286 results on '"Beale, M"'
Search Results
2. Defects generated by oxidation of BF 2 + implanted silicon
- Author
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Albin, S, primary, Lambert, R, additional, Davidson, S M, additional, and Beale, M I J, additional
- Published
- 2020
- Full Text
- View/download PDF
3. Development of in vitro trans-complementation methodologies for investigating polymerase function in clinically significant hepatitis B virus phenotypes
- Author
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Beale, M. A.
- Subjects
616 - Abstract
In chronic hepatitis B virus (HBV) infection, the loss of hepatitis B e antigen (HBeAg) and seroconversion to anti -HBe coincide with a decrease in viral load and reduction in clinical hepatitis. This thesis describes a programme of work undertaken to investigate viruses causing an unusually aggressive phenotype of anti-HBe positive chronic hepatitis with high viral load. The thesis is broadly divided into two sections. The first describes a genomi cs approach to investigating these viruses. A large multiple alignment of whole genome H BV sequences was generated using sequences retrieved from GenBank. This alignment was used for phylogenetic studies, as well as providing the reference set for developing a whole genome HBV next generation sequencing technique. A scheme for whole genome sequencing was developed using the SEQUENOM M assCLEAVE protocol, in which RNA transcribed PCR products are subjected to base-specific cleavage and MALDI-ToF mass spectrometry, followed by computer-aided pattern matching. Specific issues encountered with this technology will be described in depth. Phylogenetic and bioinformatic analysis of DNA sequencing information obtained for clinically significant viruses will also be described. The replication cycle of HBV remains poorly understood, partially due to the limitations of existing in vivo and in vitro models. The second half of the thesis describes the development of in vitro culture methods for investigating HBV replication. Mammalian expression vectors were designed and generated to express elements of the HBV. Transfection of individual vectors into human hepatoma cell lines was performed, and protein expression and viral DNA characterised using a number of techniques, including immunofluorescent microscopy, ELISA, western blotting and qPCR. This was followed by co-transfection experiments to demonstrate trans-complementation of the viral genome and restoration of viral replication. Once fully optimised, these techniques will allow comparisons of replication efficiency between viruses to be performed in a safe and flexible manner.
- Published
- 2013
4. SARS-CoV-2 evolution during treatment of chronic infection
- Author
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Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., Roberts, D. J., Chandra, A., Temperton, N., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Estee Torok, M., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Abnizova, I., Aigrain, L., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Goodwin, S., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Liddle, J., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Makunin, A., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mccarthy, S., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Puethe, C., Quail, M., Rajan, D., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Scott, C., Seekings, P., Shirley, L., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Jansen Van, P., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Whitwham, A., Widaa, S., Williams, M., Wilson, M., Wright, S., Farr, B. W., Quail, M. A., Thurston, S. A. J., Bronner, I. F., Redshaw, N. M., Lensing, S. V., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Sharrocks, K., Blane, E., Modis, Y., Leigh, K. E., Briggs, J. A. G., van Gils, M. J., Smith, K. G. C., Bradley, J. R., Doffinger, R., Ceron-Gutierrez, L., Barcenas-Morales, G., Pollock, D. D., Goldstein, R. A., Smielewska, A., Skittrall, J. P., Gouliouris, T., Goodfellow, I. G., Gkrania-Klotsas, E., Illingworth, C. J. R., Mccoy, L. E., Gupta, R. K., Medical Microbiology and Infection Prevention, AII - Infectious diseases, Collier, Dami A [0000-0001-5446-4423], Jahun, Aminu [0000-0002-4585-1701], Temperton, Nigel [0000-0002-7978-3815], Modis, Yorgo [0000-0002-6084-0429], Briggs, John AG [0000-0003-3990-6910], Goldstein, Richard A [0000-0001-5148-4672], Skittrall, Jordan P [0000-0002-8228-3758], Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], McCoy, Laura E [0000-0001-9503-7946], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository
- Subjects
0301 basic medicine ,Male ,Time Factors ,viruses ,Passive ,Antibodies, Viral ,CITIID-NIHR BioResource COVID-19 Collaboration ,2.1 Biological and endogenous factors ,Viral ,Aetiology ,Neutralizing ,Lung ,Phylogeny ,neutralising antibodies ,Infectivity ,education.field_of_study ,Genome ,Multidisciplinary ,Alanine ,biology ,High-Throughput Nucleotide Sequencing ,Viral Load ,Spike Glycoprotein ,Virus Shedding ,Adenosine Monophosphate ,Aged ,Antibodies, Neutralizing ,COVID-19 ,Chronic Disease ,Genome, Viral ,Humans ,Immune Evasion ,Immune Tolerance ,Immunization, Passive ,Immunosuppression Therapy ,Mutagenesis ,Mutant Proteins ,Mutation ,SARS-CoV-2 ,Spike Glycoprotein, Coronavirus ,Evolution, Molecular ,Infectious Diseases ,Pneumonia & Influenza ,Antibody ,Infection ,Viral load ,Biotechnology ,Evolution ,General Science & Technology ,antibody escape, Convalescent plasma ,030106 microbiology ,Population ,evasion ,Antibodies ,Virus ,Article ,Vaccine Related ,resistance ,03 medical and health sciences ,Immune system ,COVID-19 Genomics UK (COG-UK) Consortium ,Biodefense ,Genetics ,Viral shedding ,education ,COVID-19 Serotherapy ,QR355 ,Prevention ,Wild type ,Molecular ,Pneumonia ,Virology ,COVID-19 Drug Treatment ,Coronavirus ,Emerging Infectious Diseases ,Good Health and Well Being ,030104 developmental biology ,biology.protein ,Immunization ,immune suppression ,mutation - Abstract
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ΔH69/ΔV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals.
- Published
- 2021
5. NMR Spectroscopy in Plant Metabolomics
- Author
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Ward, J. L., Beale, M. H., Nagata, Toshiyuki, editor, Lörz, Horst, editor, Widholm, Jack M., editor, Saito, Kazuki, editor, Dixon, Richard A., editor, and Willmitzer, Lothar, editor
- Published
- 2006
- Full Text
- View/download PDF
6. Multi-platform metabolomics analyses of a broad collection of fragrant and non-fragrant rice varieties reveals the high complexity of grain quality characteristics
- Author
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Mumm, R., Hageman, J. A., Calingacion, M. N., de Vos, R. C. H., Jonker, H. H., Erban, A., Kopka, J., Hansen, T. H., Laursen, K. H., Schjoerring, J. K., Ward, J. L., Beale, M. H., Jongee, S., Rauf, A., Habibi, F., Indrasari, S. D., Sakhan, S., Ramli, A., Romero, M., Reinke, R. F., Ohtsubo, K., Boualaphanh, C., Fitzgerald, M. A., and Hall, R. D.
- Published
- 2016
- Full Text
- View/download PDF
7. Genomic reconstruction of the SARS-CoV-2 epidemic in England
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Vöhringer, HS, Sanderson, T, Sinnott, M, De Maio, N, Nguyen, T, Goater, R, Schwach, F, Harrison, I, Hellewell, J, Ariani, CV, Gonçalves, S, Jackson, DK, Johnston, I, Jung, AW, Saint, C, Sillitoe, J, Suciu, M, Goldman, N, Panovska-Griffiths, J, Abnizova, I, Aigrain, L, Alderton, A, Ali, M, Allen, L, Amato, R, Anderson, R, Ariani, C, Austin-Guest, S, Bala, S, Barrett, J, Bassett, A, Battleday, K, Beal, J, Beale, M, Beaver, C, Bellany, S, Bellerby, T, Bellis, K, Berger, D, Berriman, M, Betteridge, E, Bevan, P, Binley, S, Bishop, J, Blackburn, K, Bonfield, J, Boughton, N, Bowker, S, Brendler-Spaeth, T, Bronner, I, Brooklyn, T, Buddenborg, SK, Bush, R, Caetano, C, Cagan, A, Carter, N, Cartwright, J, Monteiro, TC, Chapman, L, Chillingworth, T-J, Clapham, P, Clark, R, Clarke, A, Clarke, C, Cole, D, Cook, E, Coppola, M, Cornell, L, Cornwell, C, Corton, C, Crackett, A, Cranage, A, Craven, H, Craw, S, Crawford, M, Cutts, T, Dabrowska, M, Davies, M, Davies, R, Dawson, J, Day, C, Densem, A, 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Gerstung, M
- Abstract
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.
- Published
- 2021
8. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
- Author
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M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Betteridge, E., Farr, B. W., Goodwin, S., Quail, M. A., Scott, C., Shirley, L., Thurston, S. A. J., Rajan, D., Bronner, I. F., Aigrain, L., Redshaw, N. M., Lensing, S. V., Mccarthy, S., Makunin, A., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Bonfield, J., Puethe, C., Whitwham, A., Liddle, J., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Abnizova, I., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Quail, M., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Seekings, P., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Van, P. J., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Widaa, S., Williams, M., Wilson, M., Wright, S., Harvey, W., Virgin, H. W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., and Gupta, R. K.
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0301 basic medicine ,Male ,Models, Molecular ,Passive ,Antibodies, Viral ,Neutralization ,0302 clinical medicine ,Models ,Monoclonal ,80 and over ,Viral ,Neutralizing antibody ,Neutralizing ,Aged, 80 and over ,Vaccines ,Vaccines, Synthetic ,Multidisciplinary ,biology ,Antibodies, Monoclonal ,C500 ,Middle Aged ,C700 ,Spike Glycoprotein ,Vaccination ,Spike Glycoprotein, Coronavirus ,Female ,Angiotensin-Converting Enzyme 2 ,Antibody ,Aged ,Antibodies, Neutralizing ,COVID-19 ,COVID-19 Vaccines ,HEK293 Cells ,Humans ,Immune Evasion ,Immunization, Passive ,Mutation ,Neutralization Tests ,SARS-CoV-2 ,medicine.drug_class ,B100 ,Monoclonal antibody ,Antibodies ,Virus ,03 medical and health sciences ,Immune system ,medicine ,COVID-19 Serotherapy ,QR355 ,Synthetic ,Molecular ,Virology ,Coronavirus ,030104 developmental biology ,Immunization ,biology.protein ,030217 neurology & neurosurgery - Abstract
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b22. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine.
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- 2021
9. Probing Gibberellin Receptors in the Avena fatua Aleurone
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Hooley, R., Beale, M. H., Smith, S. J., Takahashi, Nobutaka, editor, Phinney, Bernard O., editor, and MacMillan, Jake, editor
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- 1991
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10. Novel Affinity Probes for Gibberellin Receptors in Aleurone Protoplasts of A vena Fatua
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Hooley, R., Beale, M. H., Smith, S. J., MacMillan, J., Pharis, Richard P., editor, and Rood, Stewart B., editor
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- 1990
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11. Impact of the recent earthquake and tsunami on Chilean port
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Caselli, F, primary, Beale, M, additional, and Reyes, M, additional
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- 2014
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12. O01.8 Contemporary syphilis is characterised by rapid global spread of pandemic Treponema pallidum lineages
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Beale, M, primary, Marks, M, additional, Cole, M, additional, Lee, M, additional, Pitt, R, additional, Ruis, C, additional, Naidu, P, additional, Unemo, M, additional, Krajden, M, additional, Lukehart, S, additional, Morshed, M, additional, Fifer, H, additional, and Thomson, N, additional
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- 2021
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13. The Dog that Doesn't Bark: Federal Regulation of Industrial Air Pollution in Canada
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Beale, M. (Mike) and Beale, M. (Mike)
- Abstract
In a well-known Sherlock Holmes story, Holmes solved a murder mystery by pointing to the [“curious incident of the dog in the night-time”](https://brieflywriting.com/2012/07/25/the-dog-that-didnt-bark-what-we-can-learn-from-sir-arthur-conan-doyle-about-using-the-absence-of-expected-facts/). “The dog did nothing in the night-time”, countered the Scotland Yard detective on the case. “That was the curious incident” replied Holmes. [Health Canada](https://www.canada.ca/en/health-canada/services/publications/healthy-living/2021-health-effects-indoor-air-pollution.html) estimates that air pollution accounts for 15,300 premature deaths annually in Canada. All the key air pollutants are found on Canada’s [list of toxic substances](https://www.canada.ca/en/environment-climate-change/services/canadian-environmental-protection-act-registry/substances-list/toxic.html), giving Environment and Climate Change Canada (ECCC) full authority to regulate emissions. And yet there are only a handful of federal regulations addressing air pollution from industrial/stationary sources. This case study addresses the question – why doesn’t the dog bark?
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- 2021
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14. Exploring genetic diversity, population structure, and phylogeography in Paracoccidioides species using AFLP markers
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Roberto, T. N., de Carvalho, J. A., Beale, M. A., Hagen, F., Fisher, M. C., Hahn, R. C., de Camargo, Z. P., Rodrigues, A. M., Roberto, T. N., de Carvalho, J. A., Beale, M. A., Hagen, F., Fisher, M. C., Hahn, R. C., de Camargo, Z. P., and Rodrigues, A. M.
- Abstract
Paracoccidioidomycosis (PCM) is a life-threatening systemic fungal infection acquired after inhalation of Paracoccidioides propagules from the environment. The main agents include members of the P. brasiliensis complex (phylogenetically-defined species S1, PS2, PS3, and PS4) and P. lutzii. DNA-sequencing of protein-coding loci (e.g., GP43, ARF, and TUB1) is the reference method for recognizing Paracoccidioides species due to a lack of robust phenotypic markers. Thus, developing new molecular markers that are informative and cost-effective is key to providing quality information to explore genetic diversity within Paracoccidioides. We report using new amplified fragment length polymorphism (AFLP) markers and mating-type analysis for genotyping Paracoccidioides species. The bioinformatic analysis generated 144 in silico AFLP profiles, highlighting two discriminatory primer pairs combinations (#1 EcoRI-AC/MseI-CT and #2 EcoRI-AT/MseI-CT). The combinations #1 and #2 were used in vitro to genotype 165 Paracoccidioides isolates recovered from across a vast area of South America. Considering the overall scored AFLP markers in vitro (67–87 fragments), the values of polymorphism information content (PIC = 0.3345–0.3456), marker index (MI = 0.0018), effective multiplex ratio (E = 44.6788–60.3818), resolving power (Rp = 22.3152–34.3152), discriminating power (D = 0.5183–0.5553), expected heterozygosity (H = 0.4247–0.4443), and mean heterozygosity (Havp = 0.00002–0.00004), demonstrated the utility of AFLP markers to speciate Paracoccidioides and to dissect both deep and fine-scale genetic structures. Analysis of molecular variance (AMOVA) revealed that the total genetic variance (65-66 %) was due to variability among P. brasiliensis complex and P. lutzii (PhiPT = 0.651–0.658, P < 0.0001), supporting a highly structured population. Heterothallism was the exclusive mating strategy, and the distributions of MAT1-1 or MAT1-2 idiomorphs were not significantly skewed (1:1 ratio) f
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- 2021
15. CONTEMPORARY SYPHILIS IS CHARACTERISED BY RAPID GLOBAL SPREAD OF PANDEMIC TREPONEMA PALLIDUM LINEAGES
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Beale, M., Marks, M., Cole, M., Lee, M., Pitt, R., Ruis, C., Naidu, P., Unemo, Magnus, Krajden, M., Lukehart, S., Morshed, M., Fifer, H., Thomson, N., Beale, M., Marks, M., Cole, M., Lee, M., Pitt, R., Ruis, C., Naidu, P., Unemo, Magnus, Krajden, M., Lukehart, S., Morshed, M., Fifer, H., and Thomson, N.
- Abstract
Background: Syphilis is an important sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The last two decades have seen syphilis incidence rise in many high-income countries, yet the evolutionary and epidemiological relationships that underpin this are poorly understood, as is the global T. pallidum population structure. Methods: We assembled a geographically and temporally diverse collection of clinical and laboratory samples, performing direct sequencing on the majority, and combining these with 133 publicly available sequences to compile a dataset comprising 726 T. pallidum genomes. We analysed the resulting genomes using detailed phylogenetic analysis and clustering. Results: We show that syphilis globally can be described by only two deeply branching lineages, Nichols and SS14. We show that both of these lineages can be found circulatingcon currently in 12 of the 23 countries sampled. To provide further phylodynamic resolution we subdivided Treponema pallidum subspecies pallidum into 17 distinct sublineages. Importantly, like SS14, we provide evidence that two Nichols sublineages have expanded clonally across 9 countries contemporaneously with SS14. Moreover, pairwise genome analysis showed that recent isolates circulating in 14 different countries were genetically identical in their core genome to those from other countries, suggesting frequent exchange through international transmission pathways. This contrasts with the majority of samples collected prior to 1983, which are phylogenetically distinct from these more recently isolated sublineages. Bayesian temporal analysis provided evidence of a population bottleneck and decline occurring during the late 1990s, followed by a rapid population expansion a decade later. This was driven by the dominant T. pallidum sublineages circulating today, many of which are resistant to macrolides. Conclusion: Combined we show that the population of contemporary syphilis in high-inco
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- 2021
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16. Policing the COVID-19 pandemic: police officer well-being and commitment to democratic modes of policing
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Kyprianides, A., primary, Bradford, B., additional, Beale, M., additional, Savigar-Shaw, L., additional, Stott, C., additional, and Radburn, M., additional
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- 2021
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17. Is there evidence of recent hepatitis E virus infection in English and North Welsh blood donors?
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Beale, M. A., Tettmar, K., Szypulska, R., Tedder, R. S., and Ijaz, S.
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- 2011
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18. Structural and functional studies on the sialic acids of rabbit IgG
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Beale, M. M.
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572 ,Biochemistry - Published
- 1984
19. A structural and electrical study of B+ and BF2+ implanted silicon
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Beale, M. I. J.
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530.41 ,Solid-state physics - Published
- 1983
20. An integrated national scale SARS-CoV-2 genomic surveillance network
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Aanensen, DM, Abudahab, K, Adams, A, Afifi, S, Alam, MT, Alderton, A, Alikhan, N-F, Allan, J, Almsaud, M, Alrezaihi, A, Alruwaili, M, Amato, R, Andersson, M, Angyal, A, Aranday-Cortes, E, Ariani, C, Armstrong, SD, Asamaphan, P, Attwood, S, Aydin, A, Badhan, A, Baker, D, Baker, P, Balcazar, CE, Ball, J, Barton, AE, Bashton, M, Baxter, L, Beale, M, Beaver, C, Beckett, A, Beer, R, Beggs, A, Bell, A, Bellis, KL, Bentley, EG, Berriman, M, Betteridge, E, Bibby, D, Bicknell, K, Birchley, A, Black, G, Blane, B, Bloomfield, S, Bolt, F, Bonsall, DG, Bosworth, A, Bourgeois, Y, Boyd, O, Bradshaw, D, Breuer, J, Bridgewater, H, Brooks, T, Broos, A, Brown, JR, Brown, RL, Brunker, K, Bucca, G, Buck, D, Bull, M, Butcher, E, Caddy, SL, Caller, LG, Cambell, S, Carlile, M, Carmichael, S, Carrilero, L, Castellano, S, Chaloner, J, Chand, M, Chapman, MR, Chappell, J, Charles, I, Chauhan, AJ, Chawla, A, Cheng, E, Churcher, CM, Clark, G, Clark, JJ, Collins, J, Colquhoun, R, Connor, TR, Constantinidou, C, Coombes, J, Corden, S, Cottrell, S, Cowell, A, Curran, MD, Curran, T, Dabrera, G, Danesh, J, Darby, AC, De Cesare, M, Martins, LDO, De Silva, TI, Debebe, B, Dervisevic, S, Dewar, RA, Dia, M, Dorman, M, Dougan, G, Dover, L, Downing, F, Drury, E, Du Plessis, L, Dyal, PL, Eccles, R, Edwards, S, Ellaby, N, Elliott, S, Eltringham, G, Elumogo, N, Essex, S, Evans, CM, Evans, J, Nascimento, FF, Fairley, DJ, Farr, B, Feltwell, T, Ferguson, N, Filipe, ADS, Findlay, J, Forrest, LM, Forrest, S, Foulser, L, Francois, S, Fraser, C, Frost, L, Gallagher, E, Gallagher, MD, Garcia-Dorival, I, Gaskin, A, Gatica-Wilcox, B, Gavriil, A, Geidelberg, L, Gemmell, M, Gerada, A, Gifford, L, Gilbert, L, Gilmore, P, Gilroy, R, Girgis, S, Glaysher, S, Golubchik, T, Goncalves, S, Goodfellow, I, Goodwin, S, Graham, C, Graham, L, Grammatopoulos, D, Green, A, Green, LR, Greenaway, J, Gregory, R, Groves, DC, Groves, N, Guest, M, Gunson, R, Haldenby, S, Hall, G, Hamilton, WL, Han, X, Harris, KA, Harrison, EM, Hartley, C, Herrera, C, Hesketh, A, Heyburn, D, Hill, V, Hiscox, JA, Holden, M, Holmes, A, Holmes, N, Holt, GS, Hopes, R, Hosmillo, M, Houldcroft, CJ, Howson-Wells, H, Hubb, J, Hughe, J, Hughes, M, Hutchings, S, Impey, R, Iturriza-Gomara, M, Jackson, A, Jackson, B, Jackson, DK, Jahun, AS, James, K, Jamrozy, D, Jeffries, A, Jesudason, N, John, M, Johnson, J, Johnson, KJ, Johnson, N, Johnston, I, Jones, B, Jones, R, Jones, S, Jorgensen, D, Kane, L, Kay, GL, Kay, S, Keatley, J-P, Keeley, AJ, Khakh, M, Khokhar, FA, Kitchen, C, Knight, B, Kolyva, A, Kraemer, M, Kristiansen, M, Kumziene-Summerhayes, S, Kwiatkowski, D, Lackenby, A, Langford, C, Lawniczak, M, Thanh, L-V, Lee, D, Letchford, L, Li, K, Li, L, Liggett, S, Lindsey, BB, Livett, R, Lloyd, A, Lo, S, Lockhart, M, Loh, J, Loman, NJ, Loose, M, Lucaci, A, Ludden, C, Luu, L, Lyons, RA, MacIntyre-Cockett, G, MacLean, A, Mair, D, Maksimovic, J, Manley, R, Manso, C, Manson, J, Martincorena, I, Masoli, J, Mather, AE, Mbisa, T, McCluggage, K, McClure, P, McCrone, JT, McDonald, S, McHugh, MP, McKenna, JM, McMinn, L, McMurray, C, Meadows, L, Menegazzo, M, Meredith, LW, Merrick, I, Mestek-Boukhibar, L, Miah, S, Michell, S, Michelsen, ML, Molnar, Z, Moore, C, Moore, N, Morgan, M, Morgan, S, Muddyman, D, Muir, DA, Muir, P, Myers, R, Nastouli, E, Naydenova, P, Nelson, A, Nelson, C, Nelson, R, Nicholls, S, Nichols, J, Niebel, M, Niola, P, Nomikou, K, O'Grady, J, O'Toole, AN, O'Toole, E, Olateju, C, Orton, RJ, Osman, H, Ott, S, Pacchiarini, N, Padgett, D, Page, AJ, Palmer, S, Panchbhaya, YN, Pandey, S, Park, N, Parker, MD, Parkhill, J, Parr, YA, Parsons, PJ, Partridge, DG, Patel, M, Patterson, S, Payne, B, Peacock, SJ, Penrice-Randal, R, Perry, M, Platt, S, Poplawski, R, Prakash, R, Prestwood, L, Price, A, Price, JR, Puethe, C, Pybus, O, Pymont, H, Quail, M, Quick, J, Raghwani, J, Ragonnet-Cronin, M, Rahman, S, Rainbow, L, Rajatileka, S, Rambaut, A, Ramsay, M, Randell, PA, Randle, NP, Raviprakash, V, Raza, M, Silva, PR, Rey, S, Richter, A, Robertson, DL, Robinson, TI, Robson, SC, Rooke, S, Rowan, A, Rowe, W, Roy, S, Rudder, S, Ruis, C, Sang, F, Scarlett, G, Schaefer, U, Scott, C, Scott, G, Sethi, D, Shaaban, S, Shah, R, Sharma, P, Shawli, GT, Shepherd, J, Sherriff, N, Shirley, L, Sillitoe, J, Simpson, DA, Singer, JB, Siveroni, I, Smith, C, Smith, CP, Smith, DL, Smith, N, Smith, W, Smith-Palmer, A, Smollett, K, Southgate, J, Spellman, K, Spencer-Chapman, M, Sridhar, S, Stanley, R, Stark, R, Stewart, JP, Stockton, J, Stuart, C, Studholme, D, Swainston, N, Swindells, E, Taha, Y, Tariq, MA, Taylor, B, Taylor, GP, Taylor, S, Taylor-Joyce, G, Tedim, AP, Temperton, B, Templeton, KE, Thomson, EC, Thomson, NM, Thornton, A, Thurston, S, Todd, J, Tong, L, Tonkin-Hill, G, Torok, ME, Trebes, A, Trotter, AJ, Tsoleridis, T, Tucker, RM, Tutill, HJ, Underwood, A, Unnikrishnan, M, Vamos, E, Vasylyeva, T, Vattipally, S, Victoria, A, Vipond, B, Volz, EM, Wain, J, Wang, D, Warwick-Dugdale, J, Wastnedge, E, Watkins, J, Watts, J, Webber, M, Weeks, S, Weldon, D, Whitehead, M, Williams, CA, Williams, C, Williams, D, Williams, R, Williams, TC, Wise, E, Wright, V, Wyles, MD, Wyllie, S, Yakovleva, A, Yasir, M, Yeats, C, Yew, WC, Young, GR, Yu, X, and Zarebski, A
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Microbiology (medical) ,Scale (ratio) ,SARS-CoV-2 ,viruses ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,COVID-19 ,COVID-19 Genomics UK (COG-UK) consortiumcontact@cogconsortium.uk ,C500 ,Genome, Viral ,Genomics ,Biology ,C700 ,Microbiology ,Article ,Infectious Diseases ,Virology ,Humans ,Cartography - Abstract
The Coronavirus Disease 2019 (COVID-19) Genomics UK Consortium (COG-UK) was launched in March, 2020, with £20 million support from UK Research and Innovation, the UK Department of Health and Social Care, and Wellcome Trust. The goal of this consortium is to sequence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for up to 230 000 patients, health-care workers, and other essential workers in the UK with COVID-19, which will help to enable the tracking of SARS-CoV-2 transmission, identify viral mutations, and integrate with health data to assess how the viral genome interacts with cofactors and consequences of COVID-19.
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- 2020
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21. Policing the COVID-19 pandemic: police officer well-being and commitment to democratic modes of policing.
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Kyprianides, A., Bradford, B., Beale, M., Savigar-Shaw, L., Stott, C., and Radburn, M.
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POLICE ,COVID-19 pandemic ,POLICE attitudes ,ORGANIZATIONAL legitimacy ,ORGANIZATIONAL identification ,PUBLIC health officers ,METROPOLITAN areas ,RURAL geography - Abstract
Police organisations have a wealth of experience in responding to emergencies, but COVID-19 is unprecedented in terms of the speed, scale and complexity of developing doctrine and its implementation by officers. The crisis also threw into sharp relief the fact that police policy and, crucially, practice are always implemented within wider social, political and economic contexts. Using online survey data collected from 325 police officers based at forces operating across different UK contexts (cities, conurbations, towns and rural areas), we seek to understand officer experiences and perceptions of policing COVID-19. In particular, we examine whether (internally) organisational climate and (externally) the UK government's response to COVID-19 were important to (a) officers' support for police use of force at times of emergency, (b) officer's support for procedurally just policing at times of emergency, and (c) their health and well-being; and whether identification and perceptions of self-legitimacy mediate the associations between these variables. We show that a positive organisational climate was associated with less support for police use of force, more support for procedurally just policing and increased police officer health and well-being. Our results, however, suggest potential negative correlates of police officer self-legitimacy: higher levels of self-legitimacy were associated with poorer police officer health and well-being and increased support for police use of force. These results have important implications for our understanding of police officer well-being and police officers' commitment to democratic modes of policing when faced with policing a pandemic. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Current status of the multinational Arabidopsis community
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Parry, Geraint, Provart, Nicholas J., Brady, Siobhan M., Uzilday, Baris, Adams, K., Araújo, W., Aubourg, S., Baginsky, S., Bakker, E., Bärenfaller, K., Batley, J., Beale, M., Beilstein, M., Belkhadir, Y., Berardini, T., Bergelson, J., Blanco-Herrera, F., Brady, S., Braun, Hans-Peter, Briggs, S., Brownfield, L., Cardarelli, M., Castellanos-Uribe, M., Coruzzi, G., Dassanayake, M., Jaeger, G.D., Dilkes, B., Doherty, C., Ecker, J., Edger, P., Edwards, D., Kasmi, F.E., Eriksson, M., Exposito-Alonso, M., Falter-Braun, P., Fernie, A., Ferro, M., Fiehn, O., Friesner, J., Greenham, K., Guo, Y., Hamann, T., Hancock, A., Hauser, M.-T., Heazlewood, J., Ho, C.-H., Hõrak, H., Huala, E., Hwang, I., Iuchi, S., Jaiswal, P., Jakobson, L., Jiang, Y., Jiao, Y., Jones, A., Kadota, Y., Khurana, J., Kliebenstein, D., Knee, E., Kobayashi, M., Koch, M., Krouk, G., Larson, T., Last, R., Lepiniec, L., Li, S., Lurin, C., Lysak, M., Maere, S., Malinowski, R., Maumus, F., May, S., Mayer, K., Mendoza-Cozatl, D., Mendoza-Poudereux, I., Meyers, B., Micol, J.L., Millar, H., Mock, H.-P., Mukhtar, K., Mukhtar, S., Murcha, M., Nakagami, H., Nakamura, Y., Nicolov, L., Nikolau, B., Nowack, M., Nunes-Nesi, A., Palmgren, M., Parry, G., Patron, N., Peck, S., Pedmale, U., Perrot-Rechenmann, C., Pieruschka, R., Pío-Beltrán, J., Pires, J.C., Provart, N., Rajjou, L., Reiser, L., Reumann, S., Rhee, S., Rigas, S., Rolland, N., Romanowski, A., Santoni, V., Savaldi-Goldstein, S., Schmitz, R., Schulze, W., Seki, M., Shimizu, K.K., Slotkin, K., Small, I., Somers, D., Sozzani, R., Spillane, C., Srinivasan, R., Taylor, N., Tello-Ruiz, M.-K., Thelen, J., Tohge, T., Town, C., Toyoda, T., Uzilday, B., Peer, Y.V.D., Wijk, K., Gillhaussen, P.V., Walley, J., Ware, D., Weckwerth, W., Whitelegge, J., Wienkoop, S., Wright, C., Wrzaczek, M., Yamazaki, M., Yanovsky, M., Žárský, V., Zhong, X., Biological Systems Engineering, Organisms and Environment Research Division, Cardiff School of Biosciences, Cardiff University, University of Toronto, University of California [Davis] (UC Davis), University of California, Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, 06099 Halle, Germany, Department of Ecology and Evolution [Chicago], University of Chicago, Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité de recherche en génomique végétale (URGV), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Rothamsted Research, Biotechnology and Biological Sciences Research Council (BBSRC), University of Arizona, Gregor Mendel Institute (GMI) - Vienna Biocenter (VBC), Austrian Academy of Sciences (OeAW), University of California (UC), Center for Genomics and Systems Biology, Department of Biology [New York], New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU)-New York University [New York] (NYU), NYU System (NYU)-NYU System (NYU), Flanders Institute for Biotechnology, National Center for Atmospheric Research [Boulder] (NCAR), Max Planck Institute of Molecular Plant Physiology (MPI-MP), Max-Planck-Gesellschaft, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Agricultural Sustainability Institute and Department of Neurobiology, Physiology, and Behavior, Norwegian University of Science and Technology (NTNU), University of Melbourne, King Abdullah University of Science and Technology (KAUST), University of Chinese Academy of Sciences [Beijing] (UCAS), The Sainsbury Laboratory [Norwich] (TSL), IBM Research – Tokyo, University Medical Center Groningen [Groningen] (UMCG), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre for Novel Agricultural Products, Department of Biology, University of York [York, UK], Biologie des Semences (LBS), Institut National de la Recherche Agronomique (INRA)-Institut National Agronomique Paris-Grignon (INA P-G), Sichuan University [Chengdu] (SCU), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Plant Systems Biology, Unité de Recherche Génomique Info (URGI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Nottingham, UK (UON), Institute of Bioinformatics and System Biology (IBIS), Helmholtz Zentrum München = German Research Center for Environmental Health, Saint Mary's University [Halifax], Max Planck Institute for Plant Breeding Research (MPIPZ), National Institute of Genetics (NIG), University of Copenhagen = Københavns Universitet (UCPH), Division of Biology [La Jolla], University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC), Earlham Institute [Norwich], Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, University of Missouri [Columbia] (Mizzou), University of Missouri System, Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Plant Biology, Carnegie Institution for Science, Dynamique du protéome et biogenèse du chloroplaste (ChloroGenesis), Physiologie cellulaire et végétale (LPCV), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Plateforme de Spectrométrie de Masse Protéomique - Mass Spectrometry Proteomics Platform (MSPP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plant Systems Biology, Institute of Physiology and Biotechnology of plants, RIKEN Center for Sustainable Resource Science [Yokohama] (RIKEN CSRS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Unité de recherche Génétique et amélioration des plantes (GAP), Institut National de la Recherche Agronomique (INRA), Department of Biology, Duke University, Genetics and Biotechnology Lab, Plant & AgriBiosciences Research Centre (PABC), School of Natural Sciences, National University of Ireland [Galway] (NUI Galway), Universidade Federal de São Paulo, RIKEN Plant Science Center and RIKEN Bioinformatics and Systems Engineering Division, Cold Spring Harbor Laboratory (CSHL), University of Vienna [Vienna], University of California [Los Angeles] (UCLA), Department of Plant Molecular Biology, Université de Lausanne = University of Lausanne (UNIL), UKRI-BBSRC grant BB/M004376/1, HHMI Faculty Scholar Fellowship, Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) 118Z137, UK Research & Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC) BB/M004376/1, Sainsbury Lab, Norwich Research Park, Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Helmholtz-Zentrum München (HZM), University of Copenhagen = Københavns Universitet (KU), University of California-University of California, Carnegie Institution for Science [Washington], Université de Lausanne (UNIL), Ege Üniversitesi, Organismal and Evolutionary Biology Research Programme, Plant Biology, Viikki Plant Science Centre (ViPS), Receptor-Ligand Signaling Group, University of Zurich, Parry, Geraint, Provart, Nicholas J, and Brady, Siobhan M
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0106 biological sciences ,Arabidopsis thaliana ,[SDV]Life Sciences [q-bio] ,White Paper ,Genetics and Molecular Biology (miscellaneous) ,Plant Science ,Biochemistry ,01 natural sciences ,Dewey Decimal Classification::500 | Naturwissenschaften::580 | Pflanzen (Botanik) ,Research community ,Arabidopsis ,1110 Plant Science ,0303 health sciences ,Ecology ,biology ,1184 Genetics, developmental biology, physiology ,ddc:580 ,Multinational corporation ,MAP ,590 Animals (Zoology) ,Life Sciences & Biomedicine ,Arabidopsis research community ,Evolution ,Steering committee ,Multinational Arabidopsis Steering Committee ,Library science ,1301 Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Business and Economics ,10127 Institute of Evolutionary Biology and Environmental Studies ,03 medical and health sciences ,Behavior and Systematics ,Political science ,[SDV.BV]Life Sciences [q-bio]/Vegetal Biology ,MASC ,roadmap ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Plant Sciences ,Botany ,15. Life on land ,11831 Plant biology ,biology.organism_classification ,White Papers ,collaboration ,1105 Ecology, Evolution, Behavior and Systematics ,QK1-989 ,Arabidopsis Thaliana ,Collaboration ,Research Network ,Roadmap ,570 Life sciences ,1182 Biochemistry, cell and molecular biology ,2303 Ecology ,010606 plant biology & botany - Abstract
The multinational Arabidopsis research community is highly collaborative and over the past thirty years these activities have been documented by the Multinational Arabidopsis Steering Committee (MASC). Here, we (a) highlight recent research advances made with the reference plantArabidopsis thaliana; (b) provide summaries from recent reports submitted by MASC subcommittees, projects and resources associated with MASC and from MASC country representatives; and (c) initiate a call for ideas and foci for the "fourth decadal roadmap," which will advise and coordinate the global activities of the Arabidopsis research community., UKRI-BBSRC grant [BB/M004376/1]; HHMI Faculty Scholar Fellowship; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [118Z137], UKRI-BBSRC grant, Grant/Award Number: BB/M004376/1; HHMI Faculty Scholar Fellowship; the Scientific and Technological Research Council of Turkey, Grant/Award Number: 118Z137
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- 2020
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23. Canada’s Fisheries Act: The Evolution of a Modern Pollution Prevention Regulatory Regime
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Beale, M. (Mike) and Beale, M. (Mike)
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The pollution prevention provisions of Canada’s Fisheries Act, and the regulations made pursuant to those provisions, form the core of Canada’s federal water pollution regime. The Act applies nationally, and the sectoral regulations apply to an ever-expanding list of activities. The regime is actively enforced. The Canada’s Fisheries Act and the Canadian Environmental Protection Act, 1999 (CEPA) 1 together form the key underpinnings for Environment and Climate Change Canada’s pollution regulations. The Canada’s Fisheries Act also takes an unusual approach to pollution prevention: a general prohibition against pollution in the Act itself, while the regulations under the Act permit pollution under specified conditions. The Canada’s Fisheries Act itself is over 150 years old. Where did the modern regime come from, and how did it take the form it has today? That is the subject matter of this Case Study.
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- 2020
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24. The global epidemiology of emerging Histoplasma species in recent years
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Rodrigues, A M, Beale, M A, Hagen, F, Fisher, M C, Terra, P P D, de Hoog, S, Brilhante, R S N, de Aguiar Cordeiro, R, de Souza Collares Maia Castelo-Branco, D, Rocha, M F G, Sidrim, J J C, de Camargo, Z P, Rodrigues, A M, Beale, M A, Hagen, F, Fisher, M C, Terra, P P D, de Hoog, S, Brilhante, R S N, de Aguiar Cordeiro, R, de Souza Collares Maia Castelo-Branco, D, Rocha, M F G, Sidrim, J J C, and de Camargo, Z P
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Histoplasmosis is a serious infectious disease in humans caused by Histoplasma spp. (Onygenales), whose natural reservoirs are thought to be soil enriched with bird and bat guano. The true global burden of histoplasmosis is underestimated and frequently the pulmonary manifestations are misdiagnosed as tuberculosis. Molecular data on epidemiology of Histoplasma are still scarce, even though there is increasing recognition of histoplasmosis in recent years in areas distant from the traditional endemic regions in the Americas. We used multi-locus sequence data from protein coding loci (ADP-ribosylation factor, H antigen precursor, and delta-9 fatty acid desaturase), DNA barcoding (ITS1/2+5.8s), AFLP markers and mating type analysis to determine the genetic diversity, population structure and recognise the existence of different phylogenetic species among 436 isolates of Histoplasma obtained globally. Our study describes new phylogenetic species and the molecular characteristics of Histoplasma lineages causing outbreaks with a high number of severe outcomes in Northeast Brazil between 2011 and 2015. Genetic diversity levels provide evidence for recombination, common ancestry and clustering of Brazilian isolates at different geographic scales with the emergence of LAm C, a new genotype assigned to a separate population cluster in Northeast Brazil that exhibited low diversity indicative of isolation. The global survey revealed that the high genetic variability among Brazilian isolates along with the presence of divergent cryptic species and/or genotypes may support the hypothesis of Brazil being the center of dispersion of Histoplasma in South America, possibly with the contribution of migratory hosts such as birds and bats. Outside Brazil, the predominant species depends on the region. We confirm that histoplasmosis has significantly broadened its area of occurrence, an important feature of emerging pathogens. From a practical point of view, our data point to the emer
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- 2020
25. Coal-Fired Electricity – a Regulatory Case Study, in a Narrative of Canada-US Harmonization
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Beale, M. (Mike) and Beale, M. (Mike)
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Canada’s coal-fired electricity regulations were published in 2012 and were the first federal regulations targeting greenhouse gas (GHG) emissions from stationary sources. They have since been strengthened. This case study tells the policy story of how the regulations came about, and how in the space of 18 months the government’s regulatory approach evolved from one based on emissions intensity, to cap-and-trade, to capital stock turnover. It also tells the technical story of how a simple regulation based on the length of time a facility has to operate can still build in elements of trading and other flexibilities. It ends with some observations around lessons learned.
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- 2019
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26. The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis
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Basu, P., Sandhu, N., Bhatt, A., Singh, A., Balhana, R., Gobe, I., Crowhurst, N. A., Mendum, T. A., Gao, L., Ward, J. L., Beale, M. H., McFadden J., and Beste, D. J. V.
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Glucogenesis ,Host-pathogen interaction ,Enzyme ,Tuberculosis ,Mycobacterium tuberculosis ,Microbial Pathogenesis ,Microbiology ,Microbial metabolism - Abstract
Enzymes at the phosphoenolpyruvate (PEP)–pyruvate–oxaloacetate or anaplerotic (ANA) node control the metabolic flux to glycolysis, gluconeogenesis, and anaplerosis. Here we used genetic, biochemical, and 13C isotopomer analysis to characterize the role of the enzymes at the ANA node in intracellular survival of the world's most successful bacterial pathogen, Mycobacterium tuberculosis (Mtb). We show that each of the four ANA enzymes, pyruvate carboxylase (PCA), PEP carboxykinase (PCK), malic enzyme (MEZ), and pyruvate phosphate dikinase (PPDK), performs a unique and essential metabolic function during the intracellular survival of Mtb. We show that in addition to PCK, intracellular Mtb requires PPDK as an alternative gateway into gluconeogenesis. Propionate and cholesterol detoxification was also identified as an essential function of PPDK revealing an unexpected role for the ANA node in the metabolism of these physiologically important intracellular substrates and highlighting this enzyme as a tuberculosis (TB)-specific drug target. We show that anaplerotic fixation of CO2 through the ANA node is essential for intracellular survival of Mtb and that Mtb possesses three enzymes (PCA, PCK, and MEZ) capable of fulfilling this function. In addition to providing a back-up role in anaplerosis we show that MEZ also has a role in lipid biosynthesis. MEZ knockout strains have an altered cell wall and were deficient in the initial entry into macrophages. This work reveals that the ANA node is a focal point for controlling the intracellular replication of Mtb, which goes beyond canonical gluconeogenesis and represents a promising target for designing novel anti-TB drugs.
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- 2018
27. Identification of the connections in biologically inspired neural networks
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Demuth, H, Leung, K, Beale, M, and Hicklin, J
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Cybernetics - Abstract
We developed an identification method to find the strength of the connections between neurons from their behavior in small biologically-inspired artificial neural networks. That is, given the network external inputs and the temporal firing pattern of the neurons, we can calculate a solution for the strengths of the connections between neurons and the initial neuron activations if a solution exists. The method determines directly if there is a solution to a particular neural network problem. No training of the network is required. It should be noted that this is a first pass at the solution of a difficult problem. The neuron and network models chosen are related to biology but do not contain all of its complexities, some of which we hope to add to the model in future work. A variety of new results have been obtained. First, the method has been tailored to produce connection weight matrix solutions for networks with important features of biological neural (bioneural) networks. Second, a computationally efficient method of finding a robust central solution has been developed. This later method also enables us to find the most consistent solution in the presence of noisy data. Prospects of applying our method to identify bioneural network connections are exciting because such connections are almost impossible to measure in the laboratory. Knowledge of such connections would facilitate an understanding of bioneural networks and would allow the construction of the electronic counterparts of bioneural networks on very large scale integrated (VLSI) circuits.
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- 1990
28. Periodic Sampling Errors in Scanned Ultrasonic Holography
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Beale, M I J and Metherell, A. F., editor
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- 1980
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29. Current Filaments in ZnS:Mn DC Thin Film Electroluminescent Devices
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Beale, M. I. J., Kirton, J., Slater, M., Lotsch, H. K. V., editor, Shionoya, Shigeo, editor, and Kobayashi, Hiroshi, editor
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- 1989
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30. Gibberellins: Structure-Activity Relationships and the Design of Molecular Probes
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Beale, M. H., Hooley, R., MacMillan, J., and Bopp, Martin, editor
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- 1986
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31. CLASP - A RANDOMIZED TRIAL OF LOW-DOSE ASPIRIN FOR THE PREVENTION AND TREATMENT OF PREECLAMPSIA AMONG 9364 PREGNANT-WOMEN
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BEROYZ, G, CASALE, R, FARREIROS, A, PALERMO, M, MARGULIES, M, VOTO, L, FABREGUES, G, RAMALINGAM, R, DAVIES, T, BRYCE, R, BOYD, W, CARMODY, F, KING, J, VACCA, A, FAY, R, WALTERS, W, ANTONAS, B, BENNETT, P, BROOM, T, CROWTHER, C, DERHAM, R, GEORGE, K, HAGUE, W, HASENHOHR, G, HEYSEN, D, KORNMAN, L, OLOUGHLIN, S, MORRIS, D, PRIDMORE, B, ROBINSON, J, SVIGOS, D, SWEET, R, BEALE, M, BENNETT, M, BOSCH, E, FISHER, C, HORRAUTZ, S, SYMINGTON, I, SZIRT, A, FORBES, K, FREEMAN, A, POPPER, E, WILSON, J, PERMEZEL, M, BOWDITCH, J, REYNOLDS, G, MOULINASSE, R, BIETLOT, Y, KIRKPATRICK, C, COULON, R, DELVOYE, P, DEMATOS, C, SIMONINI, S, LEJEUNE, B, NEERDAELS, C, ALEXANDER, S, GOESSENS, L, HANSSENS, M, SPITZ, B, VANASSCHE, A, WECKHUYSEN, R, PARBOOSINGH, J, HARMAN, C, REY, E, BURROWS, R, BELCHER, J, GARNER, P, SYLVAIN, J, NIMROD, C, THOMAS, B, DEININGER, F, LAO, T, LI, C, FRIEDMAN, S, BORNSTEIN, J, SHALIT, A, MATZKEL, A, POMERANZ, M, GELSNER, M, MANKUTA, D, WIZNITZER, A, LEVINE, S, ADEEB, N, CHANDRAN, R, NASRI, N, SHARIFF, J, ANSELL, D, LAKE, Y, GOROCHOVA, L, MERIAKRI, V, ROMANUGA, N, DOTZ, I, SHEUV, B, VIKHLYAEVA, E, ANDREEV, K, GOLUBEVA, L, GORODCOV, V, ADELANTADO, J, SANTONJA, J, HOLMBERG, H, BUCHHAVE, P, LEANDERSSON, U, LILJESTRAND, J, RYDHSTROEM, H, SWEDIN, G, BJORKLUND, A, GENNSER, G, SANDEN, M, DAHLGREN, S, HAMMARBACK, S, SMEDS, A, SIDENVALL, M, ENEROTH, E, SZABOLCS, A, DANIELSSON, I, LINDQVIST, P, HOGSTEDT, S, WALLENBURG, H, BREMER, H, BRIET, J, DEBIEMEYERINK, A, DONKERS, B, LAMPING, P, SCHIERBEEK, J, VANDERLEEUWHARMSEN, L, THE, H, VANBODEGOM, F, VANEGMONDLINDEN, A, FLU, P, KUIJKEN, J, MORREL, B, STRAUB, M, VIERHOUT, M, KEIRSE, M, VANROOSMALEN, J, HOHNER, C, HUTTEN, J, BENNEN, J, ROEX, A, WIJFFELS, T, OOSTERHOFF, H, OTTEN, J, VANDERKLEI, T, RAMONDT, J, VANDERMOER, P, DEGRAAFF, J, SIJSMA, E, DEGREVE, O, SMIT, D, SMULDERS, P, NIJHUIS, J, ZONDERVAN, H, LIND, J, SCHOOT, B, MONKHORST, M, STUT, J, VANDAM, L, VANOTTERLO, L, VLAANDEREN, W, EGGENS, J, SANTEMA, J, VERHOEFF, A, HAMID, S, JOHN, I, KHAN, G, SHAH, S, SHEIKH, E, SINHA, C, ABRAMOVICH, D, CAMPBELL, D, FISHER, P, GALL, S, HALL, M, JANDIAL, V, PARKIN, D, SMITH, N, SUTHERLAND, H, SWAPP, G, TEMPLETON, A, TERRY, P, KALAM, A, MAGEE, S, MARTIN, D, SPEARING, G, ALDERMAN, B, MURRAY, A, SUTHERST, J, HYATT, D, SAUNDERS, P, BURGESS, S, COCHRANE, G, WHITE, A, ARMSTRONG, M, MCNICHOL, E, OSBOURNE, G, PRICE, J, CRICHTON, J, EVANS, D, ANDERSON, R, HULL, M, JAMES, D, NIVEN, P, STIRRAT, G, WARDLE, P, GARDNER, P, PADGETT, L, ALAILY, A, NASH, G, GINZ, B, SMITH, M, RICHARDS, C, ARMAR, A, ARMSTRONG, N, MANNING, E, PERSAD, K, COLLINGWOOD, M, COLLINS, R, CROWTHER, J, FARRELL, B, HAFNER, B, HANDOLL, H, HEINEMAN, J, KNIGHT, S, MEAD, G, RADLEY, A, SPENCE, S, REID, W, TREHARNE, I, HEASLEY, R, LOWRY, D, MYLES, T, WALLACE, R, GEALS, M, GORDON, G, TRAIN, T, HUTCHON, D, MACDONALD, J, STOREY, R, ANDERSON, G, WORTH, R, ERIAN, J, MCQUEEN, J, TATFORD, E, TERRY, M, NEALE, R, HOWAT, R, KENNEDY, J, MACNAUGHTON, M, MCEWAN, H, WALKER, J, HUTCHESON, R, KEMP, V, READ, M, SIMMS, M, SWINGLER, G, HUSEMEYER, R, CHAPMAN, M, MAXWELL, D, ELDER, M, FUSI, L, HAWKINS, D, NICOLINI, U, WINSTON, R, BURTON, E, FAIRBANK, J, SIMMONS, S, SPING, J, TRICKEY, N, GILLARD, M, HUDSON, C, SETCHELL, M, WATHEN, N, CANTY, S, WHITELEY, P, CAMPBELL, J, FEENEY, J, HAY, D, IMRIE, A, PALMER, A, PURDIE, D, SPECK, E, TYRRELL, S, MCLEAN, J, BROWN, V, DUNCAN, S, JOHNSON, D, MILLAR, D, BUCKLEY, D, CHARNOCK, M, DOVE, P, ELLIS, J, GILLMER, M, MCVITTIE, J, MANNION, V, REDMAN, C, SELLERS, S, TURNBULL, A, NEWMAN, M, CAMPBELL, S, CARDOSO, L, GIBB, D, HARRINGTON, K, PARSONS, J, NICOLAIDES, K, STUDD, J, DIXON, R, GIE, C, PICKLES, C, SEAR, R, GRAHAM, R, KIRWAN, P, SMITH, G, ANWAR, M, ALAZZAWI, F, DAVIDSON, A, DECHAZEL, R, DRIFE, J, GILL, F, LANG, G, MACAFEE, J, MACVICAR, J, NAFTALIN, N, NEUBERG, R, TAYLOR, D, LEAVER, E, TIMOTHY, I, BREESON, A, LAMB, M, VELACOTT, I, VERNER, V, HORWELL, D, LOBB, M, SELIGMAN, S, SCOTT, A, HALL, S, MACKENZIE, W, SMITH, E, VETHANAVAGAN, S, VERZIN, J, WEIR, P, WHITE, R, CLARK, H, FAWDRY, R, LYNCH, C, MCCUNE, G, BOWENSIMPKINS, P, CALVERT, J, EMERY, S, JACKSON, W, STOKES, I, WARD, A, BROWNING, A, COX, C, LITTLE, D, STIBBE, H, MCINTOSH, A, SNODGRASS, C, WAGSTAFF, T, HOWIE, P, BIBBY, J, DAVIES, W, ELLIOTT, B, SHAXTED, E, MCGARRY, J, DAW, E, BAKER, K, CLUBB, A, GOUGH, J, GRANT, M, MENON, V, OBHARI, M, OBRIEN, P, BROWN, R, RYALL, A, WALTON, S, BAKER, J, BRUCE, J, LIU, D, JOHNSON, I, TYACK, A, COWIE, D, NYSENBAUM, A, BAMFORD, P, GARRIOCH, D, HILL, J, GRANT, A, FELTON, D, HACKMAN, B, FALCONER, A, FREEMAN, F, GREENE, K, JACKSON, J, HUNTER, G, GRATTON, D, MAULIK, T, YOUSSEF, H, BANWELL, G, HARTWELL, R, WILSON, P, BOND, A, FORBESSMITH, P, BARRON, L, DAVISON, J, DUNLOP, W, LIND, T, TACCHI, D, BALFOUR, R, MUTCH, L, COLTART, T, DESWIET, M, EDMONDS, D, LOEFFLER, F, MALVERN, J, OSBOURNE, J, RODECK, C, SIMS, C, SPENCER, J, BONE, C, MACDONALD, A, DREW, N, BALLARD, R, THONET, R, HANNA, L, MORCOS, S, HOLT, E, COOPER, J, CALLEN, P, FOZZARD, C, GRUNDY, M, STANLEY, S, DANIEL, D, GOLDING, R, WIENER, J, BUCKINGHAM, M, HEARD, M, LETCHWORTH, A, BOOMLA, K, CLARK, A, GRUDZINSKAS, J, HARTGILL, J, ORAM, D, ROBSON, J, SAVAGE, W, BLUNT, V, LANE, J, OWEN, A, REDFORD, D, BEARD, R, BOSTOCK, J, MEASDAY, B, MELVILLE, H, DORNAN, J, TRAUB, A, UTIDJIAN, M, AULD, A, KRASZEWSKI, A, MACK, D, MCDOUGALL, N, MOWAT, J, DOCHERTY, P, MCKENNA, D, SMEDLEY, G, WILDE, J, SMITH, R, WATNEY, P, MCDONNELL, J, TROMAMS, P, CALDER, A, GLASIER, A, GREER, I, JOHNSTONE, F, LISTON, W, LIVINGSTONE, J, NEILSON, J, SMITH, S, WEST, C, BULLOUGH, C, JONES, A, MACKAY, G, COOPER, K, RUOSS, C, JOYCE, D, MCCOY, D, MCLEOD, F, SAVAGE, P, SMITH, P, TURNER, G, KANE, L, ROSENBERG, D, SHANNON, R, BROMHAM, D, BUCHAN, P, CROMPTON, A, JARVIS, G, LILFORD, R, MACDONALD, H, THORNTON, J, PINKER, G, BEVAN, J, FRANCIS, J, KETTLE, M, HOLMES, H, KERRWILSON, R, SUTTON, M, BEYNON, J, HOOKER, J, FERGUSSON, I, MORTON, K, TAYLOR, R, DAVIS, J, LOW, R, STEWART, J, ASHWORTH, F, SOONAWALLA, K, TEBBUTT, I, USHERWOOD, M, VOIGT, J, COHEN, S, GODFREY, K, MCNAB, G, MURRAY, B, GUDGEON, D, FOULKES, J, STANNARD, P, JAMSHIDI, R, MULHOLLAND, J, BOND, E, DUNLOP, J, FOGARTY, P, BRANT, H, LACHELIN, L, LLOYDJONES, R, SIDDLE, N, SILVERSTONE, A, STEELE, S, WARD, R, EDDIE, D, VERNONPARRY, J, CIETAK, K, KENNEDY, C, REED, M, SANTCASSIA, L, BEGG, H, FRAMPTON, J, GRIFFIN, D, LEWIS, B, NESTROP, A, SHERIDAN, R, TIPTON, R, BOBER, S, BROUGH, F, STAFFORD, J, HOUSE, M, PAWSON, M, REES, D, VENN, R, ANDERSON, T, HUGHES, J, REGINALD, P, HENSON, G, MORGAN, H, ALLEN, I, HANNAY, W, LENNOX, C, CALLENDER, R, MCLEAN, R, GOLDKRAND, J, and FIDALGO, C
- Subjects
medicine.medical_specialty ,Randomized controlled trial ,law ,business.industry ,Internal medicine ,medicine ,General Medicine ,medicine.disease ,business ,law.invention ,Preeclampsia ,Low dose aspirin - Published
- 2016
- Full Text
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32. Preparation and characterization of monoclonal antibodies which recognise different gibberellin epitopes
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Knox, J. P., Beale, M. H., Butcher, G. W., and MacMillan, J.
- Published
- 1987
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33. ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation
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Beste, D, Bonde, B, Hawkins, N, Ward, J, Beale, M, Noack, S, Nöh, K, Kruger, N, Ratcliffe, R, and McFadden, J
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QH301-705.5 ,Immunologic diseases. Allergy ,RC581-607 ,Biology (General) - Abstract
Mycobacterium tuberculosis requires the enzyme isocitrate lyase (ICL) for growth and virulence in vivo. The demonstration that M. tuberculosis also requires ICL for survival during nutrient starvation and has a role during steady state growth in a glycerol limited chemostat indicates a function for this enzyme which extends beyond fat metabolism. As isocitrate lyase is a potential drug target elucidating the role of this enzyme is of importance; however, the role of isocitrate lyase has never been investigated at the level of in vivo fluxes. Here we show that deletion of one of the two icl genes impairs the replication of Mycobacterium bovis BCG at slow growth rate in a carbon limited chemostat. In order to further understand the role of isocitrate lyase in the central metabolism of mycobacteria the effect of growth rate on the in vivo fluxes was studied for the first time using ¹³C-metabolic flux analysis (MFA). Tracer experiments were performed with steady state chemostat cultures of BCG or M. tuberculosis supplied with ¹³C labeled glycerol or sodium bicarbonate. Through measurements of the ¹³C isotopomer labeling patterns in protein-derived amino acids and enzymatic activity assays we have identified the activity of a novel pathway for pyruvate dissimilation. We named this the GAS pathway because it utilizes the Glyoxylate shunt and Anapleurotic reactions for oxidation of pyruvate, and Succinyl CoA synthetase for the generation of succinyl CoA combined with a very low flux through the succinate--oxaloacetate segment of the tricarboxylic acid cycle. We confirm that M. tuberculosis can fix carbon from CO₂ into biomass. As the human host is abundant in CO₂ this finding requires further investigation in vivo as CO₂ fixation may provide a point of vulnerability that could be targeted with novel drugs. This study also provides a platform for further studies into the metabolism of M. tuberculosis using ¹³C-MFA.
- Published
- 2011
34. The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato
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Ward, J. L., Forcat, S., Beckmann, M., Bennett, M., Miller, S. J., Baker, J. M., Hawkins, N. D., Vermeer, C. P., Lu, C., Lin, W., Truman, W. M., Beale, M. H., Draper, J., Mansfield, J. W., and Grant, M.
- Subjects
Plant Sciences - Abstract
P>The outcome of bacterial infection in plants is determined by the ability of the pathogen to successfully occupy the apoplastic space and deliver a constellation of effectors that collectively suppress basal and effector-triggered immune responses. In this study, we examined the metabolic changes associated with establishment of disease using analytical techniques that interrogated a range of chemistries. We demonstrated clear differences in the metabolome of Arabidopsis thaliana leaves infected with virulent Pseudomonas syringae within 8 h of infection. In addition to confirmation of changes in phenolic and indolic compounds, we identified rapid alterations in the abundance of amino acids and other nitrogenous compounds, specific classes of glucosinolates, disaccharides, and molecules that influence the prevalence of reactive oxygen species. Our data illustrate that, superimposed on defence suppression, pathogens reconfigure host metabolism to provide the sustenance required to support exponentially growing populations of apoplastically localized bacteria. We performed a detailed baseline study reporting the metabolic dynamics associated with bacterial infection. Moreover, we have integrated these data with the results of transcriptome profiling to distinguish metabolomic pathways that are transcriptionally activated from those that are post-transcriptionally regulated.
- Published
- 2010
35. Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development
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Mehrshahi, P., Gonzalez-Jorge, S., Akhtar, T. A., Ward, J. L., Santoyo-Castelazo, A., Marcus, S. E., Lara-Nunez, A., Ravanel, S., Hawkins, N. D., Beale, M. H., Barrett, D. A., Knox, J. P., Gregory, J. F. Iii, Hanson, A. D., Bennett, M. J., and Dellapenna, D.
- Published
- 2010
36. Recent applications of NMR spectroscopy in plant metabolomics
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Ward, J. L., Baker, J. M., and Beale, M. H.
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Biochemistry & Molecular Biology - Abstract
Recent research has established NMR as a key method for high-throughput comparative analysis of plant extracts. We discuss recent examples of the use of NMR to provide metabolomic data for various applications in plant science and look forward to the key role that NMR will play in data provision for plant systems biology.
- Published
- 2007
37. Economic Aspects of Gas Gathering in the North Sea
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Beggs, R., primary and Beale, M., additional
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- 1979
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38. Chickpea wilt: identification and toxicity of 8-0 -methyl-fusarubin from Fusarium acutatum
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Gopalakrishnan, S., Beale, M. H., Ward, J. L., and Strange, R. N.
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- 2005
39. AIDS-related mycoses: the way forward
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Brown, G.D., Meintjes, G., Kolls, J.K., Gray, C., Horsnell, W., Achan, B., Alber, G., Aloisi, M., Armstrong-James, D., Beale, M., Bicanic, T., Black, J., Bohjanen, P., Botes, A., Boulware, D.R., Bunjun, R., Carr, W., Casadevall, A., Chang, C., Chivero, E., Corcoran, C., Cross, A., Dawood, H., Day, J., Bernardis, F. De, Jager, V. de, Repentigny, L. de, Denning, D., Eschke, M., Finkelman, M., Govender, N., Gow, N., Graham, L., Gryschek, R., Hammond-Aryee, K., Harrison, T., Heard, N., Hill, M., Hoving, J.C., Janoff, E., Jarvis, J., Kayuni, S., King, K., Kullberg, B.J., Lalloo, D.G., Letang, E., Levitz, S., Limper, A., Longley, N., Machiridza, T.R., Mahabeer, Y., Martinsons, N., Meiring, S., Meya, D., Miller, R., Molloy, S., Morris, L., Mukaremera, L., Musubire, A.K., Muzoora, C., Nair, A., Kimbowa, J. Nakiwala, Netea, M.G., Nielsen, K., O'Hern, J., Okurut, S., Parker, A., Patterson, T., Pennap, G., Perfect, J., Prinsloo, C., Rhein, J., Rolfes, M.A., Samuel, C., Schutz, C., Scriven, J., Sebolai, O.M., Sojane, K., Sriruttan, C., Stead, D., Steyn, A., Thawer, N.K., Thienemann, F., Hohenberg, M. Von, Vreulink, J.M., Wessels, J., Wood, K., Yang, Y.L., Brown, G.D., Meintjes, G., Kolls, J.K., Gray, C., Horsnell, W., Achan, B., Alber, G., Aloisi, M., Armstrong-James, D., Beale, M., Bicanic, T., Black, J., Bohjanen, P., Botes, A., Boulware, D.R., Bunjun, R., Carr, W., Casadevall, A., Chang, C., Chivero, E., Corcoran, C., Cross, A., Dawood, H., Day, J., Bernardis, F. De, Jager, V. de, Repentigny, L. de, Denning, D., Eschke, M., Finkelman, M., Govender, N., Gow, N., Graham, L., Gryschek, R., Hammond-Aryee, K., Harrison, T., Heard, N., Hill, M., Hoving, J.C., Janoff, E., Jarvis, J., Kayuni, S., King, K., Kullberg, B.J., Lalloo, D.G., Letang, E., Levitz, S., Limper, A., Longley, N., Machiridza, T.R., Mahabeer, Y., Martinsons, N., Meiring, S., Meya, D., Miller, R., Molloy, S., Morris, L., Mukaremera, L., Musubire, A.K., Muzoora, C., Nair, A., Kimbowa, J. Nakiwala, Netea, M.G., Nielsen, K., O'Hern, J., Okurut, S., Parker, A., Patterson, T., Pennap, G., Perfect, J., Prinsloo, C., Rhein, J., Rolfes, M.A., Samuel, C., Schutz, C., Scriven, J., Sebolai, O.M., Sojane, K., Sriruttan, C., Stead, D., Steyn, A., Thawer, N.K., Thienemann, F., Hohenberg, M. Von, Vreulink, J.M., Wessels, J., Wood, K., and Yang, Y.L.
- Abstract
Item does not contain fulltext, The contribution of fungal infections to the morbidity and mortality of HIV-infected individuals is largely unrecognized. A recent meeting highlighted several priorities that need to be urgently addressed, including improved epidemiological surveillance, increased availability of existing diagnostics and drugs, more training in the field of medical mycology, and better funding for research and provision of treatment, particularly in developing countries.
- Published
- 2014
40. NMR Spectroscopy in Plant Metabolomics
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Ward, J. L., primary and Beale, M. H., additional
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41. Jake MacMillan: A pioneering chemist in plant biology
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Hedden, P., primary and Beale, M. H., additional
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- 2014
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42. Alcohol industry's response to BMJ investigation of consultation on minimum price for alcohol
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Beale, M., primary, Simmons, B., additional, Price, B., additional, and Frost, D., additional
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- 2014
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43. Can photorespiritory amino acid metabolism be short-circuited?
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Carvalho, J. F. C., Parry, M. A. J., Madgwick, P. J., Keys, A. J., Beale, M., Ward, J. L., Lea, P. J., Carvalho, J. F. C., Parry, M. A. J., Madgwick, P. J., Keys, A. J., Beale, M., Ward, J. L., and Lea, P. J.
- Published
- 2003
44. Is there evidence of recent hepatitis E virus infection in English and North Welsh blood donors?
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Beale, M. A., primary, Tettmar, K., additional, Szypulska, R., additional, Tedder, R. S., additional, and Ijaz, S., additional
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- 2010
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45. ChemInform Abstract: The Preparation of Gibberellin Hapten-Protein Conjugates. Part 2. Conjugates and Gibberellin Affinity Probes Formed via the Addition of . alpha.,ω-Dithiols to C-16-enes.
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BEALE, M. H., primary
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- 2010
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46. ChemInform Abstract: Biosynthesis of C5-C20 Terpenoid Compounds
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BEALE, M. H., primary
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- 2010
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47. ChemInform Abstract: Molecular Modelling, Synthesis, and Biological Activity of Methyl 3- Methyljasmonate and Related Derivatives.
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WARD, J. L., primary, GASKIN, P., additional, BEALE, M. H., additional, SESSIONS, R., additional, KODA, Y., additional, and WASTERNACK, C., additional
- Published
- 2010
- Full Text
- View/download PDF
48. ChemInform Abstract: A Radio-Iodinated Abscisic Acid Photoaffinity Probe.
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KOHLER, A. D., primary, BEALE, M. H., additional, ROLLASON, R., additional, BARRATT, D. H. P., additional, LEWIS, M. J., additional, VAN DER MEULEN, R. M., additional, and WANG, M., additional
- Published
- 2010
- Full Text
- View/download PDF
49. ChemInform Abstract: Stereochemistry of the Oxidation of Gibberellin 20-Alcohols, GA15 and GA44, to 20-Aldehydes by Gibberellin 20-Oxidases.
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WARD, J. L., primary, JACKSON, G. J., additional, BEALE, M. H., additional, GASKIN, P., additional, HEDDEN, P., additional, MANDER, L. N., additional, PHILLIPS, A. L., additional, SETO, H., additional, TALON, M., additional, WILLIS, C. L., additional, WILSON, T. M., additional, and ZEEVAART, J. A. D., additional
- Published
- 2010
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50. The genetic backbone modulates the phenotype of hepatitis B surface antigen mutants
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Beale, M. A., primary, Ijaz, S., additional, and Tedder, R. S., additional
- Published
- 2009
- Full Text
- View/download PDF
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