoV-2 infection and 50 control cases. SARS-CoV-2 infection was diagnosed by polymerase chain reaction (PCR) test in patients. Fetal echocardiographic evaluations were performed at 24-37 weeks of gestation in pregnant women who recovered from the infection and control group. Results: The median value of ultrasound evaluation was 34 (2.6) weeks of gestation in the recovery from the SARS-CoV-2 infection (RSI) group, and 32 (7.6) weeks in the control group (p=0.565). Left cardiac output (LCO) z score was significantly lower in the RSI group than the control group (p=0,041). LCO and combine cardiac output (CCO) z score were significantly lower in the severe disease group than mild, moderate disease groups, and controls (p=0,019 and p=0,013). CCO (mL/min/kg) was decreased in the severe disease group when compared with control and mild disease groups (p=0,044). Fetal distress, preterm delivery rate, and neonatal intensive care unit (NICU) admission were found to be higher in the severe disease group compared to the control group (p=0,010, p=0,009, and p

To assess the placental elasticity using point shear wave velocity (pSWV) in pregnant women who had recovered from coronavirus COVID-19.A total of 40 pregnant women who had recovered from moderate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 40 healthy pregnant women were included in this study. We evaluated placental elasticity by using transabdominal pSWV method. Three measurements were made, and their average was accepted as the mean placental velocity value in each case. The results were compared between the post-COVID-19 and control groups.The mean pSWV values were significantly higher in the post-COVID-19 group compared to the control group, indicating that the women with a history of COVID-19 had stiffer placentas. Furthermore, the pSWV values were significantly and positively correlated with the uterine artery pulsatility index. We also found that the NICU requirement was statistically higher in the post-COVID 19 group.The pregnant women who had recovered from COVID-19 had rigid placentas than the healthy controls. The use of pSWV for the assessment of placental velocity may provide valuable information in the diagnosis and management of post-COVID-19 patients as a complementary tool to the existing ultrasonography methods.

To compare the clinical features and perinatal outcomes of pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pre-variant and post-variant periods.This prospective cohort study includes pregnant women with SARS-CoV-2 who were followed-up at Ankara City Hospital between 11, March 2020 and 15, September 2021. Demographic features, clinical characteristics and pregnancy outcomes were compared between the pre-variant (n = 1416) and post-variant (n = 519) groups.The rates of severe and critical cases significantly increased in the post-variant group (9.7% vs 2%, p 0.001). The rates of respiratory support (26.8% vs 7.3%, p 0.001), ICU admission (12.9% vs 1.8%, p 0.001) and maternal mortality (2.9% vs 0.4%, p 0.001) were significantly higher in the post-variant group. A significant increase was observed for pregnancy complications in the post-variant group (45.6% vs 18.8%, p = 0.007). The rates of preterm delivery (26.4% vs 4.4%, p 0.001) and NICU admission (34% vs 18.8%, p 0.001) were significantly higher in the post-variant group. Positive, weak, statistically significant correlations were observed between the post-variant period, disease severity and maternal mortality (r = 0.19, r = 0.12 and p 0.001).Post-variant COVID-19 period was associated with a severe course of the disease and increased rates of adverse obstetric outcomes in pregnant patients.