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8 results on '"Beasley, M.G."'

2. Changes in carotid artery compliance with age

Author

Baskett, J.J., Lewis, R.R., Beasley, M.G., and Gosling, R.G.

Subjects
Carotid artery -- Ultrasonic imaging, Aging -- Physiological aspects, Vascular resistance -- Research, Health, Psychology and mental health, Seniors, Social sciences
Abstract

Summary Doppler-shifted ultrasound was used to measure arterial compliance non-invasively in the internal and external carotid pathways of 270 male and 388 female asymptomatic volunteers aged 5 to 90 years. There was a significant decrease in the compliance of both arteries from 5 to 50 years of age (p < 0.001), when it then levelled out. Arteries of women were more compliant than those of men at ages 35 to 60 vears.

Published
1990

4. EFFECT OF ORAL CONTRACEPTIVES ON RESTING BLOOD FLOW IN THE LEG.

Author

Gosling, R.G. and Beasley, M.G.

Subjects
BLOOD flow, ORAL contraceptives, CONTRACEPTIVE drugs, MENSTRUAL cycle, WOMEN'S health
Abstract

Resting blood flow in the leg was measured twice per week, by venous occlusion plethysmography, for two or more menstrual cycles in 11 normal female volunteers, 5 of whom were taking an oral contraceptive. Both groups showed a wide range of resting flow, with lowest values doubling or occasionally nearly trebling in any one menstrual cycle. In I subject a repeatable cyclic variation was found. The mean resting flow of the group taking oral contraceptives was found to be lower (0.1 < P < 0.2) and the range of flow values over the menstrual cycle smaller, than those of the subjects not using the pill. The lower flow values found for subjects on the pill suggests a possible mechanism linking use of oral contraceptives with the occurrence of venous thrombosis. However venous distensibilities estimated from plethysmographic observations indicate that the thrombogenic effect of low flow values may be offset by decreased distensibility, and hence it may be possible to maintain normal blood velocities. [ABSTRACT FROM AUTHOR]

Published
1977
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8. Outcome of treatment in young adults with phenylketonuria detected by routine neonatal screening between 1964 and 1971

Author

BEASLEY, M.G., COSTELLO, P.M., and SMITH, I.

Abstract

Intellectual status at 18 years is reported in 192 patients with phenylketonuria born in the UK between 1964 and 1971, together with their school progress. Mean IQs expressed as standard deviation scores (IQ-SDS) were significantly below estimated population norms, and showed a small decrease from 14 to 18 years of age (mean IQ-SDS −1.06 ± 1.3 at 14 years and −1.28 ± 1.07 at 18 years, t = 5.7, p< 0.0001). At 18 years, 27% of subjects had IQs over 2 SDs below the estimated population mean. IQ-SDS at 18 years, although significantly related to average phenylalanine control both between birth and 14 years, and between 14 and 18 years, was not independently related to either variable after allowing for IQ-SDS at 14 years. We conclude that general ability in young adults with early treated phenylketonuria, although reduced in comparison with their peers and closely related to phenylalanine control in early childhood, is not directly influenced by phenylalanine control in the four years preceding the 18th birthday. The apparent fall in IQ-SDS between 14 and 18 years may be due to methodological problems in the analysis of longitudinal IQ data without a control group, rather than providing evidence of intellectual decline.

Published
1994

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