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468 results on '"Bednarski, Brian"'

11. Benchmarking Outcomes for Definitive Treatment of Young-Onset, Locally Advanced Rectal Cancer

Author

Taku, Nicolette, Yi-Qian, Y. Nancy, Chang, George J., Ludmir, Ethan B., Raghav, Kanwal Pratap Singh, Rodriguez-Bigas, Miguel A., Holliday, Emma Brey, Smith, Grace L., Minsky, Bruce D., Overman, Michael J., Messick, Craig, Boyce-Fappiano, David, Koong, Albert C., Skibber, John Michael, Koay, Eugene Jon, Dasari, Arvind, Taniguchi, Cullen M., Bednarski, Brian K., Morris, Van K., Kopetz, Scott, and Das, Prajnan

Published
2022
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18. Local recurrences in western low rectal cancer patients treated with or without lateral lymph node dissection after neoadjuvant (chemo)radiotherapy: An international multi-centre comparative study

Author

Kroon, Hidde M., Malakorn, Songphol, Dudi-Venkata, Nagendra N., Bedrikovetski, Sergei, Liu, Jianliang, Kenyon-Smith, Tim, Bednarski, Brian K., Ogura, Atsushi, van de Velde, Cornelis J.H., Rutten, Harm J.T., Beets, Geerard L., Thomas, Michelle L., Kusters, Miranda, Chang, George J., and Sammour, Tarik

Published
2021
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20. The prognostic impact of tumor deposits in colorectal cancer: More than just N1c.

Author

Bhutiani, Neal, Peacock, Oliver, Uppal, Abhineet, Hu, Chung‐Yuan, Bednarski, Brian K., Taggart, Melissa W., Dasari, Arvind, Morris, Van K., Kaur, Harmeet, Kopetz, Scott, Holliday, Emma B., Das, Prajnan, You, Y. Nancy, and Chang, George J.

Abstract

Background: The identification of tumor deposits (TD) currently plays a limited role in staging for colorectal cancer (CRC) aside from N1c lymph node designation. The objective of this study was to determine the prognostic impact, beyond American Joint Committee on Cancer N1c designation, of TDs among patients with primary CRC. Methods: Patients who had resected stage I–III primary CRC diagnosed between 2010 and 2019 were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Cancer‐specific survival (CSS) stratified by TD status and lymph node (N) status was calculated using the Kaplan–Meier method and multivariable Cox proportional hazards regression analyses. Results: In total, 147,783 patients with primary CRC were identified. TDs were present in 15,444 patients (10.5%). The presence of TDs was significantly associated with adverse tumor characteristics, including advanced pathologic stage, nodal status, and metastasis status. The presence of TDs was associated with worse CSS (hazard ratio [HR], 3.12; 95% confidence interval [CI], 3.02–3.22), as it was for each given N category (e.g., N2a and TD‐negative [HR, 2.50; 95% CI, 2.37–2.64] vs. N2a and TD‐positive [HR, 3.75; 95% CI, 3.49–4.03]). The presence of multiple TDs was also associated with decreased CSS for each given N category compared with a single TD (e.g. N2a with one TD [HR, 3.09; 95% CI, 2.65–3.61] vs. N2a with two or more TDs [HR, 4.32; 95% CI, 3.87–4.82]). Conclusions: TDs were identified as an independent predictor of a worse outcome in patients with CRC. The presence of TDs confers distinctly different CSS and provides important prognostic information among patients with CRC and warrants further investigation as a unique variable in future iterations of CRC staging. The presence of tumor deposits confers distinctly different cancer‐specific survival beyond lymph node categories and provides important added prognostic information among patients with colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Total Neoadjuvant Therapy for Rectal Cancer: Which Regimens to Use?

Author

Ochiai, Kentaro, Bhutiani, Neal, Ikeda, Atsushi, Uppal, Abhineet, White, Michael G., Peacock, Oliver, Messick, Craig A., Bednarski, Brian K., You, Yi-Qian Nancy, Skibber, John M., Chang, George J., and Konishi, Tsuyoshi

Subjects
PATIENT compliance, RADIOTHERAPY, CHEMORADIOTHERAPY, TREATMENT effectiveness, DISEASE remission, PRESERVATION of organs, tissues, etc., DECISION making in clinical medicine, RECTUM tumors, CANCER chemotherapy, COMBINED modality therapy, QUALITY assurance
Abstract

Simple Summary: Total neoadjuvant therapy (TNT) for rectal cancer is expected to improve oncologic outcomes and organ preservation. Clinicians need to understand the advantages and limitations of the available regimens for multidisciplinary decision making. This article reviews the updated evidence on TNT and addresses tailor-made use of TNT regimens based on tumor location and local and systemic risk. Total neoadjuvant therapy (TNT) is a novel strategy for rectal cancer that administers both (chemo)radiotherapy and systemic chemotherapy before surgery. TNT is expected to improve treatment compliance, tumor regression, organ preservation, and oncologic outcomes. Multiple TNT regimens are currently available with various combinations of the treatments including induction or consolidation chemotherapy, triplet or doublet chemotherapy, and long-course chemoradiotherapy or short-course radiotherapy. Evidence on TNT is rapidly evolving with new data on clinical trials, and no definitive consensus has been established on which regimens to use for improving outcomes. Clinicians need to understand the advantages and limitations of the available regimens for multidisciplinary decision making. This article reviews currently available evidence on TNT for rectal cancer. A decision making flow chart is provided for tailor-made use of TNT regimens based on tumor location and local and systemic risk. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Association of pathologic nodal status with minimal residual disease after neoadjuvant treatment and resection of locally advanced rectal cancer.

Author

Uppal, Abhineet, primary, Bhutiani, Neal, additional, Shen, John Paul Y.C., additional, Alfaro, Kristin, additional, Kell, Robert J., additional, Yousef, Mahmoud M.G., additional, Yousef, Abdelrahman M.G., additional, Konishi, Tsuyoshi, additional, Holliday, Emma, additional, Morris, Van K., additional, Dasari, Arvind, additional, Willis, Jason, additional, Newhook, Timothy E., additional, Bednarski, Brian K., additional, You, Y. Nancy, additional, Peacock, Oliver, additional, Messick, Craig, additional, Das, Prajnan, additional, Chang, George J., additional, and Kopetz, Scott, additional

Published
2024
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27. The current multidisciplinary management of rectal cancer.

Author

Bhutiani, Neal, Peacock, Oliver, Uppal, Abhineet, You, Y. Nancy, Bednarski, Brian K., Skibber, John M., Messick, Craig, White, Michael G., Chang, George J., and Konishi, Tsuyoshi

Subjects
RECTAL cancer, PRESERVATION of organs, tissues, etc., NEOADJUVANT chemotherapy, LYMPH nodes
Abstract

Multidisciplinary management of rectal cancer has rapidly evolved over the last several years. This review describes recent data surrounding total neoadjuvant therapy, organ preservation, and management of lateral pelvic lymph nodes. It then presents our treatment algorithm for management of rectal cancer at The University of Texas MD Anderson Cancer Center in the context of this and other existing literature. As part of this discussion, the review describes how we tailor management based upon both patient and tumor‐related factors in an effort to optimize patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Perioperative and oncological outcomes following robotic en bloc multivisceral resection for colorectal cancer.

Author

DiBrito, Sandra R., Manisundaram, Naveen, Kim, Youngwan, Peacock, Oliver, Hu, Chung‐Yuan, Bednarski, Brian, You, Y. Nancy, Uppal, Abhineet, Tillman, Matthew, Konishi, Tsuyoshi, Kaur, Harmeet, Palmquist, Sarah, Holliday, Emma, Dasari, Arvind, and Chang, George J.

Subjects
COLORECTAL cancer, RECTAL surgery, ONCOLOGIC surgery, VAS deferens, MINIMALLY invasive procedures, SEMINAL vesicles
Abstract

Aim: As multidisciplinary treatment strategies for colorectal cancer have improved, aggressive surgical resection has become commonplace. Multivisceral and extended resections offer curative‐intent resection with significant survival benefit. However, limited data exist regarding the feasibility and oncological efficacy of performing extended resection via a minimally invasive approach. The aim of this study was to determine the perioperative and long‐term outcomes following robotic extended resection for colorectal cancer. Method: We describe the population of patients undergoing robotic multivisceral resection for colorectal cancer at our single institution. We evaluated perioperative details and investigated short‐ and long‐term outcomes, using the Kaplan–Meier method to analyse overall and recurrence‐free survival. Results: Among the 86 patients most tumours were T3 (47%) or T4 (47%) lesions in the rectum (78%). Most resections involved the anterior compartment (72%): bladder (n = 13), seminal vesicle/vas deferens (n = 27), ureter (n = 6), prostate (n = 15) and uterus/vagina/adnexa (n = 27). Three cases required conversion to open surgery; 10 patients had grade 3 complications. The median hospital stay was 4 days. Resections were R0 (>1 mm) in 78 and R1 (0 to ≤1 mm) in 8, with none being R2. The average nodal yield was 26 and 48 (55.8%) were pN0. Three‐year overall survival was 88% and median progression‐free survival was 19.4 months. Local recurrence was 6.1% and distant recurrence was 26.1% at 3 years. Conclusion: Performance of multivisceral and extended resection on the robotic platform allows patients the benefit of minimally invasive surgery while achieving oncologically sound resection of colorectal cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Do resected colorectal cancer patients need early chest imaging? Impact of clinicopathologic characteristics on time to development of pulmonary metastases

Author

Deboever, Nathaniel, primary, Bayley, Erin M., additional, Eisenberg, Michael A., additional, Hofstetter, Wayne L., additional, Mehran, Reza J., additional, Rice, David C., additional, Rajaram, Ravi, additional, Roth, Jack A., additional, Sepesi, Boris, additional, Swisher, Stephen G., additional, Vaporciyan, Ara A., additional, Walsh, Garrett L., additional, Bednarski, Brian K., additional, Morris, Van K., additional, and Antonoff, Mara B., additional

Published
2023
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35. Lung surveillance following colorectal cancer pulmonary metastasectomy: Utilization of clinicopathologic risk factors to guide strategy

Author

Deboever, Nathaniel, primary, Bayley, Erin M., additional, Eisenberg, Michael A., additional, Hofstetter, Wayne L., additional, Mehran, Reza J., additional, Rice, David C., additional, Rajaram, Ravi, additional, Roth, Jack A., additional, Sepesi, Boris, additional, Swisher, Stephen G., additional, Vaporciyan, Ara A., additional, Walsh, Garrett L., additional, Bednarski, Brian K., additional, Morris, Van K., additional, and Antonoff, Mara B., additional

Published
2023
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36. PROSPECTIVE STUDY TO EVALUATE SAFETY OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR MANAGEMENT OF COLORECTAL POLYPS > 4 CM IN SIZE AS AN OUTPATIENT PROCEDURE: A US ACADEMIC CANCER CENTER EXPERIENCE

Author

Ge, Phillip, primary, Tillman, Matthew, additional, Coronel, Emmanuel, additional, Casanova, Deanndra, additional, Bednarski, Brian, additional, Konishi, Tsuyoshi, additional, Messick, Craig, additional, Peacock, Oliver, additional, Skibber, John, additional, Uppal, Abhineet, additional, You, Y. Nancy, additional, Chang, George, additional, and Gottumukkala, Raju, additional

Published
2023
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43. Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer

Author

Hernandez, Sharia, primary, Das, Prajnan, additional, Holliday, Emma B., additional, Shen, Li, additional, Lu, Wei, additional, Johnson, Benny, additional, Messick, Craig A., additional, Taniguchi, Cullen M., additional, Skibber, John, additional, Ludmir, Ethan B., additional, You, Y. Nancy, additional, Smith, Grace Li, additional, Bednarski, Brian, additional, Kostousov, Larisa, additional, Koay, Eugene J., additional, Minsky, Bruce D., additional, Tillman, Matthew, additional, Portier, Shaelynn, additional, Eng, Cathy, additional, Koong, Albert C., additional, Chang, George J., additional, Foo, Wai Chin, additional, Wang, Jing, additional, Soto, Luisa Solis, additional, and Morris, Van K., additional

Published
2023
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45. Rectal Adenocarcinoma Presenting as a Cervical Mass: A Case Report.

Author

Stanietzky, Nir, Bednarski, Brian, Shafer, Aaron, Taggart, Melissa W., Peacock, Oliver, and Vikram, Raghunandan

Subjects
*ADENOCARCINOMA, *CROSS-sectional imaging, *UTERINE hemorrhage, *GYNECOLOGIC oncology, *INVASIVE diagnosis, *OVERALL survival, *RECTAL cancer
Abstract

Objective: Challenging differential diagnosis Background: Invasive cervical tumors are often seen in clinical practice. However, there are multiple structures within the pelvis, and invasion of the cervix from another site must be included in the differential diagnosis. In such cases, a multidisciplinary approach is needed to define the organ of tumor origin. Ensuring proper staging and histologic analysis are critical for optimal management. Case Report: We present a case of a 68-year-old woman who presented to her gynecologist with painless post-menopausal vaginal bleeding. She was diagnosed with a locally aggressive cervical adenocarcinoma, which was histologically confirmed by an in-office biopsy. She was referred to the gynecologic oncology service at a tertiary care hospital for definitive management, where a thorough clinical workup was performed. Physical exam revealed that the mass had invaded the anterior rectal wall. Through a multidisciplinary approach and a repeat biopsy, she was correctly diagnosed with an invasive rectal adenocarcinoma. She was treated with neoadjuvant chemoradiotherapy and underwent curative surgery. Had she been incorrectly treated as having a primary cervical adenocarcinoma, there would have been no role for surgery. The change in the organ of primary drastically altered the patient’s management and outcome. She is currently undergoing surveillance with cross-sectional imaging. Conclusions: Cervical masses originating from non-gynecologic organs can be difficult to differentiate on physical exam and histologic analysis. When a mass involves the rectum, an invasive primary rectal adenocarcinoma must be included in the differential. This will have a significant impact on patient management and ultimately on patient survival. [ABSTRACT FROM AUTHOR]

Published
2023
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