951 results on '"Beatrice F"'
Search Results
2. SPEN is required for Xist upregulation during initiation of X chromosome inactivation
- Author
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Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, and Joost Gribnau
- Subjects
Science - Abstract
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
- Published
- 2021
- Full Text
- View/download PDF
3. Transcriptome analysis of the zebrafish atoh7−/− Mutant, lakritz, highlights Atoh7‐dependent genetic networks with potential implications for human eye diseases
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Giuseppina Covello, Fernando J. Rossello, Michele Filosi, Felipe Gajardo, Anne‐Laure Duchemin, Beatrice F. Tremonti, Michael Eichenlaub, Jose M. Polo, David Powell, John Ngai, Miguel L. Allende, Enrico Domenici, Mirana Ramialison, and Lucia Poggi
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Ath5 ,human retina ,inherited eye diseases ,retinal ganglion cells ,transcriptome analysis ,Biology (General) ,QH301-705.5 - Abstract
Abstract Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing ATOH7 as a retinal disease gene. Remarkably, such studies uncovered ATOH7 variants associated with global eye defects including optic nerve hypoplasia, microphthalmia, retinal vascular disorders, and glaucoma. The complex genetic networks and cellular decisions arising downstream of atoh7 expression, and how their dysregulation cause development of such disease traits remains unknown. To begin to understand such Atoh7‐dependent events in vivo, we performed transcriptome analysis of wild‐type and atoh7 mutant (lakritz) zebrafish embryos at the onset of retinal ganglion cell differentiation. We investigated in silico interplays of atoh7 and other disease‐related genes and pathways. By network reconstruction analysis of differentially expressed genes, we identified gene clusters enriched in retinal development, cell cycle, chromatin remodeling, stress response, and Wnt pathways. By weighted gene coexpression network, we identified coexpression modules affected by the mutation and enriched in retina development genes tightly connected to atoh7. We established the groundwork whereby Atoh7‐linked cellular and molecular processes can be investigated in the dynamic multi‐tissue environment of the developing normal and diseased vertebrate eye.
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- 2020
- Full Text
- View/download PDF
4. Loss of function mutations in essential genes cause embryonic lethality in pigs.
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Martijn F L Derks, Arne B Gjuvsland, Mirte Bosse, Marcos S Lopes, Maren van Son, Barbara Harlizius, Beatrice F Tan, Hanne Hamland, Eli Grindflek, Martien A M Groenen, and Hendrik-Jan Megens
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Genetics ,QH426-470 - Abstract
Lethal recessive alleles cause pre- or postnatal death in homozygous affected individuals, reducing fertility. Especially in small size domestic and wild populations, those alleles might be exposed by inbreeding, caused by matings between related parents that inherited the same recessive lethal allele from a common ancestor. In this study we report five relatively common (up to 13.4% carrier frequency) recessive lethal haplotypes in two commercial pig populations. The lethal haplotypes have a large effect on carrier-by-carrier matings, decreasing litter sizes by 15.1 to 21.6%. The causal mutations are of different type including two splice-site variants (affecting POLR1B and TADA2A genes), one frameshift (URB1), and one missense (PNKP) variant, resulting in a complete loss-of-function of these essential genes. The recessive lethal alleles affect up to 2.9% of the litters within a single population and are responsible for the death of 0.52% of the total population of embryos. Moreover, we provide compelling evidence that the identified embryonic lethal alleles contribute to the observed heterosis effect for fertility (i.e. larger litters in crossbred offspring). Together, this work marks specific recessive lethal variation describing its functional consequences at the molecular, phenotypic, and population level, providing a unique model to better understand fertility and heterosis in livestock.
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- 2019
- Full Text
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5. Transcriptome analysis of the zebrafish atoh7−/− Mutant, lakritz, highlights Atoh7‐dependent genetic networks with potential implications for human eye diseases
- Author
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Covello, Giuseppina, Rossello, Fernando J, Filosi, Michele, Gajardo, Felipe, Duchemin, Anne‐Laure, Tremonti, Beatrice F, Eichenlaub, Michael, Polo, Jose M, Powell, David, Ngai, John, Allende, Miguel L, Domenici, Enrico, Ramialison, Mirana, and Poggi, Lucia
- Subjects
Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Neurosciences ,Eye Disease and Disorders of Vision ,Aetiology ,2.1 Biological and endogenous factors ,Eye ,Ath5 ,human retina ,inherited eye diseases ,retinal ganglion cells ,transcriptome analysis ,Biological sciences - Abstract
Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the development of retinal ganglion cells. Several studies have emerged establishing ATOH7 as a retinal disease gene. Remarkably, such studies uncovered ATOH7 variants associated with global eye defects including optic nerve hypoplasia, microphthalmia, retinal vascular disorders, and glaucoma. The complex genetic networks and cellular decisions arising downstream of atoh7 expression, and how their dysregulation cause development of such disease traits remains unknown. To begin to understand such Atoh7-dependent events in vivo, we performed transcriptome analysis of wild-type and atoh7 mutant (lakritz) zebrafish embryos at the onset of retinal ganglion cell differentiation. We investigated in silico interplays of atoh7 and other disease-related genes and pathways. By network reconstruction analysis of differentially expressed genes, we identified gene clusters enriched in retinal development, cell cycle, chromatin remodeling, stress response, and Wnt pathways. By weighted gene coexpression network, we identified coexpression modules affected by the mutation and enriched in retina development genes tightly connected to atoh7. We established the groundwork whereby Atoh7-linked cellular and molecular processes can be investigated in the dynamic multi-tissue environment of the developing normal and diseased vertebrate eye.
- Published
- 2020
6. Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation.
- Author
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Spinelli, Sonia, Barbieri, Federica, Averna, Monica, Florio, Tullio, Pedrazzi, Marco, Tremonti, Beatrice F., Capraro, Michela, and De Tullio, Roberta
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- 2024
- Full Text
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7. The Timurid Empire
- Author
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Manz, Beatrice F., Pajares, Alberto Bernabé, Series Editor, Fink, Sebastian, Series Editor, Gunter, Ann C., Series Editor, Potts, Dan T., Series Editor, Rollinger, Robert, Series Editor, Ruffing, Kai, Series Editor, Degen, Julian, editor, and Gehler, Michael, editor
- Published
- 2020
- Full Text
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8. Psychological Treatment for Patients Receiving Radiation: Results of NRG Oncology/RTOG 0841
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Small, William, Jr., Pugh, Stephanie L., Wagner, Lynne I., Kirshner, Jeffrey, Sidhu, Kulbir, Bury, Martin J., DeNittis, Albert S., Alpert, Tracy E., Tran, Binh, Bloom, Beatrice F., Mai, Julie, and Bruner, Deborah Watkins
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- 2021
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9. Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
- Author
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Espejo-Serrano, Carmen, Aitken, Catriona, Tan, Beatrice F., May, Danielle G., Chrisopulos, Rachel J., Roux, Kyle J., Demmers, Jeroen Aa, Mackintosh, Samuel G., Gribnau, Joost, Bustos, Francisco, Gontan, Cristina, Findlay, Greg M., Espejo-Serrano, Carmen, Aitken, Catriona, Tan, Beatrice F., May, Danielle G., Chrisopulos, Rachel J., Roux, Kyle J., Demmers, Jeroen Aa, Mackintosh, Samuel G., Gribnau, Joost, Bustos, Francisco, Gontan, Cristina, and Findlay, Greg M.
- Abstract
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is mutated in an X-linked intellectual disability disorder. However, the precise mechanisms by which ubiquitylation drives specific transcriptional responses are not known. Here, we show that RNF12 is recruited to specific genomic locations via a consensus sequence motif, which enables co-localisation with REX1 substrate at gene promoters. Surprisingly, RNF12 chromatin recruitment is achieved via a non-catalytic basic region and comprises a previously unappreciated N-terminal autoinhibitory mechanism. Furthermore, RNF12 chromatin targeting is critical for REX1 ubiquitylation and downstream RNF12-dependent gene regulation. Our results demonstrate a key role for chromatin in regulation of the RNF12-REX1 axis and provide insight into mechanisms by which protein ubiquitylation enables programming of gene expression.
- Published
- 2024
10. Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
- Author
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Espejo-Serrano, Carmen, primary, Aitken, Catriona, additional, Tan, Beatrice F, additional, May, Danielle G, additional, Chrisopulos, Rachel J, additional, Roux, Kyle J, additional, Demmers, Jeroen AA, additional, Mackintosh, Samuel G, additional, Gribnau, Joost, additional, Bustos, Francisco, additional, Gontan, Cristina, additional, and Findlay, Greg M, additional
- Published
- 2024
- Full Text
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11. SPEN is required for Xist upregulation during initiation of X chromosome inactivation
- Author
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Robert-Finestra, Teresa, Tan, Beatrice F., Mira-Bontenbal, Hegias, Timmers, Erika, Gontan, Cristina, Merzouk, Sarra, Giaimo, Benedetto Daniele, Dossin, François, van IJcken, Wilfred F. J., Martens, John W. M., Borggrefe, Tilman, Heard, Edith, and Gribnau, Joost
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- 2021
- Full Text
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12. Achieving Dramatic School Improvement: An Exploratory Study. A Cross-Site Analysis from the Evaluation of Comprehensive School Reform Program Implementation and Outcomes Study
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Office of Planning, Evaluation and Policy Development (ED), Policy and Program Studies Service, Aladjem, Daniel K., Birman, Beatrice F., and Orland, Martin
- Abstract
This exploratory study describes approaches to improving schools through retrospective, in-depth qualitative case studies. To select schools to be examined, the authors sought to identify Comprehensive School Reform (CSR) schools demonstrating two distinctive patterns of improved student achievement between 2000 and 2005, rapid-improvement (i.e., schools that made quick and dramatic improvements in student achievement over a one or two year time period) as well as slow-and-steady (i.e., schools that made noteworthy student achievement improvements but over a four or five year timeframe). This process led the authors to study 11 schools. This report provides examples of how some schools appear to be achieving noteworthy gains in student outcomes; while achieving these gains appears to be relatively rare, there also appears to be multiple ways to do so. This study points to the dynamic settings in which many low-performing schools operate and the need for ongoing investigation of how schools can achieve impressive results and sustain them in constantly changing environments. Researchers, policymakers, and practitioners in recent years have paid much attention to the scientific search for "what works" to improve schools and turn them around. This study's findings draw attention to the fact that turning schools around is not just about adopting a set of effective or promising practices. It is about recognizing that "one best system" does not exist--that no single approach can guarantee improvement in a particular school. It is also about implementing practices well, while at the same time navigating and adapting to a constantly changing landscape. Appended are: (1) Detailed Methodology; (2) Data Collection Instruments; and (3) Site Abstracts. (Contains 56 exhibits and 32 footnotes.)
- Published
- 2010
13. An Exploratory Analysis of Adequate Yearly Progress, Identification for Improvement, and Student Achievement in Two States and Three Cities. Technical Report
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Department of Education (ED), Office of Planning, Evaluation and Policy Development, Gill, Brian, Lockwood, J.R., III, Martorell, Francisco, Setodji, Claude Messan, Booker, Kevin, Vernez, Georges, Birman, Beatrice F., and Garet, Michael S.
- Abstract
Title I of the federal Elementary and Secondary Education Act, as reauthorized by the No Child Left Behind Act (NCLB), requires states to establish standards, assessments, and accountability systems to ensure that every child achieves proficiency in reading and mathematics by the year 2014. This report describes exploratory analyses of the effects of components of the No Child Left Behind accountability system on the achievement of students in affected Title I schools. The analyses used school-level and student-level assessment data from two states and three school districts, employing a quasi-experimental regression discontinuity method to examine whether schools that fell short of "adequate yearly progress" (AYP) or were identified for improvement under NCLB showed subsequent improvements in student achievement. The purpose of the analysis was to explore the usefulness of the regression discontinuity method for examining the effects of the NCLB accountability system. This analysis was conducted under the National Longitudinal Study of No Child Left Behind (NLS-NCLB), which is examining the implementation of key NCLB provisions at the district and school levels. This report divides into five parts. Following the Introduction in Part 1, Part 2 contains: Using RD to Examine the Effects of Not Making AYP and Identification for Improvement. Part 3 continues with: School-Level RD Analysis in Two States; and Part 4 presents: RD Analysis of Student-Level Achievement Data in Three Large Districts. Part 5 concludes with: Summary and Implications. Appended are: (1) Supplemental Tables for Subgroups of Students, and (2) Selection of Sites Included in This Report. (Contains 23 exhibits.)
- Published
- 2009
14. State and Local Implementation of the 'No Child Left Behind Act.' Volume VIII--Teacher Quality under 'NCLB': Final Report
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Office of Planning, Evaluation and Policy Development (ED), Policy and Program Studies Service, Birman, Beatrice F., Boyle, Andrea, Le Floch, Kerstin Carlson, Elledge, Amy, Holtzman, Deborah, Song, Mengli, Thomsen, Kerri, Walters, Kirk, and Yoon, Kwang-Suk
- Abstract
This report presents findings about teacher quality from two longitudinal studies, the National Longitudinal Study of "No Child Left Behind" (NLS-"NCLB"), and the Study of State Implementation of Accountability and Teacher Quality Under "No Child Left Behind" (SSI-"NCLB"). The research teams for these two studies have collaborated to provide an integrated evaluation of the implementation of key "NCLB" provisions at the state level (SSI-"NCLB") and at the district and school levels (NLS-"NCLB"). Together the two studies are the basis for a series of reports on the topics of accountability, teacher quality, Title I school choice and supplemental educational services, and targeting and resource allocation. This is the eighth volume in this report series. Based on findings from the two studies, this report describes the progress that states, districts, and schools have made implementing the teacher and paraprofessional qualification provisions of "NCLB" through 2006-07. Reported findings indicate that: (1) Most teachers met their states' requirements to be considered highly qualified under "NCLB"; (2) The percentage of teachers who were not highly qualified under "NCLB" was higher for special education teachers and middle school teachers, and for teachers in high-poverty and high-minority schools; (3) Despite "NCLB" emphasis on sustained, intensive, classroom-focused professional development, a relatively small proportion of teachers reported taking part in content-focused professional development related to teaching reading or mathematics for an extended period of time; and (4) According to state-reported data for 2005-06, 86 percent of Title I instructional paraprofessionals were qualified under "NCLB." The report concludes that, in general, states and districts are working to implement and comply with the "NCLB" requirements for teacher qualifications: States have set guidelines for highly qualified teachers under "NCLB" and have been updating their data systems. According to states, 94 percent of teachers were designated as highly qualified under "NCLB" in 2006-07, and approximately 94 percent of all paraprofessionals reported holding a qualification that would meet the "NCLB" criteria. States and districts are also working to develop strategies designed to recruit and retain highly qualified teachers, particularly in traditionally disadvantaged schools. Issues recommended for further investigation include: (1) Variations among state policies concerning highly qualified teachers raise questions about whether some states have set high enough standards for teacher qualifications under "NCLB" to ensure that teachers have a solid understanding of the subjects they teach; (2) Variation in teachers' highly qualified status across types of teachers and schools highlights enduring inequities in access to highly qualified teachers; (3) Because many teachers were not aware or notified of their "NCLB" status, they may not have taken necessary steps to become highly qualified; and (4) The low proportion of teachers participating in content-focused professional development over an extended period of time suggests that more can be done to deepen teachers' content knowledge. Four appendixes are included: (1) Description of NLS-"NCLB" and SSI-"NCLB" Methodologies; (2) Supplemental NLS-"NCLB" Exhibits and Standard Error Reports; (3) Supplemental State Exhibits; and (4) Definition of professional Development in Section 9101(34) of the "ESEA" ["Elementary and Secondary Education Act of 1965"]. (Contains 87 footnotes and 139 exhibits.)
- Published
- 2009
15. State and Local Implementation of the 'No Child Left Behind Act.' Volume II--Teacher Quality under 'NCLB': Interim Report
- Author
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Department of Education, Washington, DC., Birman, Beatrice F., Le Floch, Kerstin Carlson, Klekotka, Amy, Ludwig, Meredith, Taylor, James, Walters, Kirk, Wayne, Andrew, and Yoon, Kwang-Suk
- Abstract
This report presents findings about teacher quality from two longitudinal studies, the National Longitudinal Study of "No Child Left Behind" (NLS-"NCLB"), and the Study of State Implementation of Accountability and Teacher Quality Under "No Child Left Behind" (SSI-"NCLB"). The research teams for these two studies have collaborated to provide an integrated evaluation of the implementation of key "NCLB" provisions at the state level (SSI-"NCLB") and at the district and school levels (NLS-"NCLB"). Together the two studies are the basis for a series of reports on the topics of accountability, teacher quality, Title I school choice and supplemental educational services, and targeting and resource allocation. This report describes the progress that states, districts, and schools have made implementing the teacher and paraprofessional qualification provisions of the "No Child Left Behind Act" through 2004-05. The studies found that: (1) Most teachers met their states' requirements to be considered highly qualified under "NCLB." However, state policies concerning highly qualified teachers varied greatly, both in the passing scores that new teachers must meet to demonstrate content knowledge on assessments and in the extent to which state "HOUSSE" policies give existing teachers credit for years of prior teaching experience versus emphasizing more direct measures of content knowledge and teaching performance. (2) The percentage of teachers who are not highly qualified under "NCLB" is higher for special education teachers, teachers of LEP (limited English proficiency) students and middle school teachers, as well as for teachers in high-poverty and high-minority schools. Moreover, even among teachers who were considered highly qualified, teachers in high-poverty schools had less experience and were less likely to have a degree in the subject they taught. (3) Although nearly all teachers reported taking part in content-focused professional development related to teaching reading or mathematics, a relatively small proportion participated in such learning opportunities for an extended period of time. (4) About two-thirds of instructional paraprofessionals were considered qualified under "NCLB," but nearly a third (28 percent) did not know their status or did not provide a response to the study questions. Most paraprofessionals reported working under the direct supervision of a teacher, but some Title I instructional paraprofessionals indicated that they worked with students on their own without close supervision from a teacher. In general, the SSI-"NCLB" and NLS-"NCLB" studies indicate that states and districts are working to implement and comply with the "NCLB" requirements for teacher and paraprofessional qualifications. This is the second volume in this report series. The following are appended: (1) Description of NLS-"NCLB" and SSI-"NCLB" Methodologies; (2) Supplemental NLS-"NCLB" Exhibits and Standard Error Reports; and (3) Supplemental State Exhibits. (Contains 125 exhibits.) [This report was prepared for the Policy and Program Studies Services, Office of Planning, Evaluation and Policy Development, U.S. Department of Education. For "Volume I: Title I School Choice, Supplemental Educational Services, and Student Achievement, see ED497259.]
- Published
- 2007
16. Does Professional Development Change Teaching Practice? Results from a Three-Year Study.
- Author
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American Institutes for Research in the Behavioral Sciences, Washington, DC., Porter, Andrew C., Garet, Michael S., Desimone, Laura, Yoon, Kwang Suk, and Birman, Beatrice F.
- Abstract
This report, the third in a series of reports from the longitudinal evaluation of the Eisenhower Professional Development Program, examines the effects of professional development on improving classroom teaching practice. The Eisenhower Professional Development Program, Title II of the Elementary and Secondary Education Act, is the federal government's largest investment that focuses solely on developing the classroom teachers' knowledge and skills. Drawing on longitudinal data from approximately 300 teachers, this report discusses the impact of the types of professional development activities supported by the Eisenhower Professional Development Program. Results indicate that professional development focused on specific, higher order teaching strategies increased teachers' uses of these strategies in the classroom. This effect was even stronger when the professional development activity was a reform type, rather than traditional. Teachers in the sample did not consistently receive high quality professional development, and teachers in the same school tended to have quite different professional development experiences. There was little change in overall teaching practice from 1996-99. Despite little average change over time in teaching practice, individual teachers varied in their classroom practices, and moderate variation occurred in the classroom practices of individual teachers from year to year. (SM)
- Published
- 2000
17. Designing Effective Professional Development: Lessons from the Eisenhower Program [and] Technical Appendices.
- Author
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American Institutes for Research, Washington, DC., Garet, Michael S., Birman, Beatrice F., Porter, Andrew C., Desimone, Laura, and Herman, Rebecca
- Abstract
The professional development of teachers is a crucial element of the nation's efforts to improve education. In recent years, these efforts have sought to foster high standards for teaching and learning for all of the nation's children, and almost all states have met federal requirements for developing challenging statewide content standards. Such standards seek a fundamental shift in what students learn. However, children's learning will be transformed only if high standards are reflected in teachers' classroom practice. Education reforms will not succeed without teachers who are immersed in the subjects they teach and who know how to foster both basic knowledge and advanced thinking and problem solving among their students. The Eisenhower Professional Development Program, Title II of the Elementary and Secondary Education Act (ESEA), is the federal government's largest investment that is solely focused on developing the knowledge and skills of classroom teachers. This is the second report of the National Evaluation of the Eisenhower Professional Development Program, Part B (State and Local Activities), a multi-year evaluation being conducted by the American Institutes for Research (AIR) under a contract with the U.S. Department of Education's Planning and Evaluation Service. The first report was based on six exploratory case studies of school districts conducted during the first months of the evaluation. This second report describes the current status of the program, based primarily on data from national probability samples of districts, SAHE grantees (i.e., the institutions of higher education and nonprofit organizations supported through the SAHE component of the program), and teachers, as well as on data from 10 in-depth case studies in 5 states. Contains 140 references. (Author/WRM)
- Published
- 1999
18. The Eisenhower Professional Development Program: Emerging Themes from Six Districts. 1998.
- Author
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American Institutes for Research, Washington, DC., Birman, Beatrice F., Reeve, Alison L., and Sattler, Cheryl L.
- Abstract
This is the first report from a 3-year evaluation of Part B of the Eisenhower Professional Development Program, the U.S. Department of Education's single largest investment dedicated to developing teachers' knowledge and skills. The report presents 10 emerging themes about the program resulting from exploratory case studies of 6 school districts conducted in 1997. The case studies involved onsite visits, interviews, and focus groups with key players. Information is presented in six sections: (1) Introduction; (2) Types of Professional Development Activities Supported with Eisenhower Funds and their Connection to High-Quality Professional Development; (3) The Relationship Between the Eisenhower Program and Other Education Programs; (4) The Participation of Teachers of Diverse Student Populations; (5) Planning and Tracking Progress of the Eisenhower Program and the Role of Performance Indicators; and (6) Conclusions and the Implications for Subsequent Phases of this Evaluation. Results suggest that district officials are aware of some key elements of high quality professional development, including the importance of aligning professional development with high standards. They are moving toward funding more activities that fit current conceptions of high quality. However, reports from district administrators, teachers, and professional developers raise many questions that must be addressed. Three appendixes offer Eisenhower Program performance indicators; an overview of the evaluation of the Eisenhower Program; and selection criteria for sites and focus group participants. (Contains 47 references.) (SM)
- Published
- 1998
19. Personal text public body : an interdisciplinary approach investigating embodied performances of sexuality and gender
- Author
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Allegranti, Beatrice F.
- Subjects
615.8 - Published
- 2007
20. Education Policy Analysis and Program Evaluation: Shifting Methods, Politics, and Temperament
- Author
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Birman, Beatrice F.
- Published
- 2003
21. Analysis of the Effect of Varying Trash Receptacle Distance to the Littering Behavior of Metro Manila Bus Commuters
- Author
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Balane, Jan Alessa J., Felizardo, Karina O., Lopez-Tan, Ma. Christina Beatrice F., Kacprzyk, Janusz, Series editor, Rebelo, Francisco, editor, and Soares, Marcelo, editor
- Published
- 2016
- Full Text
- View/download PDF
22. Evaluating the Effectiveness of Education Funding Streams
- Author
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Birman, Beatrice F., primary and Porter, Andrew C., additional
- Published
- 2018
- Full Text
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23. The Empire of Tamerlane as an Adaptation of the Mongol Empire: An answer to David Morgan, "The Empire of Tamerlane: An Unsuccessful Re-Run of the Mongol State?"
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MANZ, BEATRICE F.
- Published
- 2016
24. Historical Background
- Author
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Manz, Beatrice F., primary
- Published
- 2018
- Full Text
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25. Introduction
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Manz, Beatrice F., primary
- Published
- 2018
- Full Text
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26. Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank
- Author
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Michael J. Stein, Hansjörg Baurecht, Patricia Bohmann, Béatrice Fervers, Emma Fontvieille, Heinz Freisling, Christine M. Friedenreich, Julian Konzok, Laia Peruchet-Noray, Anja M. Sedlmeier, Michael F. Leitzmann, and Andrea Weber
- Subjects
Physical activity patterns ,Colorectal cancer ,UK Biobank ,Raw accelerometry ,Medicine - Abstract
Abstract Background Physical activity reduces colorectal cancer risk, yet the diurnal timing of physical activity in colorectal cancer etiology remains unclear. Methods This study used 24-h accelerometry time series from UK Biobank participants aged 42 to 79 years to derive circadian physical activity patterns using functional principal component analysis. Multivariable Cox proportional hazard models were used to examine associations with colorectal cancer risk. Results Among 86,252 participants (56% women), 529 colorectal cancer cases occurred during a median 5.3-year follow-up. We identified four physical activity patterns that explained almost 100% of the data variability during the day. A pattern of continuous day-long activity was inversely associated with colorectal cancer risk (hazard ratio (HR) = 0.94, 95% confidence interval (CI) = 0.89–0.99). A second pattern of late-day activity was suggestively inversely related to risk (HR = 0.93, 95% CI = 0.85–1.02). A third pattern of early- plus late-day activity was associated with decreased risk (HR = 0.89, 95% CI = 0.80–0.99). A fourth pattern of mid-day plus night-time activity showed no relation (HR = 1.02, 95% CI = 0.88–1.19). Our results were consistent across various sensitivity analyses, including the restriction to never smokers, the exclusion of the first 2 years of follow-up, and the adjustment for shift work. Conclusions A pattern of early- plus late-day activity is related to reduced colorectal cancer risk, beyond the benefits of overall activity. Further research is needed to confirm the role of activity timing in colorectal cancer prevention.
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- 2024
- Full Text
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27. Overcoming times of crisis: unveiling coping strategies and mental health in a transnational general population sample during and after the COVID-19 pandemic
- Author
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Timo Schurr, Beatrice Frajo-Apor, Silvia Pardeller, Barbara Plattner, Franziska Tutzer, Anna Schmit, Andreas Conca, Martin Fronthaler, Christian Haring, Bernhard Holzner, Markus Huber, Josef Marksteiner, Carl Miller, Verena Perwanger, Roger Pycha, Martin Schmidt, Barbara Sperner-Unterweger, and Alex Hofer
- Subjects
COVID-19 ,Crisis ,Coping ,Mental health ,Psychological distress ,Austria ,Psychology ,BF1-990 - Abstract
Abstract Background The COVID-19 pandemic has had an unparalleled impact, precipitating not only direct threats to physical health but also widespread economic and psychological challenges. This study aims to explore the dynamics of coping behaviour and psychological distress (PD) across different phases of the pandemic within an adult general population sample, spanning Austria and Italy. Methods An online questionnaire-based panel study was conducted between 2020 and 2023 including three measurements. We collected data on sociodemographic variables, coping responses (Brief COPE), and PD (Brief-Symptom-Checklist). Statistical analyses were conducted within a linear-mixed-model framework. Multiple imputation and sensitivity analysis were applied to validate the results obtained by complete case analysis. Results The study follows 824 participants and reveals a marginal decrease in overall PD from the first to the second follow-up, particularly in clinically relevant phobic anxiety (35.6% and 34.5% to 25.4%). Most coping behaviours exhibited stable mean-levels with intra-individual variability across the study period. Maladaptive coping strategies were consistently linked to increased PD, whereas adaptive strategies were associated with decreased PD. Conclusion Our findings underscore the complex nature of coping behaviours and PD during and after the pandemic, suggesting that while mean-levels of PD and coping responses remained relatively stable, most coping strategies were subject to intra-individual change. Maladaptive strategies were associated with increased PD, pinpointing to the need for interventions that establish the foundation for adaptive coping mechanisms and promote their application. Further research should explore the reciprocal influences of mental health on coping behaviour, incorporating interventional designs to unravel the nuances of these relationships.
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- 2024
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28. Using intervention mapping to facilitate and sustain return-to work after breast cancer: protocol for the FASTRACS multicentre randomized controlled trial
- Author
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Jean-Baptiste Fassier, Laure Guittard, Béatrice Fervers, Sabrina Rouat, Philippe Sarnin, Julien Carretier, Guillaume Broc, Laurent Letrilliart, Julien Péron, and Marion Lamort-Bouché
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Breast neoplasms ,Cancer survivors ,Intervention studies ,Theory-driven evaluation ,Work disability prevention ,Return to work ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Women with breast cancer face many barriers to return to work (RTW) after their cancer. The main objective of the FASTRACS-RCT is to evaluate the impact of the FASTRACS (Facilitate and Sustain Return to Work after Breast Cancer) intervention on the sustainable RTW of breast cancer patients, 12 months after the end of active treatment. Methods FASTRACS-RCT is a prospective, national, multicentre, randomized, controlled and open-label study. A total of 420 patients with early breast cancer scheduled for surgery and (neo)adjuvant chemotherapy, will be randomly assigned (1:1 ratio) to: (i) the intervention arm comprising four steps over 6 months : Handing over the intervention tools; transitional medical consultation with the general practitioner (GP); pre-RTW visit with the company’s occupational physician (OP); catch-up visit with a hospital-based RTW expert (if sick leave > 10 months) (ii) the control arm to receive usual care. The design of the FASTRACS intervention was informed by intervention mapping for complex interventions in health promotion planning, and involved patients and representatives of relevant stakeholders. Specific tools were developed to bridge the gap between the hospital, the GP, the OP and the workplace: a toolkit for breast cancer patients comprising a theory-based guide; specific checklists for the GP and the OP, respectively; and a theory-based guide for workplace actors (employer, manager, colleagues). The primary endpoint will associate sustainable RTW (full-time or part-time work at 50% or more of working time, for at least 28 consecutive days) and days off work. It will be assessed at 4, 8 and 12 months after the end of active oncological treatment. Secondary endpoints will include quality of life, anxiety, depression, RTW self-efficacy, physical activity, social support, job accommodations, work productivity, job status, and the usefulness and acceptability of the intervention’s tools. Discussion FASTRACS-RCT will be supplemented by a realist evaluation approach aimed at understanding the influence of context in activating the intervention’s mechanisms and effects. If the expected impact of the intervention is confirmed, the intervention will be adapted and scaled-up for other cancers and chronic diseases to better integrate healthcare and work disability prevention. Trial registration NCT04846972 ; April 15, 2021.
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- 2024
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29. Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer
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Pauline Desnavailles, Delphine Praud, Blandine Le Provost, Hidetaka Kobayashi, Floriane Deygas, Amina Amadou, Thomas Coudon, Lény Grassot, Elodie Faure, Florian Couvidat, Gianluca Severi, Francesca Romana Mancini, Béatrice Fervers, Cécile Proust-Lima, and Karen Leffondré
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Breast cancer ,Long-term exposure ,Polychlorobiphenyl ,Benzo[a]pyrene ,Trajectories of exposure ,Environmental carcinogens ,Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect. Objective To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk. Methods We used data from the XENAIR case–control study, nested within the ongoing prospective French E3N cohort which enrolled 98,995 women aged 40–65 years in 1990–1991. Cases were incident cases of primary invasive breast cancer diagnosed from cohort entry to 2011. Controls were randomly selected by incidence density sampling, and individually matched to cases on delay since cohort entry, and date, age, department of residence, and menopausal status at cohort entry. Annual mean outdoor PCB153 and BaP concentrations at residential addresses from 1990 to 2011 were estimated using the CHIMERE chemistry-transport model. Latent class mixed models were used to identify profiles of exposure trajectories from cohort entry to the index date, and conditional logistic regression to estimate their association with the odds of breast cancer. Results 5058 cases and 5059 controls contributed to the analysis. Five profiles of trajectories of PCB153 exposure were identified. The class with the highest PCB153 concentrations had a 69% increased odds of breast cancer compared to the class with the lowest concentrations (95% CI 1.08, 2.64), after adjustment for education and matching factors. The association between identified BaP trajectories and breast cancer was weaker and suffered from large CI. Conclusions Our results support an association between long term exposure to PCB153 and the risk of breast cancer, and encourage further studies to account for lifetime exposure to persistent organic pollutants.
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- 2024
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30. Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development
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Dupont, Cathérine, primary, Schäffers, Olivier J. M., additional, Tan, Beatrice F., additional, Merzouk, Sarra, additional, Bindels, Eric M., additional, Zwijsen, An, additional, Huylebroeck, Danny, additional, and Gribnau, Joost, additional
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- 2023
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31. A Computational Environment for Aircraft Design and Acquisition Engineering
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Haehnel, Robert B., primary, Hardin, Deanna L., additional, Bates, Jordan T., additional, Christensen, Scott D., additional, Arnold, Thomas L., additional, Brown, Marvin S., additional, Bauer, Andrew C., additional, Brannon, Quyen T., additional, Church, Joshua Q., additional, Catlett, Amanda R., additional, Coumbe, Theresa R., additional, Schofield, Dallon C., additional, and Roget, Beatrice F., additional
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- 2023
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32. Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development
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Cathérine Dupont, Olivier J. M. Schäffers, Beatrice F. Tan, Sarra Merzouk, Eric M. Bindels, An Zwijsen, Danny Huylebroeck, Joost Gribnau, Developmental Biology, Obstetrics & Gynecology, Hematology, and Cell biology
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Multidisciplinary - Abstract
The murine embryonic–trophoblast–extra-embryonic endoderm (ETX) model is an integrated stem cell–based model to study early postimplantation development. It is based on the self-assembly potential of embryonic, trophoblast, and hypoblast/primitive/visceral endoderm-type stem cell lines (ESC, TSC, and XEN, respectively) to arrange into postimplantation egg cylinder–like embryoids. Here, we provide an optimized method for reliable and efficient generation of ETX embryoids that develop into late gastrulation in static culture conditions. It is based on transgenic Gata6 -overproducing ESCs and modified assembly and culture conditions. Using this method, up to 43% of assembled ETX embryoids exhibited a correct spatial distribution of the three stem cell derivatives at day 4 of culture. Of those, 40% progressed into ETX embryoids that both transcriptionally and morphologically faithfully mimicked in vivo postimplantation mouse development between E5.5 and E7.5. The ETX model system offers the opportunity to study the murine postimplantation egg cylinder stages and could serve as a source of various cell lineage precursors.
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- 2023
33. Comparison of lifestyle and practice patterns between male and female Canadian ophthalmologists
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McAlister, Chryssa, Jin, Ya-Ping, Braga-Mele, Rosa, DesMarchais, Beatrice F., and Buys, Yvonne M.
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- 2014
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34. Development and evaluation of a point-of-care ultrasound curriculum for paramedics in Germany – a prospective observational study and comparison
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Christopher Jonck, Andreas Michael Weimer, Beatrice Fundel, Wolfgang Heinz, Daniel Merkel, Hendrik Fiedel, Carlotta Ille, Roman Kloeckner, Holger Buggenhagen, Tim Piepho, and Johannes Weimer
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Point-of-care sonography ,POCUS ,Ultrasound training ,Curriculum development ,Imaging ,Sonography ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Point-of-care ultrasound (POCUS) is steadily growing in use in prehospital emergency medicine. While currently used primarily by emergency physicians, POCUS could also be employed by paramedics to support diagnosis and decision-making. Yet to date, no paramedicine-targeted POCUS curricula exist in Germany. Furthermore, given time and resource constraints in paramedic training, it is unclear whether paramedics could feasibly learn POCUS for prehospital deployment. Hence, this study outlines the development and implementation of a comprehensive POCUS curriculum for paramedics. Through this curriculum, we investigate whether paramedics can attain proficiency in POCUS comparable to other user groups. Methods In this prospective observational study, we first developed a blended learning-based POCUS curriculum specifically for paramedics, focusing on basic principles, the RUSH-Protocol and ultrasound guided procedures. Participants underwent digital tests to measure their theoretical competence before (T1) and after the digital preparation phase (T2), as well as at the end of the on-site phase (T3). At time point T3, we additionally measured practical competence using healthy subjects and simulators. We compared the theoretical competence and the practical competence on a simulator with those of physicians and medical students who had also completed ultrasound training. Furthermore, we carried out self-assessment evaluations, as well as evaluations of motivation and curriculum satisfaction. Results The paramedic study group comprised n = 72 participants. In the theoretical test, the group showed significant improvement between T1 and T2 (p
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- 2024
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35. Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation
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Margot Guth, Corinne Pilorget, Marie Lefevre, Astrid Coste, Aurélie Danjou, Brigitte Dananché, Delphine Praud, Olivia Pérol, Myriam Daudin, Marie-Ange Clarotti, Stéphanie Lattes, Céline Bouillon, Adèle Paul, Joachim Schüz, Louis Bujan, Ann Olsson, Béatrice Fervers, Barbara Charbotel, and The TESTIS study group
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exposure assessment ,occupational exposure ,occupational health ,organic solvent ,cancer ,trichloroethylene ,risk assessment ,risk estimation ,exposure assessment method ,testicular germ cell tumor ,testis study ,testicular cancer ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVES: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men. METHODS: This study examined occupational exposures to solvents and TGCT risk based on the lifetime work histories of 454 cases and 670 controls, aged 18–45 years, of the French national TESTIS case–control study. Solvent exposure was estimated using: (i) exposure assignment by job-exposure matrix (JEM) and (ii) JEM combined with self-reported exposure data from specific questionnaires (SQ) and expert assessment (EA). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression models. RESULTS: Both approaches (JEM and JEM+SQ+EA) showed a consistent association between TGCT and trichloroethylene exposure (exposed versus not exposed; JEM=OR 1.80 [95% confidence interval (CI) 1.12–2.90] and JEM+SQ+EA= OR 2.59 (95% CI 1.42–4.72). Both approaches also observed positive associations with ketone esters and fuels & petroleum-based solvents. CONCLUSION: The results suggest that some organic solvents might be involved in the pathogenesis of TGCT among occupationally exposed men. The combined use of JEM+SQ+EA seemed to limit misclassification by considering individual exposure variability and is, therefore, an appealing approach to assess occupational exposures in epidemiological studies.
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- 2024
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36. Lomustine with or without reirradiation for first progression of glioblastoma, LEGATO, EORTC-2227-BTG: study protocol for a randomized phase III study
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Matthias Preusser, Tomáš Kazda, Emilie Le Rhun, Felix Sahm, Marion Smits, Jens Gempt, Johan AF Koekkoek, Angelo F Monti, Marcell Csanadi, János György Pitter, Helen Bulbek, Beatrice Fournier, Caroline Quoilin, Thierry Gorlia, Michael Weller, Giuseppe Minniti, and on behalf of the European Organisation for Research, Treatment of Cancer (EORTC) Brain Tumor Group
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Glioblastoma ,Progression ,Lomustine ,Reirradiation ,LEGATO ,Randomized controlled trial ,Medicine (General) ,R5-920 - Abstract
Abstract Background Chemotherapy with lomustine is widely considered as standard treatment option for progressive glioblastoma. The value of adding radiotherapy to second-line chemotherapy is not known. Methods EORTC-2227-BTG (LEGATO, NCT05904119) is an investigator-initiated, pragmatic (PRECIS-2 score: 34 out of 45), randomized, multicenter phase III trial in patients with first progression of glioblastoma. A total of 411 patients will be randomized in a 1:1 ratio to lomustine (110 mg/m2 every 6 weeks) or lomustine (110 mg/m2 every 6weeks) plus radiotherapy (35 Gy in 10 fractions). Main eligibility criteria include histologic confirmation of glioblastoma, isocitrate dehydrogenase gene (IDH) wild-type per WHO 2021 classification, first progression at least 6 months after the end of prior radiotherapy, radiologically measurable disease according to RANO criteria with a maximum tumor diameter of 5 cm, and WHO performance status of 0–2. The primary efficacy endpoint is overall survival (OS) and secondary endpoints include progression-free survival, response rate, neurocognitive function, health-related quality of life, and health economic parameters. LEGATO is funded by the European Union’s Horizon Europe Research program, was activated in March 2024 and will enroll patients in 43 sites in 11 countries across Europe with study completion projected in 2028. Discussion EORTC-2227-BTG (LEGATO) is a publicly funded pragmatic phase III trial designed to clarify the efficacy of adding reirradiation to chemotherapy with lomustine for the treatment of patients with first progression of glioblastoma. Trial registration ClinicalTrials.gov NCT05904119. Registered before start of inclusion, 23 May 2023
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- 2024
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37. The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model
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Beatrice Fageräng, Maximilian Peter Götz, Leon Cyranka, Corinna Lau, Per H. Nilsson, Tom Eirik Mollnes, and Peter Garred
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aspergillus fumigatus ,inflammatory response ,complement ,toll-like receptors ,cd14 ,cytokines ,Medicine ,Internal medicine ,RC31-1245 - Abstract
Introduction: We aimed to elucidate the inflammatory response of Aspergillus fumigatus conidia in a whole-blood model of innate immune activation and to compare it with the well-characterized inflammatory reaction to Escherichia coli. Methods: Employing a human lepirudin whole-blood model, we analyzed complement and leukocyte activation by measuring the sC5b-9 complex and assessing CD11b expression. A 27-multiplex system was used for quantification of cytokines. Selective cell removal from whole blood and inhibition of C3, C5, and CD14 were also applied. Results: Our findings demonstrated a marked elevation in sC5b-9 and CD11b post-A. fumigatus incubation. Thirteen cytokines (TNF, IL-1β, IL-1ra, IL-4, IL-6, IL-8, IL-17, IFNγ, MCP-1, MIP-1α, MIP-1β, FGF-basic, and G-CSF) showed increased levels. A generally lower level of cytokine release and CD11b expression was observed with A. fumigatus conidia than with E. coli. Notably, monocytes were instrumental in releasing all cytokines except MCP-1. IL-1ra was found to be both monocyte and granulocyte-dependent. Pre-inhibiting with C3 and CD14 inhibitors resulted in decreased release patterns for six cytokines (TNF, IL-1β, IL-6, IL-8, MIP-1α, and MIP-1β), with minimal effects by C5-inhibition. Conclusion: A. fumigatus conidia induced complement activation comparable to E. coli, whereas CD11b expression and cytokine release were lower, underscoring distinct inflammatory responses between these pathogens. Complement C3 inhibition attenuated cytokine release indicating a C3-level role of complement in A. fumigatus immunity.
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- 2024
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38. Covid-19 and the role of smoking: The protocol of the multicentric prospective study COSMO-IT (covid19 and smoking in italy)
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Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, Tinghino, B, Cattaruzza M. S., Gorini G., Bosetti C., Boffi R., Lugo A., Veronese C., Carreras G., Santucci C., Stival C., Pacifici R., Zaga V., Gallus S., Giulietti F., Sarzani R., Spannella F., Del Donno M., Tartaglione S., Marrazzo G., Pelaia G., D'agosto V., Berti A., Voller F., Cardellicchio S., Cresci C., Foschino Barbaro M. P., De Palma R., Negrini S., Sicbaldi V., Serafini A., Bisconti M., Refolo L., Landoni G., Rovere P., Veronesi G., Faverio P., Garavello W., Pesci A., Giacobbe R., Martucci P., Parrella R., Scarano F., Aiello M., Chetta A., Franco C., Mangia A., Carrozzi L., Maggi Monzani F. F., Pistelli F., Russo P., Sanna A., Barreca F. M., Conti V., Rossi E., Ruli M., Ruli S., Varzaneh S. E., Principe R., Guerrini S., Sebastiani A., Galluccio G., Pezzuto A., Ricci A., Casali E., Mastroianni C., Pirina P., Polo F., Beatrice F., Romagnoli M., Baraldo M., Cojutti P. G., Graziano E., Pecori D., Tascini C., Tinghino B., Cattaruzza, M, Gorini, G, Bosetti, C, Boffi, R, Lugo, A, Veronese, C, Carreras, G, Santucci, C, Stival, C, Pacifici, R, Zaga, V, Gallus, S, Giulietti, F, Sarzani, R, Spannella, F, Del Donno, M, Tartaglione, S, Marrazzo, G, Pelaia, G, D'Agosto, V, Berti, A, Voller, F, Cardellicchio, S, Cresci, C, Foschino Barbaro, M, De Palma, R, Negrini, S, Sicbaldi, V, Serafini, A, Bisconti, M, Refolo, L, Landoni, G, Rovere, P, Veronesi, G, Faverio, P, Garavello, W, Pesci, A, Giacobbe, R, Martucci, P, Parrella, R, Scarano, F, Aiello, M, Chetta, A, Franco, C, Mangia, A, Carrozzi, L, Maggi Monzani, F, Pistelli, F, Russo, P, Sanna, A, Barreca, F, Conti, V, Rossi, E, Ruli, M, Ruli, S, Varzaneh, S, Principe, R, Guerrini, S, Sebastiani, A, Galluccio, G, Pezzuto, A, Ricci, A, Casali, E, Mastroianni, C, Pirina, P, Polo, F, Beatrice, F, Romagnoli, M, Baraldo, M, Cojutti, P, Graziano, E, Pecori, D, Tascini, C, Tinghino, B, Cattaruzza M. S., Gorini G., Bosetti C., Boffi R., Lugo A., Veronese C., Carreras G., Santucci C., Stival C., Pacifici R., Zaga V., Gallus S., Giulietti F., Sarzani R., Spannella F., Del Donno M., Tartaglione S., Marrazzo G., Pelaia G., D'agosto V., Berti A., Voller F., Cardellicchio S., Cresci C., Foschino Barbaro M. P., De Palma R., Negrini S., Sicbaldi V., Serafini A., Bisconti M., Refolo L., Landoni G., Rovere P., Veronesi G., Faverio P., Garavello W., Pesci A., Giacobbe R., Martucci P., Parrella R., Scarano F., Aiello M., Chetta A., Franco C., Mangia A., Carrozzi L., Maggi Monzani F. F., Pistelli F., Russo P., Sanna A., Barreca F. M., Conti V., Rossi E., Ruli M., Ruli S., Varzaneh S. E., Principe R., Guerrini S., Sebastiani A., Galluccio G., Pezzuto A., Ricci A., Casali E., Mastroianni C., Pirina P., Polo F., Beatrice F., Romagnoli M., Baraldo M., Cojutti P. G., Graziano E., Pecori D., Tascini C., and Tinghino B.
- Abstract
The emergency caused by Covid-19 pandemic raised interest in studying lifestyles and comorbidities as important determinants of poor Covid-19 prognosis. Data on tobacco smoking, alcohol consumption and obesity are still limited, while no data are available on the role of e-cigarettes and heated tobacco products (HTP). To clarify the role of tobacco smoking and other lifestyle habits on COVID-19 severity and progression, we designed a longitudinal observational study titled COvid19 and SMOking in ITaly (COSMO-IT). About 30 Italian hospitals in North, Centre and South of Italy joined the study. Its main aims are: 1) to quantify the role of tobacco smoking and smoking cessation on the severity and progression of COVID-19 in hospitalized patients; 2) to compare smoking prevalence and severity of the disease in relation to smoking in hospitalized COVID-19 patients versus patients treated at home; 3) to quantify the association between other lifestyle factors, such as e-cigarette and HTP use, alcohol and obesity and the risk of unfavourable COVID-19 outcomes. Socio-demographic, lifestyle and medical history information will be gathered for around 3000 hospitalized and 700-1000 home-isolated, laboratory-confirmed, COVID-19 patients. Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for COVID-19, prevention strategies are of extreme importance. This project, designed to highly contribute to the international scientific debate on the role of avoidable lifestyle habits on COVID-19 severity, will provide valuable epidemiological data in order to support important recommendations to prevent COVID-19 incidence, progression and mortality.
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- 2020
39. Screening for depression in cancer patients receiving radiotherapy: Feasibility and identification of effective tools in the NRG Oncology RTOG 0841 trial
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Wagner, Lynne I., Pugh, Stephanie L., Small, William, Jr, Kirshner, Jeffrey, Sidhu, Kulbir, Bury, Martin J., DeNittis, Albert S., Alpert, Tracy E., Tran, Binh, Bloom, Beatrice F., Mai, Julie, Yeh, Alexander, Sarma, Kalika, Becker, Mark, James, Jennifer, and Bruner, Deborah Watkins
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- 2017
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40. Determinants of physical activity commitment in adolescents and young adults with cancer: sociological protocol for a hospital-based mixed methods study (ETAPE-AJA)
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Amandine Bertrand, Perrine Marec-Berard, Béatrice Fervers, Olivia Pérol, Charlotte Bruneau, Claire Perrin, and Rodolf Mongondry
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Medicine - Abstract
Introduction Adolescents and young adults (AYA) with cancer undergo physical transformations due to disease and treatments occurring alongside puberty and adolescence. Although physical activity is recommended for its benefits, its practice among AYA with cancer remains insufficient. The aim of the Éducation Thérapeutique et Activité Physique: Engagement des Adolescents et Jeunes Adultes atteints de cancer study is to identify the evolution of AYA with cancer medical knowledge and powers (power to act, to express oneself) over life and cancer care, and their role in commitment in adapted physical activity (APA) and therapeutic patient education during and after oncological treatments.Methods and analysis This prospective mixed methods monocentre study will be conducted in a French comprehensive cancer centre. Observations will be conducted two times a week during medical consultations, APA interventions and therapeutic education sessions for AYA with cancer. Semidirective interviews will involve 70 participants, including AYA with cancer aged 15–25, health professionals, APA teachers and parents. Quantitative data will be collected on AYA’s social characteristics and participation in physical activity intervention and therapeutic education sessions. A correspondence factor analysis will supplement inductive analysis of ethnographic qualitative data, involving patient coresearchers. The results will help to improve the understanding of AYAs’ medical knowledge and powers, their commitment in physical activity and to develop strategies to increase their participation.Ethics and dissemination This study complies with reference methodology MR004 of the French National Data Protection Authority and was registered by the Data Protection Officer of the Leon Berard Cancer Center on the activity registry of the institution (Ref. N°R201-004-259; 5 July 2022). Ethics approval has been obtained from the Centre Léon Bérard ethics board (Ref. N°2022–006; 20 July 2022). Oral informed consent will be obtained from all participants before data collection. The results of this study will be published in peer-reviewed scientific journals, national and international conferences.
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- 2024
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41. New perspectives on the role of biological factors in anorexia nervosa: Brain volume reduction or oxidative stress, which came first?
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Ludovica Gaiaschi, Erica Cecilia Priori, Martina Maria Mensi, Manuela Verri, Daniela Buonocore, Sandra Parisi, Lilian Nathalie Quintero Hernandez, Ilaria Brambilla, Beatrice Ferrari, Fabrizio De Luca, Federica Gola, Giulia Rancati, Luca Capone, Adele Andriulo, Silvia Damiana Visonà, Gian Luigi Marseglia, Renato Borgatti, and Maria Grazia Bottone
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Eating disorders ,Anorexia nervosa ,Brain atrophy ,Oxidative stress ,Mitochondrial dysfunction ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Anorexia nervosa (AN) is an eating disorder (ED) that has seen an increase in its incidence in the last thirty years. Compared to other psychosomatic disorders, ED can be responsible for many major medical complications, moreover, in addition to the various systemic impairments, patients with AN undergo morphological and physiological changes affecting the cerebral cortex. Through immunohistochemical studies on portions of postmortem human brain of people affected by AN and healthy individuals, and western blot studies on leucocytes of young patients and healthy controls, this study investigated the role in the afore-mentioned processes of altered redox state. The results showed that the brain volume reduction in AN could be due to an increase in the rate of cell death, mainly by apoptosis, in which mitochondria, main cellular organelles affected by a decreased dietary intake, and a highly compromised intracellular redox balance, may play a pivotal role
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- 2024
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42. Improving Teachers' In-Service Professional Development in Mathematics and Science: The Role of Postsecondary Institutions.
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Desimone Laura, Garet, Michael S., Birman, Beatrice F., Porter, Andrew, and Yoon, Kwang Suk
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As part of national evaluation of Eisenhower Professional Development Program, examines management and implementation strategies contributing to high-quality inservice teacher professional development in mathematics and science. Finds higher quality professional development is related to management and implementation strategies such as continuous improvement efforts. (Contains 4 tables and 63 references.)(PKP)
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- 2003
43. Multi-pollutant exposure profiles associated with breast cancer risk: A Bayesian profile regression analysis in the French E3N cohort
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Camille Giampiccolo, Amina Amadou, Thomas Coudon, Delphine Praud, Lény Grassot, Elodie Faure, Florian Couvidat, Gianluca Severi, Francesca Romana Mancini, Béatrice Fervers, and Pascal Roy
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Breast cancer ,Air pollutants ,Mixture ,Correlated exposures ,Bayesian profile regression ,Cluster ,Environmental sciences ,GE1-350 - Abstract
Background: Human exposure to air pollution involves complex mixtures of multiple correlated air pollutants. To date, very few studies have assessed the combined effects of exposure to multiple air pollutants on breast cancer (BC) risk. Objectives: We aimed to assess the association between combined exposures to multiple air pollutants and breast cancer risk. Methods: The study was based on a case-control study nested within the French E3N cohort (5222 incident BC cases/5222 matched controls). For each woman, the average of the mean annual exposure to eight pollutants (benzo(a)oyrene, cadmium, dioxins, polychlorinated biphenyls (PCB153), nitrogen dioxide (NO2), ozone, particulate matter and fine particles (PMs)) was estimated from cohort inclusion in 1990 to the index date. We used the Bayesian Profile Regression (BPR) model, which groups individuals according to their exposure and risk levels, and assigns a risk to each cluster identified. The model was adjusted on a combination of matching variables and confounders to better consider the design of the nested case-control study. Odds ratios (OR) and their 95 % credible intervals (CrI) were estimated. Results: Among the 21 clusters identified, the cluster characterised by low exposures to all pollutants, except ozone, was taken as reference. A consistent increase in BC risk compared to the reference cluster was observed for 3 clusters: cluster 9 (OR=1.61; CrI=1.13,2.26), cluster 16 (OR=1.59; CrI=1.10,2.30) and cluster 15 (OR=1.38; CrI=1.00,1.88) characterised by high levels of NO2, PMs and PCB153. The other clusters showed no consistent association with BC. Discussion: This is the first study assessing the effect of exposure to a mixture of eight air pollutants on BC risk, using the BPR approach. Overall, results showed evidence of a positive joint effect of exposure to high levels to most pollutants, particularly high for NO2, PMs and PCB153, on the risk of BC.
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- 2024
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44. Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistors
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Chenhong Zhang, Lorenzo Margotti, Francesco Decataldo, Alberto Piccioni, Hongzhi Wang, Beatrice Fraboni, Yaogang Li, and Tobias Cramer
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nanotemplated deposition ,nanochannel ,organic electrochemical transistors ,organic mixed ionic electronic conductors ,track‐etched membranes ,vertical transistors ,Electric apparatus and materials. Electric circuits. Electric networks ,TK452-454.4 ,Physics ,QC1-999 - Abstract
Abstract Thin films of organic mixed ionic electronic conductors (OMIECs) constitute the functional layer in organic electrochemical transistors (OECTs), organic bioelectronic transducers and other ionic‐electronic devices. The thin‐film configuration constrains devices to be fabricated on impermeable substrates in the form of 2D microstructures with lateral electrodes to drive an electronic current through the thin film. In order to alleviate such constraints, novel OMIEC deposition methods are needed that produce alternatives to thin‐film devices and that are compatible with permeable substrates and electronic transport in the vertical direction. Here OMIECs filled nanoporous membranes are introduced as functional layer in devices with mixed ionic electronic transport. Electropolymerization of ethylenedioxythiophene (EDOT) monomers is used to fabricate OMIEC filled nanochannels. Electronic and ionic transport through such nanochannels are investigated and modulation of electronic as well as ionic carrier density by action of a third gate electrode is demonstrated. The novel OMIEC nanochannels enable the fabrication of vertical OECTs with high transconductance and organic ionic transistors using only additive fabrication methods.
- Published
- 2024
- Full Text
- View/download PDF
45. Analysis of the Effect of Varying Trash Receptacle Distance to the Littering Behavior of Metro Manila Bus Commuters
- Author
-
Balane, Jan Alessa J., primary, Felizardo, Karina O., additional, and Lopez-Tan, Ma. Christina Beatrice F., additional
- Published
- 2016
- Full Text
- View/download PDF
46. Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
- Author
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Gerritz, Samuel W., Cianci, Christopher, Kim, Sean, Pearce, Bradley C., Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F., Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A., Edavettal, Suzanne, McDonnell, Patricia A., Lewis, Hal A., Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T., Metzler, William, Bryson, James, Healy, Matthew D., Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H., Hoffmann, Hans-Heinrich, Langley, David R., Meanwell, Nicholas A., and Krystal, Mark
- Published
- 2011
47. Microbial lampenflora composition: the case study of the 'Stiffe' show cave
- Author
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Pellegrini, M., Beatrice, F., Djebaili, R., Vaccarelli, I., Ercole, C., Spera, D. M., D’Alessandro, A. M., and Del Gallo, M.
- Published
- 2022
48. How Do District Management and Implementation Strategies Relate to the Quality of the Professional Development That Districts Provide to Teachers?
- Author
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Desimone, Laura, Porter, Andrew C., and Birman, Beatrice F.
- Abstract
Examined policy mechanisms and processes that districts used to provide high quality inservice professional development to teachers. Data from a national probability sample of professional development coordinators in districts that received federal funding for professional development highlighted specific management and implementation strategies related to quality of professional development (e.g., alignment with standards and assessments, teacher participation in planning, and district cofunding). (Contains references.) (SM)
- Published
- 2002
49. Evaluating the Effectiveness of Education Funding Streams.
- Author
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Birman, Beatrice F. and Porter, Andrew C.
- Abstract
Discusses the challenges involved in evaluating federal education programs that provide funds to schools and districts, such as Title I, but do not require a fixed set of activities, reflecting on previous evaluations of federal education funding streams, analyzing the strengths and weaknesses of various evaluation designs, and making the case for an evaluation design that combines nationally representative surveys with longitudinal impact studies. (Contains references.) (SM)
- Published
- 2002
50. SPEN is required for Xist upregulation during initiation of X chromosome inactivation
- Author
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Hegias Mira-Bontenbal, François Dossin, John W.M. Martens, Sarra Merzouk, Tilman Borggrefe, Edith Heard, Beatrice F. Tan, Teresa Robert-Finestra, Wilfred F. J. van IJcken, Joost Gribnau, Benedetto Daniele Giaimo, Erika Timmers, Cristina Gontan, Developmental Biology, Cell biology, and Medical Oncology
- Subjects
Male ,Transcriptional Activation ,Molecular biology ,Science ,General Physics and Astronomy ,Stem cells ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,X-inactivation ,Mice ,Downregulation and upregulation ,Genes, X-Linked ,X Chromosome Inactivation ,Developmental biology ,Animals ,Gene silencing ,Promoter Regions, Genetic ,Psychological repression ,Mice, Knockout ,Multidisciplinary ,Gene Expression Regulation, Developmental ,RNA-Binding Proteins ,Cell Differentiation ,Mouse Embryonic Stem Cells ,General Chemistry ,Chromatin Assembly and Disassembly ,Up-Regulation ,Chromatin ,Antisense RNA ,Cell biology ,DNA-Binding Proteins ,Mice, Inbred C57BL ,Female ,RNA, Long Noncoding ,XIST ,Tsix ,Transcriptome ,human activities - Abstract
At initiation of X chromosome inactivation (XCI), Xist is monoallelically upregulated from the future inactive X (Xi) chromosome, overcoming repression by its antisense transcript Tsix. Xist recruits various chromatin remodelers, amongst them SPEN, which are involved in silencing of X-linked genes in cis and establishment of the Xi. Here, we show that SPEN plays an important role in initiation of XCI. Spen null female mouse embryonic stem cells (ESCs) are defective in Xist upregulation upon differentiation. We find that Xist-mediated SPEN recruitment to the Xi chromosome happens very early in XCI, and that SPEN-mediated silencing of the Tsix promoter is required for Xist upregulation. Accordingly, failed Xist upregulation in Spen−/− ESCs can be rescued by concomitant removal of Tsix. These findings indicate that SPEN is not only required for the establishment of the Xi, but is also crucial in initiation of the XCI process., SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
- Published
- 2021
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