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13 results on '"Bechere, Roberto"'

1. Febbre catarrale maligna in Sardegna: un caso clinico.

Author

Coradduzza, Elisabetta, Scivoli, Rosario, Pintus, Davide, Rocchigiani, Angela Maria, Cancedda, Maria Giovanna, Sanna, Daria, Macciocu, Simona, Scarpa, Fabio, Bechere, Roberto, Puggioni, Giantonella, and Ligios, Ciriaco

Abstract

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Published
2024

2. ORF virus causes tumor-promoting inflammation in sheep and goats.

Author

Pintus, Davide, Cancedda, Maria G., Puggioni, Giantonella, Scivoli, Rosario, Rocchigiani, Angela M., Maestrale, Caterina, Coradduzza, Elisabetta, Bechere, Roberto, Silva-Flannery, Luciana, Bullock, Hannah A., Macciocu, Simona, Montesu, Maria A., Marras, Vincenzo, Dore, Simone, Ritter, Jana M., and Ligios, Ciriaco

Subjects
VASCULAR endothelial growth factor receptors, EPIDERMAL growth factor receptors, VASCULAR endothelial growth factors, POLYMERASE chain reaction, SHEEP diseases
Abstract

ORF virus (ORFV) causes contagious ecthyma ("ORF"), a disease of sheep and goats characterized by lesions ranging from vesicles and pustules to atypical papilloma-like and angiomatous lesions in the skin and mucosae. The authors investigated the molecular factors leading to the ORF-associated atypical tumor-like changes. Fifteen lambs, 15 kids, and an adult ram clinically affected by natural ORFV infection were enrolled in the study and examined by several methods. ORFV was detected by viral culture or real-time polymerase chain reaction (RT-PCR) in the lesioned tissues and in the blood of the clinically affected sheep and goats. Surprisingly, ORFV was also detected in the blood of healthy goats from an affected herd. Microscopically, they found a pseudo-papillomatous proliferation of the epithelium, while the dermis and lamina propria were expanded by a proliferating neovascular component that highly expressed the viral vascular endothelial growth factor (vVEGF) and its host receptor vascular endothelial growth factor receptor 2 (VEGFR2). Immunohistochemistry, immunofluorescence, and in situ hybridization for mRNA showed that epidermal growth factor receptor (EGFR) was expressed in the fibrovascular component, in the infiltrating CD163+ macrophages, and in the basal stratum of the epidermis. Confocal immunofluorescence microscopy demonstrated that CD163+ macrophages were associated with VEGF and VEGFR2. Finally, they found by quantitative RT-PCR the overexpression of the interleukin-6 and VEGFR2 genes in the lesioned tissues. These findings suggest that ORFV activates an inflammatory reaction characterized by CD163+ macrophages expressing EGFR and VEGFR2, which might play an oncogenic role through synergistic action with vVEGF signaling. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Whole-Genome Sequencing of Two Canine Herpesvirus 1 (CaHV-1) Isolates and Clinicopathological Outcomes of Infection in French Bulldog Puppies

Author

Rocchigiani, Angela Maria, primary, Bertoldi, Loris, additional, Coradduzza, Elisabetta, additional, Lostia, Giada, additional, Pintus, Davide, additional, Scivoli, Rosario, additional, Cancedda, Maria Giovanna, additional, Fiori, Mariangela Stefania, additional, Bechere, Roberto, additional, Murtino, Anna Pina, additional, Pala, Giovanni, additional, Cardeti, Giusy, additional, Macioccu, Simona, additional, Dettori, Maria Antonietta, additional, Pintore, Antonio, additional, Ligios, Ciriaco, additional, and Puggioni, Giantonella, additional

Published
2024
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4. The Global Evolutionary History of Orf Virus in Sheep and Goats Revealed by Whole Genomes Data

Author

Coradduzza, Elisabetta, primary, Scarpa, Fabio, additional, Rocchigiani, Angela Maria, additional, Cacciotto, Carla, additional, Lostia, Giada, additional, Fiori, Mariangela Stefania, additional, Rodriguez Valera, Yoel, additional, De Pascali, Alessandra Mistral, additional, Brandolini, Martina, additional, Azzena, Ilenia, additional, Locci, Chiara, additional, Casu, Marco, additional, Bechere, Roberto, additional, Pintus, Davide, additional, Ligios, Ciriaco, additional, Scagliarini, Alessandra, additional, Sanna, Daria, additional, and Puggioni, Giantonella, additional

Published
2024
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5. Origin, Genetic Variation and Molecular Epidemiology of SARS-CoV-2 Strains Circulating in Sardinia (Italy) during the First and Second COVID-19 Epidemic Waves

Author

Rocchigiani, Angela Maria, primary, Ferretti, Luca, additional, Ledda, Alice, additional, Di Nardo, Antonello, additional, Floris, Matteo, additional, Bonelli, Piero, additional, Loi, Federica, additional, Idda, Maria Laura, additional, Angioi, Pier Paolo, additional, Zinellu, Susanna, additional, Fiori, Mariangela Stefania, additional, Bechere, Roberto, additional, Capitta, Paola, additional, Coccollone, Annamaria, additional, Coradduzza, Elisabetta, additional, Dettori, Maria Antonietta, additional, Fattaccio, Maria Caterina, additional, Gallisai, Elena, additional, Maestrale, Caterina, additional, Manunta, Daniela, additional, Pedditzi, Aureliana, additional, Piredda, Ivana, additional, Palmas, Bruna, additional, Salza, Sara, additional, Sechi, Anna Maria, additional, Tanda, Barbara, additional, Madrau, Maria Paola, additional, Sanna, Maria Luisa, additional, Cherchi, Simonetta, additional, Ponti, Nicoletta, additional, Masala, Giovanna, additional, Sirica, Roberto, additional, Evangelista, Eloisa, additional, Oggiano, Annalisa, additional, Puggioni, Giantonella, additional, Ligios, Ciriaco, additional, and Dei Giudici, Silvia, additional

Published
2023
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7. Malignant Catarrhal Fever in Sardinia (Italy): A Case Report

Author

Coradduzza, Elisabetta, primary, Scivoli, Rosario, additional, Pintus, Davide, additional, Rocchigiani, Angela Maria, additional, Cancedda, Maria Giovanna, additional, Sanna, Daria, additional, Macciocu, Simona, additional, Scarpa, Fabio, additional, Bechere, Roberto, additional, Puggioni, Giantonella, additional, and Ligios, Ciriaco, additional

Published
2022
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8. A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ORF Virus through the Whole Genome Sequencing of the First Italian Strains

Author

Coradduzza, Elisabetta, primary, Sanna, Daria, additional, Scarpa, Fabio, additional, Azzena, Ilenia, additional, Fiori, Mariangela S., additional, Scivoli, Rosario, additional, Rocchigiani, Angela M., additional, Bechere, Roberto, additional, Dettori, Maria A., additional, Pintus, Davide, additional, Evangelista, Eloisa, additional, Casu, Marco, additional, Ligios, Ciriaco, additional, and Puggioni, Giantonella, additional

Published
2022
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9. Experimental infection of Aedes (Stegomyia) albopictus and Culex pipiens mosquitoes with Bluetongue virus.

Author

Ledda, Salvatore, Foxi, Cipriano, Puggioni, Giantonella, Bechere, Roberto, Rocchigiani, Angela Maria, Scivoli, Rosario, Coradduzza, Elisabetta, Cau, Simona, Vento, Luigi, and Satta, Giuseppe

Subjects
CULEX pipiens, BLUETONGUE virus, AEDES albopictus, AEDES, MOSQUITOES, CERATOPOGONIDAE
Abstract

Bluetongue disease (BT), caused by Bluetongue virus (BTV), infects wild and domestic ruminants, causing severe economic damage in the cattle and sheep industry. Proven vectors of BTV are biting midges belonging to the Culicoides genus, but other arthropods are considered potential vectors, such as ticks, mosquitoes, wingless flies, and sand flies. The present study represents the first attempt to evaluate the vectorial capacity of Culex pipiens and Aedes albopictus for BTV. Mosquitoes were artificially fed with blood containing BTV serotype 1. Infection, dissemination and transmission rates were evaluated at 0, 3, 7, 14 and 21 days after an infected blood meal. Viral RNA was only detected up to 3 days post infection in the bodies of both species. This study indicates that the two Italian populations of Cx. pipiens and Ae. albopictus are not susceptible to BTV infection. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Molecular Insights into the Genetic Variability of ORF Virus in a Mediterranean Region (Sardinia, Italy)

Author

Coradduzza, Elisabetta, primary, Sanna, Daria, additional, Rocchigiani, Angela M., additional, Pintus, Davide, additional, Scarpa, Fabio, additional, Scivoli, Rosario, additional, Bechere, Roberto, additional, Dettori, Maria A., additional, Montesu, Maria A., additional, Marras, Vincenzo, additional, Lobrano, Renato, additional, Ligios, Ciriaco, additional, and Puggioni, Giantonella, additional

Published
2021
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13. Characterization and phylogenteic analysis of Usutu virus isolates in Sardinia

Author

Bechere, Roberto, Alberti, Alberto, and Puggioni , Giantonella

Subjects
viruses, VET/05 Malattie infettive degli animali domestici
Abstract

Flaviviruses are Arbovirus, a group of viruses able to propagate both in Arthropodes and in Vertebrates, including human. Upon infection, human can develop a variety of signs such as encephalitis, meningitis and fever. Natural transmission cycle occurs between ornithophilic mosquitoes (vector) and birds that serve as reservoir or amplifying host. Our study focuses on the Usutu virus (USUV). USUV is an enveloped virus with a protein capside enclosing a positive-strand RNA genome with a size of about 11 kb. USUV was detected in Sardinia for the first time in 2013. Aim of the project is to detect USUV circulating in Sardinia through the screening of pools of mosquitoes caught with dedicated traps, and the monitoring of wild and sinanthropic birds. Viral full genomic sequencing through the technique of “primer-walking” with home designed primers is performed on viral variants obtained from positive samples. Viral strains molecular characterization and phylogenetic analysis is also performed by using dedicated software. Local strains are closely related to Italian strains and in particular with “Bologna 2009". We obtained the complete genome sequences of the isolates designated strains “91418_Sassari2013” and “62059_Sardegna2015”. We found some important molecular features, more of them associate with increase of virulence and capacity to infect mammals includes humans. Results have implications in the molecular epidemiology of Usutu virus in the Mediterranean area and in the study of pathogenicity of this Flavivirus.

Published
2017

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