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5. Synthetic and Hybrid Tissues

Author

Bayley, Hagan, Zhou, Linna, Gargaud, Muriel, editor, Irvine, William M., editor, Amils, Ricardo, editor, Claeys, Philippe, editor, Cleaves, Henderson James, editor, Gerin, Maryvonne, editor, Rouan, Daniel, editor, Spohn, Tilman, editor, Tirard, Stéphane, editor, and Viso, Michel, editor

Published
2023
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6. Multi-responsive hydrogel structures from patterned droplet networks

Author

Downs, Florence G, Lunn, David J, Booth, Michael J, Sauer, Joshua B, Ramsay, William J, Klemperer, R George, Hawker, Craig J, and Bayley, Hagan

Subjects
Chemical Sciences, Bioengineering, Generic health relevance, Organic Chemistry, Chemical sciences
Abstract

Responsive hydrogels that undergo controlled shape changes in response to a range of stimuli are of interest for microscale soft robotic and biomedical devices. However, these applications require fabrication methods capable of preparing complex, heterogeneous materials. Here we report a new approach for making patterned, multi-material and multi-responsive hydrogels, on a micrometre to millimetre scale. Nanolitre aqueous pre-gel droplets were connected through lipid bilayers in predetermined architectures and photopolymerized to yield continuous hydrogel structures. By using this droplet network technology to pattern domains containing temperature-responsive or non-responsive hydrogels, structures that undergo reversible curling were produced. Through patterning of gold nanoparticle-containing domains into the hydrogels, light-activated shape change was achieved, while domains bearing magnetic particles allowed movement of the structures in a magnetic field. To highlight our technique, we generated a multi-responsive hydrogel that, at one temperature, could be moved through a constriction under a magnetic field and, at a second temperature, could grip and transport a cargo.

Published
2020

10. Enzyme‐Enabled Droplet Biobattery for Powering Synthetic Tissues.

Author

Liu, Juan, Qing, Yujia, Zhou, Linna, Chen, Shaomeng, Li, Xuefei, Zhang, Yujia, and Bayley, Hagan

Subjects
BIOELECTRONICS, ARTIFICIAL implants, SYNTHETIC enzymes, MEDICAL equipment, NICOTINAMIDE
Abstract

Enzyme‐enabled biobatteries are promising green options to power the next‐generation of bioelectronics and implantable medical devices. However, existing power sources based on enzymatic biofuel chemistry exhibit limited scale‐down feasibility due to the solid and bulky battery structures. Therefore, miniature and soft alternatives are needed for integration with implants and tissues. Here, a biobattery built from nanolitre droplets, fuelled by the enzyme‐enabled oxidation of reduced nicotinamide adenine dinucleotide, generates electrical outputs and powers ion fluxes in droplet networks. Optimization of the droplet biobattery components ensures a stable output current of ~13,000 pA for over 24 h, representing a more than 600‐fold increase in output over previous approaches, including light‐driven processes. The enzyme‐enabled droplet biobattery opens new avenues in bioelectronics and bioiontronics, exemplified by tasks such as the ability to drive chemical signal transmission in integrated synthetic tissues. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Stochastic Sensing of Chloride Anions Using an α‐Hemolysin Pore with a semiaza‐Bambusuril Adapter.

Author

Reany, Ofer, Romero‐Ruiz, Mercedes, Khurana, Raman, Mondal, Pravat, Keinan, Ehud, and Bayley, Hagan

Subjects
BINDING sites, ANIONS, CHLORIDES, DETECTORS, PROTEINS
Abstract

Pores containing molecular adapters provide internal selective binding sites, thereby allowing the stochastic sensing of analytes. Herein, we demonstrate that semiaza‐bambusuril (BU) acts as a non‐covalent molecular adapter when lodged within the lumen of the wild‐type α‐hemolysin (WT‐αHL) protein pore. Because the bambusurils are recognized as anion receptors, the anion binding site within the adapter‐nanopore complex allows the detection of chloride anions, thus converting a non‐selective pore into an anion sensor. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Constructing ion channels from water-soluble α-helical barrels

Author

Scott, Alistair J., Niitsu, Ai, Kratochvil, Huong T., Lang, Eric J. M., Sengel, Jason T., Dawson, William M., Mahendran, Kozhinjampara R., Mravic, Marco, Thomson, Andrew R., Brady, R. Leo, Liu, Lijun, Mulholland, Adrian J., Bayley, Hagan, DeGrado, William F., Wallace, Mark I., and Woolfson, Derek N.

Published
2021
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15. Innovative Science

Author

Braben, Donald W, Allen, John F, Amos, William, Ball, Richard, Bayley, Hagan, Birkhead, Tim, Cameron, Peter, Campbell, Eleanor, Cogdell, Richard, Colquhoun, David, Davies, Steve, Dowler, Rod, Edwards, Peter, Engle, Irene, Fernandez-Armesto, Felipe, Fitzgerald, Desmond, Frampton, Jon, Glover, Dame Anne, Hall, John, Heslop-Harrison, Pat, Herschbach, Dudley, Huang, Sui, Kimble, H Jeff, Kroto, Sir Harry, Ladyman, James, Lawrence, Peter, Leake, Mark, Leroi, Armand, Logan, David, MacIntyre, Angus, Marchesi, Julian, Mattick, John, McLeish, Colin McInnes. Tom, Medley, Graham, Miller, Thomas, Nesse, Randolph, Pollack, Gerald, Pelloni, Beatrice, Randall, Douglas, Ray, David, Roberts, Sir Richard J, Seddon, Ken, Self, Colin, Swinney, Harry, Troy, Chris Thomas. William, Tucker, Robin, Vita-Finzi, Claudio, and Wild, David

Subjects
Physics - Physics and Society
Abstract

Sir, We write as senior scientists about a problem vital to the scientific enterprise and prosperity. Nowadays, funding is a lengthy and complex business. First, universities themselves must approve all proposals for submission. Funding agencies then subject those that survive to peer review, a process by which a few researchers, usually acting anonymously, assess a proposal's chances that it will achieve its goals, is the best value for money, is relevant to a national priority and will impact on a socio-economic problem. Only 25% of proposals received by the funding agencies are funded. These protracted processes force researchers to exploit existing knowledge, severely discourage open-ended studies and are hugely time-consuming. They are also new: before 1970, few researchers wrote proposals. Now they are virtually mandatory.

Published
2015

17. Nano on reflection

Author

Bursten, Julia R, Roco, Mihail C, Yang, Wei, Zhao, Yuliang, Chen, Chunying, Savolainen, Kai, Gerber, Christoph, Kataoka, Kazunori, Krishnan, Yamuna, Bayley, Hagan, Nazar, Linda, Milana, Silvia, Vandersypen, Lieven, Weiss, Paul S, and Schummer, Joachim

Subjects
Biomedical and Clinical Sciences, Engineering, Nanotechnology, Nanoscience & Nanotechnology
Published
2016

21. Lipid binding attenuates channel closure of the outer membrane protein OmpF

Author

Liko, Idlir, Degiacomi, Matteo T., Lee, Sejeong, Newport, Thomas D., Gault, Joseph, Reading, Eamonn, Hopper, Jonathan T. S., Housden, Nicholas G., White, Paul, Colledge, Matthew, Sula, Altin, Wallace, B. A., Kleanthous, Colin, Stansfeld, Phillip J., Bayley, Hagan, Benesch, Justin L. P., Allison, Timothy M., and Robinson, Carol V.

Published
2018

39. New technologies for DNA analysis – a review of the READNA Project

Author

McGinn, Steven, Bauer, David, Brefort, Thomas, Dong, Liqin, El-Sagheer, Afaf, Elsharawy, Abdou, Evans, Geraint, Falk-Sörqvist, Elin, Forster, Michael, Fredriksson, Simon, Freeman, Peter, Freitag, Camilla, Fritzsche, Joachim, Gibson, Spencer, Gullberg, Mats, Gut, Marta, Heath, Simon, Heath-Brun, Isabelle, Heron, Andrew J., Hohlbein, Johannes, Ke, Rongqin, Lancaster, Owen, Le Reste, Ludovic, Maglia, Giovanni, Marie, Rodolphe, Mauger, Florence, Mertes, Florian, Mignardi, Marco, Moens, Lotte, Oostmeijer, Jelle, Out, Ruud, Pedersen, Jonas Nyvold, Persson, Fredrik, Picaud, Vincent, Rotem, Dvir, Schracke, Nadine, Sengenes, Jennifer, Stähler, Peer F., Stade, Björn, Stoddart, David, Teng, Xia, Veal, Colin D., Zahra, Nathalie, Bayley, Hagan, Beier, Markus, Brown, Tom, Dekker, Cees, Ekström, Björn, Flyvbjerg, Henrik, Franke, Andre, Guenther, Simone, Kapanidis, Achillefs N., Kaye, Jane, Kristensen, Anders, Lehrach, Hans, Mangion, Jonathan, Sauer, Sascha, Schyns, Emile, Tost, Jörg, van Helvoort, Joop M.L.M., van der Zaag, Pieter J., Tegenfeldt, Jonas O., Brookes, Anthony J., Mir, Kalim, Nilsson, Mats, Willcocks, James P., and Gut, Ivo G.

Published
2016
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43. A Lipid-Based Droplet Processor for Parallel Chemical Signals

Author

Cazimoglu, Idil, Booth, Michael J., and Bayley, Hagan

Subjects
Computer science, Lipid Bilayers, General Physics and Astronomy, sensors, Signal, Article, Nanopores, Synthetic biology, Molecule, General Materials Science, Lipid bilayer, multisomes, business.industry, General Engineering, Process (computing), Proteins, Water, Lipid Droplets, Modular design, Nanopore, droplet interface bilayers (DIBs), Membrane, drug delivery, alpha hemolysin, synthetic biology, Biological system, business
Abstract

A key goal of bottom-up synthetic biology is to construct cell- and tissue-like structures. Underpinning cellular life is the ability to process several external chemical signals, often in parallel. Until now, cell- and tissue-like structures have been constructed with no more than one signaling pathway. Many pathways rely on signal transport across membranes using protein nanopores. However, such systems currently suffer from the slow transport of molecules. We have optimized the application of these nanopores to permit fast molecular transport, which has allowed us to construct a processor for parallel chemical signals from the bottom up in a modular fashion. The processor comprises three aqueous droplet compartments connected by lipid bilayers and operates in an aqueous environment. It can receive two chemical signals from the external environment, process them orthogonally, and then produce a distinct output for each signal. It is suitable for both sensing and enzymatic processing of environmental signals, with fluorescence and molecular outputs. In the future, such processors could serve as smart drug delivery vehicles or as modules within synthetic tissues to control their behavior in response to external chemical signals.

Published
2021

45. Functional Integration of 3D-Printed Cerebral Cortical Tissue into a Brain Lesion

Author

Jin, Yongcheng, primary, Mikhailova, Ellina, additional, Lei, Ming, additional, Cowley, Sally, additional, Sun, Tianyi, additional, Yang, Xingyun, additional, Zhang, Yujia, additional, Liu, Kaili, additional, Catarino, Daniel, additional, Soares, Luana Campos, additional, Bandiera, Sara, additional, Szele, Francis G., additional, Molnar, Zoltan, additional, Zhou, Linna, additional, and Bayley, Hagan, additional

Published
2022
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46. Functional truncated membrane pores

Author

Stoddart, David, Ayu, Mariam, Höfler, Lajos, Raychaudhuri, Pinky, Klingelhoefer, Jochen W., Maglia, Giovanni, Heron, Andrew, and Bayley, Hagan

Published
2014

49. The role of lipids in mechanosensation

Author

Pliotas, Christos, Dahl, A Caroline E, Rasmussen, Tim, Mahendran, Kozhinjampara R, Smith, Terry K, Marius, Phedra, Gault, Joseph, Banda, Thandiwe, Rasmussen, Akiko, Miller, Samantha, Robinson, Carol V, Bayley, Hagan, Sansom, Mark S P, Booth, Ian R, and Naismith, James H

Published
2015
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