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2. Vaccine effectiveness against severe laboratory-confirmed influenza in children: Results of two consecutive seasons in Italy

Author

Menniti-Ippolito, Francesca, Da Cas, Roberto, Traversa, Giuseppe, Santuccio, Carmela, Felicetti, Patrizia, Tartaglia, Loriana, Trotta, Francesco, Di Pietro, Pasquale, Barabino, Paola, Renna, Salvatore, Riceputi, Laura, Tovo, Pier-Angelo, Gabiano, Clara, Urbino, Antonio, Baroero, Luca, Le Serre, Daniele, Virano, Silvia, Perilongo, Giorgio, Daverio, Marco, Gnoato, Elisa, Maretti, Michela, Galeazzo, Beatrice, Rubin, Giulia, Scanferla, Stefania, Da Dalt, Liviana, Stefani, Chiara, Zerbinati, Claudia, Chiappini, Elena, Sollai, Sara, De Martino, Maurizio, Mannelli, Francesco, Becciani, Sabrina, Giacalone, Martina, Montano, Simona, Remaschi, Giulia, Stival, Alessia, Furbetta, Mario, Abate, Piera, Leonardi, Ilaria, Pirozzi, Nicola, Raucci, Umberto, Reale, Antonino, Rossi, Rossella, Russo, Cristina, Mancinelli, Livia, Manuela, Onori, Carlo, Concato, Mores, Nadia, Romagnoli, Costantino, Chiaretti, Antonio, Compagnone, Adele, Riccardi, Riccardo, Delogu, Giovanni, Sali, Michela, Prete, Valentina, Tipo, Vincenzo, Dinardo, Michele, Auricchio, Fabiana, Polimeno, Teodoro, Sodano, Giuseppe, Maccariello, Alessandra, Rafaniello, Concita, Fucà, Fortunata, Di Rosa, Eleonora, Altavilla, Domenica, Mecchio, Anna, and Arrigo, Teresa

Published
2014
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6. Recommendations Concerning the First-Line Treatment of Children with Tuberculosis

Author

Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Bocchino, Marialuisa, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, ANDREA, BOCCHINO, MARIALUISA, Principi, Nicola, Galli, Luisa, Lancella, Laura, Tadolini, Marina, Migliori, Giovanni Battista, Villani, Alberto, Esposito, Susanna, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, Vecchio, Andrea Lo, Scotto, Riccardo, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, D'Ambrosio, Lia, Centis, Rosella, Cirillo, Daniela, Tortoli, Enrico, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Matteelli, Alberto, Scaglione, Francesco, LO VECCHIO, Andrea, For the Italian Pediatric TB Study Group, Null, and DI COMITE, Amelia

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Tuberculosi, 030106 microbiology, Drug Resistance, Breastfeeding, Antitubercular Agents, Child, Drug Resistance, Microbial, Humans, Isoniazid, Medication Adherence, Tuberculosis, Pulmonary, Tuberculous meningitis, 03 medical and health sciences, Antitubercular Agent, Microbial, 0302 clinical medicine, Pharmacotherapy, 030225 pediatrics, medicine, Pharmacology (medical), Adverse effect, Ethambutol, Perinatology and Child Health, business.industry, Tuberculous pericarditis, Pulmonary, Pyrazinamide, medicine.disease, Settore MED/38, Surgery, Pediatrics, Perinatology and Child Health, business, medicine.drug, Human
Abstract

This document describes the recommendations of a group of scientific societies concerning the first-line therapeutic approach to paediatric tuberculosis (TB). The treatment of pulmonary TB should be based on the existence of parenchymal involvement and the risk of antibiotic resistance. The treatment of extra-pulmonary TB is based on the regimens used for severe pulmonary TB. The administration of corticosteroids is recommended only in cases of miliary TB, tuberculous meningitis and tuberculous pericarditis. Vitamin B6 may be indicated in the case of isoniazid-treated TB in breastfeeding infants, severely malnourished subjects, or patients with other diseases at high risk of vitamin deficiency. Once having started treatment, children with TB should be carefully followed up in order to evaluate compliance, the response to treatment, the need for treatment changes, and the presence of drug-related adverse events. Primary care paediatricians can support reference centres in providing family healthcare education and encouraging treatment compliance.

Published
2016

7. How to manage children who have come into contact with patients affected by tuberculosis

Author

Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, BOCCHINO, MARIALUISA, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Lancella, Laura, Vecchio, Andrea Lo, Chiappini, Elena, Tadolini, Marina, Cirillo, Daniela, Tortoli, Enrico, de Martino, Maurizio, Guarino, Alfredo, Principi, Nicola, Villani, Alberto, Esposito, Susanna, Galli, Luisa, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, Scotto, Riccardo, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Russo, Cristina, Bosis, Samantha, Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Bernardi, Filippo, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, Luca, Castagnola, Elio, Losurdo, Giuseppe, Codecasa, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Garazzino, Silvia, Le Serre, Daniele, Raffaldi, Irene, Marseglia, Gianluigi, Mascolo, Amelia, Di Comite, Amelia, Stronati, Mauro, Matteelli, Alberto, Migliori, Giovanni Battista, Centis, Rossella, D'Ambrosio, Lia, Pasinato, Angela, Scaglione, Franco, Scala, Elisabetta, and Tomà, Paolo

Subjects
Pulmonary and Respiratory Medicine, Microbiology (medical), Pediatrics, medicine.medical_specialty, Tuberculosis, Contacts, Tuberculosi, IGRA, LTBI, Multidrug-resistant tuberculosis, Mycobacterium tuberculosis, Disease, Mycobacterium tuberculosi, Article, lcsh:Infectious and parasitic diseases, Molecular typing, Contact, Medicine, lcsh:RC109-216, Index case, lcsh:RC705-779, Immune status, biology, business.industry, Transmission (medicine), lcsh:Diseases of the respiratory system, biology.organism_classification, medicine.disease, Multidrug-resistant tuberculosi, Infectious Diseases, Chemoprophylaxis, Immunology, business
Abstract

Childhood tuberculosis (TB) indicates a recent infection, particularly in children aged

Published
2015

8. Acute diplopia in the pediatric Emergency Department. A cohort multicenter Italian study

Author

Raucci, Umberto, primary, Parisi, Pasquale, additional, Vanacore, Nicola, additional, La Penna, Francesco, additional, Ferro, Valentina, additional, Calistri, Lucia, additional, Bondone, Claudia, additional, Midulla, Fabio, additional, Suppiej, Agnese, additional, Falsaperla, Raffaele, additional, Cordelli, Duccio Maria, additional, Palmieri, Antonella, additional, Verrotti, Alberto, additional, Becciani, Sabrina, additional, Aguzzi, Sonia, additional, Mastrangelo, Mario, additional, Pelizza, Federica, additional, Greco, Filippo, additional, Carbonari, Giulia, additional, Tallone, Ramona, additional, Bottone, Gabriella, additional, Trenta, Italo, additional, Masi, Stefano, additional, Villa, Maria Pia, additional, and Reale, Antonino, additional

Published
2017
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10. Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

Author

Lisa Iorio, Anna, additional, da Ros, Martina, additional, Fantappiè, Ornella, additional, Lucchesi, Maurizio, additional, Facchini, Ludovica, additional, Stival, Alessia, additional, Becciani, Sabrina, additional, Guidi, Milena, additional, Favre, Claudio, additional, de Martino, Maurizio, additional, Genitori, Lorenzo, additional, and Sardi, Iacopo, additional

Published
2016
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12. First Human Case of Meningitis and Sepsis in a Child Caused by Actinobacillus suis or Actinobacillus equuli

Author

Montagnani, Carlotta, primary, Pecile, Patrizia, additional, Moriondo, Maria, additional, Petricci, Patrizia, additional, Becciani, Sabrina, additional, Chiappini, Elena, additional, Indolfi, Giuseppe, additional, Rossolini, Gian Maria, additional, Azzari, Chiara, additional, de Martino, Maurizio, additional, and Galli, Luisa, additional

Published
2015
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13. Central-line associated bloodstream infections in a tertiary care children's University hospital: a prospective study.

Author

Venturini, Elisabetta, Montagnani, Carlotta, Benni, Alessandra, Becciani, Sabrina, Biermann, Klaus Peter, De Masi, Salvatore, Chiappini, Elena, de Martino, Maurizio, and Galli, Luisa

Subjects
BLOOD diseases, CHILD health services, HOSPITAL administration, PNEUMONIA in children, PATIENT acceptance of health care, HEALTH outcome assessment, CENTRAL line-associated bloodstream infections
Abstract

Background: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital. Methods: The study involved all children aged less than 18 years admitted to Meyer Children's University Hospital, Florence, Italy who had a central line access between the October 15th, 2014 and the April 14th, 2015. CLABSI were defined according to the Center for Disease Control and Prevention criteria. CLABSI incidence rates with 95% confidence limits were calculated and stratified for the study variables. For each factor the relative risk and 95% confidence intervals were evaluated. Statistical analysis was performed using the statistical software SPSS for Windows, version 22.0 (SPSS Inc., Chicago, IL), p < 0.05 was considered statistically significant. Results: CLABSI rate was 3.73/1000 (95% CI: 2.54-5.28) central line-days. A higher CLABSI incidence was seen with female gender (p = 0.045) and underlying medical conditions (excepting prematurity, surgical diseases and malignancy) (p = 0.06). In our study 5 infections, were caused by extended-spectrum β-lactamase producing organisms and in one case by carbapenem-resistant Klebsiella pneumoniae. Conclusions: Our study confirms the spreading of multi-resistant pathogens as causes of healthcare associated infections in children. An increased incidence rate of CLABSI in our study was related to underlying medical conditions. Pediatric studies focusing on healthcare infections in this type of patients should be done in order to deepen our understanding on associated risk factors and possible intervention areas. [ABSTRACT FROM AUTHOR]

Published
2016
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15. Blood-Brain Barrier and Breast Cancer Resistance Protein: A Limit to the Therapy of CNS Tumors and Neurodegenerative Diseases

Author

Iorio, Anna, Ros, Martina, Fantappiè, Ornella, Lucchesi, Maurizio, Facchini, Ludovica, Stival, Alessia, Becciani, Sabrina, Guidi, Milena, Favre, Claudio, Martino, Maurizio, Genitori, Lorenzo, and Sardi, Iacopo

Abstract

The treatment of brain tumors and neurodegenerative diseases, represents an ongoing challenge. In Central Nervous System (CNS) the achievement of therapeutic concentration of chemical agents is complicated by the presence of distinct set of efflux proteins, such as ATP-Binding Cassette (ABC) transporters localized on the Blood-Brain Barrier (BBB). The activity of ABC transporters seems to be a common mechanism that underlies the poor response of CNS diseases to therapies. The molecular characterization of Breast Cancer Resistance Protein (BCRP/ABCG2), as an ABC transporter conferring multidrug resistance (MDR), has stimulated many studies to investigate its activity on the BBB, its involvement in physiology and CNS diseases and its role in limiting the delivery of drugs in CNS. In this review, we highlight the activity and localization of BCRP on the BBB and the action that this efflux pump has on many conventional drugs or latest generation molecules used for the treatment of CNS tumors and other neurodegenerative diseases.

Published
2016

16. Prevention of hospital infections caused by multi-drug resistant bacteria.

Author

Becciani, Sabrina, Sival, Alessia, Giacalone, Marina, Montano, Simona, and Galli, Luisa

Abstract

Copyright of Children's Nurses: Italian Journal of Pediatric Nursing Science / Infermieri dei Bambini: Giornale Italiano di Scienze Infermieristiche Pediatriche is the property of Societa Italiana di Scienze Infermieristiche Pediatriche and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

17. La prevenzione delle infezioni ospedaliere da batteri multiresistenti.

Author

Becciani, Sabrina, Sival, Alessia, Giacalone, Marina, Montano, Simona, and Galli, Luisa

Subjects
CROSS infection prevention, DRUG resistance in microorganisms, PEDIATRIC nursing, CHILDREN
Abstract

Copyright of Children's Nurses: Italian Journal of Pediatric Nursing Science / Infermieri dei Bambini: Giornale Italiano di Scienze Infermieristiche Pediatriche is the property of Societa Italiana di Scienze Infermieristiche Pediatriche and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

19. Le polmoniti associate a ventilazione assistita nel bambino.

Author

Anziati, Martina, Tersigni, Chiara, Becciani, Sabrina, Biermann, Klaus, Montagnani, Carlotta, and Galli, Luisa

Subjects
PNEUMONIA diagnosis, PNEUMONIA prevention, PNEUMONIA treatment, PNEUMONIA, MECHANICAL ventilators, CHILDREN
Published
2014

20. La Proteina C-reattiva. Utilizzo e significato in ambito pediatrico.

Author

Giacalone, Martina, Becciani, Sabrina, Stivai, Alessia, Remaschi, Giulia, De Gaudio, Marina, and Galli, Luisa

Subjects
INFECTION, C-reactive protein, CHILDREN'S health, INFLAMMATION, PEDIATRICS, CHILDREN, DIAGNOSIS
Abstract

Copyright of Children's Nurses: Italian Journal of Pediatric Nursing Science / Infermieri dei Bambini: Giornale Italiano di Scienze Infermieristiche Pediatriche is the property of Societa Italiana di Scienze Infermieristiche Pediatriche and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014

21. La pertosse nel personale sanitario di area pediatrica.

Author

Stival, Alessia, Becciani, Sabrina, Giacalone, Martina, Chiappini, Elena, and Galli, Luisa

Subjects
CROSS infection prevention, WHOOPING cough vaccines, CHILDREN'S hospitals, CROSS infection, INDUSTRIAL hygiene, PEDIATRIC nursing, ANTIBIOTIC prophylaxis, WHOOPING cough, PREVENTION, VACCINATION, THERAPEUTICS
Abstract

Copyright of Children's Nurses: Italian Journal of Pediatric Nursing Science / Infermieri dei Bambini: Giornale Italiano di Scienze Infermieristiche Pediatriche is the property of Societa Italiana di Scienze Infermieristiche Pediatriche and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

22. First Human Case of Meningitis and Sepsis in a Child Caused by Actinobacillus suisor Actinobacillus equuli

Author

Montagnani, Carlotta, Pecile, Patrizia, Moriondo, Maria, Petricci, Patrizia, Becciani, Sabrina, Chiappini, Elena, Indolfi, Giuseppe, Rossolini, Gian Maria, Azzari, Chiara, de Martino, Maurizio, and Galli, Luisa

Abstract

ABSTRACTWe report the first human case of meningitis and sepsis caused in a child by Actinobacillus suisor A. equuli, a common opportunistic pathogen of swine or horses, respectively. Identification was performed by matrix-assisted laser desorption ionization–time of flight mass spectrometry and real-time PCR assay. A previous visit to a farm was suspected as the source of infection.

Published
2015
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23. Acute diplopia in the pediatric Emergency 'Department. A cohort multicenter Italian study

Author

Valentina Ferro, Raffaele Falsaperla, Agnese Suppiej, Maria Pia Villa, Umberto Raucci, Duccio Maria Cordelli, Lucia Calistri, Pasquale Parisi, Antonino Reale, Stefano Masi, Nicola Vanacore, Giulia Carbonari, Gabriella Bottone, Francesco La Penna, Italo Trenta, Sabrina Becciani, Ramona Tallone, Alberto Verrotti, Antonella Palmieri, Fabio Midulla, Sonia Aguzzi, Filippo Greco, Federica Pelizza, Mario Mastrangelo, Claudia Bondone, Raucci, Umberto, Parisi, Pasquale, Vanacore, Nicola, La Penna, Francesco, Ferro, Valentina, Calistri, Lucia, Bondone, Claudia, Midulla, Fabio, Suppiej, Agnese, Falsaperla, Raffaele, Cordelli, Duccio Maria, Palmieri, Antonella, Verrotti, Alberto, Becciani, Sabrina, Aguzzi, Sonia, Mastrangelo, Mario, Pelizza, Federica, Greco, Filippo, Carbonari, Giulia, Tallone, Ramona, Bottone, Gabriella, Trenta, Italo, Masi, Stefano, Villa, Maria Pia, and Reale, Antonino

Subjects
Male, Pediatrics, medicine.medical_specialty, genetic structures, Adolescent, double vision, Disease, NO, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Age Factor, diplopia, Monocular Diplopia, Diplopia, child, neuroimaging, business.industry, emergency, Age Factors, Retrospective cohort study, General Medicine, life threatening condition, eye diseases, Hospitalization, Binocular Diplopia, Italy, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, Acute Disease, 030221 ophthalmology & optometry, Etiology, Female, Neurology (clinical), Cohort Studie, medicine.symptom, business, Emergency Service, Hospital, 030217 neurology & neurosurgery, Human, Cohort study
Abstract

Background Acute diplopia (AD) is an uncommon and distressing symptom of numerous ocular and neurological conditions, with potentially serious sequelaes. No data are present in pediatrics on the presentation and management of AD. Aim This study investigated characteristics, etiology and health care utilization of the pediatric population with AD accessed to pediatric Emergency Departments (ED), trying to identify “red flags” associated with potentially life -threatening (LT) conditions. Methods We conducted a cohort multicenter study on children with AD in ten Italian hospitals. Patients were classified into diagnostic categories, comparing children with and without LT disease. Results 621 children presented AD at a rate of 3.6 per 10.000. The most frequent diagnosis among no-LT conditions (81.2%) were headache, ocular disorders and minor post-traumatic disease, while LT conditions (18.8%) were represented by brain tumors, demyelinating conditions, idiopathic intracranial hypertension and major post-traumatic diseases. The LT group showed a significantly higher age, with the odds increased by 1% for each month of age. Monocular diplopia occurred in 16.1%, but unlike adult one-fifth presented LT conditions. Binocular diplopia, associated ocular manifestations or extraocular neurological signs were significantly more common in the LT group. At regression logistic analysis strabismus and ptosis were associated with LT conditions. Conclusion The majority of children presented no-LT conditions and more than one-fourth of patients had headache. Monocular diplopia in the LT group was never isolated but associated with other signs or symptoms. Our study was able to identify some specific ocular disturbances or neurologic signs potentially useful for ED physician to recognize patients with serious pathologies.

Published
2017

24. Recommendations for treating children with drug-resistant tuberculosis

Author

Galli L., Lancella L., Garazzino S., Tadolini M., Matteelli A., Migliori G. B., Principi N., Villani A., Esposito S. Italian Pediatric TB Study Group: Samantha Bosis, Claudia Tagliabue, Laura Senatore, Beatrice Ascolese, Laura Cursi, Annalisa Grandin, Caterina Marabotto, Maurizio de Martino, Elena Chiappini, Carlotta Montagnani, Daniele Ciofi, Filippo Festini, Martina Anziati, Sabrina Becciani, Giulia Remaschi, Sara Sollai, Chiara Tersigni, Elisabetta Venturini, Alfredo Guarino, Andrea Lo Vecchio, Riccardo Scotto, Fi lippo Bernardi, Elisa Bertazzoni, Francesco Blasi, Marialuisa Bocchino, Luca Assante, Elio Castagnola, Giuseppe Losurdo, Giannina Gaslini, Luigi Codec, Giuseppe Di Mauro, Marino Faccini, Clara Gabiano, Daniele Le Serre, Irene Raffaldi, Regina Margherita, Gianluigi Marseglia, Amelia Mascolo, Mauro Stronati, Rosella Centis, Lia D'Ambrosio, Angela Pasinato, Cristina Russo, Franco Scaglione, Elisabetta Scala, Paolo Tomà, Susanna Esposito, Luisa Galli, Laura Lancella, Nicola Principi, Samantha Bosis, Silvi a Garazzino, Alberto Villani, Filippo Bernardi, Luigi Codecasa, Alberto Matteelli, Enrico Tortoli, Francesco Scaglione, Daniela Cirillo, Giovanni Battista Migliori, Marina Tadolini, L., Galli, L., Lancella, S., Garazzino, M., Tadolini, A., Matteelli, G. B., Migliori, N., Principi, A., Villani, Italian Pediatric TB Study Group: Samantha Bosis, Esposito S., Tagliabue, Claudia, Senatore, Laura, Ascolese, Beatrice, Cursi, Laura, Grandin, Annalisa, Marabotto, Caterina, de Martino, Maurizio, Chiappini, Elena, Montagnani, Carlotta, Ciofi, Daniele, Festini, Filippo, Anziati, Martina, Becciani, Sabrina, Remaschi, Giulia, Sollai, Sara, Tersigni, Chiara, Venturini, Elisabetta, Guarino, Alfredo, LO VECCHIO, Andrea, Scotto, Riccardo, lippo Bernardi, Fi, Bertazzoni, Elisa, Blasi, Francesco, Bocchino, Marialuisa, Assante, LUCA ROSARIO, Castagnola, Elio, Losurdo, Giuseppe, Gaslini, Giannina, Codec, Luigi, Di Mauro, Giuseppe, Faccini, Marino, Gabiano, Clara, Le Serre, Daniele, Raffaldi, Irene, Margherita, Regina, Marseglia, Gianluigi, Mascolo, Amelia, Stronati, Mauro, Centis, Rosella, D'Ambrosio, Lia, Pasinato, Angela, Russo, Cristina, Scaglione, Franco, Scala, Elisabetta, Tomà, Paolo, Esposito, Susanna, Galli, Luisa, Lancella, Laura, Lo Vecchio, Andrea, Principi, Nicola, Bosis, Samantha, a Garazzino, Silvi, Villani, Alberto, Bernardi, Filippo, Assante, Luca, Codecasa, Luigi, Matteelli, Alberto, Tortoli, Enrico, Scaglione, Francesco, Cirillo, Daniela, Battista Migliori, Giovanni, Tadolini, Marina, Garazzino, Silvia, and Migliori, Giovanni Battista

Subjects
0301 basic medicine, Pediatrics, medicine.medical_specialty, Tuberculosis, Extensively Drug-Resistant Tuberculosis, 030106 microbiology, Antitubercular Agents, Pediatric tuberculosi, Anti-tuberculosis drugs, MDR-TB, Mycobacterium tuberculosi, Mycobacterium tuberculosis, 03 medical and health sciences, Therapeutic approach, Antitubercular Agent, 0302 clinical medicine, Tuberculosis, Multidrug-Resistant, Children, Pediatric tuberculosis, XDR-TB, Pharmacology, Humans, Medicine, 030212 general & internal medicine, Adverse effect, Child, Cause of death, biology, business.industry, Anti-tuberculosis drug, Extensively drug-resistant tuberculosis, medicine.disease, biology.organism_classification, Settore MED/38, Systematic review, Infectious disease (medical specialty), Extensively Drug-Resistant Tuberculosi, Practice Guidelines as Topic, business, Human
Abstract

Tuberculosis (TB) is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world. The number of cases of multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), which are characterised by high mortality rates, is increasing. The therapeutic management of children with MDR- and XDR-TB is complicated by a lack of knowledge, and the fact that many potentially useful drugs are not registered for pediatric use and there are no formulations suitable for children in the first years of life. Furthermore, most of the available drugs are burdened by major adverse events that need to be taken into account, particularly in the case of prolonged therapy. This document describes the recommendations of a group of scientific societies on the therapeutic approach to pediatric MDR- and XDR-TB. On the basis of a systematic literature review and their personal clinical experience, the experts recommend that children with active TB caused by a drug-resistant strain of Mycobacterium tuberculosis should always be referred to a specialised centre because of the complexity of patient management, the paucity of pediatric data, and the high incidence of adverse events due to second-line anti-TB treatment.

Published
2016

25. Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy

Author

Menniti Ippolito, F, Da Cas, R, Traversa, G, Santuccio, C, Felicetti, P, Tartaglia, L, Trotta, F, Di Pietro, P, Barabino, P, Renna, S, Riceputi, L, Tovo, Pier Angelo, Gabiano, C, Urbino, A, Baroero, L, Le Serre, D, Virano, S, Perilongo, G, Daverio, M, Gnoato, E, Maretti, M, Galeazzo, B, Rubin, G, Scanferla, S, Da Dalt, L, Stefani, C, Zerbinati, C, Chiappini, E, Sollai, S, De Martino, M, Mannelli, F, Becciani, S, Giacalone, M, Montano, S, Remaschi, G, Stival, A, Furbetta, M, Abate, P, Leonardi, I, Pirozzi, N, Raucci, U, Reale, A, Rossi, R, Russo, C, Mancinelli, L, Manuela, O, Carlo, C, Mores, N, Romagnoli, C, Chiaretti, A, Compagnone, A, Riccardi, R, Delogu, G, Sali, M, Prete, V, Tipo, V, Dinardo, M, Auricchio, F, Polimeno, T, Sodano, G, Maccariello, A, Rafaniello, C, Fucà, F, Di Rosa, E, Altavilla, D, Mecchio, A, Arrigo, T, Italian Multicentre Study Group for Drug, Vaccine Safety in Children, Menniti Ippolito, Francesca, Da Cas, Roberto, Traversa, Giuseppe, Santuccio, Carmela, Felicetti, Patrizia, Tartaglia, Loriana, Trotta, Francesco, Di Pietro, Pasquale, Barabino, Paola, Renna, Salvatore, Riceputi, Laura, Tovo, Pier Angelo, Gabiano, Clara, Urbino, Antonio, Baroero, Luca, Le Serre, Daniele, Virano, Silvia, Perilongo, Giorgio, Daverio, Marco, Gnoato, Elisa, Maretti, Michela, Galeazzo, Beatrice, Rubin, Giulia, Scanferla, Stefania, Da Dalt, Liviana, Stefani, Chiara, Zerbinati, Claudia, Chiappini, Elena, Sollai, Sara, De Martino, Maurizio, Mannelli, Francesco, Becciani, Sabrina, Giacalone, Martina, Montano, Simona, Remaschi, Giulia, Stival, Alessia, Furbetta, Mario, Abate, Piera, Leonardi, Ilaria, Pirozzi, Nicola, Raucci, Umberto, Reale, Antonino, Rossi, Rossella, Russo, Cristina, Mancinelli, Livia, Manuela, Onori, Carlo, Concato, Mores, Nadia, Romagnoli, Costantino, Chiaretti, Antonio, Compagnone, Adele, Riccardi, Riccardo, Delogu, Giovanni, Sali, Michela, Prete, Valentina, Tipo, Vincenzo, Dinardo, Michele, Auricchio, Fabiana, Polimeno, Teodoro, Sodano, Giuseppe, Maccariello, Alessandra, Rafaniello, Concetta, Fucà, Fortunata, Di Rosa, Eleonora, Altavilla, Domenica, Mecchio, Anna, and Arrigo, Teresa

Subjects
Male, Pediatrics, Laboratory-confirmed case, Emergency Medical Services, Immunology and Microbiology (all), Laboratory-confirmed cases, Case-control study, Children, Influenza vaccine effectiveness, Seasonal influenza, Influenza vaccine effectivene, Emergency medical services, Medicine, Child, Vaccine effectiveness, Vaccination, Hospitalization, Systematic review, Infectious Diseases, Treatment Outcome, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Italy, Influenza Vaccines, Child, Preschool, Molecular Medicine, Veterinary (all), Female, Case-Control Studie, Influenza Vaccine, Settore BIO/19 - MICROBIOLOGIA GENERALE, Human, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, Adolescent, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Immunology and Microbiology(all), Influenza, Human, Humans, Influenza-like illness, General Veterinary, General Immunology and Microbiology, business.industry, Emergency Medical Service, Public Health, Environmental and Occupational Health, Infant, Emergency department, veterinary(all), Confidence interval, Surgery, Case-Control Studies, Case-control study, Children, Influenza vaccine effectiveness, Laboratory-confirmed cases, influenza in children, business
Abstract

•Vaccine effectiveness in children visiting an Emergency Department for influenza.•Test negative case-control study in 11 paediatric centres in two influenza seasons.•Vaccine effectiveness in preventing ED visits: 38% (95% CI -52% to 75%).•Add information for recommendation for vaccination in children. Objective: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. Methods: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. Results: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). Discussion: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children. © 2014 The Authors.

Published
2013

26. Neonatal Cerebellar Hemorrhage and Facial Nerve Palsy: An Unusual Association.

Author

Coviello C, Remaschi G, Becciani S, Montano S, Corsini I, Mussa F, Basile M, and Dani C

Abstract

Cerebellar hemorrhage is rare in term newborns and is most often seen after traumatic birth. Lifelong sequelae include motor and cognitive impairment. We report the uncommon case of a late preterm infant born by spontaneous delivery who showed right peripheral facial palsy at 24 hours of life. Cranial ultrasound showed lateral ventricles dilatation and a diffuse hyperechoic round lesion in the right cerebellar hemisphere. The computed tomography scan confirmed a hemorrhagic lesion in the right cerebellar hemisphere and in the vermis with midline shift and intraventricular bleeding. Ommaya reservoir was inserted and used for a few days. The facial palsy gradually recovered to a complete remission after 6 weeks. Follow-up examinations at 12 and 18 months evidenced infant's delayed motor function, hyperreflexia, tremors, and speech delay., Competing Interests: Conflict of Interest None declared.

Published
2020
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27. Erratum: Neonatal Cerebellar Hemorrhage and Facial Nerve Palsy: An Unusual Association.

Author

Coviello C, Remaschi G, Becciani S, Montano S, Corsini I, Mussa F, Basile M, and Dani C

Abstract

[This corrects the article DOI: 10.1055/s-0040-1715162.][This corrects the article DOI: 10.1055/s-0040-1715162.]., (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)

Published
2020
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28. Absence of human cytomegalovirus infection in childhood brain tumors.

Author

Sardi I, Lucchesi M, Becciani S, Facchini L, Guidi M, Buccoliero AM, Moriondo M, Baroni G, Stival A, Farina S, Genitori L, and de Martino M

Abstract

Human cytomegalovirus (HCMV) is a common human pathogen which induces different clinical manifestations related to the age and the immune conditions of the host. HCMV infection seems to be involved in the pathogenesis of adult glioblastomas. The aim of our study was to detect the presence of HCMV in high grade gliomas and other pediatric brain tumors. This hypothesis might have important therapeutic implications, offering a new target for adjuvant therapies. Among 106 pediatric patients affected by CNS tumors we selected 27 patients with a positive HCMV serology. The serological analysis revealed 7 patients with positive HCMV IGG (≥14 U/mL), whom had also a high HCMV IgG avidity, suggesting a more than 6 months-dated infection. Furthermore, HCMV IGM were positive (≥22 U/mL) in 20 patients. Molecular and immunohistochemical analyses were performed in all the 27 samples. Despite a positive HCMV serology, confirmed by ELISA, no viral DNA was shown at the PCR analysis in the patients' neoplastic cells. At immunohistochemistry, no expression of HCMV antigens was observed in tumoral cells. Our results are in agreement with recent results in adults which did not evidence the presence of HCMV genome in glioblastoma lesions. We did not find any correlation between HCMV infection and pediatric CNS tumors.

Published
2015

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