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8 results on '"Beato, João N."'

2. Evaluation of Corneal Structure and Endothelial Morphological Characteristics in Type 2 Diabetic and Non-Diabetic Patients

Author

Beato, João N, Esteves-Leandro, João, Reis, David, Falcão, Manuel, Rosas, Vítor, Carneiro, Ângela, and Falcão Reis, Fernando

Subjects
genetic structures, endothelium, diabetes mellitus, Clinical Ophthalmology, central corneal thickness, sense organs, eye diseases, Original Research
Abstract

João N Beato,1,2 João Esteves-Leandro,1 David Reis,3 Manuel Falcão,1,2 Vítor Rosas,1 Ângela Carneiro,1,2 Fernando Falcão Reis1,2 1Department of Ophthalmology, São João Hospital, Porto, Portugal; 2Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal; 3Faculty of Medicine, University of Porto, Porto, PortugalCorrespondence: João N BeatoDepartment of Ophthalmology, São João Hospital, Al Prof Hernâni Monteiro, Porto 4200-319, PortugalTel +351 225 51 2168Fax +351 225 51 3669Email joao.nuno.beato@gmail.comPurpose: To compare corneal structure and endothelial morphological features between patients with type 2 diabetes mellitus (DM) and non-diabetic patients; and determine if the DM duration, glycated hemoglobin (HbA1c) levels, and diabetic retinopathy (DR) stage affect corneal morphological properties.Patients and Methods: Sixty diabetic patients and 47 age- and sex-matched controls were enrolled in this cross-sectional study. DM group was analyzed according disease duration, HbA1c levels, and presence of retinopathy. Endothelial cell density (ECD) and morphology (average and coefficient of variation [CV] of cell size, percentage of hexagonal cells) were recorded using non-contact specular microscopy. Central corneal thickness (CCT) and corneal volume were measured by scheimpflug tomography. Univariate and multivariate linear regression analyses were performed to evaluate the relationship between demographical, clinical, and ocular variables with CCT and ECD.Results: There were no statistically significant differences in the endothelium cell density or morphology between DM and non-DM groups (p> 0.05). Also, there was no statistical difference between groups for CCT or corneal volume (p> 0.05). Multivariate linear regression analysis showed that older age (p=0.028) was significantly associated with lower ECD; CCT was found to be significantly greater in males (p< 0.001) and positively associated with corneal volume (p< 0.001).Conclusion: The present study did not find any statistically significant differences between the corneal structural and endothelial characteristics of diabetic and non-diabetic subjects; other demographical parameters, such as age and gender, seem to be more determinant for the corneal properties.Keywords: diabetes mellitus, endothelium, central corneal thickness

Published
2020

8. Agreement between IOLMaster ® 500 and Pentacam ® HR for keratometry assessment in type 2 diabetic and non-diabetic patients.

Author

Beato JN, Esteves-Leandro J, Reis D, Matos R, Falcão M, Rosas V, Carneiro Â, and Falcão-Reis F

Abstract

Aim: To evaluate inter-device agreement of anterior keratometry obtained by the IOLMaster ® 500 and Pentacam ® HR in type 2 diabetic and non-diabetic patients., Methods: Corneal measurements were sequentially performed in 60 diabetes mellitus (DM) and 48 age and sex-matched controls undergoing cataract surgery. Variables recorded included flat and steep keratometry, mean keratometry (K m ), astigmatism magnitude, axis location, J0 and J45 components. Bland-Altman plots and intraclass correlation coefficients were used for examination of agreement. Subgroup analyses were performed for astigmatism magnitude, diabetes duration, hemoglobin A1c (HbA1c) levels and diabetic retinopathy (DR) stage., Results: Agreement for K m and astigmatism magnitude were considered good and moderate, with 95% limits of agreement (LoA) of -1.09 to 1.23 diopters (D) and -0.83 to 0.86 D in DM group, respectively; and -0.59 to 0.72 D and -0.98 to 0.75 D in non-DM group, respectively. In contrast, the 95% LoA for corneal axis exceeded the clinically relevant margins in both groups. In the total sample, only 41 eyes (38%) had a smaller than 5-degree difference. Diabetes duration, HbA1c levels and DR stage were not found to significantly affect agreement. Logistic regression showed that higher corneal power ( P =0.021) and astigmatism magnitude ( P =0.011) were associated with a decreased risk of having a difference in axis location greater than 10-degrees., Conclusion: In both groups, IOLMaster and Pentacam agree well for corneal power and moderately for astigmatism. However, axis location disagreement is frequent in eyes with flatter corneas and small amounts of astigmatism., (International Journal of Ophthalmology Press.)

Published
2020
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