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8 results on '"Bazhenova GE"'

2. [Dynamics of changes in the protease-inhibitory balance in blood plasma of dogs with experimental acute pancreatitis].

Author

Belova LA, Privalov GV, Bazhenova GE, Shtukaturov MIu, Makarovskiĭ VV, Brekhov EI, Malakhov VN, and Ogloblina OG

Subjects
Acute Disease, Animals, Dogs, Female, Male, Pancreatitis blood, Protease Inhibitors blood
Abstract

Changes of proteinase-inhibitory system values in blood plasma of dogs with experimental acute pancreatitis (EAP) were studied in dynamics. Their diagnostic and prognostic values was appraised. Essential shifts were revealed in the proteinase-inhibitory balance in blood plasma of dogs with EAP of various severity. The concentration of trypsin- and chymotrypsin-like proteinases exceeded the normal values 1.8-3.3 times in these animals. Coefficients expressing the relation of antitryptic and antichymotryptic activities to the activities of the corresponding proteinases in the blood plasma of animals with EAP were indicative of diminished blood plasma inhibitory potential as compared to that in intact animals. The authors are the first to show the diagnostic and prognostic value of the antichymotryptic activity/chymotrypsin in blood plasma of dogs with EAP.

Published
1991

3. [Evaluation of the degree of trauma in biliary tract surgery using a laser method in relation to the status of the plasma protease inhibitor system].

Author

Skobelkin OK, Bazhenova GE, Kirpichev AG, and Ogloblina OG

Subjects
Adult, Aged, Cholecystectomy adverse effects, Cholecystitis enzymology, Female, Humans, Middle Aged, Prognosis, Safety, alpha 1-Antitrypsin Deficiency, Cholecystectomy methods, Cholecystitis surgery, Chymotrypsin blood, Laser Therapy methods, Postoperative Complications etiology, Trypsin blood, alpha 1-Antitrypsin analysis
Published
1991

4. [Specific proteinase plasma sorption in surgery with artificial blood circulation].

Author

Partigulov SA, Bazhenova GE, Oglovlina OG, Belova LA, Vodiasov VD, Sorochinskaia EI, and Akchurin RS

Subjects
Adult, Female, Homeostasis, Humans, Male, Middle Aged, Postoperative Complications, Protease Inhibitors pharmacology, Coronary Artery Bypass, Endopeptidases blood, Extracorporeal Circulation
Abstract

Cardiosurgery with artificial circulation (AC) is attended with activation of plasma cascade proteolytic systems, which leads to homeostatic disturbances and postoperative complications. AC with the use of specific proteinase plasma sorption in a column with sepharose-immobilized acid-base proteinase inhibitor from human urine prevents activation of proteinase in the plasma. Application of specific plasma sorption facilitates rapid restoration of the plasma protein concentration lowered during AC, improves the course of the postoperative period, and reduces the risk of pulmonary, cardiovascular, and nervous complications.

Published
1990

5. [Correction (in vitro) of proteinase inhibitor balance in the blood of patients after cardiosurgical interventions].

Author

Ogloblina OG, Bazhenova GE, Belova LA, Shevchenko OP, and Dmitriev AA

Subjects
Adult, Chymotrypsin antagonists & inhibitors, Enzyme Activation, Female, Glycoproteins, Heart Diseases surgery, Humans, In Vitro Techniques, Male, Middle Aged, Pancreatic Elastase antagonists & inhibitors, Postoperative Period, Chymotrypsin blood, Extracorporeal Circulation, Heart Diseases enzymology, Pancreatic Elastase blood, Trypsin blood
Abstract

Proteinase-inhibitor balance in human plasma before and after artificial blood circulation was examined. It was shown that trypsinlike and chemotrypsinlike proteinases activities after this procedure were 1.6 and 2.8 times higher and antitryptic activity 1.2 times lower than in the same patients before the procedure. The 40-50% decrease of proteinase activity in human plasma after artificial blood circulation was observed as a result of in vitro plasmasorption on immobilized human urinary trypsin inhibitor.

Published
1988

7. [Variants of procedures of artificial blood circulation and the proteinase activity of the blood].

Author

Partigulov SA, Bazhenova GE, Ogloblina OG, Belova LA, Sorochinskaia EI, Vodiasov VD, and Akchurin RS

Subjects
Blood Transfusion, Autologous, Cell Separation, Female, Humans, Male, Middle Aged, Endopeptidases blood, Extracorporeal Circulation methods
Abstract

The use of a "Cell-Saver" technique prevented hyperproteolysis and deletion of proteinase inhibitors in the blood plasma of patients during cardiopulmonary bypass. The technique also improved the course of the postoperative period, decreased the incidence of lung complications and prevented effectively postoperative bleedings. A prognostic value of alpha 1-proteinase inhibitor to trypsin activity ratio in the blood plasma of patients subject of cardiopulmonary bypass surgery has been demonstrated.

Published
1989

8. [Role of blood coagulation disorders in the pathogenesis of massive and supermassive blood losses in tubercular surgery patients].

Author

Rumiantsev VB, Makinskiĭ AI, Generalova RV, Nevenglovskiĭ IE, and Bazhenova GE

Subjects
Acute Disease, Adult, Blood Coagulation Disorders blood, Blood Coagulation Tests, Blood Volume, Female, Hemorrhage blood, Humans, Intraoperative Complications blood, Intraoperative Complications etiology, Male, Postoperative Complications blood, Postoperative Complications etiology, Tuberculosis, Pulmonary blood, Tuberculosis, Pulmonary surgery, Blood Coagulation Disorders complications, Hemorrhage etiology, Tuberculosis, Pulmonary complications
Published
1985

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