10 results on '"Beaini S"'
Search Results
2. Feasibility of Achieving a Zero-Net-Energy, Zero-Net-Cost Homes
- Author
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Al-Beaini, S., primary, Borgeson, S., additional, Coffery, B., additional, Gregory, D., additional, Konis, K., additional, Scown, C., additional, Simjanovic, J., additional, Stanley, J., additional, Strogen, B., additional, and Walker, I., additional
- Published
- 2009
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3. Étude rétrospective portant sur 59 patients atteints de myélome et traités par dialyse : effets du bortézomib sur la survie des patients et la survie rénale
- Author
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Beaini, S., primary, Levy, B., additional, Viglietti, D., additional, Métivier, F., additional, Malphettes, M., additional, Fermand, J.P., additional, and Peraldi, M.N., additional
- Published
- 2014
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4. Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG.
- Author
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Jomaa N, Nasreddine W, Hmeimess G, Beaini S, Beydoun A, Hotait M, Wazne J, and Beydoun A
- Subjects
- Humans, Young Adult, Adult, Prospective Studies, Seizures drug therapy, Seizures epidemiology, Electroencephalography methods, Recurrence, Valproic Acid, Epilepsy
- Abstract
Objective: The decision to initiate treatment in patients with a first unprovoked seizure remains controversial. Studies have reported a recurrence rate ranging from 21%-50%, but most have included patients with different etiologies, electroencephalography (EEG) findings, and seizure types. This study aimed to determine the risk of recurrence in patients with a first unprovoked generalized tonic-clonic (GTC) seizure with evidence of generalized spike-wave discharges (GSWDs) on EEG and compare the efficacy of antiseizure medications (ASMs) in preventing recurrence., Methods: This prospective study included consecutive patients who presented with a single GTC seizure, evidence of GSWDs on EEG, and a follow-up period of at least 1 year. All patients underwent extensive evaluation, including a 3-hour sleep-deprived video-EEG recording and an epilepsy protocol brain magnetic resonance imaging (MRI). Treatment with ASMs was recommended for all patients. The decision regarding the specific ASM to be used was left to the treating physician's discretion., Results: A total of 57 patients with a median age of 19 years were included. A total of 41 patients agreed to be started on an ASM while 16 declined. Seizure recurred in 6 of 41 patients (14.6%) in the treated group compared to 11 of 16 (68.8%) in the untreated group (p = .00006). Valproate was significantly more efficacious than levetiracetam or lamotrigine (p = .04). Of the 15 patients who discontinued ASM treatment after remaining seizure-free for an average of 30 months, 6 (40%) experienced a seizure recurrence., Significance: Patients with a first unprovoked GTC seizure and evidence of GSWDs on EEG have a high risk of recurrence if left untreated. Valproate is the most efficacious ASM for preventing recurrence in this population. A sizeable proportion of patients can be successfully tapered off medication after a period of seizure freedom. This study provides valuable information for guiding treatment decisions in this patient population., (© 2023 International League Against Epilepsy.)
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- 2023
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5. Neurofibromatosis type 1 system-based manifestations and treatments: a review.
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Saleh M, Dib A, Beaini S, Saad C, Faraj S, El Joueid Y, Kotob Y, Saoudi L, and Emmanuel N
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- Humans, Genes, Neurofibromatosis 1, Mutation, Neurofibromatosis 1 complications, Neurofibromatosis 1 genetics, Neurofibromatosis 1 therapy
- Abstract
Introduction: Neurofibromatosis type 1 (NF1) is a genetic disorder caused by a mutation in the NF1 gene. This disease presents with various system-based manifestations, including cardiac, musculoskeletal, and neuronal issues, which have been well-studied in previous research and have prompted the development of current and emerging treatments. These treatments, mainly medications targeting specific manifestations of NF1, aim to mitigate the negative impacts of the disease on patients' lives. NF1 is associated with an increased risk of malignancy and a significant decrease in life expectancy. In this paper, we review the current and emerging treatments for NF1 in relation to its system-based manifestations., Methods: We conducted an extensive literature search using specific keywords through databases such as PubMed, Scopus, and Cochrane. The articles we found were compiled and subjected to strict inclusion and exclusion criteria., Results: Pharmacological advances have led to the development of products that hold promise as future treatments for NF1. Given the diverse manifestations that can affect multiple organ systems in patients with NF1, it is important to consider a variety of treatment options to achieve optimal results. However, one of the major challenges in diagnosing and treating NF1 is that patients present asymptomatically, making it necessary to rely on clinical features for diagnosis., Conclusion: In conclusion, NF1 is a complex disease with varying manifestations and a growing field of pharmacologic treatments. The information presented in this article synthesizes current knowledge and available therapies for NF1., (© 2023. Fondazione Società Italiana di Neurologia.)
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- 2023
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6. Hyperventilation-induced high-amplitude rhythmic slowing: A mimicker of absence seizures in children.
- Author
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Nasreddine W, Fakhredin M, Makke Y, Hmaimess G, Sabbagh S, Beaini S, El Tourjuman O, and Beydoun A
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- Adolescent, Child, Female, Humans, Male, Brain Waves physiology, Electroencephalography, Hyperventilation complications, Hyperventilation physiopathology, Seizures diagnosis, Seizures physiopathology
- Abstract
Purpose: Hyperventilation (HV) in children can lead to HV-induced high-amplitude rhythmic slowing (HIHARS) on the EEG (electroencephalogram) which is sometimes associated with altered awareness (AA) and concomitant semiological features. Our aims were to determine the frequency of HIHARS in children, to assess if the associated semiological features were temporally related to HV, and to evaluate if specific semiological features can differentiate HIHARS with AA from absence seizures., Methods: Consecutive children with suspected new onset seizure(s) underwent HV and awareness testing during video-EEG acquisition. Hyperventilation-induced high-amplitude rhythmic slowing was defined as 2.5- to 5-Hz generalized rhythmic slowing with amplitude ≥100 μv lasting for ≥3 s. The associated semiological features were compared between the group of children with HIHARS and AA, an age- and gender-matched control group without HIHARS, and in children who experienced absence seizures during HV., Results: One hundred sixteen children with a mean age of 9.8 years were included. Hyperventilation-induced high-amplitude rhythmic slowing occurred in 39 children (33.6%) with AA documented in 30 (76.9%). The probability of developing AA during HIHARS was significantly and positively correlated with the HIHARS duration. The frequencies of HIHARS were not significantly different between children diagnosed with seizure(s) and those with nonepileptic spells. Hyperventilation cessation and staring did not occur in any child of the control group. Fidgeting and yawning were significantly more common in the group with HIHARS with AA while staring and blinking were significantly more frequent in the group of children with absence seizures., Conclusions: We ascertained that HIHARS with AA is a relatively common occurrence in children and most likely represents an age-related nonepileptic phenomenon. When associated with fidgeting or yawning, it can help differentiate this phenomenon from absence seizures. However, recording the concomitant presence of generalized spike wave discharges on the EEG remains essential to confirm the diagnosis of absence seizures., Competing Interests: Declaration of competing interest None., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2020
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7. VEGF-C attenuates renal damage in salt-sensitive hypertension.
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Beaini S, Saliba Y, Hajal J, Smayra V, Bakhos JJ, Joubran N, Chelala D, and Fares N
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- Animals, Blood Pressure drug effects, Fibrosis, Hypertension blood, Inflammation blood, Inflammation pathology, Inflammation Mediators blood, Kidney drug effects, Kidney physiopathology, Kidney Function Tests, Lymphangiogenesis drug effects, Male, Mice, Inbred BALB C, Nitric Oxide Synthase Type III metabolism, Oxidative Stress drug effects, Skin metabolism, Transcription Factors metabolism, Hypertension pathology, Kidney pathology, Sodium Chloride, Dietary adverse effects, Vascular Endothelial Growth Factor C pharmacology
- Abstract
Salt-sensitive hypertension is a major risk factor for renal impairment leading to chronic kidney disease. High-salt diet leads to hypertonic skin interstitial volume retention enhancing the activation of the tonicity-responsive enhancer-binding protein (TonEBP) within macrophages leading to vascular endothelial growth factor C (VEGF-C) secretion and NOS3 modulation. This promotes skin lymphangiogenesis and blood pressure regulation. Whether VEGF-C administration enhances renal and skin lymphangiogenesis and attenuates renal damage in salt-sensitive hypertension remains to be elucidated. Hypertension was induced in BALB/c mice by a high-salt diet. VEGF-C was administered subcutaneously to high-salt-treated mice as well as control animals. Analyses of kidney injury, inflammation, fibrosis, and biochemical markers were performed in vivo. VEGF-C reduced plasma inflammatory markers in salt-treated mice. In addition, VEGF-C exhibited a renal anti-inflammatory effect with the induction of macrophage M2 phenotype, followed by reductions in interstitial fibrosis. Antioxidant enzymes within the kidney as well as urinary RNA/DNA damage markers were all revelatory of abolished oxidative stress under VEGF-C. Furthermore, VEGF-C decreased the urinary albumin/creatinine ratio and blood pressure as well as glomerular and tubular damages. These improvements were associated with enhanced TonEBP, NOS3, and lymphangiogenesis within the kidney and skin. Our data show that VEGF-C administration plays a major role in preserving renal histology and reducing blood pressure. VEGF-C might constitute an interesting potential therapeutic target for improving renal remodeling in salt-sensitive hypertension., (© 2018 Wiley Periodicals, Inc.)
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- 2019
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8. Catastrophic relapses following initiation of dimethyl fumarate in two patients with neuromyelitis optica spectrum disorder.
- Author
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Yamout BI, Beaini S, Zeineddine MM, and Akkawi N
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- Adult, Fatal Outcome, Female, Humans, Middle Aged, Multiple Sclerosis diagnosis, Multiple Sclerosis drug therapy, Recurrence, Blindness chemically induced, Diagnostic Errors, Dimethyl Fumarate adverse effects, Immunosuppressive Agents adverse effects, Myelitis chemically induced, Neuromyelitis Optica diagnosis, Neuromyelitis Optica drug therapy, Quadriplegia chemically induced
- Abstract
We report two cases of neuromyelitis optica spectrum disorder (NMOSD) who were misdiagnosed as multiple sclerosis (MS) and developed catastrophic relapses following initiation of dimethyl fumarate. Both patients developed a severe myelitis extending from the cervical cord to the medulla with significant cord swelling, resulting in complete quadriplegia and respiratory difficulties, in addition to severe bilateral visual loss in one patient. It is of note that both catastrophic relapses occurred 2 and 3 months following initiation of dimethyl fumarate.
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- 2017
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9. Enhancing dropwise condensation through bioinspired wettability patterning.
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Ghosh A, Beaini S, Zhang BJ, Ganguly R, and Megaridis CM
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- Hot Temperature, Water chemistry, Biomimetics methods, Hydrodynamics, Wettability
- Abstract
Dropwise condensation (DWC) heat transfer depends strongly on the maximum diameter (Dmax) of condensate droplets departing from the condenser surface. This study presents a facile technique implemented to gain control of Dmax in DWC within vapor/air atmospheres. We demonstrate how this approach can enhance the corresponding heat transfer rate by harnessing the capillary forces in the removal of the condensate from the surface. We examine various hydrophilic-superhydrophilic patterns, which, respectively, sustain and combine DWC and filmwise condensation on the substrate. The material system uses laser-patterned masking and chemical etching to achieve the desired wettability contrast and does not employ any hydrophobizing agent. By applying alternating straight parallel strips of hydrophilic (contact angle ∼78°) mirror-finish aluminum and superhydrophilic regions (etched aluminum) on the condensing surface, we show that the average maximum droplet size on the less-wettable domains is nearly 42% of the width of the corresponding strips. An overall improvement in the condensate collection rate, up to 19% (as compared to the control case of DWC on mirror-finish aluminum) was achieved by using an interdigitated superhydrophilic track pattern (on the mirror-finish hydrophilic surface) inspired by the vein network of plant leaves. The bioinspired interdigitated pattern is found to outperform the straight hydrophilic-superhydrophilic pattern design, particularly under higher humidity conditions in the presence of noncondensable gases (NCG), a condition that is more challenging for maintaining sustained DWC.
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- 2014
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10. Alkali-metal pyrazolate complexes with unusual pyrazolate coordination modes and pseudocubane motifs.
- Author
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Beaini S, Deacon GB, Erven AP, Junk PC, and Turner DR
- Abstract
The dimeric complex [Li(Ph2pz)(OEt2)]2 (1) and tetrameric cluster [Na(Ph2pz)(thf)]4 (2) were prepared by treatment of alkali-metal reagents (nBuLi and Na{N(SiMe3)2}, respectively) with 3,5-diphenylpyrazole (Ph2pzH) in Et2O (1) or THF (2). The polymer [Na(tBu2pz)]n (3) was obtained from reaction at elevated temperature in a sealed tube between Na metal and 3,5-di-tert-butylpyrazole (tBu2pzH). The complex [Na4(tBu2pz)2(thf)3(obds)]2 (4; obds = (OSiMe2)2O) was obtained as a minor product from prolonged treatment of tBu2pzH with elemental sodium in a silicone-greased flask. All four alkali-metal pyrazolato complexes were characterized by IR and 1H NMR spectroscopy and X-ray crystallography.The Li dimer 1 displays mu-eta(2):eta(1) lithium-pyrazolato binding, in which both lithium atoms are four-coordinate. Room- and variable-temperature NMR studies (1H, 13C, and 7Li) of 1 suggest similar behavior in solution, with peaks coalescing at low temperatures. Complexes 2 and 4 display distorted cubane structures. In 2, all the sodium atoms are five-coordinate, whereas 4 contains two sodium/pyrazolate/thf clusters (4:2:3 ratio) bridged by two obds(2-) units, as well as two four-coordinate and two five-coordinate sodium atoms. Compound 3 is composed of two independent chains with the unusual coordination modes mu3-eta(5):eta(2):eta(2), mu3-eta(5):eta(2):eta(1), and mu3-eta(4):eta(2):eta(1), with five-, six-, and seven-coordinate sodium atoms. Two oxo-centered M8 cage complexes [(tBu2pz)6Li8O] (5) and [(tBu2pz)6Na8O] (6) were obtained as by-products from attempted preparation of [Li(tBu2pz)] and [Na(tBu2pz)], respectively, and their structures were determined.
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- 2007
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