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8. Wnt/β-Catenin–Activated Nonpilomatrical Carcinoma of the Skin: A Case Series

Author

Kervarrec, Thibault, Cheok Lei, Kuan, Sohier, Pierre, Macagno, Nicolas, Jullie, Marie-Laure, Frouin, Eric, Goto, Keisuke, Taniguchi, Kohei, Hamard, Aymeric, Taillandier, Antoine, Tallet, Anne, Collin, Christine, Sahin, Yusuf, Barry, Fatoumata, Taibjee, Saleem, Cokelaere, Kristof, Houben, Roland, Schrama, David, Nardin, Charline, Aubin, Francois, Doucet, Laurent, Pissaloux, Daniel, Tirode, Franck, Fouchardière, Arnaud de la, Balme, Brigitte, Laurent-Roussel, Sara, Becker, Jürgen C., von Deimling, Andreas, Samimi, Mahtab, Cribier, Bernard, Battistella, Maxime, Calonje, Eduardo, and Guyétan, Serge

Published
2024
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11. Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma – analysis of the DeCOG prospective multicenter cohort study ADOREG/TRIM

Author

Placke, Jan-Malte, Kimmig, Mona, Griewank, Klaus, Herbst, Rudolf, Terheyden, Patrick, Utikal, Jochen, Pföhler, Claudia, Ulrich, Jens, Kreuter, Alexander, Mohr, Peter, Gutzmer, Ralf, Meier, Friedegund, Dippel, Edgar, Welzel, Julia, Engel, Daniel Robert, Kreft, Sophia, Sucker, Antje, Lodde, Georg, Krefting, Frederik, Stoffels, Ingo, Klode, Joachim, Roesch, Alexander, Zimmer, Lisa, Livingstone, Elisabeth, Hadaschik, Eva, Becker, Jürgen C., Weichenthal, Michael, Tasdogan, Alpaslan, Schadendorf, Dirk, and Ugurel, Selma

Published
2023
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12. Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial

Author

van Akkooi, Alexander, van Houdt, Winan, Wilhelm, Tabea, Farmer, Kimberley, Ulrich, Claas, Gambichler, Thilo, Bluhm, Leonie, Schinagl, Heidemarie, Kellner, Ivonne, Herbst, Rudolf, Meiß, Frank, Rafei-Shamsabadi, David, Sell, Sabine, Kaatz, Martin, Wulfken, Lena, Hartmann, Martin, Kähler, Katharina, Ziemer, Mirjana, Simon, Jan, Terheyden, Patrick, Thaci, Diamant, Loquai, Carmen, Mitzel-Rink, Heidrun, Grabbe, Stephan, Stege, Henner, Gaiser, Maria, Utikal, Jochen, Berking, Carola, Heinzerling, Lucie, Schlaak, Max, Tomsitz, Dirk, Dyballa, Jörg, Magnolo, Nina, Weishaupt, Carsten, Berneburg, Mark, Garbe, Claus, Flatz, Lukas, Gesierich, Anja, Schilling, Bastian, Becker, Jürgen C, Ugurel, Selma, Leiter, Ulrike, Meier, Friedegund, Gutzmer, Ralf, Haferkamp, Sebastian, Zimmer, Lisa, Livingstone, Elisabeth, Eigentler, Thomas K, Hauschild, Axel, Kiecker, Felix, Hassel, Jessica C, Mohr, Peter, Fluck, Michael, Thomas, Ioannis, Garzarolli, Marlene, Grimmelmann, Imke, Drexler, Konstantin, Spillner, Alexandra N, Eckhardt, Sebastian, and Schadendorf, Dirk

Published
2023
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14. Identification of Epigenetically Regulated Genes Distinguishing Intracranial from Extracranial Melanoma Metastases

Author

Westphal, Dana, Meinhardt, Matthias, Grützmann, Konrad, Schöne, Lisa, Steininger, Julian, Neuhaus, Lena T., Wiegel, Miriam, Schrimpf, Daniel, Aust, Daniela E., Schröck, Evelin, Baretton, Gustavo B., Beissert, Stefan, Juratli, Tareq A., Schackert, Gabriele G., Gravemeyer, Jan, Becker, Jürgen C., von Deimling, Andreas, Koelsche, Christian, Klink, Barbara, Meier, Friedegund, Schulz, Alexander, Muders, Michael H., and Seifert, Michael

Published
2023
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15. Characterisation and outcome of RAC1 mutated melanoma

Author

Lodde, Georg C., Jansen, Philipp, Herbst, Rudolf, Terheyden, Patrick, Utikal, Jochen, Pföhler, Claudia, Ulrich, Jens, Kreuter, Alexander, Mohr, Peter, Gutzmer, Ralf, Meier, Friedegund, Dippel, Edgar, Weichenthal, Michael, Sucker, Antje, Placke, Jan-Malte, Zaremba, Anne, Albrecht, Lea Jessica, Kowall, Bernd, Galetzka, Wolfgang, Becker, Jürgen C., Tasdogan, Alpaslan, Zimmer, Lisa, Livingstone, Elisabeth, Hadaschik, Eva, Schadendorf, Dirk, Ugurel, Selma, and Griewank, Klaus

Published
2023
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16. Cutaneous Aspects of Leukemia

Author

Ugurel, Selma, Becker, Jürgen C., Kaufmann, Roland, Section editor, Plewig, Gerd, editor, French, Lars, editor, Ruzicka, Thomas, editor, Kaufmann, Roland, editor, and Hertl, Michael, editor

Published
2022
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17. Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma

Author

Gluud, Maria, Pallesen, Emil M. H., Buus, Terkild B., Gjerdrum, Lise Mette Rahbek, Lindahl, Lise M., Kamstrup, Maria R., Bzorek, Michael, Danielsen, Maria, Bech, Rikke, Monteiro, Madalena N., Blümel, Edda, Willerslev-Olsen, Andreas, Lykkebo-Valløe, Anders, Vadivel, Chella Krishna, Krejsgaard, Thorbjørn, Bonefeld, Charlotte Menne, Geisler, Carsten, Becker, Jürgen C., Koralov, Sergei B., Iversen, Lars, Litman, Thomas, Woetmann, Anders, and Ødum, Niels

Published
2023
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18. German S3 guideline “actinic keratosis and cutaneous squamous cell carcinoma” – Long version of the update 2023

Author

Leiter, Ulrike, Heppt, Markus V., Steeb, Theresa, Alter, Mareike, Amaral, Teresa, Bauer, Andrea, Bechara, Falk G., Becker, Jürgen C., Breitbart, Eckhard W., Breuninger, Helmut, Diepgen, Thomas, Dirschka, Thomas, Eigentler, Thomas, El Gammal, A.K. Stephan, Felcht, Moritz, Flaig, Michael J., Follmann, Markus, Fritz, Klaus, Grabbe, Stephan, Greinert, Rüdiger, Gutzmer, Ralf, Hauschild, Axel, Hillen, Uwe, Ihrler, Stephan, John, Swen Malte, Kofler, Lukas, Koelbl, Oliver, Krause-Bergmann, Albrecht, Kraywinkel, Klaus, Krohn, Steffen, Langer, Thomas, Loquai, Carmen, Löser, Christoph R., Mohr, Peter, Nashan, Dorothée, Nothacker, Monika, Pfannenberg, Christina, Salavastru, Carmen, Schmitz, Lutz, Stockfleth, Eggert, Szeimies, Rolf-Markus, Ulrich, Claas, Voelter-Mahlknecht, Susanne, Vordermark, Dirk, Weichenthal, Michael, Welzel, Julia, Wermker, Kai, Wiegand, Susanne, Garbe, Claus, and Berking, Carola

Published
2023
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20. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases

Author

Kervarrec, Thibault, primary, Westphal, Danna, additional, Pissaloux, Daniel, additional, Legrand, Mélanie, additional, Tirode, Franck, additional, Neuhart, Anne, additional, Drouot, Francoise, additional, Becker, Jürgen C, additional, Macagno, Nicolas, additional, Seris, Alice, additional, Jouary, Thomas, additional, Beltzung, Fanny, additional, Jullie, Marie‐Laure, additional, Harms, Paul W, additional, Cribier, Bernard, additional, Mourah, Samia, additional, Jouenne, Fanélie, additional, Fromont, Gaelle, additional, Louveau, Baptiste, additional, Mancini, Maxence, additional, Kazakov, Dmitry V, additional, de la Fouchardière, Arnaud, additional, and Battistella, Maxime, additional

Published
2024
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21. A Prospective Study Investigating Immune Checkpoint Molecule and CD39 Expression on Peripheral Blood Cells for the Prognostication of COVID-19 Severity and Mortality

Author

Gambichler, Thilo, primary, Rüth, Jonas, additional, Goesmann, Silke, additional, Höxtermann, Stefan, additional, Skrygan, Marina, additional, Susok, Laura, additional, Becker, Jürgen C., additional, Overheu, Oliver, additional, Schmidt, Wolfgang, additional, and Reinacher-Schick, Anke, additional

Published
2024
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23. S1‐Leitlinie Talgdrüsenkarzinom

Author

Utikal, Jochen, primary, Nagel, Pia, additional, Müller, Verena, additional, Becker, Jürgen C., additional, Dippel, Edgar, additional, Frisman, Alexander, additional, Gschnell, Martin, additional, Griewank, Klaus, additional, Hadaschik, Eva, additional, Helbig, Doris, additional, Hillen, Uwe, additional, Leiter, Ulrike, additional, Pföhler, Claudia, additional, Krönig, Lisa, additional, Ziemer, Mirjana, additional, and Ugurel, Selma, additional

Published
2024
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24. Persister state-directed transitioning and vulnerability in melanoma

Author

Chauvistré, Heike, Shannan, Batool, Daignault-Mill, Sheena M., Ju, Robert J., Picard, Daniel, Egetemaier, Stefanie, Váraljai, Renáta, Gibhardt, Christine S., Sechi, Antonio, Kaschani, Farnusch, Keminer, Oliver, Stehbens, Samantha J., Liu, Qin, Yin, Xiangfan, Jeyakumar, Kirujan, Vogel, Felix C. E., Krepler, Clemens, Rebecca, Vito W., Kubat, Linda, Lueong, Smiths S., Forster, Jan, Horn, Susanne, Remke, Marc, Ehrmann, Michael, Paschen, Annette, Becker, Jürgen C., Helfrich, Iris, Rauh, Daniel, Kaiser, Markus, Gul, Sheraz, Herlyn, Meenhard, Bogeski, Ivan, Rodríguez-López, José Neptuno, Haass, Nikolas K., Schadendorf, Dirk, and Roesch, Alexander

Published
2022
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25. Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): final results of a randomised, double-blind, phase 2 trial

Author

Livingstone, Elisabeth, Zimmer, Lisa, Hassel, Jessica C, Fluck, Michael, Eigentler, Thomas K, Loquai, Carmen, Haferkamp, Sebastian, Gutzmer, Ralf, Meier, Friedegund, Mohr, Peter, Hauschild, Axel, Schilling, Bastian, Menzer, Christian, Kiecker, Felix, Dippel, Edgar, Roesch, Alexander, Ziemer, Mirjana, Conrad, Beate, Körner, Silvia, Simon, Jan-Christoph, Herbst, Rudolf A, Berking, Carola, Utikal, Jochen, Sell, Sabine, Martens, Uwe M, Terheyden, Patrick, Stadler, Rudolf, Windemuth-Kieselbach, Christine, Schwarz, Leonora, Garbe, Claus, Becker, Jürgen C, and Schadendorf, Dirk

Published
2022
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27. Single-cell RNA and T-cell receptor sequencing unveil mycosis fungoides heterogeneity and a possible gene signature.

Author

Srinivas, Nalini, Peiffer, Lukas, Horny, Kai, Kuan Cheok Lei, Buus, Terkild B., Kubat, Linda, Meng Luo, Menghong Yin, Spassova, Ivelina, Sucker, Antje, Farahpour, Farnoush, Kehrmann, Jan, Ugurel, Selma, Livingstone, Elisabeth, Gambichler, Thilo, Ødum, Niels, and Becker, Jürgen C.

Abstract

Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL). Comprehensive analysis of MF cells in situ and ex vivo is complicated by the fact that is challenging to distinguish malignant from reactive T cells with certainty. Methods: To overcome this limitation, we performed combined single-cell RNA (scRNAseq) and T-cell receptor TCR sequencing (scTCRseq) of skin lesions of cutaneous MF lesions from 12 patients. A sufficient quantity of living T cells was obtained from 9 patients, but 2 had to be excluded due to unclear diagnoses (coexisting CLL or revision to a fixed toxic drug eruption). Results: From the remaining patients we established single-cell mRNA expression profiles and the corresponding TCR repertoire of 18,630 T cells. TCR clonality unequivocally identified 13,592 malignant T cells. Reactive T cells of all patients clustered together, while malignant cells of each patient formed a unique cluster expressing genes typical of naive/memory, such as CD27, CCR7 and IL7R, or cytotoxic T cells, e.g., GZMA, NKG7 and GNLY. Genes encoding classic CTCL markers were not detected in all clusters, consistent with the fact that mRNA expression does not correlate linearly with protein expression. Nevertheless, we successfully pinpointed distinctive gene signatures differentiating reactive malignant from malignant T cells: keratins (KRT81, KRT86), galectins (LGALS1, LGALS3) and S100 genes (S100A4, S100A6) being overexpressed in malignant cells. Conclusions: Combined scRNAseq and scTCRseq not only allows unambiguous identification of MF cells, but also revealed marked heterogeneity between and within patients with unexpected functional phenotypes. While the correlation between mRNA and protein abundance was limited with respect to established MF markers, we were able to identify a single-cell gene expression signature that distinguishes malignant from reactive T cells. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Introducing MCC-PS: a novel prognostic score for Merkel cell carcinoma.

Author

Rached, Nessr Abu, Becker, Jürgen C., Lonsdorf, Anke S., Keller, Aric, Zeglis, Ioannis A., and Gambichler, Thilo

Subjects
MERKEL cell carcinoma, RECEIVER operating characteristic curves, INTERNATIONAL normalized ratio, PROGRESSION-free survival, SKIN cancer
Abstract

Introduction: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a poor prognosis, which only improved with the introduction of immunotherapies. An MCC prediction model with high diagnostic accuracy is lacking. The aim was to develop an MCC prognostic score (MCC-PS) based on combinations of previously proposed risk factors. Methods: A multicentric, retrospective study was conducted to develop MCCPS, which included age, neuron-specific enolase (NSE), C-reactive protein (CRP), creatinine, bilirubin, and international normalized ratio (INR). Creatinine, bilirubin, and INR were used to calculate the model of end-stage liver disease (MELD) score. A total of 98 patients were included in the study, including 36.7% with stage I according to American Joint Committee on Cancer 2018 (n = 36), 30.6% with stage II (n = 30), 25.5% with stage III (n = 25), and 7.1% with stage IV (n = 7). Survival data of MCC patients were correlated with selected laboratory parameters and risk factors. Primary endpoint was MCC-specific survival (MSS) and the secondary endpoint was progression-free survival. Several statistical methods were used to develop the prognostic score, including correlation analysis, Kaplan-Meier curves, Cox regression, and time-dependent receiver operating characteristic analysis. Results: The MCC-PS is based on the sum of the following baseline variables: elevated CRP (≥5.5 mg/l), elevated NSE (≥22.8 μg/l), MELD score ≥ 11, and age ≥ 75 years. An MELD score ≥ 11 was scored as 4 points, elevated NSE level as 3 points, elevated CRP level as 2 points, and age ≥ 75 years as 1 point. A high-risk group according to the MCC-PS was characterized by a score of 4 or more points. The high-risk group was associated with a worse prognosis than the lowrisk group (1-year MSS 62%, 2-year 43.1%, 5-year 17.6% as compared to 1-year MSS 79.5%, 3-year 75%, 5-year 72%). Notably, the developed MCC-PS predicts MCC outcome measures with high accuracy (3-year MSS: area under the curve (AUC) 0.934, sensitivity 87.5% and specificity 82.2%; 5-year MSS: AUC 0.93, sensitivity 89% and specificity 82%). Conclusion: MCC-PS is the first prognostic score predicting MCC outcome with a high accuracy based on five easily available laboratory parameters and patient's age. An MCC-PS of 4 or more indicates a high-risk patient associated with a poor prognosis. Conclusion: MCC-PS is the first prognostic score predicting MCC outcome with a high accuracy based on five easily available laboratory parameters and patient's age. An MCC-PS of 4 or more indicates a high-risk patient associated with a poor prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Merkel cell polyomavirus pan‐T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1.

Author

Lei, Kuan Cheok, Srinivas, Nalini, Chandra, Mitalee, Kervarrec, Thibault, Coyaud, Etienne, Spassova, Ivelina, Peiffer, Lukas, Houben, Roland, Shuda, Masahiro, Hoffmann, Daniel, Schrama, David, and Becker, Jürgen C.

Subjects
MERKEL cells, GENE regulatory networks, CANCER cells, POLYOMAVIRUSES, MERKEL cell carcinoma, TRANSCRIPTION factors
Abstract

Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV‐encoded T‐antigens (TAs) are pivotal for sustaining MCC's oncogenic phenotype, i.e., repression of TAs results in reactivation of the RB pathway and subsequent cell cycle arrest. However, the MCC cell line LoKe, characterized by a homozygous loss of the RB1 gene, exhibits uninterrupted cell cycle progression after shRNA‐mediated TA repression. This unique feature allows an in‐depth analysis of the effects of TAs beyond inhibition of the RB pathway, revealing the decrease in expression of stem cell‐related genes upon panTA‐knockdown. Analysis of gene regulatory networks identified members of the E2F family (E2F1, E2F8, TFDP1) as key transcriptional regulators that maintain stem cell properties in TA‐expressing MCC cells. Furthermore, minichromosome maintenance (MCM) genes, which encodes DNA‐binding licensing proteins essential for stem cell maintenance, were suppressed upon panTA‐knockdown. The decline in stemness occurred simultaneously with neural differentiation, marked by the increased expression of neurogenesis‐related genes such as neurexins, BTG2, and MYT1L. This upregulation can be attributed to heightened activity of PBX1 and BPTF, crucial regulators of neurogenesis pathways. The observations in LoKe were confirmed in an additional MCPyV‐positive MCC cell line in which RB1 was silenced before panTA‐knockdown. Moreover, spatially resolved transcriptomics demonstrated reduced TA expression in situ in a part of a MCC tumor characterized by neural differentiation. In summary, TAs are critical for maintaining stemness of MCC cells and suppressing neural differentiation, irrespective of their impact on the RB‐signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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31. T antigen–specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma

Author

Hansen, Ulla Kring, primary, Church, Candice D., additional, Carnaz Simões, Ana Micaela, additional, Frej, Marcus Svensson, additional, Bentzen, Amalie Kai, additional, Tvingsholm, Siri A., additional, Becker, Jürgen C., additional, Fling, Steven P., additional, Ramchurren, Nirasha, additional, Topalian, Suzanne L., additional, Nghiem, Paul T., additional, and Hadrup, Sine Reker, additional

Published
2024
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38. Analyses of combined Merkel cell carcinomas with neuroblastic components suggests that loss of T antigen expression in Merkel cell carcinoma may result in cell cycle arrest and neuroblastic transdifferentiation.

Author

Kervarrec, Thibault, Appenzeller, Silke, Gramlich, Susanne, Coyaud, Etienne, Bachiri, Kamel, Appay, Romain, Macagno, Nicolas, Tallet, Anne, Bonenfant, Christine, Lecorre, Yannick, Kapfer, Jean, Kettani, Sami, Srinivas, Nalini, Lei, Kuan Cheok, Lange, Anja, Becker, Jürgen C, Sarosi, Eva Maria, Sartelet, Hervé, von Deimling, Andreas, and Touzé, Antoine

Subjects
MERKEL cell carcinoma, MERKEL cells, OLDER men, SQUAMOUS cell carcinoma, DNA methylation
Abstract

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by genomic integration of the Merkel cell polyomavirus (MCPyV). MCPyV‐negative cases often present as combined MCCs, which represent a distinctive subset of tumors characterized by association of an MCC with a second tumor component, mostly squamous cell carcinoma. Up to now, only exceptional cases of combined MCC with neuroblastic differentiation have been reported. Herein we describe two additional combined MCCs with neuroblastic differentiation and provide comprehensive morphologic, immunohistochemical, transcriptomic, genetic and epigenetic characterization of these tumors, which both arose in elderly men and appeared as an isolated inguinal adenopathy. Microscopic examination revealed biphasic tumors combining a poorly differentiated high‐grade carcinoma with a poorly differentiated neuroblastic component lacking signs of proliferation. Immunohistochemical investigation revealed keratin 20 and MCPyV T antigen (TA) in the MCC parts, while neuroblastic differentiation was confirmed in the other component in both cases. A clonal relation of the two components can be deduced from 20 and 14 shared acquired point mutations detected by whole exome analysis in both combined tumors, respectively. Spatial transcriptomics demonstrated a lower expression of stem cell marker genes such as SOX2 and MCM2 in the neuroblastic component. Interestingly, although the neuroblastic part lacked TA expression, the same genomic MCPyV integration and the same large T‐truncating mutations were observed in both tumor parts. Given that neuronal transdifferentiation upon TA repression has been reported for MCC cell lines, the most likely scenario for the two combined MCC/neuroblastic tumors is that neuroblastic transdifferentiation resulted from loss of TA expression in a subset of MCC cells. Indeed, DNA methylation profiling suggests an MCC‐typical cellular origin for the combined MCC/neuroblastomas. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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40. T-Cell Repertoire in Combination with T-Cell Density Predicts Clinical Outcomes in Patients with Merkel Cell Carcinoma

Author

Farah, Maya, Reuben, Alexandre, Spassova, Ivelina, Yang, Richard K., Kubat, Linda, Nagarajan, Priyadharsini, Ning, Jing, Li, Wen, Aung, Phyu P., Curry, Jonathan L., Torres-Cabala, Carlos A., Hudgens, Courtney W., Ugurel, Selma, Schadendorf, Dirk, Gumbs, Curtis, Little, Latasha D., Futreal, Andrew, Wistuba, Ignacio I., Prieto, Victor G., Wang, Linghua, Wong, Michael K., Wargo, Jennifer A., Becker, Jürgen C., and Tetzlaff, Michael T.

Published
2020
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42. S1‐Leitlinie Talgdrüsenkarzinom: S1‐Guideline Sebaceous Carcinoma.

Author

Utikal, Jochen, Nagel, Pia, Müller, Verena, Becker, Jürgen C., Dippel, Edgar, Frisman, Alexander, Gschnell, Martin, Griewank, Klaus, Hadaschik, Eva, Helbig, Doris, Hillen, Uwe, Leiter, Ulrike, Pföhler, Claudia, Krönig, Lisa, Ziemer, Mirjana, and Ugurel, Selma

Abstract

Copyright of Journal der Deutschen Dermatologischen Gesellschaft is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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43. S1‐Guideline Sebaceous Carcinoma.

Author

Utikal, Jochen, Nagel, Pia, Müller, Verena, Becker, Jürgen C., Dippel, Edgar, Frisman, Alexander, Gschnell, Martin, Griewank, Klaus, Hadaschik, Eva, Helbig, Doris, Hillen, Uwe, Leiter, Ulrike, Pföhler, Claudia, Krönig, Lisa, Ziemer, Mirjana, and Ugurel, Selma

Abstract

Summary: Sebaceous gland carcinomas are rare malignant cutaneous adnexal tumors with sebocytic differentiation. The typical predilection area is the head and neck region, where sebaceous gland carcinomas are the most common malignant adnexal tumors of the skin. According to their localization a distinction is made between periocular and extraocular sebaceous gland carcinomas. Muir‐Torre syndrome (MTS) should always be ruled out if it is suspected. In terms of prognosis, sebaceous gland carcinomas are potentially aggressive tumors with a clear tendency to recur and metastasize. Only small extraocular sebaceous gland carcinomas that have been completely resected have a very good prognosis. Sebaceous gland carcinomas most frequently metastasize lymphogenously to regional or distant lymph nodes; organ metastasis occurs less frequently. Periocular sebaceous gland carcinomas have a higher metastasis rate (up to 15%) than extraocular sebaceous gland carcinomas (up to 2%). Complete micrographically controlled surgery (MCS) of the primary tumor is the therapy of first choice, regardless of periocular or extraocular localization. Adjuvant or therapeutic radiotherapy may be considered. There is currently no established standard therapy for advanced, inoperable, or metastatic sebaceous gland carcinomas. Local procedures and systemic therapies such as chemotherapy or immunotherapy can be considered. The procedure should be determined individually by an interdisciplinary tumor board. Close follow‐up care is recommended for these potentially aggressive carcinomas. [ABSTRACT FROM AUTHOR]

Published
2024
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47. S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 2: Epidemiologie und Ätiologie, Diagnostik, Therapie des invasiven Plattenepithelkarzinoms der Haut, Nachsorge und Prävention

Author

Leiter, Ulrike, primary, Heppt, Markus V., additional, Steeb, Theresa, additional, Alter, Mareike, additional, Amaral, Teresa, additional, Bauer, Andrea, additional, Bechara, Falk G., additional, Becker, Jürgen C., additional, Breitbart, Eckhard W., additional, Breuninger, Helmut, additional, Diepgen, Thomas, additional, Dirschka, Thomas, additional, Eigentler, Thomas, additional, El Gammal, A. K. Stephan, additional, Felcht, Moritz, additional, Flaig, Michael J., additional, Follmann, Markus, additional, Fritz, Klaus, additional, Grabbe, Stephan, additional, Greinert, Rüdiger, additional, Gutzmer, Ralf, additional, Hauschild, Axel, additional, Hillen, Uwe, additional, Ihrler, Stephan, additional, John, Swen Malte, additional, Kofler, Lukas, additional, Koelbl, Oliver, additional, Krause‐Bergmann, Albrecht, additional, Kraywinkel, Klaus, additional, Krohn, Steffen, additional, Langer, Thomas, additional, Loquai, Carmen, additional, Löser, Christoph R., additional, Mohr, Peter, additional, Nashan, Dorothée, additional, Nothacker, Monika, additional, Pfannenberg, Christina, additional, Salavastru, Carmen, additional, Schmitz, Lutz, additional, Stockfleth, Eggert, additional, Szeimies, Rolf‐Markus, additional, Ulrich, Claas, additional, Voelter‐Mahlknecht, Susanne, additional, Vordermark, Dirk, additional, Weichenthal, Michael, additional, Welzel, Julia, additional, Wermker, Kai, additional, Wiegand, Susanne, additional, Garbe, Claus, additional, and Berking, Carola, additional

Published
2023
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48. S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“ – update 2023, part 2: epidemiology and etiology, diagnostics, surgical and systemic treatment of cutaneous squamous cell carcinoma (cSCC), surveillance and prevention

Author

Leiter, Ulrike, primary, Heppt, Markus V., additional, Steeb, Theresa, additional, Alter, Mareike, additional, Amaral, Teresa, additional, Bauer, Andrea, additional, Bechara, Falk G., additional, Becker, Jürgen C., additional, Breitbart, Eckhard W., additional, Breuninger, Helmut, additional, Diepgen, Thomas, additional, Dirschka, Thomas, additional, Eigentler, Thomas, additional, ElGammal, A. K. Stephan, additional, Felcht, Moritz, additional, Flaig, Michael J., additional, Follmann, Markus, additional, Fritz, Klaus, additional, Grabbe, Stephan, additional, Greinert, Rüdiger, additional, Gutzmer, Ralf, additional, Hauschild, Axel, additional, Hillen, Uwe, additional, Ihrler, Stephan, additional, John, Swen Malte, additional, Kofler, Lukas, additional, Koelbl, Oliver, additional, Krause‐Bergmann, Albrecht, additional, Kraywinkel, Klaus, additional, Krohn, Steffen, additional, Langer, Thomas, additional, Loquai, Carmen, additional, Löser, Christoph R., additional, Mohr, Peter, additional, Nashan, Dorothée, additional, Nothacker, Monika, additional, Pfannenberg, Christina, additional, Salavastru, Carmen, additional, Schmitz, Lutz, additional, Stockfleth, Eggert, additional, Szeimies, Rolf‐Markus, additional, Ulrich, Claas, additional, Voelter‐Mahlknecht, Susanne, additional, Vordermark, Dirk, additional, Weichenthal, Michael, additional, Welzel, Julia, additional, Wermker, Kai, additional, Wiegand, Susanne, additional, Garbe, Claus, additional, and Berking, Carola, additional

Published
2023
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49. S3‐Leitlinie “Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Update 2023, Teil 1: Therapie der aktinischen Keratose, Morbus Bowen, Cheilitis actinica, berufsbedingte Erkrankung und Versorgungsstrukturen

Author

Heppt, Markus V., primary, Leiter, Ulrike, additional, Steeb, Theresa, additional, Alter, Mareike, additional, Amaral, Teresa, additional, Bauer, Andrea, additional, Bechara, Falk G., additional, Becker, Jürgen C., additional, Breitbart, Eckhard W., additional, Breuninger, Helmut, additional, Diepgen, Thomas, additional, Dirschka, Thomas, additional, Eigentler, Thomas, additional, El Gammal, A. K. Stephan, additional, Felcht, Moritz, additional, Flaig, Michael J., additional, Follmann, Markus, additional, Fritz, Klaus, additional, Grabbe, Stephan, additional, Greinert, Rüdiger, additional, Gutzmer, Ralf, additional, Hauschild, Axel, additional, Hillen, Uwe, additional, Ihrler, Stephan, additional, John, Swen Malte, additional, Kofler, Lukas, additional, Koelbl, Oliver, additional, Krause‐Bergmann, Albrecht, additional, Kraywinkel, Klaus, additional, Krohn, Steffen, additional, Langer, Thomas, additional, Loquai, Carmen, additional, Löser, Christoph R., additional, Mohr, Peter, additional, Nashan, Dorothée, additional, Nothacker, Monika, additional, Pfannenberg, Christina, additional, Salavastru, Carmen, additional, Schmitz, Lutz, additional, Stockfleth, Eggert, additional, Szeimies, Rolf‐Markus, additional, Ulrich, Claas, additional, Voelter‐Mahlknecht, Susanne, additional, Vordermark, Dirk, additional, Weichenthal, Michael, additional, Welzel, Julia, additional, Wermker, Kai, additional, Wiegand, Susanne, additional, Garbe, Claus, additional, and Berking, Carola, additional

Published
2023
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50. S3 guideline „actinic keratosis and cutaneous squamous cell carcinoma“– update 2023, part 1: treatment of actinic keratosis, actinic cheilitis, cutaneous squamous cell carcinoma in situ (Bowen's disease), occupational disease and structures of care

Author

Heppt, Markus V., primary, Leiter, Ulrike, additional, Steeb, Theresa, additional, Alter, Mareike, additional, Amaral, Teresa, additional, Bauer, Andrea, additional, Bechara, Falk G., additional, Becker, Jürgen C., additional, Breitbart, Eckhard W., additional, Breuninger, Helmut, additional, Diepgen, Thomas, additional, Dirschka, Thomas, additional, Eigentler, Thomas, additional, El Gammal, A. K. Stephan, additional, Felcht, Moritz, additional, Flaig, Michael J., additional, Follmann, Markus, additional, Fritz, Klaus, additional, Grabbe, Stephan, additional, Greinert, Rüdiger, additional, Gutzmer, Ralf, additional, Hauschild, Axel, additional, Hillen, Uwe, additional, Ihrler, Stephan, additional, John, Swen Malte, additional, Kofler, Lukas, additional, Koelbl, Oliver, additional, Krause‐Bergmann, Albrecht, additional, Kraywinkel, Klaus, additional, Krohn, Steffen, additional, Langer, Thomas, additional, Loquai, Carmen, additional, Löser, Christoph R., additional, Mohr, Peter, additional, Nashan, Dorothée, additional, Nothacker, Monika, additional, Pfannenberg, Christina, additional, Salavastru, Carmen, additional, Schmitz, Lutz, additional, Stockfleth, Eggert, additional, Szeimies, Rolf‐Markus, additional, Ulrich, Claas, additional, Voelter‐Mahlknecht, Susanne, additional, Vordermark, Dirk, additional, Weichenthal, Michael, additional, Welzel, Julia, additional, Wermker, Kai, additional, Wiegand, Susanne, additional, Garbe, Claus, additional, and Berking, Carola, additional

Published
2023
Full Text
View/download PDF

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