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323 results on '"Beckers, E."'

1. Revue bibliographique : la prise en compte des transferts horizontaux dans les modèles hydrologiques

Author

Beckers, E. and Degré, A.

Subjects
Interflow, subsurface flow, hydrological model, horizontal hydraulic conductivity, Darcy coefficient, Biotechnology, TP248.13-248.65, Environmental sciences, GE1-350
Abstract

Modelling of interflows in soils: a review. This review sums up the different schemes in hydrological modelling. Moreover, it underlines how the interflows are taken into account and draws the first lines to improve their physically based representation. In the mood of the change in agricultural practices, especially concerning the conventional tillage reduction in support of conservational tillage, it seems to be necessary to propose a better description of decisive parameters like horizontal hydraulic conductivity. More precisely, the dependence of this parameter with the water retention curve has to be described in order to represent fluxes at the plot scale and at the watershed scale. Under these circumstances, an approach with in situ measurements and physically based modelling is suggested.

Published
2011

2. L'hydrologie, une partenaire de la géomorphopédologie pour une gestion transéchelle des grands enjeux environnementaux

Author

Colard, F., Sohier, C., Degré, A., Rauw, J., Bauwens, A., Kummert, N., and Beckers, E.

Subjects
Hydrology, géomorphology, soil sciences, water-soil-plant relationships, erosion, nitrate, simulation models, Belgium, Biotechnology, TP248.13-248.65, Environmental sciences, GE1-350
Abstract

Hydrology: a partner of geomorphopedology in the scope of a scale-through environmental management. Unsaturated soil and subsoil are often called "critical zone" considering their major interfacing role in our environment. Dealing with solute transfer or water and soil conservation, hydrologic research relies on pedologic descriptions. It is the case from micro to macro scale analysis. Hydrodynamic parameters are derived from pedologic information on soil. They allow hydrologists to quantify and spatially describe the dynamic exchanges between water, soil, crops and atmosphere. The modelling of water and solute transfer through soil and vadose zone also needs them. The paper presents some research highlights on soil behaviour, hydrological modelling and forecasting under climate change. Erosion is another major topic. Soil is a poorly renewable resource. Soil conservation and soft hydraulic management in watersheds deserve more attention. They can help limiting nutrient and sediment transfer to surface water. Again, pedologic information is the starting point of conceptualization and modelling. Furthermore, the Soil Map of Belgium includes information on geomorphology and landscape descriptions which date from decades. They are of first importance to calibrate and validate detachment, transport and sedimentation models. In the current context of high environmental concern, it is demonstrated how hydrology and pedology have to be partners in order to deal with such major issues.

Published
2011

3. ADAMTS‐13 and bleeding phenotype in von Willebrand disease

Author

Boender, Johan, Nederlof, Angelique, Meijer, Karina, Mauser‐Bunschoten, Evelien P., Cnossen, Marjon H., Fijnvandraat, Karin, van der Bom, Johanna G., de Meris, Joke, Laros‐van Gorkom, Britta A.P., van Galen, Karin P.M., Eikenboom, Jeroen, de Maat, Moniek P.M, Leebeek, Frank W.G., Coppens, M., Nieuwenhuizen, L., Tamminga, R.Y.J., Ypma, P.F., Smiers, F.J.W., Beckers, E., Brons, P., and Atiq, F.

Published
2020
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4. OC 71.4 Management Patterns of Antithrombotics and Outcomes in Patients with Hematological Malignancy and Thrombocytopenia: A Prospective Registry (Matter Study)

Author

Leader, A., primary, Spectre, G., additional, Chistolini, A., additional, Beckers, E., additional, Elling, T., additional, Beggiato, E., additional, Hamulyák, E., additional, Ram, R., additional, Cerqui, E., additional, Samuelson Bannow, B., additional, Siragusa, S., additional, Carrer, A., additional, Avnery, O., additional, Del Principe, M., additional, Giaccherini, C., additional, Russo, L., additional, Schieppati, F., additional, ten Cate-Hoek, A., additional, ten Cate, H., additional, and Falanga, A., additional

Published
2023
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6. PB0642 Determinants of the Bleeding Phenotype in Persons with Non-Severe Hemophilia

Author

Kloosterman, F., primary, Zwagemaker, A., additional, Bagot, C., additional, Beckers, E., additional, Boyce, S., additional, Brons, P., additional, Castaman, G., additional, Collins, P., additional, Eikenboom, J., additional, Hay, C., additional, Jackson, S., additional, Leebeek, F., additional, Male, C., additional, Meijer, K., additional, Nieuwenhuizen, L., additional, Shapiro, S., additional, Coppens, M., additional, Fijnvandraat, K., additional, and Gouw, S., additional

Published
2023
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7. PB0214 Evaluation of Innovative Laboratory Tests to Predict a Thrombotic Phenotype in a Family with Dysfibrinogenemia and a Novel FGG Mutation

Author

Monard, A., primary, Heubel-Moenen, F., additional, Castoldi, E., additional, de simone, I., additional, van der Meijden, P., additional, Wichapong, K., additional, van Doorn, W., additional, Spada, S., additional, Hellenbrand, D., additional, Stork, A., additional, ten Cate, H., additional, Beckers, E., additional, and Henskens, Y., additional

Published
2023
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8. Inhibitor development and mortality in non‐severe hemophilia A

Author

Eckhardt, C.L., Loomans, J.I., van Velzen, A.S., Peters, M., Mauser‐Bunschoten, E.P., Schwaab, R., Mazzucconi, M.G., Tagliaferri, A., Siegmund, B., Reitter‐Pfoertner, S.E., van der Bom, J.G., Fijnvandraat, K., Kamphuisen, P.W., Peerlinck, K., Oldenburg, J., Santagostino, E., Astermark, J., Eckhardt, C.L, van Velzen, A.S, Streefkerk, N., Loomans, J.L., van Eijkelenburg, A., Jansen, A.J., Kruijt, C.C., van Tienoven, B., van Baar, A.C.G., Corten, I.W., Meijer, K., Nijziel, M.R., Dors, N., Hamulyak, K., Beckers, E., Brons, P.P., Laros‐van Gorkom, B.A.P., van Heerde, W.L., Leebeek, F., Kruip, M., Cnossen, M.H., Mauser‐Bunschoten, E., Fischer, K., Smiers, F.J., Hermans, C., Klamroth, R., Escuriola‐Ettingshausen, C., Königs, C., Petrini, P., Holmström, M., Mäkipernaa, A., Male, C., Pabinger, I., Keenan, R.D., Liesner, R., Khair, K., Yee, T.T., Hart, D.P., Rangarajan, S., Mitchell, M., Thompson, G., Haya, S., Moret, A., Cid, A.R., Jimenez‐Yuste, V., Mancuso, M.E., Mazzuconni, M.G., Santoro, C., Morfini, M., Castaman, G., Schinco, P., Rivolta, G.F., Platokouki, H., and McRae, S.

Published
2015
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9. Ultra high-field MRI indications that exposure to blue enriched light increases attention brain responses during an oddball task

Author

Balda, F., Paparella, I., Campbell, I., Beckers, E., Sharifpour, R., Berger, A., Koshmanova, E., Mortazavi, N., Lamalle, L., Phillips, C., Maquet, P., Sherif, S., Vandewalle, G., Psychology 4, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, QE Operations research, RS: GSBE other - not theme-related research, and RS: FSE DACS Mathematics Centre Maastricht

Published
2022

14. Prevalence, burden and treatment effects of vaginal bleeding in women with (suspected) congenital platelet disorders throughout life: a cross-sectional study

Author

Punt, Marieke C., Ruigrok, Nienke D., Bloemenkamp, Kitty W.M., Uitslager, Nanda, Urbanus, Rolf T., Groot, Evelyn, Kremer Hovinga, Idske C.L., Schutgens, R. E.G., van Galen, K. P.M., Kruip, M. J.H.A., Beckers, E. A.M., Coppens, M., Eikenboom, J., Tamminga, R. Y.J., Hematology, and Pediatrics

Subjects
Adult, medicine.medical_specialty, Platelet disorder, Miscarriage, Menstruation, Quality of life, Cost of Illness, Surveys and Questionnaires, medicine, Prevalence, Humans, Vaginal bleeding, Public Health Surveillance, Age of Onset, Menorrhagia, Netherlands, Pregnancy, business.industry, Obstetrics, Disease Management, Hematology, Middle Aged, medicine.disease, Cross-Sectional Studies, Treatment Outcome, Cohort, Menarche, Quality of Life, Female, Blood Platelet Disorders, Disease Susceptibility, Uterine Hemorrhage, medicine.symptom, business
Abstract

Congenital platelet disorders (CPDs) are rare bleeding disorders that are associated with mucocutaneous bleeds. However, data on vaginal bleeding in women with CPDs are scarce. A set of generic and bleeding-specific questionnaires were used to evaluate the prevalence of vaginal bleeding, its impact on quality of life (QoL) and sexual functioning and the consequences for pregnancy, miscarriage and delivery in a cohort of women who were referred for diagnostic evaluation for CPDs. A total of 78 women included in the study were either diagnosed with a CPD (n = 35) or were clinically suspected of a CPD (n = 43). Heavy menstrual bleeding (HMB) was reported by a large proportion of women, which mainly started at menarche. In all, 76% of women received any kind of HMB treatment, often leading to surgical prodecures. HMB was shown to have a high impact on QoL, which improved upon treatment. Even though women reported that vaginal bleeding affects sexuality, this topic is not frequently discussed with physicians. Heavy blood loss frequently occurred after miscarriage/delivery, often requiring treatment. Women with (suspected) CPDs frequently encounter HMB, negatively impacting daily life and sexual functioning. Together with peripartum bleeding, these data highlight the burden of vaginal bleeding in CPDs and importance of adequate treatment.

Published
2022

16. Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling.

Author

Janssen, Alexander, Hoogendoorn, Mark, Cnossen, Marjon H., Mathôt, Ron A. A., Cnossen, M. H., Reitsma, S. H., Leebeek, F. W. G., Mathôt, R. A. A., Fijnvandraat, K., Coppens, M., Meijer, K., Schols, S. E. M., Eikenboom, H. C. J., Schutgens, R. E. G., Beckers, E. A. M., Ypma, P., Kruip, M. J. H. A., Polinder, S., Tamminga, R. Y. J., and Brons, P.

Subjects
FIXED effects model, BLOOD coagulation factor VIII antibodies, PHARMACOKINETICS, BLOOD coagulation factor VIII, RANDOM forest algorithms, MACHINE learning
Abstract

In population pharmacokinetic (PK) models, interindividual variability is explained by implementation of covariates in the model. The widely used forward stepwise selection method is sensitive to bias, which may lead to an incorrect inclusion of covariates. Alternatives, such as the full fixed effects model, reduce this bias but are dependent on the chosen implementation of each covariate. As the correct functional forms are unknown, this may still lead to an inaccurate selection of covariates. Machine learning (ML) techniques can potentially be used to learn the optimal functional forms for implementing covariates directly from data. A recent study suggested that using ML resulted in an improved selection of influential covariates. However, how do we select the appropriate functional form for including these covariates? In this work, we use SHapley Additive exPlanations (SHAP) to infer the relationship between covariates and PK parameters from ML models. As a case‐study, we use data from 119 patients with hemophilia A receiving clotting factor VIII concentrate peri‐operatively. We fit both a random forest and a XGBoost model to predict empirical Bayes estimated clearance and central volume from a base nonlinear mixed effects model. Next, we show that SHAP reveals covariate relationships which match previous findings. In addition, we can reveal subtle effects arising from combinations of covariates difficult to obtain using other methods of covariate analysis. We conclude that the proposed method can be used to extend ML‐based covariate selection, and holds potential as a complete full model alternative to classical covariate analyses. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Deep compartment models: A deep learning approach for the reliable prediction of time‐series data in pharmacokinetic modeling.

Author

Janssen, Alexander, Leebeek, Frank W. G., Cnossen, Marjon H., Mathôt, Ron A. A., Fijnvandraat, K., Coppens, M., Meijer, K., Schols, S. E. M., Eikenboom, H. C. J., Schutgens, R. E. G., Beckers, E. A. M., Ypma, P., Kruip, M. J. H. A., Polinder, S., Tamminga, R. Y. J., Brons, P., Fischer, K., van Galen, K. P. M., Nieuwenhuizen, L., and Driessens, M. H. E.

Subjects
DEEP learning, DRUG monitoring, ORDINARY differential equations, BLOOD coagulation factor VIII, DATA modeling, HEMOPHILIACS
Abstract

Nonlinear mixed effect (NLME) models are the gold standard for the analysis of patient response following drug exposure. However, these types of models are complex and time‐consuming to develop. There is great interest in the adoption of machine‐learning methods, but most implementations cannot be reliably extrapolated to treatment strategies outside of the training data. In order to solve this problem, we propose the deep compartment model (DCM), a combination of neural networks and ordinary differential equations. Using simulated datasets of different sizes, we show that our model remains accurate when training on small data sets. Furthermore, using a real‐world data set of patients with hemophilia A receiving factor VIII concentrate while undergoing surgery, we show that our model more accurately predicts a priori drug concentrations compared to a previous NLME model. In addition, we show that our model correctly describes the changing drug concentration over time. By adopting pharmacokinetic principles, the DCM allows for simulation of different treatment strategies and enables therapeutic drug monitoring. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Prevalence and 6‐month recovery of olfactory dysfunction: a multicentre study of 1363 COVID‐19 patients

Author

Lechien, J. R., primary, Chiesa‐Estomba, C. M., additional, Beckers, E., additional, Mustin, V., additional, Ducarme, M., additional, Journe, F., additional, Marchant, A., additional, Jouffe, L., additional, Barillari, M. R., additional, Cammaroto, G., additional, Circiu, M. P., additional, Hans, S., additional, and Saussez, S., additional

Published
2021
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21. Desmopressin in moderate hemophilia A patients: a treatment worth considering

Author

Loomans, J.I., Kruip, M.J.H.A., Carcao, M., Jackson, S., Velzen, A.S. van, Peters, M., Santagostino, E., Platokouki, H., Beckers, E., Voorberg, J., Bom, J.G. van der, Fijnvandraat, K., RISE Consortium, Graduate School, ARD - Amsterdam Reproduction and Development, ACS - Amsterdam Cardiovascular Sciences, General Paediatrics, Paediatric Infectious Diseases / Rheumatology / Immunology, Other departments, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, Hematology, MUMC+: MA Hematologie (9), and RS: CARIM - R1.01 - Blood proteins & engineering

Subjects
Adult, medicine.medical_specialty, Adolescent, VONWILLEBRANDS-DISEASE, medicine.medical_treatment, VON-WILLEBRANDS DISEASE, 030204 cardiovascular system & hematology, Hemophilia A, Gastroenterology, Young Adult, 03 medical and health sciences, BLEEDING DISORDERS, 0302 clinical medicine, Predictive Value of Tests, hemic and lymphatic diseases, Internal medicine, von Willebrand Factor, medicine, Humans, Deamino Arginine Vasopressin, Young adult, Child, Desmopressin, INTRANASAL SPRAY, DDAVP, Factor VIII, FACTOR-VIII, TRANSPLANTATION, business.industry, Moderate hemophilia A, Hematology, Middle Aged, MILD, Prognosis, ENDOTHELIAL-CELLS, Transplantation, Treatment Outcome, Editorial, Nasal spray, Predictive value of tests, Mutation, Factor VIII level, business, NASAL SPRAY, hormones, hormone substitutes, and hormone antagonists, 030215 immunology, medicine.drug, Cohort study
Abstract

Desmopressin increases endogenous factor VIII levels in hemophilia A. Large inter-individual variation in the response to desmopressin is observed. Patients with a lower baseline factor VIII activity tend to show a reduced response, therefore, desmopressin is less frequently used in moderate hemophilia A patients (baseline factor VIII activity 1-5 international units/deciliter), even though factor VIII levels may rise substantially in some of them. We aim to describe the response to desmopressin in moderate hemophilia A patients and to identify predictors. We selected data on 169 patients with moderate hemophilia from the multicenter Response to DDAVP In non-severe hemophilia A patients: in Search for dEterminants (RISE) cohort study. Adequate response to desmopressin was defined as a peak factor VIII level ≥ 30, and excellent response as ≥ 50 international units/deciliter after desmopressin administration. We used univariate and multiple linear regression techniques to analyze predictors of the peak factor VIII level. Response was considered adequate in 68 patients (40%), of whom 25 showed excellent response (15%). Intravenous administration, age, pre-desmopressin factor VIII activity and von Willebrand factor antigen, peak von Willebrand factor activity and desmopressin-induced rise in von Willebrand factor antigen were significant predictors of peak factor VIII level and explained 65% of the inter-individual variation. In 40% of moderate hemophilia A patients, desmopressin response was adequate, thus it is important not to with-hold this group of patients from desmopressin responsiveness. Among the six predictors that we identified for desmopressin-induced factor VIII rise, factor VIII activity and desmopressin-induced rise in von Willebrand factor antigen had the strongest effect.

Published
2018

29. A Lung Injury and Old Platelets: SI23

Author

Middelburg, R., Borkent, B., Jansen, M., van de Watering, L., Wiersum-Osselton, J., Schipperus, M., Beckers, E., Briët, E., and van der Bom, J.

Published
2011

37. Donors with a rare pheno (geno) type

Author

Reesink, H. W., Engelfriet, C. P., Schennach, H., Gassner, C., Wendel, S., Fontão-Wendel, R., de Brito, M. A., Sistonen, P., Matilainen, J., Peyrard, T., Pham, B. N., Rouger, P., Le Pennec, P. Y., Flegel, W. A., von Zabern, I., Lin, C. K., Tsoi, W. C., Hoffer, I., Barotine-Toth, K., Joshi, S. R., Vasantha, K., Yahalom, V., Asher, O., Levene, C., Villa, M. A., Revelli, N., Greppi, N., Marconi, M., Tani, Y., Folman, C. C., de Haas, M., Koopman, M. M. W., Beckers, E., Gounder, D. S., Flanagan, P., Wall, L., Aranburu Urtasun, E., Hustinx, H., Niederhauser, C., Flickinger, C., Nance, S. J., and Meny, G. M.

Published
2008

38. Dosis-Harmonisierung für die Leber-SBRT

Author

Moustakis, Christos, Wilke, L, Chan, Mark, Schmitt, Daniela, Andratschke, Nicolaus, Boda-Heggemann, Judith, Tanadini-Lang, Stephanie, Albers, D, Alraun, M, Bäumer, Christian, Beckers, E, Brunner, Thomas, Dierl, M, Droege, S, Duma, M-N, Ebrahimi Tazeh Maha, F, Eich, H.T.T., Fleckenstein, J, Ganswindt, U, Gauer, Tobias, Gikka, E, Hafner, M., Haverkamp, U, Heinz, C, Henkenberens, C, Köhn, J, Krieger, T, Hennig, A, Kornhuber, C, Loufti-Kraus, Britta, Mayr, M, Pfeiler, Tina, Pollul, G, Ramm, U, Roeder, F, Salz, H, Schmidhalter, D, Schöffler, J, Schubert, K., Ulm, C, Walke, M, Weigel, R, Wiehle, R, Wiezorek, T, Wolf, U, Zimmer, J, Baus, Wolfgang, Guckenberger, Matthias, and Blanck, Oliver

Published
2019

49. A contrast crisis

Author

Beckers, E A M, Strack van Schijndel, R J M, and Weijmer, M C

Published
2000

50. Referenz Planvergleichsstudie für Leber-SBRT – Ergebnisse DEGRO AG/DGMP AK Stereotaxie

Author

Moustakis, Christos, Blanck, Oliver, Andratschke, Nicolaus, Boda-Heggemann, Judith, Wilke, J, Tanadini-Lang, Stephanie, Albers, D, Alraun, M, Bäumer, Christian, Beckers, E, Blaschek, M, Brunner, Thomas, Chan, Mark, Dierl, M, Droege, S, Duma, M-N, Ebrahimi Tazeh Maha, F, Eich, H.T.T., Fleckenstein, J, Ganswindt, U, Garbe, S, Gikka, E, Heinz, C, Henkenberens, C, Hennig, A, Köhn, J, Kornhuber, C, Kretschmer, M, Krieger, T, Loufti-Kraus, Britta, Mayr, M, Mensing, T, Pfeiler, Tina, Pollul, G, Reiken, S, Roeder, F, Schmidthalter, D, Schmitt, Daniela, Schöffler, J, Ulm, C, Baus, Wolfgang, and Guckenberger, Matthias

Published
2018

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