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752 results on '"Beaune,Philippe"'

3. From Design to Visualization of Spatial OLAP Applications: A First Prototyping Methodology

Author

Bimonte, Sandro, Hassan, Ali, Beaune, Philippe, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Link, Sebastian, editor, and Trujillo, Juan C., editor

Published
2016
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7. Recall-Oriented Evaluation for Information Retrieval Systems

Author

Audeh, Bissan, Beaune, Philippe, Beigbeder, Michel, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Lupu, Mihai, editor, Kanoulas, Evangelos, editor, and Loizides, Fernando, editor

Published
2013
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9. Steps Towards Making Contextualized Decisions: How to Do What You Can, with What You Have, Where You Are

Author

Bucur, Oana, Beaune, Philippe, Boissier, Olivier, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Roth-Berghofer, Thomas R., editor, Schulz, Stefan, editor, and Leake, David B., editor

Published
2006
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12. The Role of Ontologies in a Multi-agent Based Data Integration System

Author

Ghurbhurn, Rahee, Beaune, Philippe, Solignac, Hugues, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Pěchouček, Michael, editor, Petta, Paolo, editor, and Varga, László Zsolt, editor

Published
2005
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13. What Is Context and How Can an Agent Learn to Find and Use it When Making Decisions?

Author

Bucur, Oana, Beaune, Philippe, Boissier, Olivier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Pěchouček, Michael, editor, Petta, Paolo, editor, and Varga, László Zsolt, editor

Published
2005
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15. Human Epoxide Hydrolase is the Target of Germander Autoantibodies on the Surface of Human Hepatocytes: Enzymatic Implications

Author

Loeper, Jacqueline, De Berardinis, Veronique, Moulis, Claude, Beaune, Philippe, Pessayre, Dominique, Pompon, Denis, Dansette, Patrick M., editor, Snyder, Robert, editor, Delaforge, Marcel, editor, Gibson, G. Gordon, editor, Greim, Helmut, editor, Jollow, David J., editor, Monks, Terrence J., editor, and Sipes, I. Glenn, editor

Published
2001
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16. Personalized Medicine: how to Switch from the Concept to the Integration into the Clinical Development Plan to Obtain Marketing Authorization

Author

Bardou, Marc, Beaune, Philippe, Belorgey, Chantal, Bibeau, Frédéric, Boissel, Jean-Pierre, Courcier, Soizic, De Broucker, Frédérique, Demotes-Mainard, Jacques, Diaz, Isabelle, Fagon, Jean-Yves, Girault, Danièle, Goni, Sylvia, Hanf, Rémy, Hermann, Marie-Annick, Mismetti, Patrick, Morali, Monique, Pavlovic, Mira, Perrin, Elena, Plétan, Yannick, Sauce, Christophe, Vassal, Gilles, Becquemont, Laurent, Bordet, Régis, and Cellier, Dominic

Published
2012
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17. La médecine personnalisée : comment passer du concept à l’intégration dans un plan de développement clinique en vue d’une AMM ?

Author

Bardou, Marc, Beaune, Philippe, Belorgey, Chantal, Bibeau, Frédéric, Boissel, Jean-Pierre, Courcier, Soizic, De Broucker, Frédérique, Demotes-Mainard, Jacques, Diaz, Isabelle, Fagon, Jean-Yves, Girault, Danièle, Goni, Sylvia, Hanf, Rémy, Hermann, Marie-Annick, Mismetti, Patrick, Morali, Monique, Pavlovic, Mira, Perrin, Elena, Plétan, Yannick, Sauce, Christophe, Vassal, Gilles, Becquemont, Laurent, Bordet, Régis, and Cellier, Dominic

Published
2012
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38. Cyclosporine triggers endoplasmic reticulum stress in endothelial cells: a role for endothelial phenotypic changes and death

Author

Bouvier, Nicolas, Flinois, Jean Pierre, Gilleron, Jerome, Sauvage, Francois-Ludovic, Legendre, Christophe, Beaune, Philippe, Thervet, Eric, Anglicheau, Dany, and Pallet, Nicolas

Subjects
Organ transplant recipients -- Health aspects, Cyclosporine -- Dosage and administration, Endoplasmic reticulum -- Physiological aspects, Endoplasmic reticulum -- Research, Stress (Physiology) -- Research, Biological sciences
Abstract

Calcineurin inhibitors cyclosporine and tacrolimus are effective immunosuppressants, but both substances have the same intrinsic nephrotoxic potential that adversely affects allograft survival in renal transplant patients and causes end-stage renal disease in other solid organ or bone marrow transplant recipients. Endothelial cells are the first biological interface between drugs and the kidney, and calcineurin inhibitors may influence endothelial function and viability in a number of ways. Notably, endothelial cells have recently been shown to contribute to the accumulation of interstitial fibroblasts in nonrenal models, through endothelial-to-mesenchymal transition. Here we demonstrate that cyclosporine, but not tacrolimus or its metabolites, induces morphological and phenotypic endothelial changes suggestive of a partial endothelial-to-mesenchymal transition in human umbilical arterial endothelial cells. We identify for the first time a contingent of interstitial myofibroblasts that coexpress endothelial markers in rat kidneys treated with cyclosporine, suggesting that endothelial-to-mesenchymal transition could occur in vivo. Finally, our findings suggest that endoplasmic reticulum stress triggered by cyclosporine induces endothelial cells to undergo endothelial phenotypic changes suggestive of a partial endothelial-to-mesenchymal transition, whereas salubrinal partially preserves the endothelial phenotype. Inversely, tacrolimus does not induce endothelial-to-mesenchymal transition or endoplasmic reticulum stress. In conclusion, this study demonstrates for the first time that cyclosporine, and not tacrolimus, induces endoplasmic reticulum stress in endothelial cells. Our findings also suggest that endoplasmic reticulum stress contributes to endothelial cell death and phenotypic changes similar to a partial endothelial-to-mesenchymal transition. tacrolimus; endothelial-to-mesenchymal transition; epithelial-to-mesenchymal transition

Published
2009

39. Chemoinformatic Analysis of Psychotropic and Antihistaminic Drugs in the Light of Experimental Anti-SARS-CoV-2 Activities

Author

Villoutreix,Bruno O, Krishnamoorthy,Rajagopal, Tamouza,Ryad, Leboyer,Marion, Beaune,Philippe, Villoutreix,Bruno O, Krishnamoorthy,Rajagopal, Tamouza,Ryad, Leboyer,Marion, and Beaune,Philippe

Abstract

Bruno O Villoutreix,1 Rajagopal Krishnamoorthy,2 Ryad Tamouza,2 Marion Leboyer,2 Philippe Beaune3 1INSERM U1141, NeuroDiderot, Université de Paris, Hôpital Robert-Debré, Paris, F-75019, France; 2Université Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuropsychiatrie Translationnelle, AP-HP, Département Medico-Universitaire de Psychiatrie et d’Addictologie (DMU ADAPT), Hôpital Henri Mondor, Fondation FondaMental, Créteil, F-94010, France; 3INSERM U1138, Centre de Recherche des Cordeliers, Université de Paris, Paris, 75006, FranceCorrespondence: Bruno O Villoutreix Email bruno.villoutreix@inserm.frIntroduction: There is an urgent need to identify therapies that prevent SARS-CoV-2 infection and improve the outcome of COVID-19 patients.Objective: Based upon clinical observations, we proposed that some psychotropic and antihistaminic drugs could protect psychiatric patients from SARS-CoV-2 infection. This observation is investigated in the light of experimental in vitro data on SARS-CoV-2.Methods: SARS-CoV-2 high-throughput screening results are available at the NCATS COVID-19 portal. We investigated the in vitro anti-viral activity of many psychotropic and antihistaminic drugs using chemoinformatics approaches.Results and Discussion: We analyze our clinical observations in the light of SARS-CoV-2 experimental screening results and propose that several cationic amphiphilic psychotropic and antihistaminic drugs could protect people from SARS-CoV-2 infection; some of these molecules have very limited adverse effects and could be used as prophylactic drugs. Other cationic amphiphilic drugs used in other disease areas are also highlighted. Recent analyses of patient electronic health records reported by several research groups indicate that some of these molecules could be of interest at different stages of the disease progression. In addition, recently reported d

Published
2021

42. Collection of human genomic DNA from buccal cells for genetics studies: comparison between cytobrush, mouthwash, and treated card

Author

Mulot, Claire, Stucker, Isabelle, Clavel, Jacqueline, Beaune, Philippe, and Loriot, Marie-Anne

Subjects
Research, Genetics -- Research, DNA -- Research, Epidemiology -- Research, Genomics -- Research
Abstract

Alternative sources such as buccal cells have already been tested for genetic studies and epidemiological investigations. Thirty-seven volunteers participated in this study to compare cytology brushes, mouthwash, and treated cards [...]

Published
2005

50. HMGA1 enhances the transcriptional activity and binding of the estrogen receptor to its responsive element

Author

Massaad-Massade, Liliane, Navarro, Sebastien, Krummrei, Ulrike, Reeves, Raymond, Beaune, Philippe, and Barouki, Robert

Subjects
Biochemistry -- Research, Estrogen -- Receptors, Genetic transcription -- Physiological aspects, Cells -- Genetic aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the estrogen receptor. The overexpression of the HMGA1 in the malignant cell has been carried out and the results indicate that it enhances transcriptional activity of the promoters containing estrogen response element and increases the binding of the estrogen receptor to the estrogen response element .

Published
2002

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