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2. Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy

Author

Le Quintrec, Moglie, Teisseyre, Maxime, Bec, Nicole, Delmont, Emilien, Szwarc, Ilan, Perrochia, Hélène, Machet, Marie Christine, Chauvin, Anthony, Mavroudakis, Nicolas, Taieb, Guillaume, Lanfranco, Luca, Rigothier, Claire, José, Boucraut, Concetta, Catalano, Geneste, Clair, Pernin, Vincent, Larroque, Christian, Devaux, Jérôme, and Beyze, Anaïs

Published
2021
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4. Exploring Southern Ecuador's Traditional Medicine: Biological Screening of Plant Extracts and Metabolites.

Author

Bec, Nicole, Larroque, Christian, and Armijos, Chabaco

Subjects
PLANT extracts, TRADITIONAL medicine, MEDICAL screening, PLANT metabolites, CYTOTOXINS, CELL cycle
Abstract

Ecuador stands as a nation inheriting a profound ancestral legacy in the utilization of medicinal plants, reflective of the rich biodiversity embraced by various ethnic groups. Despite this heritage, many of these therapeutic resources remain insufficiently explored concerning their toxicity and potential pharmacological effects. This study focused on a comprehensive evaluation of cytotoxicity and the potential subcellular targets within various extracts and nine isolated metabolites from carefully selected medicinal plants. Assessing their impact on the breast cancer cell line (MCF7), we subsequently examined the most active fractions for effects on the cell cycle, microtubule network, centrosome duplication, γH2AX foci, and E-cadherin. The investigated crude extracts and isolated compounds from Ecuadorian medicinal plants demonstrated cytotoxic effects, influencing diverse cellular pathways. These findings lend credence to the traditional uses of Ecuadorian medicinal plants, which have served diverse therapeutic purposes. Moreover, they beckon the exploration of the specific chemicals, whether in isolation or combination, responsible for these observed activities. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Data from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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8. Supplementary Figure 1 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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9. Supplementary Figure 4 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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10. Supplementary Material and Methods; Figure Legends from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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11. Supplementary Figure 5 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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12. Supplementary Figure 2 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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13. Supplementary Figure 3 from Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity

Author

Bastid, Jeremy, primary, Regairaz, Anne, primary, Bonnefoy, Nathalie, primary, Déjou, Cécile, primary, Giustiniani, Jérôme, primary, Laheurte, Caroline, primary, Cochaud, Stéphanie, primary, Laprevotte, Emilie, primary, Funck-Brentano, Elisa, primary, Hemon, Patrice, primary, Gros, Laurent, primary, Bec, Nicole, primary, Larroque, Christian, primary, Alberici, Gilles, primary, Bensussan, Armand, primary, and Eliaou, Jean-François, primary

Published
2023
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17. Composición química y actividad Butirilcolinesterasa selectiva del aceite esencial de Piper arboreum Aubl. de Ecuador.

Author

Espinosa Espinoza, Lisseth Carolina, Salinas Rivera, Melissa, Bec, Nicole, Ramírez Robles, Jorge, Larroque, Christian, and Armijos, Chabaco

Subjects
MASS spectrometry, FLAME ionization detectors, GAS chromatography, ACETYLCHOLINESTERASE, ESSENTIAL oils, BUTYRYLCHOLINESTERASE
Abstract

Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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18. Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells

Author

Denis, Vincent, primary, Cassagnard, Nadège, additional, Del Rio, Maguy, additional, Cornillot, Emmanuel, additional, Bec, Nicole, additional, Larroque, Christian, additional, Jeanson, Laura, additional, Jarlier, Marta, additional, Combès, Eve, additional, Robert, Bruno, additional, Gongora, Céline, additional, Martineau, Pierre, additional, and Dariavach, Piona, additional

Published
2022
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26. Composición química y actividad AChE-BuChE del aceite esencial de palo santo Bursera graveolens (Kunth) Triana & Planch de Jipijapa, Ecuador.

Author

Saltos, Ronald Eduarte, Bec, Nicole, Rivera, Melissa Salinas, Robles, Jorge Ramírez, Larroque, Christian, and Armijos, Chabaco

Subjects
WOOD chips, SPECIFIC gravity, ESSENTIAL oils, REFRACTIVE index, LIMONENE, BUTYRYLCHOLINESTERASE
Abstract

Copyright of Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas is the property of Universidad de Santiago de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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27. MALDI imaging mass spectrometry and chemometric tools to discriminate highly similar colorectal cancer tissues. Chimiométrie

Author

Mas Garcia, Sílvia, Torro, Adeline, Fernández, Luis, Bec, Nicole, Gongora, Céline, Larroque, Christian, Martineau, Pierre, de Juan, Anna, Marco, Santiago, Mas Garcia, Silvia, Information – Technologies – Analyse Environnementale – Procédés Agricoles (UMR ITAP), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

28. Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Author

Zellweger, Ralph, Chauvin, Maëva, Bec, Nicole, Larroque, Christian, Lopes, Massimo, Basbous, Jihane, Aze, Antoine, CHALOIN, Laurent, Lebdy, Rana, Hodroj, Dana, Ribeyre, Cyril, Larroque, Marion, Shepard, Caitlin, Kim, Baek, Pruvost, Alain, Moreaux, Jérôme, Maiorano, Domenico, Méchali, Marcel, Constantinou, Angelos, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cancer de Montpellier (ICM), Emory University School of Medicine, Emory University [Atlanta, GA], Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ribeyre, Cyril, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Infections rétrovirales et signalisation cellulaire (IRSC), Université Montpellier 1 (UM1)-Centre National de la Recherche Scientifique (CNRS), Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
DNA Replication, endocrine system, Transcription, Genetic, Xenopus, Antineoplastic Agents, DNA polymerase eta, Genome Integrity, Repair and Replication, law.invention, Amidohydrolases, Xenopus laevis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Plasmid, Downregulation and upregulation, law, Transcription (biology), Neoplasms, Genetics, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, Dihydrothymine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cytotoxicity, Uracil, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, biology, DNA replication, biology.organism_classification, 3. Good health, Cell Transformation, Neoplastic, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Dihydropyrimidinase, Cancer cell, Recombinant DNA, DNA
Abstract

Metabolic alterations support cellular transformation. Noticeably, cellular transformation and cancer progression is associated with accumulation of dihydrouracil and dihydrothymine. However, it remains elusive how dihydropyrimidine metabolites affect cellular phenotypes. Dihydropyrimidines are degraded by dihydropyrimidinase (DHP). This zinc metalloenzyme is upregulated in solid tumors but not in the corresponding normal tissues. Here we show that DHP silencing in transformed cell lines is cytotoxic. Increasing the level of dihydropyrimidines inhibited DNA replication and transcription. It induced replication stress signaling by ATR and p53 stabilization. Remarkably, cells lacking DHP accumulated DNA-protein crosslinks (DPCs). Among DPCs, covalently trapped translesion DNA polymerase eta contributed to the cytotoxicity of dihydropyrimidines. Furthermore, we show that the plant flavonoid dihydromyricetin inhibits the activity of recombinant human DHP. Cellular treatment with dihydromyricetin triggered DPCs-dependent DNA replication stress. This study defines dihydropyrimidines as potentially cytotoxic metabolites that may offer an opportunity for therapeutic-targeting of DHP activity in solid tumors.

Published
2020
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32. Chemical composition and selective BuChE inhibitory activity of the essential oils from aromatic plants used to prepare the traditional Ecuadorian beverage horchata lojana

Author

Armijos, Chabaco, primary, Matailo, Andrea, additional, Bec, Nicole, additional, Salinas, Melissa, additional, Aguilar, Gabriela, additional, Solano, Nidia, additional, Calva, James, additional, Ludeña, Carlos, additional, Larroque, Christian, additional, and Vidari, Giovanni, additional

Published
2020
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33. Distribution of de novo Donor-Specific Antibody Subclasses Quantified by Mass Spectrometry: High IgG3 Proportion Is Associated With Antibody-Mediated Rejection Occurrence and Severity

Author

Pernin, Vincent, primary, Beyze, Anais, additional, Szwarc, Ilan, additional, Bec, Nicole, additional, Salsac, Céline, additional, Perez-Garcia, Esther, additional, Mourad, Georges, additional, Merville, Pierre, additional, Visentin, Jonathan, additional, Perrochia, Helene, additional, Larroque, Christian, additional, Couzi, Lionel, additional, and Le Quintrec, Moglie, additional

Published
2020
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35. Low-temperature optical absorption spectra suggest a redox role for tetrahydrobiopterin in both steps of nitric oxide synthase catalysis

Author

Gorren, Antonius C.F., Bec, Nicole, Schrammel, Astrid, Werner, Ernst R., Lange, Reihard, and Mayer, Bernd

Subjects
Cytochemistry -- Research, Catalysis -- Physiological aspects, Enzymes -- Physiological aspects, Nitric oxide -- Physiological aspects, Arginine -- Physiological aspects, Biological sciences, Chemistry
Abstract

Low-temperature optical absorption spectra indicate that there may be a tetrahydrobiopterin (BH4) redox role in both steps of nitric oxide synthase catalysis. The spectral changes that follow addition of oxygen to the reduced oxygenase domain of endothelial nitric oxide synthase (NOS) in the presence of various pteridines at -30 degrees Celsius were analyzed. Incomplete and slow formation of high-spin ferric heme with 4-amino-BH4 was seen and suggests a structural basis for inhibition of NOS activity by this pteridine.

Published
2000

47. Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells

Author

Conseiller Emmanuel, Fraslon Caroline, Robert Bruno, Bec Nicole, Denis Vincent, Bascoul-Mollevi Caroline, Copois Virginie, Vié Nadia, Molina Franck, Larroque Christian, Martineau Pierre, Del Rio Maguy, and Gongora Céline

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development. Results We first observed that PSAT1 is overexpressed in colon tumors. In addition, we showed that after drug treatment, PSAT1 expression level in hepatic metastases increased in non responder and decreased in responder patients. In experiments using human cell lines, we showed that ectopic PSAT1 overexpression in colon carcinoma SW480 cell line resulted in an increase in its growth rate and survival. In addition, SW480-PSAT1 cells presented a higher tumorigenic potential than SW480 control cells in xenografted mice. Moreover, the SW480-PSAT1 cell line was more resistant to oxaliplatin treatment than the non-transfected SW480 cell line. This resistance resulted from a decrease in the apoptotic response and in the mitotic catastrophes induced by the drug treatment. Conclusion These results show that an enzyme playing a role in the L-serine biosynthesis could be implicated in colon cancer progression and chemoresistance and indicate that PSAT1 represents a new interesting target for CRC therapy.

Published
2008
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48. A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm

Author

Saven Jeffery G, Larroque Christian, Bec Nicole, Sibler Annie-Paule, Wang Wei, Stoessel Audrey, Philibert Pascal, Courtête Jérôme, Weiss Etienne, and Martineau Pierre

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background Intrabodies are defined as antibody molecules which are ectopically expressed inside the cell. Such intrabodies can be used to visualize or inhibit the targeted antigen in living cells. However, most antibody fragments cannot be used as intrabodies because they do not fold under the reducing conditions of the cell cytosol and nucleus. Results We describe the construction and validation of a large synthetic human single chain antibody fragment library based on a unique framework and optimized for cytoplasmic expression. Focusing the library by mimicking the natural diversity of CDR3 loops ensured that the scFvs were fully human and functional. We show that the library is highly diverse and functional since it has been possible to isolate by phage-display several strong binders against the five proteins tested in this study, the Syk and Aurora-A protein kinases, the αβ tubulin dimer, the papillomavirus E6 protein and the core histones. Some of the selected scFvs are expressed at an exceptional high level in the bacterial cytoplasm, allowing the purification of 1 mg of active scFv from only 20 ml of culture. Finally, we show that after three rounds of selection against core histones, more than half of the selected scFvs were active when expressed in vivo in human cells since they were essentially localized in the nucleus. Conclusion This new library is a promising tool not only for an easy and large-scale selection of functional intrabodies but also for the isolation of highly expressed scFvs that could be used in numerous biotechnological and therapeutic applications.

Published
2007
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