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4. Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK

Author

Hauck, Annalisa G V, van der Vaart, Marianne, Adams, Eleri, Baxter, Luke, Bhatt, Aomesh, Crankshaw, Daniel, Dhami, Amraj, Evans Fry, Ria, Freire, Marina B O, Hartley, Caroline, Mansfield, Roshni C, Marchant, Simon, Monk, Vaneesha, Moultrie, Fiona, Peck, Mariska, Robinson, Shellie, Yong, Jean, Poorun, Ravi, Cobo, Maria M, and Slater, Rebeccah

Published
2024
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6. Neuroimaging of neonatal nociception

Author

Baxter, Luke, Slater, Rebeccah, Jbabdi, Saad, and Duff, Eugene

Subjects
618.92, Newborn infants, Pain, Magnetic resonance imaging
Abstract

Newborn infants undergo painful procedures during standard clinical care. However, pain assessment in non-verbal infants is challenging. Improving understanding of infant pain neurophysiology, including anticipating pain responses, is central to improving pain management. Magnetic resonance imaging (MRI) is an ideal technique for examining the structure and function of the infant pain system, allowing whole-brain coverage at relatively high spatial resolutions. However, major differences between the adult and infant brain necessitate the use of infant- optimised data analysis methods. The first study involved outlining and validating an optimised infant noxious- response functional MRI data analysis pipeline to improve data quality. Using a cohort of 15 healthy newborn infants, five key analysis steps were assessed. Adopting the Developing Human Connectome Project functional MRI preprocessing pipeline improved motion and distortion correction and spatial normalisation outputs, and including spatial ICA-based denoising and minimal spatial filtering furthered these improvements. Of three term infant haemodynamic response function parameterisations, the double gamma function was most suitable. Relative to a standard adult analysis pipeline adapted for infants, the infant-optimised pipeline significantly improved data quality. The second study involved predicting infants' cerebral haemodynamic noxious- response amplitudes from resting-state activity demonstrating the potential for infant-unique brain activity to inform infant pain management. Using a cohort of 18 healthy newborn infants, nine resting-state networks were robustly identifiable, and the infants' resting-state network amplitudes predicted noxious-response amplitudes with statistically significant accuracy. Noxious-response amplitudes were related to white matter complexity using diffusion MRI, suggesting the response amplitudes were infant trait effects. Finally, the specific pattern of functional and structural neural correlates of the haemodynamic noxious-response amplitudes suggested the responses reflected brain maturity. This work advances our understanding of the newborn infant's pain system, un- derscores the central importance of MRI in furthering this basic understanding, and helps form the foundations on which further infant pain research can be conducted.

Published
2020

8. Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol

Author

Baxter, Luke, primary, Vaart, Marianne van der, additional, Cobo, Maria M, additional, Gunawan, Patricia, additional, Allegaert, Karel, additional, Davis, Jonathan M, additional, Turner, Mark, additional, Ward, Robert, additional, Darsey, Edress, additional, Sheppard, James P, additional, Bhatt, Aomesh, additional, Anker, John van den, additional, Massaro, An N, additional, Walls, Ramona L, additional, Song, Laura S, additional, Singh, Kanwaljit, additional, N/A, INC Pain working party authorship group, additional, and Slater, Rebeccah, additional

Published
2024
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12. Identifying factors that can be used to assess a country’s readiness to deploy a new vaccine or improve uptake of an underutilised vaccine: a scoping review

Author

Bhatt, Aomesh, primary, Monk, Vaneesha, additional, Bhatti, Alexandra, additional, Eiden, Amanda L, additional, Hermany, Lindsay, additional, Hansen, Natasha, additional, Connolly, Mark P, additional, Baxter, Luke, additional, Vanderslott, Samantha, additional, Mitrovich, Rachel, additional, and Slater, Rebeccah, additional

Published
2024
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13. Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome

Author

MS Neonatologie, Ansari, Amir, Pillay, Kirubin, Arasteh, Emad, Dereymaeker, Anneleen, Mellado, Gabriela Schmidt, Jansen, Katrien, Winkler, Anderson M., Naulaers, Gunnar, Bhatt, Aomesh, Huffel, Sabine Van, Hartley, Caroline, Vos, Maarten De, Slater, Rebeccah, Baxter, Luke, MS Neonatologie, Ansari, Amir, Pillay, Kirubin, Arasteh, Emad, Dereymaeker, Anneleen, Mellado, Gabriela Schmidt, Jansen, Katrien, Winkler, Anderson M., Naulaers, Gunnar, Bhatt, Aomesh, Huffel, Sabine Van, Hartley, Caroline, Vos, Maarten De, Slater, Rebeccah, and Baxter, Luke

Published
2024

14. The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants

Author

Fitzgibbon, Sean P., Harrison, Samuel J., Jenkinson, Mark, Baxter, Luke, Robinson, Emma C., Bastiani, Matteo, Bozek, Jelena, Karolis, Vyacheslav, Cordero Grande, Lucilio, Price, Anthony N., Hughes, Emer, Makropoulos, Antonios, Passerat-Palmbach, Jonathan, Schuh, Andreas, Gao, Jianliang, Farahibozorg, Seyedeh-Rezvan, O'Muircheartaigh, Jonathan, Ciarrusta, Judit, O'Keeffe, Camilla, Brandon, Jakki, Arichi, Tomoki, Rueckert, Daniel, Hajnal, Joseph V., Edwards, A. David, Smith, Stephen M., Duff, Eugene, and Andersson, Jesper

Published
2020
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17. Apnoea suppresses brain activity in infants

Author

Zandvoort, Coen S., primary, Dereymaeker, Anneleen, additional, Baxter, Luke, additional, Jansen, Katrien, additional, Naulaers, Gunnar, additional, de Vos, Maarten, additional, and Hartley, Caroline, additional

Published
2024
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19. High resolution diffusion imaging in the unfixed post-mortem infant brain at 7T

Author

Wu, Wenchuan, primary, Rieger, Sebastian W, additional, Baxter, Luke, additional, Adams, Eleri, additional, Andersson, Jesper LR, additional, Cobo, Maria M, additional, Andritsou, Foteini, additional, Bastiani, Matteo, additional, Fry, Ria Evans, additional, Frost, Robert, additional, Fitzgibbon, Sean, additional, Foxley, Sean, additional, Fowler, Darren, additional, Gallagher, Chris, additional, Howard, Amy FD, additional, Hajnal, Joseph V, additional, Moultrie, Fiona, additional, Monk, Vaneesha, additional, Porter, David Andrew, additional, Papp, Daniel, additional, Price, Anthony, additional, Sallet, Jerome, additional, Sanders, Michael, additional, Wilkinson, Dominic, additional, Slater, Rebeccah, additional, and Miller, Karla L, additional

Published
2024
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20. Identifying factors that can be used to assess a country’s readiness to deploy a new vaccine or improve uptake of an underutilized vaccine: a scoping review

Author

Bhatt, Aomesh, primary, Monk, Vaneesha, additional, Bhatti, Alexandra, additional, Eiden, Amanda L., additional, Hermany, Lindsay, additional, Hansen, Natasha, additional, Connolly, Mark P., additional, Baxter, Luke, additional, Vanderslott, Samantha, additional, Mitrovich, Rachel, additional, and Slater, Rebeccah, additional

Published
2023
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25. Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome

Author

Ansari, Amir, primary, Pillay, Kirubin, additional, Arasteh, Emad, additional, Dereymaeker, Anneleen, additional, Mellado, Gabriela Schmidt, additional, Jansen, Katrien, additional, Winkler, Anderson M., additional, Naulaers, Gunnar, additional, Bhatt, Aomesh, additional, Huffel, Sabine Van, additional, Hartley, Caroline, additional, De Vos, Maarten, additional, Slater, Rebeccah, additional, and Baxter, Luke, additional

Published
2023
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30. Brain age as an estimator of neurodevelopmental outcome: A deep learning approach for neonatal cot-side monitoring

Author

Ansari, Amir, primary, Pillay, Kirubin, additional, Baxter, Luke, additional, Arasteh, Emad, additional, Dereymaeker, Anneleen, additional, Mellado, Gabriela Schmidt, additional, Jansen, Katrien, additional, Naulaers, Gunnar, additional, Bhatt, Aomesh, additional, Van Huffel, Sabine, additional, Hartley, Caroline, additional, De Vos, Maarten, additional, and Slater, Rebeccah, additional

Published
2023
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33. Protocol for a systematic scoping review to identify factors that determine a country’s readiness to deploy a vaccination programme

Author

Bhatt, Aomesh, Hermany, Lindsay, Vanderslott, Samantha, Vaneesha Monk, Eiden, Amanda, Bhatti, Alexandra, Mitrovich, Rachel, Connolly, Mark, and Baxter, Luke

Subjects
vaccine readiness, vaccine, public health, Medicine and Health Sciences, protocol, scoping review
Abstract

A systematic scoping review to identify factors to assess a country’s readiness to deploy a new or underutilized vaccine at a national level.

Published
2023
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34. Protocol

Author

Discenza, Deb, Davis, Jonathan M, Edress Darsey, Vivas, Norma, Mehta, Varsha, Kanwaljit Singh, Baxter, Luke, Slater, Rebeccah, Matthews, Danielle, Van Den Anker, John, Hovinga, Collin, Massaro, An, Van Der Vaart, Marianne, Gunawan, Patricia Yulita, Bhatt, Aomesh, Turner, Mark, Sheppard, James, Allegaert, Karel, Cobo, Maria M., and Ward, Robert

Published
2023
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35. Search strategy

Author

Ward, Robert, Turner, Mark, Hovinga, Collin, Van Der Vaart, Marianne, Baxter, Luke, Sheppard, James, Van Den Anker, John, Massaro, An, Mehta, Varsha, Allegaert, Karel, Bhatt, Aomesh, Cobo, Maria M., Vivas, Norma, Slater, Rebeccah, Gunawan, Patricia Yulita, Matthews, Danielle, Edress Darsey, Kanwaljit Singh, Discenza, Deb, and Davis, Jonathan M

Published
2023
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36. PROSPERO registration

Author

Davis, Jonathan M, Matthews, Danielle, Hovinga, Collin, Kanwaljit Singh, Edress Darsey, Massaro, An, Mehta, Varsha, Cobo, Maria M., Sheppard, James, Discenza, Deb, Bhatt, Aomesh, Allegaert, Karel, Vivas, Norma, Baxter, Luke, Slater, Rebeccah, Van Den Anker, John, Turner, Mark, Van Der Vaart, Marianne, Ward, Robert M., and Gunawan, Patricia Yulita

Published
2023
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37. Is the measurement of noxious stimulus-evoked EEG activity a reliable, valid, and interpretable tool to assess analgesic efficacy in neonates?

Author

Discenza, Deb, Baxter, Luke, Davis, Jonathan M, Van Den Anker, John, Hovinga, Collin, Turner, Mark, Cobo, Maria M., Sheppard, James, Gunawan, Patricia Yulita, Slater, Rebeccah, Mehta, Varsha, Allegaert, Karel, Kanwaljit Singh, Ward, Robert, Bhatt, Aomesh, Vivas, Norma, Van Der Vaart, Marianne, Edress Darsey, Matthews, Danielle, and Massaro, An

Abstract

A systematic review and individual participant data (IPD) meta-analysis

Published
2023
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38. Is the measurement of noxious stimulus-evoked EEG activity a reliable, valid, and interpretable tool to assess analgesic efficacy in neonates? Protocol for a systematic review and individual participant data (IPD) meta-analysis

Author

Massaro, An, Matthews, Danielle, Edress Darsey, Hovinga, Collin, Allegaert, Karel, Ward, Robert, Gunawan, Patricia Yulita, Van Den Anker, John, Kanwaljit Singh, Bhatt, Aomesh, Vivas, Norma, Van Der Vaart, Marianne, Slater, Rebeccah, Davis, Jonathan M, Baxter, Luke, Sheppard, James, Turner, Mark, Discenza, Deb, Mehta, Varsha, and Cobo, Maria M.

Subjects
validity, Medical Sciences, reliability, Neuroscience and Neurobiology, FOS: Clinical medicine, Neurosciences, Life Sciences, Pediatrics, Developmental Neuroscience, Medicine and Health Sciences, Medical Specialties, COSMIN, biomarker, pain, nociception, EEG, neonate, interpretability, electroencephalography
Abstract

This protocol outlines details for an IPD meta-analysis on the measurement properties and interpretability of a brain-based response biomarker of infant acute somatic nociceptive pain. This registration occurred prior to individual participant data collection and analysis.

Published
2023
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40. Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity in response to an acute somatic nociceptive heel lance stimulus

Author

Aspbury, Marianne, Baxter, Luke, Cobo, Maria, van der Vaart, Marianne, Poorun, Ravi, Bhatt, Aomesh, Slater, Rebeccah, Hartley, Caroline, Pillay, Kirubin, Fitzgibbon, Sean, and Hauck, Annalisa

Subjects
Medicine and Health Sciences, Pain, noxious stimulation, EEG, Heel Lance, Infants, reproducibility, neonatal ERP
Abstract

Electroencephalography (EEG) can be used in neonates to measure brain activity changes that are evoked by noxious events, such as clinically-required immunisations, cannulation and heel lancing. EEG provides an alternative approach to infer pain experience in infants compared with more commonly used behavioural and physiological pain assessments. Establishing the generalisability and construct validity of these measures will help corroborate the use of brain-derived outcomes to evaluate the efficacy of new or existing drugs to treat neonatal pain. This study aims to test whether a measure of noxious-evoked EEG activity, that was originally derived in a sample of term-aged infants at the Oxford John Radcliffe Hospital in 2017, can reliably distinguish noxious from non-noxious events in two independent datasets retrospectively collected at University College London Hospital and prospectively collected at Royal Devon & Exeter Hospital. We aim to reproduce three published results that use this measure to quantify noxious-evoked changes in brain activity. We will use this EEG measure to quantify noxious-evoked brain activity to test (i) whether significantly larger noxious-evoked activity is recorded in response to a clinical heel lance compared to a non-noxious control heel lance procedure; (ii) whether the magnitude of the activity evoked by a noxious heel lance is equivalent in independent cohorts of infants; and (iii) whether the magnitude of the noxious-evoked brain activity increases with age in premature infants up to 37 weeks postmenstrual age. Positive replication of these studies will build confidence in the use of brain-derived signals as valid and reliable pain-related outcomes which could be used to evaluate analgesic efficacy in neonates.

Published
2022
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43. Readiness of vaccination programmes

Author

Baxter, Luke

Subjects
Scoping review, Medical Sciences, Preparedness, Vaccination programme, Deployment, Immunity, Medical Immunology, Life Sciences, Diseases, Community Health and Preventive Medicine, Influenza Virus Vaccines, Readiness, Immunology of Infectious Disease, Immune System Diseases, Medicine and Health Sciences, Protocol, Public Health, Immunology and Infectious Disease
Abstract

This is a registration of a protocol for a systematic scoping review to identify factors that create vaccination programmes ready for deployment.

Published
2022
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44. Establishing a standardised approach for the measurement of neonatal noxious-evoked brain activity

Author

Aspbury, Marianne, Baxter, Luke, van der Vaart, Marianne, Poorun, Ravi, Cobo, Maria, Hartley, Caroline, Hauck, Annalisa, Pillay, Kirubin, Fitzgibbon, Sean, Bhatt, Aomesh, and Slater, Rebeccah

Subjects
Medicine and Health Sciences, Medical Specialties, pain, EEG, neonate, Pediatrics, infant, reproducibility
Abstract

Electroencephalography (EEG) can be used in neonates to measure brain activity changes that are evoked by noxious events, such as clinically-required immunisations, cannulation and heel lancing. EEG provides an alternative approach to infer pain experience in infants compared with more commonly used behavioural and physiological pain assessments. Establishing the generalisability and validity of these measures will help corroborate the use of brain-derived outcomes to evaluate the efficacy of new or existing drugs to treat neonatal pain. This study aims to test whether an EEG template of noxious-evoked brain activity, that was originally derived in a sample of term-aged infants at the Oxford John Radcliffe Hospital in 2017, can reliably distinguish noxious from non-noxious events in two independent datasets retrospectively collected at University College London Hospital and prospectively collected at Royal Devon & Exeter Hospital. We aim to reproduce three published results that use the EEG template to quantify noxious-evoked changes in brain activity. We will test (i) whether a significantly larger noxious-evoked template magnitude is recorded in response to a clinical heel lance compared to a non-noxious control heel lance procedure; (ii) whether the scale of the template magnitude evoked by a noxious heel lance is equivalent in independent cohorts of infants; and (iii) whether the magnitude of the noxious-evoked brain activity increases with age in premature infants up to 37 weeks postmenstrual age. Positive replication of these studies will build confidence in the use of brain-derived signals as valid and reliable pain-related outcomes which could be used to evaluate analgesic efficacy in neonates.

Published
2022
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45. PROSPERO registration

Author

Baxter, Luke and Cobo, Maria

Subjects
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Abstract

The Files window in this project component contains the review PROSPERO registration details.

Published
2022
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46. Search strategy

Author

Baxter, Luke and Cobo, Maria

Subjects
Wheeze, Adolescent, Medicine and Health Sciences, Life Sciences, Infant, Bronchospasm, Ibuprofen, Child, Asthma, NSAID
Abstract

The Files window in this project component contains the review search strategy. The complete search strategy has undergone PRESS Peer Review.

Published
2022
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47. Immunization program resilience

Author

Baxter, Luke

Subjects
Scoping review, Medical Sciences, Resilience, Vaccination programme, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Immunity, Medical Immunology, Life Sciences, Diseases, Community Health and Preventive Medicine, Influenza Virus Vaccines, Crisis, Immunology of Infectious Disease, Immune System Diseases, Medicine and Health Sciences, Protocol, Public Health, Immunology and Infectious Disease
Abstract

This is a registration of a protocol for a systematic scoping review to identify factors that create resilient vaccination programmes.

Published
2022
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48. Protocol

Author

Baxter, Luke and Cobo, Maria

Subjects
Data_FILES
Abstract

The Files window in this project component contains the review protocol.

Published
2022
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49. Multicentre, randomised controlled trial to investigate the effects of parental touch on relieving acute procedural pain in neonates (Petal)

Author

Cobo, Maria M, primary, Moultrie, Fiona, additional, Hauck, Annalisa G V, additional, Crankshaw, Daniel, additional, Monk, Vaneesha, additional, Hartley, Caroline, additional, Evans Fry, Ria, additional, Robinson, Shellie, additional, van der Vaart, Marianne, additional, Baxter, Luke, additional, Adams, Eleri, additional, Poorun, Ravi, additional, Bhatt, Aomesh, additional, and Slater, Rebeccah, additional

Published
2022
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50. Proceedings of the 14th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal.

Author

Abdi, Khadar, Adams, Eleri, Agarwal, Sonika, Ergun, Mehmet Ali, Altamimi, Talal, Aral, Arzu, Arfi, Hanifa, Armour, Eric, Armstrong, Laura, Mulkey, Sarah B., Bambi, Jephté, Baxter, Luke, Benner, Eric, Bhattacharya, Soume, Biselele, Thérèse, Bolay, Hayrunnisa, Mayorga, Paula Camila, Carrasco, Melisa, Carter, Emma, and Chao, Agnes

Subjects
NEURODEVELOPMENTAL treatment for infants, CEREBRAL anoxia-ischemia, EPILEPSY, NEWBORN infants, NEURAL development, NEUROSCIENCES, FETAL brain, VERY low birth weight
Abstract

Histological chorioamnionitis as a risk factor for early brain damage in premature babies in... B Arfi H b SP 1 sp , Lebane D SP 1 sp , Abrouk S SP 2 sp I SP 1 sp Chu Mustapha Algiers, Ouled fayet, Algérie i I SP 2 sp University of Algiers, 2 Rue Didouche Mourad, Alger Ctre 16000, Algeria i B INTRODUCTION: b The early brain damage of the premature has been correlated to several risk factors and among them the histological chorioamnionitis (HC). Congenital brain malformations: Seizure incidence, EEG findings, and developmental outcomes B Armstrong L b SP 1 sp , Cooke A SP 1 sp , Harshbarger J SP 1 sp , Armour E SP 2 sp , Reddy S SP 1 sp , Pagano L SP 1 sp , Carter E SP 1 sp I SP 1 sp Vanderbilt University Medical Center, Nashville, United States, SP 2 sp University of Michigan Health, Ann Arbor, United States i B BACKGROUND: b With improvements in pre- and post-natal imaging, congenital brain malformations are increasingly found prior to onset of symptoms. Apnoea and EEG brain activity in neonates: Data from a systematic review B Usman F b SP 1,2 sp , Marchant S SP 1 sp , Baxter L SP 1 sp , Aliyu M SP 3 sp , Salihu H SP 4 sp , Adams E SP 5 sp , Hartley C SP 1 sp I SP 1 sp University Of Oxford, Oxford, United Kingdom, SP 2 sp Bayero University, Kano and Aminu Kano Teaching Hospital, Kano, Nigeria, SP 3 sp Vanderbilt University Medical Center, Nashville, USA, SP 4 sp Baylor College of Medicine, Houston, USA, SP 5 sp Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom i B BACKGROUND AND PURPOSE: b Neonates have immature respiratory control mechanisms [1] and a developing brain that is susceptible to the adverse effects of intermittent hypoxia [2]. [Extracted from the article]

Published
2023
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