Search

Your search keyword '"Beck Y"' showing total 268 results
Start Over Author "Beck Y"
268 results on '"Beck Y"'

20. Thermal Monitoring of Embankment Dams by Fiber Optics

Author

Beck, Y. L., Khan, Amir Ali, Cunat, Pierre, Guidoux, Cyril, Artières, O., Mars, Jerome, Fry, J.-J., EDF - Division Technique Générale (DTG), EDF (EDF), Geophyconsult (GeophyConsult,), GeophyConsult, Tencate Geosynthetics (Tencate Geosynthetics), TENCATE GEOSYNTHETICS, GIPSA - Signal Images Physique (GIPSA-SIGMAPHY), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), EDF-CIH, Savoie Technolac, and Mars, Jerome

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Internal erosion is the main cause of failure of earthen hydraulic structures. Moreover, it is often difficult for the operator to detect internal erosion at an early stage. For the last twenty years, leakage detection by thermometry has been developed mainly in Europe. The principle is based on the fact that a leakage through an embankment dam changes its temperature field. In this regard, fiber optics buried in the structures can be used as temperature sensors. Their principal advantage is distributed temperature measurements, at every meter along their length, and over long distances. Indeed, once deployed, optical fiber proves to be an effective mean of probing several kilometers, making it extremely useful for monitoring dikes. Various methods have been developed for analysis of temperature data acquired by these powerful sensors. Thesephysico-statistical and signal processing methods allow to propose a system for "early warning" or for long-term monitoring. Based on the results of several tests at controlled and industrial sites, this presentation will demonstrate the improvement of this surveillance methodology for the safety procedures of embankment dams

Published
2010

27. Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor

Author

Iwema, T., Billas, I.M., Beck, Y., Bonneton, François, Nierengarten, H., Chaumot, Arnaud, Richards, G., Laudet, V., Moras, D., Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Biologie des écosystèmes aquatiques (UR BELY), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), HFSP STRASBOURG, Partenaires IRSTEA, and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
CEMAGREF, MESH: Protein Structure, Quaternary, MESH: Tribolium, CONSTITUTIVE ACTIVITY, MESH: Retinoid X Receptor alpha, MESH: Drosophila melanogaster, NUCLEAR RECEPTOR, MESH: Animals, Genetically Modified, ULTRASPIRACLE, MESH: Insect Proteins, MESH: Ligands, MESH: Animals, MESH: Phylogeny, MESH: Evolution, Molecular, MESH: Humans, MESH: Molecular Sequence Data, MESH: Genes, Reporter, technology, industry, and agriculture, BELY, MESH: Transcription Factors, equipment and supplies, ECO, body regions, MESH: Binding Sites, MESH: Dimerization, embryonic structures, LIGAND-BINDING, [SDE]Environmental Sciences, RETINOID X RECEPTOR, hormones, hormone substitutes, and hormone antagonists, MESH: DNA-Binding Proteins, MESH: Models, Molecular, MESH: Receptors, Steroid
Abstract

International audience; Retinoid X receptor (RXR) and Ultraspiracle (USP) play a central role as ubiquitous heterodimerization partners of many nuclear receptors. While it has long been accepted that a broad range of ligands can activate vertebrate/mollusc RXRs, the existence and necessity of specific endogenous ligands activating RXR-USP in vivo is still matter of intense debate. Here we report the existence of a novel type of RXR-USP with a ligand-independent functional conformation. Our studies involved Tribolium USP (TcUSP) as representative of most arthropod RXR-USPs with high sequence homology to vertebrate/mollusc RXRs. The crystal structure of the ligand-binding domain of TcUSP was solved in the context of the functional heterodimer with the ecdysone receptor (EcR). While EcR exhibits a canonical ligand-bound conformation, USP adopts an original apo structure. Our functional data demonstrate that TcUSP is a constitutively silent partner of EcR and that none of the RXR ligands can bind and activate TcUSP. These findings together with a phylogenetical analysis suggest that RXR-USPs have undergone remarkable functional shifts during evolution and give insight into receptor-ligand binding evolution and dynamics.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results