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2. Whole blood transcriptome in long-COVID patients reveals association with lung function and immune response

Author

Blankestijn, Jelle M., Baalbaki, Nadia, Bazdar, Somayeh, Beekers, Inés, Beijers, Rosanne J.H.C.G., van den Bergh, Joop P., Bloemsma, Lizan D., Cornelissen, Merel E.B., Dekker, Tamara, Duitman, Jan Willem, Houweling, Laura, Jacobs, John J.L., van der Lee, Ivo, Linders, Paulien M.A., Noij, Lieke C.E., Nossent, Esther J., van de Pol, Marianne A., Sondermeijer, Brigitte M., Geelhoed, J.J. Miranda, Weersink, Els J.M., Golebski, Korneliusz, Abdel-Aziz, Mahmoud I., and Maitland-van der Zee, Anke H.

Published
2024
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4. Long COVID exhibits clinically distinct phenotypes at 3–6 months post-SARS-CoV-2 infection: results from the P4O2 consortium

Author

Blankestijn, Jelle M, primary, Abdel-Aziz, Mahmoud I, additional, Baalbaki, Nadia, additional, Bazdar, Somayeh, additional, Beekers, Inés, additional, Beijers, Rosanne J H C G, additional, Bloemsma, Lizan D, additional, Cornelissen, Merel E B, additional, Gach, Debbie, additional, Houweling, Laura, additional, Holverda, Sebastiaan, additional, Jacobs, John J L, additional, Jonker, Reneé, additional, van der Lee, Ivo, additional, Linders, Paulien M A, additional, Mohamed Hoesein, Firdaus A A, additional, Noij, Lieke C E, additional, Nossent, Esther J, additional, van de Pol, Marianne A, additional, Schaminee, Daphne W, additional, Schols, Annemie M W J, additional, Schuurman, Lisanne T, additional, Sondermeijer, Brigitte, additional, Geelhoed, J J Miranda, additional, van den Bergh, Joop P, additional, Weersink, Els J M, additional, de Wit-van Wijck, Yolanda, additional, and Maitland-van der Zee, Anke H, additional

Published
2024
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5. Hemoglobin and Its Relationship with Fatigue in Long-COVID Patients Three to Six Months after SARS-CoV-2 Infection.

Author

Bazdar, Somayeh, Bloemsma, Lizan D., Baalbaki, Nadia, Blankestijn, Jelle M., Cornelissen, Merel E. B., Beijers, Rosanne J. H. C. G., Sondermeijer, Brigitte M., van Wijck, Yolanda, Downward, George S., and Maitland-van der Zee, Anke H.

Subjects
FATIGUE (Physiology), POST-acute COVID-19 syndrome, HEMOGLOBINS, SARS-CoV-2, RANK correlation (Statistics)
Abstract

Background: While some long-term effects of COVID-19 are respiratory in nature, a non-respiratory effect gaining attention has been a decline in hemoglobin, potentially mediated by inflammatory processes. In this study, we examined the correlations between hemoglobin levels and inflammatory biomarkers and evaluated the association between hemoglobin and fatigue in a cohort of Long-COVID patients. Methods: This prospective cohort study in the Netherlands evaluated 95 (mostly hospitalized) patients, aged 40–65 years, 3–6 months post SARS-CoV-2 infection, examining their venous hemoglobin concentration, anemia (hemoglobin < 7.5 mmol/L in women and <8.5 mmol/L in men), inflammatory blood biomarkers, average FSS (Fatigue Severity Score), demographics, and clinical features. Follow-up hemoglobin was compared against hemoglobin during acute infection. Spearman correlation was used for assessing the relationship between hemoglobin concentrations and inflammatory biomarkers, and the association between hemoglobin and fatigue was examined using logistic regression. Results: In total, 11 (16.4%) participants were suffering from anemia 3–6 months after SARS-CoV-2 infection. The mean hemoglobin value increased by 0.3 mmol/L 3–6 months after infection compared to the hemoglobin during the acute phase (p-value = 0.003). Whilst logistic regression showed that a 1 mmol/L greater increase in hemoglobin is related to a decrease in experiencing fatigue in Long-COVID patients (adjusted OR 0.38 [95%CI 0.13–1.09]), we observed no correlations between hemoglobin and any of the inflammatory biomarkers examined. Conclusion: Our results indicate that hemoglobin impairment might play a role in developing Long-COVID fatigue. Further investigation is necessary to identify the precise mechanism causing hemoglobin alteration in these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The effects of the COVID‐19 pandemic on PICU admissions for severe asthma exacerbations: A single‐center experience

Author

Bazdar, Somayeh, primary, van den Berg, Sarah, additional, Rutjes, Niels W., additional, Bloemsma, Lizan D., additional, Downward, George S., additional, De Weger, Letty A., additional, Terheggen‐Lagro, Suzanne W. J., additional, van Wijck, Yolanda, additional, Maitland van der Zee, Anke H., additional, and Kapitein, Berber, additional

Published
2023
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9. Identification of long COVID phenotypes based on clinical presentation at 3 to 6 months post SARS-CoV-2 infection: results from the P4O2 consortium

Author

Blankestijn, Jelle M., primary, Abdel-Aziz, Mahmoud I., additional, Baalbaki, Nadia, additional, Bazdar, Somayeh, additional, Beekers, Inés, additional, Beijers, Rosanne J.H.C.G., additional, Bloemsma, Lizan D., additional, Cornelissen, Merel E.B., additional, Gach, Debbie, additional, Houweling, Laura, additional, Holverda, Sebastiaan, additional, Jacobs, John J., additional, Jonker, Renée, additional, Van Der Lee, Ivo, additional, Linders, Paulien M.A., additional, Hoesein, Firdaus A.A.M., additional, Noij, Lieke C.E., additional, Van De Pol, Marianne A., additional, Schaminee, Daphne W., additional, Schols, Annemie M.W.J., additional, Schuurman, Lisanne T., additional, Sondermeijer, Brigitte, additional, Geelhoed, J.J. Miranda, additional, Van Den Bergh, Joop P., additional, Weersink, Els J.M., additional, Nossent, Esther J., additional, De Wit-Van Wijck, Yolanda, additional, Maitland-Van Der Zee, Anke H., additional, and Abdel-Aziz, Mahmoud Ismael, additional

Published
2023
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10. Fatigue in post COVID-19 patients: the P4O2 COVID-19 study

Author

Cornelissen, Merel E.B., primary, Bloemsma, Lizan D., additional, Baalbaki, Nadia, additional, Bazdar, Somayeh, additional, Blankestijn, Jelle M., additional, Beekers, Inés, additional, Beijers, Rosanne J.H.C.G., additional, Van Den Bergh, Joop P., additional, Gach, Debbie, additional, Geelhoed, J.J. Miranda, additional, Holverda, Sebastiaan, additional, Houweling, Laura, additional, Jacobs, John J., additional, Jonker, Renée, additional, Van Der Lee, Ivo, additional, Linders, Paulien M.A., additional, Noij, Lieke C.E., additional, Nossent, Esther J., additional, Van De Pol, Marianne A., additional, Schaminee, Daphne W., additional, Schols, Annemie M.W.J., additional, Schuurman, Lisanne T., additional, Sondermeijer, Brigitte, additional, Vaes, Anouk W., additional, Weersink, Els J.M., additional, De Wit-Van Wijck, Yolanda, additional, Spruit, Martijn A., additional, and Maitland-Van Der Zee, Anke H., additional

Published
2023
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11. Precision Medicine for More Oxygen (P4O2)—Study Design and First Results of the Long COVID-19 Extension

Author

Baalbaki, Nadia, primary, Blankestijn, Jelle M., additional, Abdel-Aziz, Mahmoud I., additional, de Backer, Jan, additional, Bazdar, Somayeh, additional, Beekers, Inés, additional, Beijers, Rosanne J. H. C. G., additional, van den Bergh, Joop P., additional, Bloemsma, Lizan D., additional, Bogaard, Harm Jan, additional, van Bragt, Job J. M. H., additional, van den Brink, Vera, additional, Charbonnier, Jean Paul, additional, Cornelissen, Merel E. B., additional, Dagelet, Yennece, additional, Davies, Elin Haf, additional, van der Does, Anne M., additional, Downward, George S., additional, van Drunen, Cornelis M., additional, Gach, Debbie, additional, Geelhoed, J. J. Miranda, additional, Glastra, Jorrit, additional, Golebski, Kornel, additional, Heijink, Irene H., additional, Holtjer, Judith C. S., additional, Holverda, Sebastiaan, additional, Houweling, Laura, additional, Jacobs, John J. L., additional, Jonker, Renée, additional, Kos, Renate, additional, Langen, Ramon C. J., additional, van der Lee, Ivo, additional, Leliveld, Asabi, additional, Mohamed Hoesein, Firdaus A. A., additional, Neerincx, Anne H., additional, Noij, Lieke, additional, Olsson, Johan, additional, van de Pol, Marianne, additional, Pouwels, Simon D., additional, Rolink, Emiel, additional, Rutgers, Michael, additional, Șahin, Havva, additional, Schaminee, Daphne, additional, Schols, Annemie M. W. J., additional, Schuurman, Lisanne, additional, Slingers, Gitte, additional, Smeenk, Olie, additional, Sondermeijer, Brigitte, additional, Skipp, Paul J., additional, Tamarit, Marisca, additional, Verkouter, Inge, additional, Vermeulen, Roel, additional, de Vries, Rianne, additional, Weersink, Els J. M., additional, van de Werken, Marco, additional, de Wit-van Wijck, Yolanda, additional, Young, Stewart, additional, Nossent, Esther J., additional, and Maitland-van der Zee, Anke H., additional

Published
2023
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