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Your search keyword '"Beau, J. M."' showing total 162 results
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162 results on '"Beau, J. M."'

4. Conformational differences between C- and O-glycosides: The α-C-mannobiose/α-O-mannobiose case

Author

Espinosa, J. -F, Bruix, M., Jarreton, O., Troels Skrydstrup, Beau, J. -M, Jiménez-Barbero, J., Dirección General de Investigación Científica y Técnica, DGICT (España), Mizutani Foundation for Glycoscience, and Ministerio de Educación y Ciencia (España)

Subjects
Conformation analysis, Mannobiose, Molecular modeling, C-glycosides
Abstract

NMR spectroscopy and molecular mechanics calculations have demonstrated that the conformational behavior of α-C-mannobiose (1) is rather different from that of its natural analogue Manα(1→2)Man (2); this has implications for the possibility of biological use of C-disaccharides., Financial support by DGICYT(GrantPB96-0833) and by Mizutani Glycoscience Foundation is gratefully acknowledged. J.F.E. thanks Ministerio de Educacion y Ciencia for a FPU fellowship.

Published
1999

38. ChemInform Abstract: Total Synthesis of a Fully Protected Palytoxin Carboxylic Acid.

Author

ARMSTRONG, R. W., primary, BEAU, J.-M., additional, CHEON, S. H., additional, CHRIST, W. J., additional, FUJIOKA, H., additional, HAM, W.-H., additional, HAWKINS, L. D., additional, JIN, H., additional, KANG, S. H., additional, KISHI, Y., additional, MARTINELLI, M. J., additional, MCWHORTER, W. W. JUN., additional, MIZUNO, M., additional, NAKATA, M., additional, STUTZ, A. E., additional, TALAMAS, F. X., additional, TANIGUCHI, M., additional, TINO, J. A., additional, UEDA, K., additional, UENISHI, J., additional, WHITE, J. B., additional, and YONAGA, M., additional

Published
1990
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39. ChemInform Abstract: Total Synthesis of Palytoxin Carboxylic Acid and Palytoxin Amide.

Author

ARMSTRONG, R. W., primary, BEAU, J.‐M., additional, CHEON, S. H., additional, CHRIST, W. J., additional, FUJIOKA, H., additional, HAM, W.‐H., additional, HAWKINS, L. D., additional, JIN, H., additional, KANG, S. H., additional, KISHI, Y., additional, MARTINELLI, M. J., additional, MCWHORTER, W. W. JUN., additional, MIZUNO, M., additional, NAKATA, M., additional, STUTZ, A. E., additional, TALAMAS, F. X., additional, TANIGUCHI, M., additional, TINO, J. A., additional, UEDA, K., additional, UENISHI, J., additional, WHITE, J. B., additional, and YONAGA, M., additional

Published
1990
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42. Diabetic neuropathies.

Author

Vinik, Aaron I., Liuzzi, Francis J., Holland, Marie T., Stansberry, Kevin B., Le Beau, Jean M., Colen, Larry B., Vinik, A I, Holland, M T, Le Beau, J M, Liuzzi, F J, Stansberry, K B, and Colen, L B

Published
1992
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43. Nodule-inducing activity of synthetic Sinorhizobium meliloti nodulation factors and related lipo-chitooligosaccharides on alfalfa. Importance of the acyl chain structure.

Author

Demont-Caulet, N, Maillet, F, Tailler, D, Jacquinet, J C, Promé, J C, Nicolaou, K C, Truchet, G, Beau, J M, and Dénarié, J

Abstract

Sinorhizobium meliloti nodulation factors (NFs) elicit a number of symbiotic responses in alfalfa (Medicago sativa) roots. Using a semiquantitative nodulation assay, we have shown that chemically synthesized NFs trigger nodule formation in the same range of concentrations (down to 10(-10) M) as natural NFs. The absence of O-sulfate or O-acetate substitutions resulted in a decrease in morphogenic activity of more than 100-fold and approximately 10-fold, respectively. To address the question of the influence of the structure of the N-acyl chain, we synthesized a series of sulfated tetrameric lipo-chitooligosaccharides (LCOs) having fatty acids of different lengths and with unsaturations either conjugated to the carbonyl group (2E) or located in the middle of the chain (9Z). A nonacylated, sulfated chitin tetramer was unable to elicit nodule formation. Acylation with short (C8) chains rendered the LCO active at 10(-7) M. The optimal chain length was C16, with the C16-LCO being more than 10-fold more active than the C12- and C18-LCOs. Unsaturations were important, and the diunsaturated 2E,9Z LCO was more active than the monounsaturated LCOs. We discuss different hypotheses for the role of the acyl chain in NF perception.

Published
1999
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44. Chemical behaviour of cytidine-5’-monophospho-N-acetyl-β-D-neuraminic acid under neutral and alkaline conditions

Author

Vliegenthart, J.F.G., Beau, J.-M., Schauer, R., Haverkamp, J., Kamerling, J.P., and Dorland, L.

Subjects
carbohydrates (lipids), Scheikunde
Abstract

The chemical behaviour of CMP-N-acetylneuraminic acid under neutral and different alkaline conditions has been investigated. The products formed were isolated by ion-exchange chromatography and gel filtration and analysed by colorimetric methods, thin-layer chromatography, combined gas-liquid chromatography/mass spectrometry and/or 360-MHz 1H-NMR spectroscopy. A maximum stability of CMP-N-acetylneuraminic acid was observed at pH 811. In the tested pH range of 613, CMP and N-acetylneuraminic acid were formed in variable amounts as decomposition products. 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid was produced at pH > 7; the amount of this substance increased with increasing pH. In anhydrous triethylamine its yield was 50%. A new neuraminic acid derivative, N-acetyl--d-neuraminic acid 2-phosphate, could be isolated from the mixture of alkaline decomposition products of CMP-N-acetylneuraminic acid. The yield of this compound was maximum 22% in anhydrous triethylamine. Because 2-deoxy-2,3-dehydro-N-acetylneuraminic acid was formed under simulated physiological conditions, it is assumed that this compound, which occurs in tissues and fluids of man and animals, is derived from CMP-N-acetylneuraminic acid non-enzymically also under conditions in vivo.

Published
1984

45. Synthèse de l'acide 5-acétamido-3,5-didésoxy-4-O-méthyl-D-glycéro-D-galacto-2-nonulosonique (acide 4-O-méthyl-N-acétylneuraminique). Partie II

Author

Vliegenthart, J.F.G., Beau, J.-M., Sinaÿ, P., and Kamerling, J.P.

Subjects
Scheikunde
Abstract

3-Acetamido-3-deoxy-4,5:6,7-di-O-isopropylidene-D-glycero-D-galacto-heptose diethyl dithioacetal was transformed into 3-acetamido-3-deoxy-4,5:6,7-di-O-isopro-pylidene-2-O-methyl-aldehydro-D-glycero-D-galacto-heptose after O-methylation followed by desulfuration. A Wittig reaction with an excess of [ethoxy(ethoxycarbonyl)-methylene]triphenylphosphorane in the presence of benzoic acid gave a mixture of ethyl 5-acetamido-3.5-dideoxy-2-O-ethyl-6,7:8,9-di-O-isopropylidene-4-O-methyl-D-glycero-D-galacto-non-2-enonate (23 %) and the D-glycero-D-talo (22 %) isomer. An ethoxymercuration-demercuration reaction, followed by acid hydrolysis, converted the former into ethyl 4-O-methyl-N-acetylneuraminate and the latter into the C-4 stereoisomer. 4-O-Methyl-N-acetylneuraminic acid was then obtained in crystalline form, and its structure ascertained by mass spectrometry and 1H- and 13C-nuclear magnetic resonance

Published
1978

50. Lipo-chitooligosaccharidic symbiotic signals are recognized by the LysM receptor-like kinase LYR3 in the legume Medicago truncatula

Author

Fliegmann, J., Canova, S., Lachaud, C., Uhlenbroich, S., Gasciolli, V., Pichereaux, C., Rossignol, M., Rosenberg, C., Cumener, M., Pitorre, D., Benoit Lefebvre, Gough, C., Samain, E., Fort, S., Driguez, H., Vauzeilles, B., Beau, J. M., Nurisso, A., Imberty, A., Cullimore, J., Bono, J. J., inconnu, Inconnu, Centre de Recherches sur les Macromolécules Végétales (CERMAV), and Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

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