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8. Socioeconomic status of patients hospitalized for COVID-19 in the Greater Paris area

Author

Sesé, L., primary, Nguyen medical, Y., additional, Giroux Leprieur, E., additional, Annesi-Maesano, I., additional, Cavalin, C., additional, Goupil de Bouillé, J., additional, Demestier, L., additional, Dhote, R., additional, Tandjaoui-Lambiotte, Y., additional, Bauvois, A., additional, Teillet, L., additional, Curac, S., additional, Beaune, S., additional, Duchemann, B., additional, and Nunes, H., additional

Published
2021
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10. Association Between Pulmonary Embolism and COVID-19 in Emergency Department Patients Undergoing Computed Tomography Pulmonary Angiogram: The PEPCOV International Retrospective Study

Author

Freund Y, Drogrey M, Miro O, Marra A, Feral-Pierssens A, Penaloza A, Hernandez B, Beaune S, Gorlicki J, Ayar P, Truchot J, Pena B, Aguirre A, Femy F, Javaud N, Chauvin A, Chouihed T, Montassier E, Claret P, Occelli C, Roussel M, Brigant F, Ellouze S, Le Borgne P, Laribi S, Simon T, Lucidarme O, Cachanado M, Bloom B, and IMPROVING EMERGENCY CARE FHU

Abstract

Background There have been reports of procoagulant activity in patients with COVID-19. Whether there is an association between pulmonary embolism (PE) and COVID-19 in the emergency department (ED) is unknown. The aim of this study was to assess whether COVID-19 is associated with PE in ED patients who underwent a computed tomographic pulmonary angiogram (CTPA). Methods A retrospective study in 26 EDs from six countries. ED patients in whom a CTPA was performed for suspected PE during a 2-month period covering the pandemic peak. The primary endpoint was the occurrence of a PE on CTPA. COVID-19 was diagnosed in the ED either on CT or reverse transcriptase-polymerase chain reaction. A multivariable binary logistic regression was built to adjust with other variables known to be associated with PE. A sensitivity analysis was performed in patients included during the pandemic period. Results A total of 3,358 patients were included, of whom 105 were excluded because COVID-19 status was unknown, leaving 3,253 for analysis. Among them, 974 (30%) were diagnosed with COVID-19. Mean (+/- SD) age was 61 (+/- 19) years and 52% were women. A PE was diagnosed on CTPA in 500 patients (15%). The risk of PE was similar between COVID-19 patients and others (15% in both groups). In the multivariable binary logistic regression model, COVID-19 was not associated with higher risk of PE (adjusted odds ratio = 0.98, 95% confidence interval = 0.76 to 1.26). There was no association when limited to patients in the pandemic period. Conclusion In ED patients who underwent CTPA for suspected PE, COVID-19 was not associated with an increased probability of PE diagnosis. These results were also valid when limited to the pandemic period. However, these results may not apply to patients with suspected COVID-19 in general.

Published
2020

12. Statut socio-économique des patients hospitalisés pour COVID-19 en région parisienne

Author

Sese, L., primary, Nguyen, Y., additional, Giroux-Leprieur, E., additional, Annesi-Maesano, I., additional, Cavalin, C., additional, Goupil, J., additional, Demestier, L., additional, Dhote, R., additional, Tandjaoui, Y., additional, Curac, S., additional, Teillet, L., additional, Bauvois, A., additional, Beaune, S., additional, Duchemann, B., additional, and Nunes, H., additional

Published
2021
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13. Management of chest pain in the French emergency healthcare system: the prospective observational EPIDOULTHO study

Author

Charpentier, Sébastien, Beaune, S, Joly, LM, Khoury, A, Duchateau, FX, Briot, R, Renaud, B, Network , Ageron FX, and the IRU, Embodiment, social ineQualities, lifecoUrse epidemiology, cancer and chronIc diseases, intervenTions, methodologY (Equipe 5 - EQUITY), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital Rangueil, Toulouse, Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré), Optimisation Thérapeutique en Neuropsychopharmacologie (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU, hôpitaux de Rouen, service des urgences, Centre d'Investigation Clinique de Besançon (CICB), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang Bourgogne Franche-Comté-Université de Franche-Comté (UFC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre d'Epidemiologie et Biostatistiques Sorbonne Paris Cité, Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée (TIMC-IMAG-PRETA), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Universitaire Henri Mondor, Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Services des urgences [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Etablissement Français du Sang Bourgogne Franche-Comté-Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

14. Actualité scientifique

Author

de Beaune, S. A., Burnez, C., Lagarde, M.-C., Pautreau, J.-P., Espérou, J.-L., Espérou, Jean-Luc, Watté, J.-P., Géhenne, J., and DELPORTE, H.

Published
1988

19. Impact of an antimicrobial stewardship programme to optimize antimicrobial use for outpatients at an emergency department.

Author

Dinh, A., Duran, C., Davido, B., Bouchand, F., Deconinck, L., Matt, M., Sénard, O., Guyot, C., Levasseur, A.-So., Attal, J., Razazi, D., Tritz, T., Beauchet, A., Salomon, J., Beaune, S., and Grenet, J.

Abstract

Background: Antimicrobial stewardship programmes (ASPs) have been effective in optimizing antibiotic use for inpatients. However, an emergency department's fast-paced clinical setting can be challenging for a successful ASP.Aim: In April 2015, an ASP was implemented in our emergency department and we aimed to determine its impact on antimicrobial use for outpatients.Methods: This was a single-centre study comparing the quality of antibiotic prescriptions between a one-year period before ASP implementation (November 2012 to October 2013) and a one-year period after its implementation (June 2015 to May 2016). For each period, antimicrobial prescriptions for all adult outpatients (hospitalized for <24h) were evaluated by an infectious disease specialist and an emergency department physician to assess compliance with local prescribing guidelines. Inappropriate prescriptions were then classified.Findings: Before and after ASP, 34,671 and 35,925 consultations were registered at our emergency department, of which 25,470 and 26,208 were outpatients. Antimicrobials were prescribed in 769 (3.0%) and 580 (2.2%) consultations, respectively (P < 0.0001). There were 484 (62.9%) and 271 (46.7%) (P < 0.0001) instances of non-compliance with guidelines before and after ASP implementation. Non-compliance included unnecessary antimicrobial prescriptions, 197 (25.6%) vs 101 (17.4%) (P<0.0005); inappropriate spectrum, 108 (14.0%) vs 54 (9.3%) (P=0.008); excessive treatment duration, 87 (11.3%) vs 53 (9.1%) (P>0.05); and inappropriate choices, 11 (1.4%) vs 15 (2.6%) (P>0.05).Conclusion: The implementation of an ASP markedly decreased the number of unnecessary antimicrobial prescriptions, but had little impact on most other aspects of inappropriate prescribing. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Deliberate drug poisonings admitted to an emergency department in Paris area –a descriptive study and assessment of risk factors for intensive care admission.

Author

BEAUNE, S., JUVIN, P., BEAUCHET, A., CASALINO, E., and MEGARBANE, B.

Abstract

OBJECTIVE: Each year, approximately 165,000 poisonings are managed in the emergency departments (ED) in France. We performed a descriptive analysis of self-poisoned patients admitted to a university hospital ED in the Paris metropolitan area (France) aimed at investigating their outcome and the risk factors for transfer to the intensive care unit (ICU). PATIENTS AND METHODS: We retrospectively reviewed patients' records and performed multivariate logistic regression analysis to identify risk factors for ICU admission. RESULTS: During 4 years, 882 self-poisoned patients (median age, 38 years [IQR, 26-47]; sex-ratio, 1M/3F) were admitted to the ED, representing 0.7% of all referred patients. Poisonings mainly resulted from multidrug exposures (53%), including benzodiazepines (78%), serotonin reuptake inhibitors (17%), acetaminophen (13%), antipsychotics (9.5%), imidazopyridines (9.5%), antihypertensive drugs (3%), and polycyclic antidepressants (1.3%). Ethanol was involved in 20% of the exposures. Patients were briefly (<24h) monitored in the ED (55%), transferred to the psychiatric department (30%), medical ward (2%) or ICU (6%), and took an irregular discharge (7%). Among the patients transferred to the ICU, 25% were mechanically ventilated and only one died. Risk factors for ICU admission included antihypertensive (Odds ratio (OR), 40.6; 95%-confidence interval (CI), 7.5-221.9) or antipsychotic drug ingestion (OR, 5.3; CI, 2.0- 14.4), male gender (OR, 3.3; CI, 1.30-8.8), and consciousness impairment (OR, 2.1; CI, 1.8-2.5 per point lost in Glasgow coma score). CONCLUSIONS: Deliberate drug exposure represents a frequent cause of ED admission. Psychotropic drugs are most commonly involved. Transfer to the ICU is rare and predicted by male gender, drug class, and coma depth. [ABSTRACT FROM AUTHOR]

Published
2016

38. Peuplement et territoire dans la longue durée : retour sur 25 ans d'expérience

Author

Nuninger, Laure, Bertoncello, Frédérique, Favory, François, Fiches, Jean-Luc, Raynaud, Claude, Girardot, Jean-Jacques, Mathian, Hélène, Sanders, Lena, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (UAR 3124) (MSHE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Centre d'Études Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Archéologie des Sociétés Méditerranéennes (ASM), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Théoriser et modéliser pour aménager (UMR 6049) (ThéMA), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Université de Franche-Comté (UFC), Géographie-cités (GC (UMR_8504)), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), ArchaeDyn I (2005-2007): 'Spatial dynamic of settlement patterns and natural resources: toward a long‑term integrated analysis from Prehistory to the Middle Ages' (Action Concertée Incitative - ACI Spaces and Territories of French Ministry of Research and New Technologies, contract ET28), Archambault De Beaune S., Francfort H.-P., European Project, Laboratoire Chrono-environnement (UMR 6249) (LCE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Nuninger, Laure, Archaeomedes I (1992-1994). CEU DG XII (Contract EV5V-0021), Archaeomedes II (1996-1999) CEU DG XII - INCOMING, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux ( MSHE ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre d'Études Préhistoire, Antiquité, Moyen-Age ( CEPAM ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Archéologie des Sociétés Méditerranéennes ( ASM ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Ministère de la Culture et de la Communication ( MCC ) -Centre National de la Recherche Scientifique ( CNRS ), Théoriser et modéliser pour aménager ( ThéMA ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Géographie-cités ( GC ), Université Panthéon-Sorbonne ( UP1 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Maison des Sciences de l'Homme et de l'Environnement Claude Nicolas Ledoux (MSHE), and Centre National de la Recherche Scientifique (CNRS)-Université Paul-Valéry - Montpellier 3 (UPVM)-Ministère de la Culture (MC)

Subjects
territoire, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, spatial analysis, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, archéologie, [SHS.GEO] Humanities and Social Sciences/Geography, territory, archaeology, [SHS.GEO]Humanities and Social Sciences/Geography, typologie hiérarchique, hierarchical typology, [ SHS.GEO ] Humanities and Social Sciences/Geography, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory, settlement pattern, peuplement, analyse spatiale
Abstract

Like geographers, who focus on factors of attractionto understand where humans settled and how settlements are spread over space, archaeologists aim to characterize the various types of settlements and settlement patternsto reconstruct settlement choices made by past communities. This long-standing project is carried out by a team using a quantitative and spatial approach., À l'instar des géographes, cherchant à identifi er les facteurs attractifs pour l'implantation de nos habitats afin de comprendre leur répartition dans l'espace, les archéologues et les historiens cherchent à caractériser les différentes formes d'habitat et leur organisation spatiale pour comprendre les choix d'implantation des communautés du passé. Au-delà des formes de peuplement, l'enjeu est d'approfondir notre connaissance des processus de structuration territoriale, d'appropriation de l'espace, d'organisation socio-économique et d'identification politique et culturelle. Les territoires constituant notre cadre de vie sont le résultat de tous ces processus parfois méconnus ou oubliés.

Published
2012

39. La modélisation de l'information spatio-temporelle

Author

Lefebvre, Bastien, Rodier, Xavier, Saligny, Laure, Saligny, Laure, Archambault de Beaune S.& Francfort H.-P., Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés (TRACES), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Cités, Territoires, Environnement et Sociétés (CITERES), Centre National de la Recherche Scientifique (CNRS)-Université de Tours, Maison des Sciences de l'Homme de Dijon (MSH Dijon (MSHD)), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés ( TRACES ), École des hautes études en sciences sociales ( EHESS ) -Université Toulouse - Jean Jaurès ( UT2J ) -Ministère de la Culture et de la Communication ( MCC ) -Institut national de recherches archéologiques préventives ( Inrap ) -Centre National de la Recherche Scientifique ( CNRS ), Cités, Territoires, Environnement et Sociétés ( CITERES ), Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Maison des Sciences de l'Homme de Dijon ( MSH Dijon (MSHD) ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ), Ministère de la Culture et de la Communication (MCC)-École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)

Subjects
spatial dynamics, dynamiques spatiales, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, espace-temps, fonctions urbaines, space, Historical sciences, temporalité, modelling, urban function, space-time, espace, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory, city, Geographical information system, temps, Système d'information géographique, [SHS.STAT] Humanities and Social Sciences/Methods and statistics, ville, Sciences historiques, [ SHS.STAT ] Humanities and Social Sciences/Methods and statistics, time, modélisation
Published
2012

40. L’archéothanatologie, une manière nouvelle de penser l’archéologie de la mort

Author

Duday, Henri, Préhistoire et Protohistoire méditerranéennes, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Beaune, S. de and Francfort, H.-P., PACEA, UMR5199, and Beaune, S. de and Francfort, H.-P.

Subjects
[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2012

41. Archéologie et rituels

Author

Patrice Méniel, Martine Joly, Philippe Barral, Barral, Philippe, De BEAUNE S.-A., FRANCFORT H.-P., Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Antiquité classique et tardive, ORIENT ET MEDITERRANEE : Textes, Archéologie, Histoire ( OM ), Université Panthéon-Sorbonne ( UP1 ) -École pratique des hautes études ( EPHE ) -Université Paris-Sorbonne ( UP4 ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Panthéon-Sorbonne ( UP1 ) -École pratique des hautes études ( EPHE ) -Université Paris-Sorbonne ( UP4 ) -Centre National de la Recherche Scientifique ( CNRS ), Archéologie, Terre, Histoire, Sociétés [Dijon] ( ARTeHiS ), Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Équipe Antiquité classique et tardive (OM-ACT), Sorbonne Université (SU)-ORIENT ET MÉDITERRANÉE : Textes, Archéologie, Histoire (OM), Université Paris 1 Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), Ministère de la Culture et de la Communication (MCC)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution))-Université Paris 1 Panthéon-Sorbonne (UP1)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution)), and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Ministère de la Culture et de la Communication (MCC)

Subjects
âge du Fer, [SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory, religion, rituels, Haut-Empire, sanctuaires
Published
2012

42. Paléoclimats et sociétés : du local au global, du passé au futur

Author

Magny, Michel, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), De Beaune S., Francfort H.P., Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Published
2012

43. Technical invention in the Palaeolithic: what if the explanation comes from the cognitive and neuropsychological sciences?

Author

de Beaune, Sophie A., Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Beaune S. A. de, Coolidge F. and Wynn T., Archéologies environnementales, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Université Jean Moulin Lyon 3 - Faculté des Lettres et civilisations (UJML3 LC), Université Jean Moulin - Lyon 3 (UJML), and Université de Lyon-Université de Lyon

Subjects
cognitive abilities, Archaeology, Archéologie, préhistoire, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, invention technique, neurophysiologie, [SCCO.NEUR]Cognitive science/Neuroscience, prehistory, neuropsychology, technical invention, capacités cognitives
Abstract

The evolution of the cerebral capacities of humans, from the first hominids to Modern Humans, is at the heart of our interrogations. How can we explain the fact that only hominids seem to have developed the capacity for technical invention, in contrast to our closest relatives the great apes? The archaeological data allow us to observe this phenomenon but offer very little in the way of a response to this question. By examining the possible contributions of other disciplines, particularly in the cognitive and neuropsychological sciences, we can ask if there exists a cause and effect relationship between the following phenomena: - The archaeological data indicate that the technical inventions realized throughout prehistory are increasingly frequent and complex from the first hominids to Modern Humans; - The cognitive perspective seems to indicate that the processes of analogical reasoning are increasingly frequent through time, either for "statistical" reasons (a greater population density leads to a greater probability of the meeting of two ideas), or for cognitive reasons; - Finally, the paleoanthropological data show that current neurological conditions developed progressively with the frontal lobes and prefrontal cortex becoming more and more accentuated from the first hominids to Modern Humans. We will explore here the possible contribution resulting from a confrontation of these different disciplines.; La question de l'évolution des capacités cérébrales de l'homme, depuis les premiers hominidés jusqu'à l'homme moderne, est au cœur de nos préoccupations. Comment expliquer en effet que seuls les hominidés semblent avoir développé une capacité à l'invention technique, contrairement à leurs plus proches parents, les grands singes ? Les données archéologiques permettent de constater cet état de fait mais n'apportent guère de réponse à cette question. En examinant ce que peuvent apporter d'autres disciplines, et en particulier les sciences de la cognition et la neurophysiologie, on peut se demander s'il existe un lien de cause à effet entre les phénomènes suivants : - Les données archéologiques indiquent que les inventions techniques réalisées tout au long de la préhistoire, sont de plus en plus fréquentes et complexes depuis les premiers hominidés jusqu'à l'homme moderne ; - La perspective cognitive semble indiquer que les processus de raisonnement analogique sont de plus en plus fréquents au cours du temps, soit pour des raisons d'ordre " statistique " (plus grande densité de peuplement entraînant une probabilité de rencontre entre deux idées accrue), soit pour des raisons d'ordre cognitif ; - Enfin les données paléoanthropologiques montrent que les conditions neurologiques actuelles se mettent en place progressivement avec un développement des lobes frontaux et du cortex préfrontal de plus en plus accentué depuis les premiers hominidés jusqu'à l'homme actuel. Nous verrons ici ce que peut apporter la confrontation de ces différentes disciplines.

Published
2009

44. The emergence of cognitive abilities. The contribution of neuropsychology to archaeology

Author

de Beaune, Sophie A., Archéologies environnementales, Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS), Beaune S. A. de, Coolidge F. and Wynn T., Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), Université Jean Moulin Lyon 3 - Faculté des Lettres et civilisations (UJML3 LC), Université Jean Moulin - Lyon 3 (UJML), and Université de Lyon-Université de Lyon

Subjects
cognitive abilities, Archaeology, Archéologie, préhistoire, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, neurophysiologie, [SCCO.NEUR]Cognitive science/Neuroscience, prehistory, neuropsychology, capacités cognitives
Abstract

This book presents new directions in the study of cognitive archaeology. Seeking to understand the conditions that led to the development of a variety of cognitive processes during evolution, it uses evidence from empirical studies and offers theoretical speculations about the evolution of modern thinking as well. The volume draws from the fields of archaeology and neuropsychology, which traditionally have shared little in the way of theories and methods, even though both disciplines provide crucial pieces to the puzzle of the emergence and evolution of human cognition.; Cet ouvrage présente de nouvelles directions de recherche en archéologie cognitive. Cherchant à comprendre les conditions qui ont conduit au développement de processus cognitifs variés au cours de l'évolution, il réunit des études empiriques aussi bien que des spécilations plus théoriques concernant l'évolution de la pensée chez l'homme moderne. Ce volume concerne le champ de l'archéologie et de la neuropsychologie qui ont traditionnellement peu à voir aussi bien dans leurs théories que dans leurs méthodes, même si les deux disciplines apportent des pièces majeures au puzzle de l'émergence et de l'évolution de la cognition humaine.

Published
2009

45. The role of antitissue transglutaminase assay for the diagnosis and monitoring of coeliac disease: A French-Italian multicentre study

Author

Tonutti E., Visentini D., Bizzaro N., Caradonna M., Cerni L., Villalta D., Tozzoli R. F Ferrara, M Barraco, E Migali, D Mariotti, G Danzi, ML Martino, M Danzi, M Baldassarre, G Di Bitonto, M Ciccarelli, D Riello, G Bertiato, G Pedicini, RC Bocchino, F Moccia, G Alessio, P Amboni, C Ottomano, U Volta, A Granito, N Carabellese, R Amato, G Aurnia, C Spagnulo, P Clemen, F Coppola, G Spagnoletti, M Spina, T Trigilia, F Branciforte, L Giancotti, M Apollini, B Malamisura, A Sofia, M Boffardi, F Antico, P Arigliano, G Marcer, E Sala, ML Grassi, G Giana, C Staffa, V Cova, M Martinelli, A Calabrò, D Renzi, D Nigro, D Macchia, M Manfredi, E Cammelli, G Castellucci, L Ferraro, L Marchetti, G Garelli, M Colombo, E Castellano, M Cingolani, A Sabatino, A Di Blasi, M Golato, A Carlucci, G Spagnuolo, G Trivisonno, V Castelli, S Babbini, V Marrè, G Meli, S Amoroso, M Montesanti, E Mei, S Armelloni, C Gerosa, C Marcellino, C Gallo, R Pozzoli, M Peracchi, MT Bardella, C Trovato, VS Arosio, R Malberti, F Rea, MR Di Domenico, A Sergio, P Iardino, V Formicola, G Tamburro, A Massari, M Cirella, E Rondinella, A Pignero, D Scognamiglio, S Spagnuolo, S Orefice, V Romano, B Pennucci, A Maglione, S Lavecchia, A Rubino, O Leone, N Cantieri, F Michelutti, G Guariso, D Basso, S Teresi, E Gucciardino, M Di Gregorio, MA Trippiedi, P Greco, R Guadagna, E Maltese, T Imbastaro, G Lombardi, A Rossi, E Savi, L Spada, D Villalta, G Tabellini, M Saccarola, P Palumbo, G Marinucci, PM Strappini, F Viola, M Barbato, Roma, N Bizzaro, P Pasini, F Minetti, M Scogna, M Vascotto, G Morgese, F Bascietto, P Cantelmi, F Bulacanti, D Bassetti, S Santer, D Prizzon, S Loperfido, S Martelossi, T Not, A Ventura, E Tonutti, D Visentini, S Finazzi, S Salvatore, GV Melzi d’Eril, D Wolf, M Montesanto, M Negri, MG Azzeni, R Giordano, M Farina, S Micieli, V Gouilleux, O Bandin, A Tridon, M Meyer, F Bienvenu, G Beaune, S Jego, M San Marco, D Bernard, J Sarles, J Sahel, D Carre, S Benzaken, JF Demarquay, C Johanet, JJ Baudon., Tonutti E., Visentini D., Bizzaro N., Caradonna M., Cerni L., Villalta D., Tozzoli R. F Ferrara, M Barraco, E Migali, D Mariotti, G Danzi, ML Martino, M Danzi, M Baldassarre, G Di Bitonto, M Ciccarelli, D Riello, G Bertiato, G Pedicini, RC Bocchino, F Moccia, G Alessio, P Amboni, C Ottomano, U Volta, A Granito, N Carabellese, R Amato, G Aurnia, C Spagnulo, P Clemen, F Coppola, G Spagnoletti, M Spina, T Trigilia, F Branciforte, L Giancotti, M Apollini, B Malamisura, A Sofia, M Boffardi, F Antico, P Arigliano, G Marcer, E Sala, ML Grassi, G Giana, C Staffa, V Cova, M Martinelli, A Calabrò, D Renzi, D Nigro, D Macchia, M Manfredi, E Cammelli, G Castellucci, L Ferraro, L Marchetti, G Garelli, M Colombo, E Castellano, M Cingolani, A Sabatino, A Di Blasi, M Golato, A Carlucci, G Spagnuolo, G Trivisonno, V Castelli, S Babbini, V Marrè, G Meli, S Amoroso, M Montesanti, E Mei, S Armelloni, C Gerosa, C Marcellino, C Gallo, R Pozzoli, M Peracchi, MT Bardella, C Trovato, VS Arosio, R Malberti, F Rea, MR Di Domenico, A Sergio, P Iardino, V Formicola, G Tamburro, A Massari, M Cirella, E Rondinella, A Pignero, D Scognamiglio, S Spagnuolo, S Orefice, V Romano, B Pennucci, A Maglione, S Lavecchia, A Rubino, O Leone, N Cantieri, F Michelutti, G Guariso, D Basso, S Teresi, E Gucciardino, M Di Gregorio, MA Trippiedi, P Greco, R Guadagna, E Maltese, T Imbastaro, G Lombardi, A Rossi, E Savi, L Spada, D Villalta, G Tabellini, M Saccarola, P Palumbo, G Marinucci, PM Strappini, F Viola, M Barbato, Roma, and N Bizzaro, P Pasini, F Minetti, M Scogna, M Vascotto, G Morgese, F Bascietto, P Cantelmi, F Bulacanti, D Bassetti, S Santer, D Prizzon, S Loperfido, S Martelossi, T Not, A Ventura, E Tonutti, D Visentini, S Finazzi, S Salvatore, GV Melzi d’Eril, D Wolf, M Montesanto, M Negri, MG Azzeni, R Giordano, M Farina, S Micieli, V Gouilleux, O Bandin, A Tridon, M Meyer, F Bienvenu, G Beaune, S Jego, M San Marco, D Bernard, J Sarles, J Sahel, D Carre, S Benzaken, JF Demarquay, C Johanet, JJ Baudon.

Subjects
Immunoglobulin A, Adult, Male, Adolescent, Tissue transglutaminase, Reproducibility of Result, Enzyme-Linked Immunosorbent Assay, Autoantigens, Sensitivity and Specificity, Coeliac disease, Pathology and Forensic Medicine, Serology, Antigen, Autoantigen, Immunopathology, Humans, Medicine, Age Factor, Child, Autoantibodies, Transglutaminases, biology, business.industry, Age Factors, Reproducibility of Results, Infant, Original Articles, General Medicine, Biomarker, medicine.disease, Autoantibodie, Celiac Disease, Child, Preschool, Immunoglobulin G, Immunology, biology.protein, Gluten free, Female, Antibody, business, Biomarkers, Human
Abstract

Aims: Tissue transglutaminase (tTG) was recently identified as the major autoantigen in coeliac disease. The aim of this multicentre study was to evaluate the impact of a new immunoenzymatic assay for the detection of IgA anti-tGT antibodies. Methods: Seventy four Italian and French clinical laboratories participated in this study; anti-tTG IgA with an enzyme linked immunosorbent assay (ELISA) method using guinea pig liver extract as the coating antigen, anti-endomysium IgA autoantibodies (EMA), and total serum IgA were determined in 7948 patients, 1162 of whom had coeliac disease (737 untreated cases and 425 on a gluten free diet). A proportion of the sera were then sent to a reference laboratory for anti-tTG retesting with an ELISA method using recombinant human tTG antigen. Results: Seven thousand four hundred and fifty eight (93.8%) sera were EMA/antiguinea pig tTG concordant (positive or negative); 490 (6.2%) were non-concordant. The sensitivity of EMA and antiguinea pig tTG in the 737 untreated patients with coeliac disease was 92.1% and 94.8%, respectively, and the specificity was 99.8% and 99.2%, respectively. Retesting of the discordant sera showed that of the 162 sera classified as EMA negative/antiguinea pig tTG positive, only 49 were positive for human recombinant anti-tTG, and that 39 of these were also EMA positive. Furthermore, of the 36 sera classified as EMA positive/antiguinea pig tTG negative, only two were confirmed as EMA positive. Conclusions: The antiguinea pig tTG assay is more sensitive but less specific than EMA, whereas the antihuman recombinant tTG assay is far more specific and just as sensitive as antiguinea pig tTG. Testing for EMA presents considerable interpretative problems and is difficult to standardise.

Published
2003

46. Quality of life is predictive of relapse in schizophrenia

Author

Aurélie Millier, Pascal Auquier, Laurent Boyer, Samuel Aballéa, Emeline Perthame, Mondher Toumi, Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Creativ-Ceutical France, Creativ-Ceutical, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, The study was funded by H Lundbeck A/S., and Our thanks to all of the patients and staff who helped with the study: I Lindenbach, M Swiridoff, F Baehr, G Lauer, T Schwarz, V Becker, J Hoffler, K Siegrist, U Trenckmann, T Brugha, J Smith, D Bagchi, S McCormack, S Wheatley, M Angermeyer, S Bernert, R Kilian, H Matschinger, C Mory, C Roick, M Goudemand, D Beaune, S Dumont, P Bebbington, D Ellis, L Isham, S Johnson, J Pearson, E Perez, A Regan, R White, B Lachaux, P Pasi-Delay, S Declerck, JM Azorin, JP Chabannes, P Chiaroni, I Banovic, K Hansen, C Morin, L Munier, JC Nachef, C Nickel, C Sapin and V Willacy.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Composite score, lcsh:RC435-571, MEDLINE, Independent predictor, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Recovery, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Surveys and Questionnaires, lcsh:Psychiatry, Internal medicine, Interview, Psychological, medicine, Humans, Functioning, Relapse, Psychiatry, Proportional Hazards Models, Proportional hazards model, medicine.disease, Mental health, humanities, 3. Good health, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Female, Schizophrenic Psychology, Psychology, 030217 neurology & neurosurgery, Research Article, Cohort study, Compliance
Abstract

Background The objective of this study was to evaluate whether quality of life (QoL), as measured by the SF36 and the Quality of Life Interview (QoLI), is predictive of relapse for patients with schizophrenia. Methods Using data from a multicenter cohort study conducted in France, Germany, and the United-Kingdom (EuroSC), we performed Cox proportional-hazards models to estimate the associations between QoL at baseline and the occurrence of relapse over a 24-month period, with adjustment for age; gender; positive, negative and general psychopathology PANSS factors; functioning (GAF); medication; side-effects; and compliance measures. Results Our sample consisted of 1,024 patients; 540 (53%) had at least one period of relapse, and 484 (47%) had no relapse. QoL levels were the most important features predicting relapse. We found that a higher level of QoL predicts a lower rate of relapse at 24 months: HR = 0.82 (0.74; 0.91), p Conclusions QoL, as assessed by the SF36, is an independent predictor of relapse at a 24-month follow-up in schizophrenia. This finding may have implications for future use of the QoL in psychiatry. Moreover, our findings may support the development and monitoring of complementary therapeutic approaches, such as ‘recovery-oriented’ combined with traditional mental health cares to prevent relapse.

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47. Assessing respiratory epidemic potential in French hospitals through collection of close contact data (April-June 2020).

Author

Shirreff G, Huynh BT, Duval A, Pereira LC, Annane D, Dinh A, Lambotte O, Bulifon S, Guichardon M, Beaune S, Toubiana J, Kermorvant-Duchemin E, Chéron G, Cordel H, Argaud L, Douplat M, Abraham P, Tazarourte K, Martin-Gaujard G, Vanhems P, Hilliquin D, Nguyen D, Chelius G, Fraboulet A, Temime L, Opatowski L, and Guillemot D

Subjects
Adult, Humans, Child, Disease Outbreaks, Pandemics prevention & control, Hospitals, SARS-CoV-2
Abstract

The transmission risk of SARS-CoV-2 within hospitals can exceed that in the general community because of more frequent close proximity interactions (CPIs). However, epidemic risk across wards is still poorly described. We measured CPIs directly using wearable sensors given to all present in a clinical ward over a 36-h period, across 15 wards in three hospitals in April-June 2020. Data were collected from 2114 participants and combined with a simple transmission model describing the arrival of a single index case to the ward to estimate the risk of an outbreak. Estimated epidemic risk ranged four-fold, from 0.12 secondary infections per day in an adult emergency to 0.49 per day in general paediatrics. The risk presented by an index case in a patient varied 20-fold across wards. Using simulation, we assessed the potential impact on outbreak risk of targeting the most connected individuals for prevention. We found that targeting those with the highest cumulative contact hours was most impactful (20% reduction for 5% of the population targeted), and on average resources were better spent targeting patients. This study reveals patterns of interactions between individuals in hospital during a pandemic and opens new routes for research into airborne nosocomial risk., (© 2024. The Author(s).)

Published
2024
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48. Misdiagnosis of thrombotic microangiopathy in the emergency department: a multicenter retrospective study.

Author

de Boisriou I, Ellouze S, Kassasseya C, Feral-Pierssens AL, Gerlier C, Chauvin A, Beaune S, Dubreucq E, Pereira L, Chocron R, Khellaf M, Mariotte É, Zafrani L, and Peyrony O

Subjects
Adult, Humans, Retrospective Studies, Emergency Service, Hospital, Diagnostic Errors, Purpura, Thrombotic Thrombocytopenic diagnosis, Hemolytic-Uremic Syndrome diagnosis, Thrombotic Microangiopathies diagnosis
Abstract

To estimate the rate of inappropriate diagnosis in patients who visited the ED with thrombotic microangiopathy (TMA) and to assess the factors and outcomes associated with emergency department (ED) misdiagnosis. Retrospective multicenter study of adult patients admitted to the intensive care unit (ICU) for TMA from 2012 to 2021 who had previously attended the ED for a reason related to TMA. Patient characteristics and outcomes were compared in a univariate analysis based on whether a TMA diagnosis was mentioned in the ED or not. Forty patients were included. The diagnosis of TMA was not mentioned in the ED in 16 patients (40%). Patients for whom the diagnosis was mentioned in the ED had more frequently a request for schistocytes research, and therefore had more often objectified schistocytes. They also had more frequently a troponin dosage in the ED (even if the difference was not significant), an ECG performed or interpreted, and were admitted more quickly in the ICU (0 [0-0] vs 2 [0-2] days; P = 0.002). Hemoglobin levels decreased significantly in both groups, and creatinine levels increased significantly in the misdiagnosis group between ED arrival and ICU admission. In patients with a final diagnosis of TTP, the time to platelets durable recovery was shorter for those in whom the diagnosis was mentioned in the ED without reaching statistical significance (7 [5-11] vs 14 [5-21] days; P = 0.3)., (© 2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).)

Published
2024
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49. Strategies to safely rule out pulmonary embolism in COVID-19 outpatients: a multicenter retrospective study.

Author

Chassagnon G, El Hajjam M, Boussouar S, Revel MP, Khoury R, Ghaye B, Bommart S, Lederlin M, Tran Ba S, De Margerie-Mellon C, Fournier L, Cassagnes L, Ohana M, Jalaber C, Dournes G, Cazeneuve N, Ferretti G, Talabard P, Donciu V, Canniff E, Debray MP, Crutzen B, Charriot J, Rabeau V, Khafagy P, Chocron R, Leonard Lorant I, Metairy L, Ruez-Lantuejoul L, Beaune S, Hausfater P, Truchot J, Khalil A, Penaloza A, Affole T, Brillet PY, Roy C, Pucheux J, Zbili J, Sanchez O, and Porcher R

Subjects
Humans, Retrospective Studies, Outpatients, ROC Curve, COVID-19, Pulmonary Embolism
Abstract

Objectives: The objective was to define a safe strategy to exclude pulmonary embolism (PE) in COVID-19 outpatients, without performing CT pulmonary angiogram (CTPA)., Methods: COVID-19 outpatients from 15 university hospitals who underwent a CTPA were retrospectively evaluated. D-Dimers, variables of the revised Geneva and Wells scores, as well as laboratory findings and clinical characteristics related to COVID-19 pneumonia, were collected. CTPA reports were reviewed for the presence of PE and the extent of COVID-19 disease. PE rule-out strategies were based solely on D-Dimer tests using different thresholds, the revised Geneva and Wells scores, and a COVID-19 PE prediction model built on our dataset were compared. The area under the receiver operating characteristics curve (AUC), failure rate, and efficiency were calculated., Results: In total, 1369 patients were included of whom 124 were PE positive (9.1%). Failure rate and efficiency of D-Dimer > 500 µg/l were 0.9% (95%CI, 0.2-4.8%) and 10.1% (8.5-11.9%), respectively, increasing to 1.0% (0.2-5.3%) and 16.4% (14.4-18.7%), respectively, for an age-adjusted D-Dimer level. D-dimer > 1000 µg/l led to an unacceptable failure rate to 8.1% (4.4-14.5%). The best performances of the revised Geneva and Wells scores were obtained using the age-adjusted D-Dimer level. They had the same failure rate of 1.0% (0.2-5.3%) for efficiency of 16.8% (14.7-19.1%), and 16.9% (14.8-19.2%) respectively. The developed COVID-19 PE prediction model had an AUC of 0.609 (0.594-0.623) with an efficiency of 20.5% (18.4-22.8%) when its failure was set to 0.8%., Conclusions: The strategy to safely exclude PE in COVID-19 outpatients should not differ from that used in non-COVID-19 patients. The added value of the COVID-19 PE prediction model is minor., Key Points: • D-dimer level remains the most important predictor of pulmonary embolism in COVID-19 patients. • The AUCs of the revised Geneva and Wells scores using an age-adjusted D-dimer threshold were 0.587 (95%CI, 0.572 to 0.603) and 0.588 (95%CI, 0.572 to 0.603). • The AUC of COVID-19-specific strategy to rule out pulmonary embolism ranged from 0.513 (95%CI: 0.503 to 0.522) to 0.609 (95%CI: 0.594 to 0.623)., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Published
2023
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50. Prognosis of hospitalised adult patients with respiratory syncytial virus infection: a multicentre retrospective cohort study.

Author

Celante H, Oubaya N, Fourati S, Beaune S, Khellaf M, Casalino E, Ricard JD, Vieillard-Baron A, Heming N, Mekontso Dessap A, de Montmollin E, Benghanem S, Epaillard N, Layese R, and de Prost N

Subjects
Male, Humans, Adult, Female, Aged, Aged, 80 and over, Ribavirin therapeutic use, Antiviral Agents therapeutic use, Retrospective Studies, Hospitalization, Prognosis, Respiratory Syncytial Virus Infections drug therapy, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus, Human
Abstract

Objectives: Respiratory syncytial virus (RSV) is a common agent of viral respiratory infections with significant morbidity and mortality in adults. The objective of this study was to determine risk factors for mortality and invasive mechanical ventilation and to describe the characteristics of patients who received ribavirin., Methods: A retrospective multicentre observational cohort study was conducted in Great Paris area hospitals, including patients hospitalised between 1 January 2015 and 31 December 2019 for documented RSV infection. Data were extracted from the Assistance Publique-Hôpitaux de Paris Health Data Warehouse. The primary endpoint was in-hospital mortality., Results: One thousand one hundred sixty-eight patients were hospitalised for RSV infection, including 288 (24.6%) patients who required intensive care unit (ICU) admission. The median (interquartile range) age of patients was 75 (63-85) years, and 54% (n = 631/1168) of them were women. In-hospital mortality was 6.6% (n = 77/1168) in the whole cohort and 12.8% (n = 37/288) in ICU patients. Factors associated with hospital mortality were age >85 years (adjusted odds ratio [aOR] = 6.29, 95% confidence interval [2.47-15.98]), acute respiratory failure (aOR = 2.83 [1.19-6.72]), non-invasive (aOR = 12.60 [1.41-112.36]), and invasive mechanical ventilation support (aOR = 30.13 [3.17-286.27]) and neutropenia (aOR = 13.19 [3.27-53.27]). Factors associated with invasive mechanical ventilation were chronic heart (aOR = 1.98 [1.20-3.26]) or respiratory failure (aOR = 2.83 [1.67-4.80]), and co-infection (aOR = 2.62 [1.60-4.30]). Patients who were treated with ribavirin were significantly younger than others (62 [55-69] vs. 75 [63-86] years; p < 0.001), more frequently males (n = 34/48 [70.8%] vs. n = 503/1120 [44.9%]; p 0.001), and almost exclusively immunocompromised (n = 46/48 [95.8%] vs. n = 299/1120 [26.7%]; p < 0.001)., Discussion: The mortality rate of patients hospitalised with RSV infections was 6.6%. Twenty-five per cent of the patients required ICU admission., (Copyright © 2023 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)

Published
2023
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