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22 results on '"Bazzoni, Riccardo"'

4. Notch Signaling and MicroRNA: The Dynamic Duo Steering Between Neurogenesis and Glioblastomas

Author

Javed, Zeeshan, primary, Khan, Khushbukhat, additional, Raza, Qamar, additional, Sadia, Haleema, additional, Ahmad Shah, Faiez, additional, Ahmad, Touqeer, additional, Bentivegna, Angela, additional, Bazzoni, Riccardo, additional, Setzer, William N., additional, Alshehri, Mohammed M, additional, Sharifi-Rad, Javad, additional, and Daştan, Sevgi Durna, additional

Published
2021
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5. The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche

Author

Takam Kamga, Paul, Bazzoni, Riccardo, Dal Collo, Giada, Cassaro, Adriana, Tanasi, Ilaria, Russignan, Anna, Tecchio, Cristina, Krampera, Mauro, Takam Kamga, Paul, Bazzoni, Riccardo, Dal Collo, Giada, Cassaro, Adriana, Tanasi, Ilaria, Russignan, Anna, Tecchio, Cristina, and Krampera, Mauro

Abstract

Notch and Wnt signaling are highly conserved intercellular communication pathways involved in developmental processes, such as hematopoiesis. Even though data from literature support a role for these two pathways in both physiological hematopoiesis and leukemia, there are still many controversies concerning the nature of their contribution. Early studies, strengthened by findings from T-cell acute lymphoblastic leukemia (T-ALL), have focused their investigation on the mutations in genes encoding for components of the pathways, with limited results except for B-cell chronic lymphocytic leukemia (CLL); in because in other leukemia the two pathways could be hyper-expressed without genetic abnormalities. As normal and malignant hematopoiesis require close and complex interactions between hematopoietic cells and specialized bone marrow (BM) niche cells, recent studies have focused on the role of Notch and Wnt signaling in the context of normal crosstalk between hematopoietic/leukemia cells and stromal components. Amongst the latter, mesenchymal stromal/stem cells (MSCs) play a pivotal role as multipotent non-hematopoietic cells capable of giving rise to most of the BM niche stromal cells, including fibroblasts, adipocytes, and osteocytes. Indeed, MSCs express and secrete a broad pattern of bioactive molecules, including Notch and Wnt molecules, that support all the phases of the hematopoiesis, including self-renewal, proliferation and differentiation. Herein, we provide an overview on recent advances on the contribution of MSC-derived Notch and Wnt signaling to hematopoiesis and leukemia development.

Published
2021

7. Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma

Author

Russignan, Anna, primary, Dal Collo, Giada, additional, Bagnato, Anna, additional, Tamassia, Nicola, additional, Bugatti, Mattia, additional, Belleri, Mirella, additional, Lorenzi, Luisa, additional, Borsi, Enrica, additional, Bazzoni, Riccardo, additional, Gottardi, Michele, additional, Terragna, Carolina, additional, Vermi, William, additional, Giacomini, Arianna, additional, Presta, Marco, additional, Cassatella, Marco Antonio, additional, Krampera, Mauro, additional, and Tecchio, Cristina, additional

Published
2021
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10. Small Molecule Inhibitors of Microenvironmental Wnt/β-Catenin Signaling Enhance the Chemosensitivity of Acute Myeloid Leukemia

Author

Takam Kamga, Paul, primary, Dal Collo, Giada, additional, Cassaro, Adriana, additional, Bazzoni, Riccardo, additional, Delfino, Pietro, additional, Adamo, Annalisa, additional, Bonato, Alice, additional, Carbone, Carmine, additional, Tanasi, Ilaria, additional, Bonifacio, Massimiliano, additional, and Krampera, Mauro, additional

Published
2020
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Author

Takam Kamga, Paul, Dal Collo, Giada, Cassaro, Adriana, Bazzoni, Riccardo, Delfino, Pietro, Adamo, Annalisa, Bonato, Alice, Carbone, Carmine, Tanasi, Ilaria, Bonifacio, Massimiliano, Krampera, Mauro, Takam Kamga, Paul, Dal Collo, Giada, Cassaro, Adriana, Bazzoni, Riccardo, Delfino, Pietro, Adamo, Annalisa, Bonato, Alice, Carbone, Carmine, Tanasi, Ilaria, Bonifacio, Massimiliano, and Krampera, Mauro

Published
2020

13. Notch Signaling Molecules as Prognostic Biomarkers for Acute Myeloid Leukemia

Author

Takam Kamga, Paul, primary, Collo, Giada Dal, additional, Resci, Federica, additional, Bazzoni, Riccardo, additional, Mercuri, Angela, additional, Quaglia, Francesca Maria, additional, Tanasi, Ilaria, additional, Delfino, Pietro, additional, Visco, Carlo, additional, Bonifacio, Massimiliano, additional, and Krampera, Mauro, additional

Published
2019
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17. Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton

Author

Adamo, Annalisa, primary, Brandi, Jessica, additional, Caligola, Simone, additional, Delfino, Pietro, additional, Bazzoni, Riccardo, additional, Carusone, Roberta, additional, Cecconi, Daniela, additional, Giugno, Rosalba, additional, Manfredi, Marcello, additional, Robotti, Elisa, additional, Marengo, Emilio, additional, Bassi, Giulio, additional, Takam Kamga, Paul, additional, Dal Collo, Giada, additional, Gatti, Alessandro, additional, Mercuri, Angela, additional, Arigoni, Maddalena, additional, Olivero, Martina, additional, Calogero, Raffaele A., additional, and Krampera, Mauro, additional

Published
2019
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21. Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway

Author

Cilibrasi, Chiara, primary, Riva, Gabriele, additional, Romano, Gabriele, additional, Cadamuro, Massimiliano, additional, Bazzoni, Riccardo, additional, Butta, Valentina, additional, Paoletta, Laura, additional, Dalprà, Leda, additional, Strazzabosco, Mario, additional, Lavitrano, Marialuisa, additional, Giovannoni, Roberto, additional, and Bentivegna, Angela, additional

Published
2017
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22. Role of Notch Signaling Pathway in Glioblastoma Pathogenesis.

Author

Bazzoni, Riccardo and Bentivegna, Angela

Subjects
*GLIOMA treatment, *CELL proliferation, *APOPTOSIS, *BRAIN tumors, *CANCER relapse, *CELL differentiation, *CELL lines, *CELL receptors, *CELL motility, *CELLULAR signal transduction, *CENTRAL nervous system, *GENETICS, *GLIOMAS, *HOMEOSTASIS, *LIGANDS (Biochemistry), *STEM cells, *PHENOTYPES
Abstract

Notch signaling is an evolutionarily conserved pathway that regulates important biological processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation. In mammals, Notch signaling is composed of four receptors (Notch1–4) and five ligands (Dll1-3–4, Jagged1–2) that mainly contribute to the development and maintenance of the central nervous system (CNS). Neural stem cells (NSCs) are the starting point for neurogenesis and other neurological functions, representing an essential aspect for the homeostasis of the CNS. Therefore, genetic and functional alterations to NSCs can lead to the development of brain tumors, including glioblastoma. Glioblastoma remains an incurable disease, and the reason for the failure of current therapies and tumor relapse is the presence of a small subpopulation of tumor cells known as glioma stem cells (GSCs), characterized by their stem cell-like properties and aggressive phenotype. Growing evidence reveals that Notch signaling is highly active in GSCs, where it suppresses differentiation and maintains stem-like properties, contributing to Glioblastoma tumorigenesis and conventional-treatment resistance. In this review, we try to give a comprehensive view of the contribution of Notch signaling to Glioblastoma and its possible implication as a target for new therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2019
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