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Mexidol (MD, 2-ethyl-6-methyl-3-hydroxypyridine) is a registered therapeutic agent for the treatment of anxiety disorders. The chemical structure suggests that MD may also act as an antioxidant. In this study, the hydroperoxyl radical scavenging activity of MD was studied to establish baseline antioxidant activity, followed by an investigation of the effect of MD on the copper-catalysed oxidative damage in biological systems, using computational methods. It was found that MD exhibits moderate radical scavenging activity against HOO • in water and pentyl ethanoate solvents following the single electron transfer and formal hydrogen transfer mechanisms, respectively. MD can chelate Cu(II), forming complexes that are much harder to reduce than free Cu(II): MD chelation completely quenches the Cu(II) reduction by ascorbic acid and suppresses the rate of reduction reaction by O2⋅ - that are the main reductants of Cu(II) in biological environments. Therefore, MD exerts its anti-HO • activity primarily as an OIL-1 inhibitor.

L’objectif des problèmes de tournées de véhicules est la conception d’itinéraires efficaces pour fournir des biens d’un dépôt à un ensemble de clients satisfaisant des contraintes spécifiques. Les variantes classiques de ces problèmes considèrent que les routes sont effectuées par des véhicules alimentés par des moteurs à combustion interne. Ces véhicules ont une grande autonomie, le réseau d’approvisionnement est dense et le temps nécessaire au ravitaillement peut être négligé. En revanche, en raison d’une plus petite autonomie, du temps nécessaire pour recharger la batterie des véhicules électriques (VE) et de la disponibilité limitée des infrastructures de recharge, les algorithmes de tournées de VE doivent être développés. Maximiser l’autonomie entre deux recharges conduit à examiner les principaux facteurs de consommation d’énergie qui sont : le poids du véhicule et sa charge, l’efficacité du moteur, la vitesse, la conduite, la pente de la route et les possibilités de recharge du véhicule pendant la conduite. Les résultats de cette recherche permettront la gestion optimale de la logistique urbaine où la livraison de nuit, rendue possible par l’usage de ces véhicules silencieux, reste un des grands intérêts., Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège

RÉSUMÉ INTRODUCTION : Les médecins seront de plus en plus confrontés à prendre en charge des centenaires. Les études sur les électrocardiogrammes (ECG) de ces patients très âgés sont peu nombreuses et présentent des conclusions parfois contradictoires. OBJECTIF : Déterminer les caractéristiques électrocardiographiques (ECG) des centenaires et les corréler aux informations cliniques pertinentes tirées des dossiers. MÉTHODE : Nous avons étudié rétrospectivement 108 ECG de centenaires hospitalisés au CHUV. Les données ont été complétées par les diagnostics, interventions et médicaments significatifs pour l’ECG, extraits électroniquement pour chaque patient, ainsi que par les rapports échocardiographiques disponibles. Dix-huit patients ont été exclus du collectif ; 90 centenaires ayant eu un ECG ont été retenus dans l’étude. RÉSULTATS : Septante femmes (F) (78%) et 20 hommes (H) ont été inclus. Seules 5 patientes (6%) présentaient un ECG normal. Huitante % des patients étaient en rythme sinusal ; 38% présentaient des extrasystoles supraventriculaires (ESSV), essentiellement atriales, et 19% étaient en fibrillation ou flutter auriculaires. Parmi les troubles de conduction, on note 54% d’ECG avec troubles de conduction auriculaires, 38% avec troubles de conduction atrio- ventriculaires, et 43% avec des troubles de conduction intra-ventriculaires. Les critères d’hypertrophie ventriculaire gauche étaient présents sur 32% des tracés. On retient des différences significatives entre les sexes pour les paramètres suivants : rythme sinusal (F>H), FA et flutter auriculaires (H>F), ESSV (F>H), largeur de QRS (F : 94 ± 3 ms, H : 107 ± 5 ms). CONCLUSION : Une minorité d’ECG de centenaires est normale (6%). Les pathologies prédominantes sont les arythmies et les troubles de conduction. Il apparaît important de ne pas négliger les ESSV (principalement atriales), les troubles de conduction inter-auriculaires et les blocs atrio-ventriculaires du 1er degré, reconnus notamment comme facteurs de risque de la FA ; une étude prospective à large échelle se justifie pour en évaluer objectivement le risque.

This demonstration presents a music structure-based audio/visual interface for the navigation of very large scale music digital libraries. This work is a product of the Structural Analysis of Large Amounts of Music Information (SALAMI) project. © 2011 Authors.

The work contains studies of the chemical composition of adducts on the basis of terpenoids and maleic anhydride to provide controlled synthesis on the basis of their secondary products with specified performance characteristics. The determination of the qualitative and quantitative composition of the mixtures of resin acids of pine turpentine and rosin by their methyl esters was performed with GLC analysis; the components of pine resin, rosin, turpentine, adducts was performed with NMR spectroscopy, functional groups in the original terpenoid resins and products of their interaction with oxygen-containing compounds (maleopimaric acid) and terpenoidmaleic adducts by the method of IR spectroscopy. Good convergence of the results obtained by NMR spectroscopy and GLC analysis on the composition of pine resin, gum rosin and turpentine confirms their authenticity. Using the obtained experimental and calculated data the composition of terpenoidmaleic adducts wasset. When obtaining resin terpenoidmaleic adducts, the composition of turpentine solution of resin varied in the range from 30/70 to 70/30 wt %, the calculated amount of maleic anhydride to link all resin acids with conjugated double bonds and terpene hydrocarbons varied from 57.7 to 38.3 wt %. It is shown that when modification of turpentine composition from 30/70 to 70/30 wt % with maleic anhydride increases, there is a significant change in the compositions of obtained terpenoidmaleic adducts of rosin. When comparing experimental data and theoretical calculations regularity is established in the change of composition of terpenoidmaleic of rosin adducts obtained from various terpentine: content of maleopimaric acid naturally increases with the increase of resin acids and the content of terpenoidmaleic adducts decreases. It is shown th at terpinoidmaleic adducts are multicomponent sys-tems composed of maleopimaric acid, terpinolene ad ducts, and of resin acids, which do not react with maleic anhydride. By varying the composition of the turpentine and the amount of maleic anhydride, adducts with different content components can be obtained, and hence, regulating their specifications. The efficiency of using the methods of NMR and IR spectroscopy to study the composition terpenoidmaleic adducts is demonstrated.

Aims A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). Methods and results We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF ≥ 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28%), and have a history of hypertension (51 vs. 41%). Ischaemic aetiology was less common (43 vs. 59%) in patients with HF-PEF. There were 121 [95% confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95% CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95% CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40%. Conclusion Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.

Bu araştırmada, üniversite öğrencilerinin motivasyon, zaman yönetimi, sınavlara hazırlanma ve sınav kaygısının üstesinden gelebilme becerisine sahip olma durumlarının, cinsiyet, sınıf, öğretim şekli ve anabilim dalı değişkenlerine göre farklılaşıp farklılaşmadığı incelenmiştir. Araştırmanın evrenini, Kazım Karabekir Eğitim Fakültesi öğrencileri, örneklemini ise farklı anabilim dalları birinci ve son sınıflarında, 2002-2003 öğretim yılında öğrenim gören 773 öğrenci oluşturmuştur. Araştırmada veriler, araştırmacılar tarafından hazırlanan, beşli likert tipi 26 sorudan oluşan, dereceleme ölçeğiyle toplanmıştır. Araştırmada elde edilen verilerin istatistiksel analizinde, %, ‘t’ testi, ‘r’ korelasyon ve varyans analizi kullanılmıştır. Elde edilen bulgular sonucunda, cinsiyet değişkenine göre öğrenciler arasında ders çalışma becerilerine sahip olma açısından bir farklılık bulunmamıştır. Sınıf değişkenine göre de son sınıf öğrencileri lehine (p

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A substantial proportion of patients with heart failure have preserved left ventricular ejection fraction (HF-PEF). Previous studies have reported mixed results whether survival is similar to those patients with heart failure and reduced EF (HF-REF). We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF epsilon 50. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. 28), and have a history of hypertension (51 vs. 41). Ischaemic aetiology was less common (43 vs. 59) in patients with HF-PEF. There were 121 [95 confidence interval (CI): 117, 126] deaths per 1000 patient-years in those with HF-PEF and 141 (95 CI: 138, 144) deaths per 1000 patient-years in those with HF-REF. Patients with HF-PEF had lower mortality than those with HF-REF (adjusted for age, gender, aetiology, and history of hypertension, diabetes, and atrial fibrillation); hazard ratio 0.68 (95 CI: 0.64, 0.71). The risk of death did not increase notably until EF fell below 40. Patients with HF-PEF have a lower risk of death than patients with HF-REF, and this difference is seen regardless of age, gender, and aetiology of HF. However, absolute mortality is still high in patients with HF-PEF highlighting the need for a treatment to improve prognosis.

Url: http://sujest.selcuk.edu.tr/sumbtd/article/view/202, This paper is concerned with the continuous contact problem of two transversely isotropic layers resting on a circular support. The external load is applied to the layers by a rigid cylindrical block. It is assumed that the contact between all surfaces is frictionless and body forces are not taken into account. The problem is formulated in terms of singular integral equations obtained from the continuous contact position. Equations are solved numerically by using the Gauss-Chebyshev integration method. Furthermore, numerical results as pressure distributions under the rigid cylindrical block are given for different material combinations., Bu makale, çembersel destek üzerinde duran iki adet enine-izotrop katmanın sürekli temas problemini ele almaktadır. Dış yük, katmanlara bir rijit silindirik blok vasıtasıyla tatbik edilmiştir. Tüm yüzeylerin arasındaki temasın sürtünmesiz olduğu kabul edilmiş ve kütle kuvvetleri hesaba katılmamıştır. Problem, sürekli temas konumundan elde edilen tekil integral denklemler cinsinden formüle edilmiştir. Denklemler Gauss-Chebyshev integrasyon yöntemi ile nümerik olarak çözülmüştür. Bunun dışında, rijit silindirik blok altındaki basınç dağılımlarına ait sayısal sonuçlar birçok farklı malzeme kombinasyonları için verilmiştir.

Music audio structure segmentation has been a task in the Music Information Retrieval Evaluation eXchange (MIREX) since 2009. In 2010, five algorithms were evaluated against two datasets (297 and 100 songs) with an almost exclusive focus on western popular music. A new annotated dataset significantly larger in size and with a more diverse range of musical styles became available in 2011. This new dataset comprises over 1,300 songs spanning pop, jazz, classical, and world music styles. The algorithms from the 2010 iteration of MIREX are re-evaluated against this new dataset. This paper presents a detailed analysis of these evaluation results in order to gain a better understanding of the current state-of-the-art in automatic structure segmentation. These expanded analyses focus on the interaction of algorithm performance and rankings with datasets, musical styles, and annotation level. Because the new dataset contains multiple annotations for each song, we also introduce a baseline for expected human performance for this task. © 2011 International Society for Music Information Retrieval.

The HZGA San Roque Hospital (an Acute Hospital at La Plata, Argentina) assists 40 HIV patients. The present study was carried out due to the lack of adherence to the High Activity Anti-Retroviral Therapy (HAART) because of the late withdrawal of medication. The present work was implemented on HIV patients who withdraw medication from the Pharmacy Department at the Hospital. Research period lasted 12 months. The aims of this work were to quantify the degree of adherence to the treatment, to assist patients by means of pharmaceutical care so that they reach a 90 % of adherence to the treatment, to analyse the relationship between the understanding of the treatment and its administration and the degree of adherence, and, finally, to analyse the relationship between viral load (VL) and adherence. The study showed that containment and information help to raise the level of patients' adherence to HAART in 29 %. The patients' responsibility and commitment to the treatment also increased, as well as CD4 values; VL, on the other hand, decreased with respect to the beginning of the study. The interrupt far TIMID (less than 0.10) shows an improvement of 15.8 % in the number of patients who interrupted their treatment is also reflected in the survey of adherence where we have an increase of 26.2 %., Colegio de Farmacéuticos de la Provincia de Buenos Aires

Music audio structure segmentation has been a task in the Music Information Retrieval Evaluation eXchange (MIREX) since 2009. In 2010, five algorithms were evaluated against two datasets (297 and 100 songs) with an almost exclusive focus on western popular music. A new annotated dataset significantly larger in size and with a more diverse range of musical styles became available in 2011. This new dataset comprises over 1,300 songs spanning pop, jazz, classical, and world music styles. The algorithms from the 2010 iteration of MIREX are re-evaluated against this new dataset. This paper presents a detailed analysis of these evaluation results in order to gain a better understanding of the current state-of-the-art in automatic structure segmentation. These expanded analyses focus on the interaction of algorithm performance and rankings with datasets, musical styles, and annotation level. Because the new dataset contains multiple annotations for each song, we also introduce a baseline for expected human performance for this task. © 2011 International Society for Music Information Retrieval.

The OPERA experiment is designed to perform first direct observation of $\nu_{\tau}$ appearance in an almost pure $\nu_{\mu}$ beam. The OPERA detector is a hybrid setup which combines a lead/emulsion target with various electronic detectors. It is located in Gran Sasso Laboratory (LNGS), 730 km away from CERN where neutrino beam is produced. A good electron identification in the ECC brick would also allow OPERA to search for $\nu_{\mu} \to \nu_e$ oscillations. We have studied electron identification in the Emulsion Cloud Chamber (ECC) brick which was exposed to CERN SPS H4 electron beam. Emulsion scanning was performed in LNGS scanning laboratory. FEDRA framework was used for the data analysis. In total, we have found 30 electron showers in the brick. The characteristics of each shower have been studied. The background base-track contamination in the shower was estimated as 20 $\pm$ 4. This is mainly due to shower overlap of electrons and passing through cosmic rays.