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1. Histopathology DatasetGAN: Synthesizing Large-Resolution Histopathology Datasets

Author

Rizvi, S. A., Cicalese, P., Seshan, S. V., Sciascia, S., Becker, J. U., and Nguyen, H. V.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Self-supervised learning (SSL) methods are enabling an increasing number of deep learning models to be trained on image datasets in domains where labels are difficult to obtain. These methods, however, struggle to scale to the high resolution of medical imaging datasets, where they are critical for achieving good generalization on label-scarce medical image datasets. In this work, we propose the Histopathology DatasetGAN (HDGAN) framework, an extension of the DatasetGAN semi-supervised framework for image generation and segmentation that scales well to large-resolution histopathology images. We make several adaptations from the original framework, including updating the generative backbone, selectively extracting latent features from the generator, and switching to memory-mapped arrays. These changes reduce the memory consumption of the framework, improving its applicability to medical imaging domains. We evaluate HDGAN on a thrombotic microangiopathy high-resolution tile dataset, demonstrating strong performance on the high-resolution image-annotation generation task. We hope that this work enables more application of deep learning models to medical datasets, in addition to encouraging more exploration of self-supervised frameworks within the medical imaging domain., Comment: 5 pages, 2 figures, 1 table. Submitted to IEEE SPMB conference

Published
2022

6. The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell–mediated rejection, antibody‐mediated rejection, and prospects for integrative endpoints for next‐generation clinical trials

Author

Haas, M., Loupy, A., Lefaucheur, C., Roufosse, C., Glotz, D., Seron, D., Nankivell, B. J., Halloran, P. F., Colvin, R. B., Akalin, Enver, Alachkar, N., Bagnasco, S., Bouatou, Y., Becker, J. U., Cornell, L. D., van Huyen, J. P. Duong, Gibson, I. W., Kraus, Edward S., Mannon, R. B., Naesens, M., Nickeleit, V., Nickerson, P., Segev, D. L., Singh, H. K., Stegall, M., Randhawa, P., Racusen, L., Solez, K., and Mengel, M.

Published
2018
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8. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

Author

Loupy, A., Haas, M., Solez, K., Racusen, L., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E. S., Lefaucheur, C., Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A., and Mengel, M.

Published
2017
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17. Intoxikation nach Frostschutzmittelaufnahme

Author

Prinz, J., primary, Böll, B., additional, von Bergwelt-Baildon, M., additional, Burst, V., additional, Becker, J. U., additional, Carvalho-Fiel, D., additional, Shimabukuro-Vornhagen, A., additional, and Kochanek, M., additional

Published
2018
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21. RENAL HISTOPATHOLOGY. IMMUNOTACTOID GLOMEROLUPATHY: A CASE OF MONOCLONAL GAMMAPATHY OF RENAL SIGNIFICANCE

Author

Volgina, G., Gadzhikulieva, M., Uyshuk, N., Kawamura, E., Hisano, S., Nakashima, H., Saito, T., Boor, P., Babi kova, J., Martin, I. V., Bucher, E. B., Eriksson, U., Van Roeyen, C. R. C., Eitner, F., Floege, J., Peutz Kootstra, C. J., Ostendorf, T., Leh, S., Leh, F., Bjanes, T. K., Ohldieck, C., Svarstad, E., Han, B. G., Kim, J. S., Yang, J. W., Choi, S. O., Lollinga, W., Rahbar, A., De Wit, R. H., Riezebos Brilman, A., Soderberg Naucler, C., Van Son, W. J., Sanders, J. S., Smit, M. J., Van Den Born, J., Koike, K., Tsuboi, N., Ikezumi, Y., Go, K., Ogura, M., Saitoh, A., Yokoo, T., Yamaguchi, T., Nokiba, H., Hara, M., Morito, T., Kakihana, K., Ohashi, K., Ando, M., Kimura, T., Yagisawa, T., Nanmoku, K., Kurosawa, A., Sakuma, Y., Miki, A., Nukui, A., Alfieri, C. M., Regalia, A., Simonini, P., Ikehata, M., Chatziantoniou, C., Moroni, G., Rastaldi, M. P., Messa, P., Bockmeyer, C., Sauber lich, K., Zell, S., Zeuschner, P., Agustian, P. A., Wittig, J., Becker, J. U., Peters, B., Andersson, Y., Hadimeri, H., Stegmayr, B., Molne, J., Li, T., He, Y., Chen, H., Chen, J., Kobayashi, A., Mitome, J., Yamamoto, I., Mafune, A., Yamakawa, T., Nakada, Y., Tanno, Y., Ohkido, I., Yamamoto, H., Yokoyama, K., Dervishi, E., Buti, E., Nozzoli, C., Caldini, L. A., Giannakakis, Konstantinos, Minetti, E. E., Cirami, L., Bergesio, F., Ryuge, A., Nomura, A., Shimizu, H., Fujita, Y., Nishi, S., Goto, S., Nakai, K., Ito, J., Fujii, H., Hara, S., Mori, G., Ligabue, G., Cappelli, G., Pinho, A., Moreno, F., Dias, R., Vizcaino, R., Ossareh, S., Asgari, M., Abdi, E., Ataipour, Y., Malakoutian, T., Saddadi, F., and Rayatnia, M.

Published
2014

29. RENAL HISTOPATHOLOGY

Author

Volgina, G., primary, Gadzhikulieva, M., additional, Uyshuk, N., additional, Kawamura, E., additional, Hisano, S., additional, Nakashima, H., additional, Saito, T., additional, Boor, P., additional, Babi kova, J., additional, Martin, I. V., additional, Bucher, E. B., additional, Eriksson, U., additional, Van Roeyen, C. R. C., additional, Eitner, F., additional, Floege, J., additional, Peutz-Kootstra, C. J., additional, Ostendorf, T., additional, Leh, S., additional, Leh, F., additional, Bjanes, T. K., additional, Ohldieck, C., additional, Svarstad, E., additional, Han, B. G., additional, Kim, J. S., additional, Yang, J. W., additional, Choi, S. O., additional, Lollinga, W., additional, Rahbar, A., additional, De Wit, R. H., additional, Riezebos-Brilman, A., additional, Soderberg-Naucler, C., additional, Van Son, W. J., additional, Sanders, J.-S., additional, Smit, M. J., additional, Van Den Born, J., additional, Koike, K., additional, Tsuboi, N., additional, Ikezumi, Y., additional, Go, K., additional, Ogura, M., additional, Saitoh, A., additional, Yokoo, T., additional, Yamaguchi, T., additional, Nokiba, H., additional, Hara, M., additional, Morito, T., additional, Kakihana, K., additional, Ohashi, K., additional, Ando, M., additional, Kimura, T., additional, Yagisawa, T., additional, Nanmoku, K., additional, Kurosawa, A., additional, Sakuma, Y., additional, Miki, A., additional, Nukui, A., additional, Alfieri, C. M., additional, Regalia, A., additional, Simonini, P., additional, Ikehata, M., additional, Chatziantoniou, C., additional, Moroni, G., additional, Rastaldi, M. P., additional, Messa, P., additional, Bockmeyer, C., additional, Sauberlich, K., additional, Zell, S., additional, Zeuschner, P., additional, Agustian, P. A., additional, Wittig, J., additional, Becker, J. U., additional, Peters, B., additional, Andersson, Y., additional, Hadimeri, H., additional, Stegmayr, B., additional, Molne, J., additional, Li, T., additional, He, Y., additional, Chen, H., additional, Chen, J., additional, Kobayashi, A., additional, Mitome, J., additional, Yamamoto, I., additional, Mafune, A., additional, Yamakawa, T., additional, Nakada, Y., additional, Tanno, Y., additional, Ohkido, I., additional, Yamamoto, H., additional, Yokoyama, K., additional, Dervishi, E., additional, Buti, E., additional, Nozzoli, C., additional, Caldini, L. A., additional, Giannakakis, C., additional, Minetti, E. E., additional, Cirami, L., additional, Bergesio, F., additional, Ryuge, A., additional, Nomura, A., additional, Shimizu, H., additional, Fujita, Y., additional, Nishi, S., additional, Goto, S., additional, Nakai, K., additional, Ito, J., additional, Fujii, H., additional, Hara, S., additional, Mori, G., additional, Ligabue, G., additional, Cappelli, G., additional, Pinho, A., additional, Moreno, F., additional, Dias, R., additional, Vizcaino, R., additional, Ossareh, S., additional, Asgari, M., additional, Abdi, E., additional, Ataipour, Y., additional, Malakoutian, T., additional, Saddadi, F., additional, and Rayatnia, M., additional

Published
2014
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31. Beyond C4d: the ultrastructural appearances of endothelium in ABO-incompatible renal allografts

Author

Brocker, V., primary, Pfaffenbach, A., additional, Habicht, A., additional, Chatzikyrkou, C., additional, Kreipe, H. H., additional, Haller, H., additional, Scheffner, I., additional, Gwinner, W., additional, Zilian, E., additional, Immenschuh, S., additional, Schwarz, A., additional, Horn, P. A., additional, Heinemann, F. M., additional, and Becker, J. U., additional

Published
2013
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32. Renal vasculitis

Author

Manenti, L., primary, Signorini, L., additional, Gnappi, E., additional, Pilato, F. P., additional, Vaglio, A., additional, Allegri, L., additional, Buzio, C., additional, Bertram, A., additional, Lovric, S., additional, Park, J.-K., additional, Becker, J. U., additional, Haubitz, M., additional, Kirsch, T., additional, Jancova, E., additional, Hruskova, Z., additional, Lanska, V., additional, Sedova, L., additional, Olsanska, R., additional, Jilek, D., additional, Nemejc, P., additional, Tesar, V., additional, Maritati, F., additional, Urban, M., additional, Oliva, E., additional, Alberici, F., additional, Smith, R., additional, Jones, R., additional, Jayne, D., additional, Chocova, Z., additional, Mareckova, H., additional, Svobodova, B., additional, Bednarova, V., additional, and Rysava, R., additional

Published
2013
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33. Experimental models of CKD

Author

Kanlaya, R., primary, Sintiprungrat, K., additional, Thongboonkerd, V., additional, Torremade, N., additional, Bindels, R., additional, Hoenderop, J., additional, Fernandez, E., additional, Dusso, A., additional, Valdivielso, J. M., additional, Krueger, T., additional, Boor, P., additional, Schafer, C., additional, Westenfeld, R., additional, Brandenburg, V., additional, Schlieper, G., additional, Jahnen-Dechent, W., additional, Ketteler, M., additional, Jee, W., additional, Li, X., additional, Richards, B., additional, Floege, J., additional, Goncalves, J. G., additional, Canale, D., additional, de Braganca, A. C., additional, Shimizu, M. H. M., additional, Moyses, R. M. A., additional, Andrade, L., additional, Seguro, A. C., additional, Volpini, R. A., additional, Romoli, S., additional, Migliorini, A., additional, Anders, H.-J., additional, Eskova, O., additional, Neprintseva, N., additional, Tchebotareva, N., additional, Bobkova, I., additional, Kozlovskaya, L., additional, Simic, I., additional, Tabatabaeifar, M., additional, Wlodkowski, T., additional, Denc, H., additional, Mollet, G., additional, Antignac, C., additional, Schaefer, F., additional, Ekaterina, I. A., additional, Giardino, L., additional, Rastaldi, M. P., additional, Van den Heuvel, L., additional, Levtchenko, E., additional, Okina, C., additional, Okamoto, T., additional, Kamata, M., additional, Murano, J., additional, Kobayashi, K., additional, Takeuchi, K., additional, Kamata, F., additional, Sakai, T., additional, Naito, S., additional, Aoyama, T., additional, Sano, T., additional, Takeuchi, Y., additional, Kamata, K., additional, Thomasova, D., additional, Bruns, H. A., additional, Liapis, H., additional, Iwashita, T., additional, Hasegawa, H., additional, Takayanagi, K., additional, Shimizu, T., additional, Asakura, J., additional, Okazaki, S., additional, Kogure, Y., additional, Hatano, M., additional, Hara, H., additional, Inamura, M., additional, Iwanaga, M., additional, Mitani, T., additional, Mitarai, T., additional, Savin, V. J., additional, Sharma, M., additional, Wei, C., additional, Reiser, J., additional, McCarthy, E. T., additional, Sharma, R., additional, Gauchat, J.-F., additional, Eneman, B., additional, Freson, K., additional, Van Geet, C., additional, Choi, D. E., additional, Jeong, J. Y., additional, Chang, Y. K., additional, Na, K.-R., additional, Lee, K. W., additional, Shin, Y. T., additional, Ni, H.-F., additional, Chen, J.-F., additional, Zhang, M.-H., additional, Pan, M.-M., additional, Liu, B.-C., additional, Kim, S. S., additional, Suzuki, T., additional, Iyoda, M., additional, Matsumoto, K., additional, Shindo-Hirai, Y., additional, Kuno, Y., additional, Wada, Y., additional, Yamamoto, Y., additional, Shibata, T., additional, Akizawa, T., additional, Munoz-Felix, J. M., additional, Lopez-Novoa, J. M., additional, Martinez-Salgado, C., additional, Ehling, J., additional, Babickova, J., additional, Gremse, F., additional, Kiessling, F., additional, Lammers, T., additional, Lech, M., additional, Gunthner, R., additional, Lorenz, G., additional, Ryu, M., additional, Grobmayr, R., additional, Susanti, H., additional, Kobayashi, K. S., additional, Flavell, R. A., additional, Rayego-Mateos, S., additional, Morgado, J., additional, Sanz, A. B., additional, Eguchi, S., additional, Pato, J., additional, Keri, G., additional, Egido, J., additional, Ortiz, A., additional, Ruiz-Ortega, M., additional, Leduc, M., additional, Geerts, L., additional, Grouix, B., additional, Sarra-Bournet, F., additional, Felton, A., additional, Gervais, L., additional, Abbott, S., additional, Duceppe, J.-S., additional, Zacharie, B., additional, Penney, C., additional, Laurin, P., additional, Gagnon, L., additional, Detsika, M. G., additional, Duann, P., additional, Lianos, E. A., additional, Leong, K. I., additional, Chiang, C.-K., additional, Yang, C.-C., additional, Wu, C.-T., additional, Chen, L.-P., additional, Hung, K.-Y., additional, Liu, S.-H., additional, Carvalho, F. F., additional, Teixeira, V. P., additional, Almeida, W. S., additional, Schor, N., additional, Small, D. M., additional, Bennett, N. C., additional, Coombes, J., additional, Johnson, D. W., additional, Gobe, G. C., additional, Montero, N., additional, Prada, A., additional, Riera, M., additional, Orfila, M., additional, Pascual, J., additional, Rodriguez, E., additional, Barrios, C., additional, Kokeny, G., additional, Fazekas, K., additional, Rosivall, L., additional, Mozes, M. M., additional, Hornigold, N., additional, Hughes, J., additional, Mooney, A., additional, Benardeau, A., additional, Riboulet, W., additional, Vandjour, A., additional, Jacobsen, B., additional, Apfel, C., additional, Conde-Knape, K., additional, Bienvenu, J.-F., additional, Tanaka, T., additional, Yamaguchi, J., additional, Nangaku, M., additional, Niwa, T., additional, Bolati, D., additional, Shimizu, H., additional, Yisireyili, M., additional, Nishijima, F., additional, Brocca, A., additional, Virzi, G., additional, de Cal, M., additional, Ronco, C., additional, Priante, G., additional, Musacchio, E., additional, Valvason, C., additional, Sartori, L., additional, Piccoli, A., additional, Baggio, B., additional, Perkuhn, M., additional, Weibrecht, M., additional, Zok, S., additional, Martin, I. V., additional, Schoth, F., additional, Ostendorf, T., additional, Kuhl, C., additional, Karabaeva, A., additional, Essaian, A., additional, Beresneva, O., additional, Parastaeva, M., additional, Kayukov, I., additional, Smirnov, A., additional, Audzeyenka, I., additional, Kasztan, M., additional, Piwkowska, A., additional, Rogacka, D., additional, Angielski, S., additional, Jankowski, M., additional, Bockmeyer, C. L., additional, Kokowicz, K., additional, Agustian, P. A., additional, Zell, S., additional, Wittig, J., additional, Becker, J. U., additional, Nishizono, R., additional, Venkatareddy, M. P., additional, Chowdhury, M. A., additional, Wang, S. Q., additional, Fukuda, A., additional, Wickman, L. T., additional, Yang, Y., additional, Wiggins, R. C., additional, Fazio, M. R., additional, Donato, V., additional, Lucisano, S., additional, Cernaro, V., additional, Lupica, R., additional, Trimboli, D., additional, Montalto, G., additional, Aloisi, C., additional, Mazzeo, A. T., additional, Buemi, M., additional, Gawrys, O., additional, Olszynski, K. H., additional, Kuczeriszka, M., additional, Gawarecka, K., additional, Swiezewska, E., additional, Chmielewski, M., additional, Masnyk, M., additional, Rafalowska, J., additional, Kompanowska-Jezierska, E., additional, Lee, W.-C., additional, Chau, Y.-Y., additional, Lee, L.-C., additional, Chiu, C.-H., additional, Lee, C.-T., additional, Chen, J.-B., additional, Kim, W.-K., additional, and Shin, S. J., additional

Published
2013
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35. Histology and mRNA Expression: Insights Into the Pathophysiology of Thrombus Formation and Glomerular Remodeling in Thrombotic Microangiopathy in Renal Transplants

Author

Bockmeyer, C. L., primary, Agustian, P. A., additional, Dämmrich, M. E., additional, Suwelack, B., additional, Wittig, J., additional, Ahlenstiel, T., additional, Immenschuh, S., additional, Jindra, P. T., additional, Schwarz, A., additional, Vester, U., additional, Heinemann, F. M., additional, Feldkamp, T., additional, and Becker, J. U., additional

Published
2012
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37. Transplantation - basic

Author

Adamczak, M., primary, Koleganova, N., additional, Nyengaard, J. R., additional, Ritz, E., additional, Wiecek, A., additional, Slabiak Blaz, N., additional, Yi Chun, D. X., additional, Alexandre, H., additional, Sandrine, G.-S., additional, Olivier, T., additional, Isabelle, E., additional, Christophe, L., additional, Guy, T., additional, Pierre Francois, W., additional, Jean-Philippe, R., additional, Yvon, L., additional, Eric, R., additional, Muller-Krebs, S., additional, Weber, L., additional, Tsobaneli, J., additional, Reiser, J., additional, Zeier, M., additional, Schwenger, V., additional, Tinel, C., additional, Samson, M., additional, Bonnotte, B., additional, Mousson, C., additional, Machcinska, M., additional, Bocian, K., additional, Wyzgal, M., additional, Korczak-Kowalska, G., additional, Ju, M. K., additional, Huh, K. H., additional, Park, K. T., additional, Kim, S. J., additional, Cho, B. H., additional, Kim, C. D., additional, So, B. J., additional, Leee, S., additional, Kang, C. M., additional, Joo, D. J., additional, Kim, Y. S., additional, Zarzycki, M., additional, Sobich, A., additional, Matsuyama, M., additional, Hase, T., additional, Yoshimura, R., additional, Koshino, K., additional, Sakai, K., additional, Suzuki, T., additional, Nobori, S., additional, Ushigome, H., additional, Brikci-Nigassa, L., additional, Chargui, J., additional, Touraine, J.-L., additional, Yoshimura, N., additional, Cantaluppi, V., additional, Medica, D., additional, Figliolini, F., additional, Migliori, M., additional, Mannari, C., additional, Dellepiane, S., additional, Quercia, A. D., additional, Randone, O., additional, Tamagnone, M., additional, Messina, M., additional, Manzione, A. M., additional, Ranghino, A., additional, Biancone, L., additional, Segoloni, G. P., additional, Camussi, G., additional, Turk, T. R., additional, Zou, X., additional, Rauen, U., additional, De Groot, H., additional, Amann, K., additional, Kribben, A., additional, Eckardt, K.-U., additional, Bernhardt, W. M., additional, Witzke, O., additional, Lidia, G., additional, Wouter, C., additional, Eric, A., additional, Yann, L. M., additional, Christian, N., additional, Marie, E., additional, Pierre, M., additional, Zineb, A., additional, Miriana, D., additional, Annick, M., additional, Marc, A., additional, Daniel, A., additional, Wornle, M., additional, Ribeiro, A., additional, Motamedi, N., additional, Grone, H. J., additional, Cohen, C. D., additional, Schlondorff, D., additional, Schmid, H., additional, Teplan, V., additional, Banas, M., additional, Banas, B., additional, Steege, A., additional, Bergler, T., additional, Kruger, B., additional, Schnulle, P., additional, Yard, B., additional, Kramer, B. K., additional, Hoger, S., additional, Xavier, M. P., additional, Sampaio-Norton, S., additional, Gaiao, S., additional, Alves, H., additional, Oliveira, G., additional, Zaza, G., additional, Rascio, F., additional, Pontrelli, P., additional, Granata, S., additional, Rugiu, C., additional, Grandaliano, G., additional, Lupo, A., additional, Wohlfahrtova, M., additional, Brabcova, I., additional, Balaz, P., additional, Janousek, L., additional, Lodererova, A., additional, Honsova, E., additional, Wohlfahrt, P., additional, Viklicky, O., additional, Grabner, A., additional, Kentrup, D., additional, Edemir, B., additional, Sirin, Y., additional, Pavenstadt, H., additional, Schober, O., additional, Schlatter, E., additional, Schafers, M., additional, Schnockel, U., additional, Reuter, S., additional, Accetturo, M., additional, Gigante, M., additional, Tataranni, T., additional, Zito, A., additional, Schena, A., additional, Schena, F. P., additional, Stallone, G., additional, Gesualdo, L., additional, Maillard, N., additional, Masson, I., additional, Lena, A., additional, Manolie, M., additional, Christophe, M., additional, Lassen, C. K., additional, Keller, A. K., additional, Moldrup, U., additional, Bibby, B. M., additional, Jespersen, B., additional, Cvetkovic, T., additional, Velickovic Radovanovic, R., additional, Pavlovic, R., additional, Djordjevic, V., additional, Vlahovic, P., additional, Stefanovic, N., additional, Sladojevic, N., additional, Ignjatovic, A., additional, Rong, S., additional, Menne, J., additional, Haller, H., additional, Suszdak, P., additional, Tomczuk, P., additional, Gueler, F., additional, Nelli, S., additional, Sara, D., additional, Salma, E. K., additional, Naoufal, M., additional, Tarik, M., additional, Mohamed, Z., additional, Guislaine, M., additional, Mohamed Gharbi, B., additional, Benyounes, R., additional, Lu, X., additional, Shushakova, N., additional, Kirsch, T., additional, Bockmeyer, C. L., additional, Ramackers, W., additional, Wittig, J., additional, Agustian, P. A., additional, Klose, J., additional, Dammrich, M. E., additional, Kreipe, H., additional, Brocker, V., additional, Winkler, M., additional, and Becker, J. U., additional

Published
2012
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38. Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis

Author

Bockmeyer, C. L., primary, Kern, D. S., additional, Forstmeier, V., additional, Lovric, S., additional, Modde, F., additional, Agustian, P. A., additional, Steffens, S., additional, Birschmann, I., additional, Traeder, J., additional, Dammrich, M. E., additional, Schwarz, A., additional, Kreipe, H. H., additional, Brocker, V., additional, and Becker, J. U., additional

Published
2012
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39. Combination of everolimus with calcineurin inhibitor medication resulted in post-transplant haemolytic uraemic syndrome in lung transplant recipients--a case series

Author

Lovric, S., primary, Kielstein, J. T., additional, Kayser, D., additional, Brocker, V., additional, Becker, J. U., additional, Hiss, M., additional, Schiffer, M., additional, Sommerwerck, U., additional, Haller, H., additional, Struber, M., additional, Welte, T., additional, and Gottlieb, J., additional

Published
2011
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40. ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis

Author

Bockmeyer, C. L., primary, Forstmeier, V., additional, Modde, F., additional, Lovric, S., additional, Claus, R. A., additional, Schiffer, M., additional, Agustian, P. A., additional, Grothusen, C., additional, Grote, K., additional, Birschmann, I., additional, Theophile, K., additional, Kreipe, H. H., additional, Brocker, V., additional, and Becker, J. U., additional

Published
2010
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42. Reply

Author

Clajus, C., primary, Becker, J. U., additional, Stichtenoth, D. O., additional, Wortmann, J., additional, Schwarz, A., additional, and Kielstein, J. T., additional

Published
2008
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44. Banff Borderline Changes Suspicious for Acute T Cell–Mediated Rejection: Where Do We Stand?

Author

Becker, J. U., Chang, A., Nickeleit, V., Randhawa, P., and Roufosse, C.

Abstract

The definition of Banff Borderline became ambiguous when the Banff 2005 consensus modified the lower threshold from i1t1 (10–25% interstitial inflammation with mild tubulitis) to i0t1 (0–10% interstitial inflammation with mild tubulitis). We conducted a worldwide survey among members of the Renal Pathology Society about their approach to this diagnostic category. A web‐based survey was sent out to all 503 current members (153 respondents). A database search yielded which threshold for Banff i was applied in the most influential manuscripts about Borderline. Among the 139 nephropathologists using the Borderline category, 67% use the Banff 1997 definition, requiring Banff i1. Thirty‐seven percent admitted to sometimes exaggerating Banff i in the presence of tubulitis, to reach a diagnosis of Borderline. Forty‐eight percent were dissatisfied with the definition of Borderline. The majority of the most influential manuscripts used the 1997 definition, contrary to the current one. There is considerable dissatisfaction with Borderline, and practice in Banff i thresholds is variable. Until additional studies inform a revision, we suggest leaving it to each pathologist's discretion whether to use i0 or i1 as the minimal threshold. In order to avoid future ambiguity, a web‐based synopsis of all scattered current Banff definitions and rules should be created. The authors investigate the approach to the diagnosis of Banff borderline acute T cell–mediated rejection and find that most nephropathologists do not adhere to current Banff guidelines, but still use the old minimal threshold for tubulointerstitial infiltrates.

Published
2016
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45. eEOC-mediated modulation of endothelial autophagy, senescence, and EnMT in murine diabetic nephropathy.

Author

Patschan, D., Schwarze, K., Henze, E., Becker, J. U., Patschan, S., and Müller, G. A.

Subjects
DIABETIC nephropathies, AUTOPHAGY, CELLULAR aging, KIDNEY diseases, APOPTOSIS, STREPTOZOTOCIN, THERAPEUTICS
Abstract

Diabetic nephropathy is the most frequent single cause of end-stage renal disease in our society. Microvascular damage is a key event in diabetes-associated organ malfunction. Early endothelial outgrowth cells (eEOCs) act protective in murine acute kidney injury. The aim of the present study was to analyze consequences of eEOC treatment of murine diabetic nephropathy with special attention on endothelial-to-mesenchymal transdifferentiation, autophagy, senescence, and apoptosis. Male C57/Bl6N mice (8-12 wk old) were treated with streptozotocin for 5 consecutive days. Animals were injected with untreated or bone morphogenetic protein (BMP)-5-pretreated syngeneic murine eEOCs on days 2 and 5 after the last streptozotocin administration. Four, eight, and twelve weeks later, animals were analyzed for renal function, proteinuria, interstitial fibrosis, endothelial-to-mesenchymal transition, endothelial autophagy, and senescence. In addition, cultured mature murine endothelial cells were investigated for autophagy, senescence, and apoptosis in the presence of glycated collagen. Diabetes-associated renal dysfunction (4 and 8 wk) and proteinuria (8 wk) were partly preserved by systemic cell treatment. At 8 wk, antiproteinuric effects were even more pronounced after the injection of BMP-5-pretreated cells. The latter also decreased mesenchymal transdifferentiation of the endothelium. At 8 wk, intrarenal endothelial autophagy (BMP-5- treated cells) and senescence (native and BMP-5-treated cells) were reduced. Autophagy and senescence in/of cultured mature endothelial cells were dramatically reduced by eEOC supernatant (native and BMP-5). Endothelial apoptosis decreased after incubation with eEOC medium (native and BMP-5). eEOCs act protective in diabetic nephropathy, and such effects are significantly stimulated by BMP-5. The cells modulate endothelial senescence, autophagy, and apoptosis in a protective manner. Thus, the renal endothelium could serve as a therapeutic target in diabetes-associated kidney dysfunction. [ABSTRACT FROM AUTHOR]

Published
2014
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46. The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

Author

Loupy, A., Haas, M., Solez, K., Racusen, L., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E. S., Lefaucheur, C., Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A., and Mengel, M.

Subjects
Meeting Report, clinical research/practice, translational research/science, kidney transplantation/nephrology, pathology/histopathology, organ transplantation in general, rejection, rejection: antibody‐mediated (, rejection: subclinical, rejection: T cell mediated (
Abstract

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d‐negative antibody‐mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor‐specific antibody tests (anti‐HLA and non‐HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i‐IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell–mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus‐based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next‐generation clinical trials.

Published
2016
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47. The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury.

Author

Patschan, D., Hildebrandt, A., Rinneburger, J., Wessels, J. T., Patschan, S., Becker, J. U., Henze, E., Krüger, A., and Müller, G. A.

Abstract

Endothelial progenitor cells (EPCs) protect the kidney from acute ischemic injury. The aim of this study was to analyze whether pretreatment of murine "early outgrowth" EPCs (eEPCs) with the hormone melatonin increases the cells' renoprotective effects in the setting of murine acute ischemic renal failure. Male (8-12 wk old) C57Bl/6N mice were subjected to unilateral ischemia-reperfusion injury postuninephrectomy (40 min). Postischemic animals were injected with either 0.5×106 untreated syngeneic murine eEPCs or with cells, pretreated with melatonin for 1 h. Injections were performed shortly after reperfusion of the kidney. While animals injected with untreated cells developed acute renal failure, eEPC pretreatment with melatonin dramatically improved renoprotective actions of the cells. These effects were completely reversed after cell pretreatment with melatonin and the MT-1/-2 antagonist luzindole. In vitro analysis revealed that melatonin reduced the amount of tumor growth factor-β-induced eEPC apoptosis/necrosis. Secretion of vascular endothelial growth factor by the cells was markedly stimulated by the hormone. In addition, migratory activity of eEPCs was enhanced by melatonin and supernatant from melatonin-treated eEPCs stimulated migration of cultured mature endothelial cells. In summary, melatonin was identified as a new agonist of eEPCs in acute ischemic kidney injury. [ABSTRACT FROM AUTHOR]

Published
2012
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48. Epac-1 activator 8-O-cAMP augments renoprotective effects of allogeneic murine EPCs in acute ischemic kidney injury.

Author

Patschan, D., Patschan, S., Wessels, J. T., Becker, J. U., David, S., Henze, E., Goligorsky, M. S., and Muller, G. A.

Subjects
TREATMENT of acute kidney failure, CYCLIC adenylic acid, INTEGRINS, CELL membranes, KIDNEY diseases
Abstract

Endothelial progenitor cells (EPCs) protect kidneys from acute ischemic damage. The aim of this study was to identify "treatment parameters" that optimize an EPC-based therapy of acute ischemic renal failure. Male C57BL/6N mice underwent unilateral nephrectomy with simultaneous contralateral renal artery clamping for 30, 35, and 40 mm. Tagged murine EPCs were systemically injected at the time of reperfusion. In some experiments, EPCs were pretreated with the Epac (exchange protein directly activated by cAMP-1) activator 8-pCPT-2'-O-Me-cAMP (Epac-1 Ac) and the integrin binding antagonist cyclic Arg-Gly-Asp peptide (cRGD). Injections of 106 EPCs after 30 and 35 mm of renal ischemia protected animals from acute renal failure. The same effect occurred with 0.5 x 106 EPCs after a 35-mm period of ischemia. If ischemia lasted for 40 mi 0.5 x 106 cells mice did not prevent acute renal failure. To analyze whether EPC integrin receptor activation would modify the cells' renoprotective activity, EPCs were pretreated with Epac-1 Ac. Such animals did not develop acute renal failure, even if ischemia lasted for 40 mm. This effect was negated if the cells were pretreated with both EpacI Ac and cRGD. In kidneys from those animals medullopapillary EPCs were significantly accumulated. In vitro Epac-1 Ac preactivation of EPCs did not increase the overall expression intensity but induced a redistribution of β1-integrins toward the cell membranes. We conclude that EPC pretreatment with the integrin receptor activator 8-pCPT-2'-O-Me-cAMP augments the anti-ischemic potential of the cells. [ABSTRACT FROM AUTHOR]

Published
2010
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49. Immigrating progenitor cells contribute to human podocyte turnover.

Author

Becker, J. U., Hoerning, A., Schmid, K. W., and Hoyer, P. F.

Subjects
*CLINICAL pathology, *IMMUNOCYTOCHEMISTRY, *IN situ hybridization, *FLUORESCENCE in situ hybridization, *URINARY organs, *NEPHROBLASTOMA
Abstract

Podocyte depletion is a critical event in glomerular diseases in general and in the development of focal segmental glomerulosclerosis in particular. Progenitor cell immigration is a possible mechanism of podocyte replacement for the preservation of nephron function since, with rare exception, mature podocytes are thought to be incapable of replication. We examined eight paraffin-embedded renal biopsies from six male recipients of female transplant kidneys for receiver-derived podocytes. Fluorescent in situ hybridization for the Y chromosome was combined with immunofluorescence for the podocyte marker, Wilms tumor-1 antigen. Recipient-derived podocytes were found in 4 of 8 biopsies representing 3 of the 6 patients. Overall, 5 of the 740 podocytes examined in the female-donated kidneys were male derived. Our study suggests that immigrating progenitor cells are able to replace podocytes in humans; however, the importance of this process in physiologic and pathologic conditions is unknown.Kidney International (2007) 72, 1468–1473; doi:10.1038/sj.ki.5002524; published online 26 September 2007 [ABSTRACT FROM AUTHOR]

Published
2007
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50. Metabolite Concentrations and Phase Relations in D-Fructose Induced Glycolytic Oscillations.

Author

BETZ, A. and BECKER, J.-U.

Subjects
*METABOLITES, *FRUCTOSE, *YEAST, *ANAEROBIOSIS, *CELLS, *PLANTS
Abstract

The frequency of glycolytic oscillations in yeast cells is only slightly modified by the consumption rate of either glucose or fructose, but it is reduced to 1/2 to 2/3 if the ketohexose is the only substrate. Phase relations between NADH, adenine nucleotides and sugar phosphates (O-6-P, F-6-P, FDP, DAP) are independent of the hexose fermented. With fructose as a substrate the amplitudes of adenylates and hexose phosphates are distinctly smaller than with glucose. The maximum of G-6-P is higher with glucose and the minimum concentration of FDP is higher with fructose. in the transition to anaerobiosis FDP, adenosine 5'-diphosphate and adenosine 5'-phosphate are extremely high, whereas G-6-P, F-6-P and. ATP concentrations are lower if fructose is the substrate fermented. The results are indicative for different control characteristics of the phosphofructokinase step,. but on their basis it cannot be distinguished between a direct interaction of fructose (or one of its derivatives) on the phosphofructokinase kinetics or the existence of a bypass for fructose which might be able to withdraw a part of the substrate from. the control point at the phospho-fructokinase. [ABSTRACT FROM AUTHOR]

Published
1975
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