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2. Time- and Spectrally-Resolved Photoluminescence Study of Alloyed Cd x Zn 1−x Se y S 1−y /ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells.

Author

Matiushkina, Anna, Litvinov, Ilia, Bazhenova, Anastasia, Belyaeva, Tatiana, Dubavik, Aliaksei, Veniaminov, Andrei, Maslov, Vladimir, Kornilova, Elena, and Orlova, Anna

Subjects
PHOTOLUMINESCENCE, IRON oxide nanoparticles, NANOCOMPOSITE materials, QUANTUM dots, HELA cells, SEMICONDUCTOR quantum dots
Abstract

Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (Cd x Zn 1 − x Se y S 1 − y) / ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite's stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status. [ABSTRACT FROM AUTHOR]

Published
2022
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3. Time- and Spectrally-Resolved Photoluminescence Study of Alloyed Cd x Zn 1-x Se y S 1-y /ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells.

Author

Matiushkina A, Litvinov I, Bazhenova A, Belyaeva T, Dubavik A, Veniaminov A, Maslov V, Kornilova E, and Orlova A

Subjects
Alloys, Cadmium, HeLa Cells, Humans, Magnetic Iron Oxide Nanoparticles, Sulfides, Zinc, Zinc Compounds, Nanocomposites, Quantum Dots
Abstract

Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1-xSeyS1-y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite's stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.

Published
2022
Full Text
View/download PDF

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