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1. Less bleeding by omitting aspirin in non-ST-segment elevation acute coronary syndrome patients: Rationale and design of the LEGACY study

Author

van der Sangen, Niels M.R., Küçük, I. Tarik, Sivanesan, Shabiga, Appelman, Yolande, ten Berg, Jurriën M., Verburg, Ashley, Azzahhafi, Jaouad, Arkenbout, E. Karin, Kikkert, Wouter J., Pisters, Ron, Jukema, J. Wouter, Arslan, Fatih, van ‘t Hof, Arnoud, Ilhan, Mustafa, Hoebers, Loes P., van der Schaaf, René J., Damman, Peter, Woudstra, Pier, van de Hoef, Tim P., Bax, Matthijs, Anthonio, Rutger L., Polad, Jawed, Adriaenssens, Tom, Dewilde, Willem, Zivelonghi, Carlo, Laanmets, Peep, Majas, Risko, Dijkgraaf, Marcel G.W., Claessen, Bimmer E.P.M., and Henriques, José P.S.

Published
2023
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2. Ten‐Year Outcome of Recanalization or Medical Therapy for Concomitant Chronic Total Occlusion After Myocardial Infarction

Author

van Veelen, Anna, primary, Coerkamp, Casper F., additional, Somsen, Yvemarie B.O., additional, Råmunddal, Truls, additional, Ioanes, Dan, additional, Laanmets, Peep, additional, van der Schaaf, René J., additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley H., additional, Barbato, Emanuele, additional, Marques, Koen M., additional, Meuwissen, Martijn, additional, Bertrand, Olivier, additional, van der Ent, Martin, additional, Knaapen, Paul, additional, Tijssen, Jan G.P., additional, Claessen, Bimmer E.P.M., additional, Hoebers, Loes P.C., additional, Elias, Joëlle, additional, Henriques, José P.S., additional, Henriques, J.P.S., additional, Piek, J.J., additional, de Winter, R.J., additional, Koch, K.T., additional, Vis, M.M., additional, Baan, J., additional, Wykrzykowska, J., additional, Marques, K.M., additional, Meuwissen, M., additional, Koolen, J., additional, Bax, M., additional, Schotborgh, C.E., additional, van der Ent, M., additional, van der Schaaf, R.J., additional, Slagboom, T., additional, Amoroso, G., additional, Suttorp, M.J., additional, Råmunddal, T., additional, Ioanes, D., additional, Laanmets, P., additional, Eriksen, E., additional, Tuseth, V., additional, Strauss, B.H., additional, Bertrand, O., additional, and Barbato, E., additional

Published
2024
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4. The effect of revascularization of a chronic total coronary occlusion on electrocardiographic variables. A sub-study of the EXPLORE trial

Author

van Dongen, Ivo M., Kolk, Maarten Z.H., Elias, Joëlle, Meijborg, Veronique M.F., Coronel, Ruben, de Bakker, Jacques M.T., Claessen, Bimmer E.P.M., Delewi, Ronak, Ouweneel, Dagmar M., Scheunhage, Esther M., van der Schaaf, René J., Suttorp, Maarten-Jan, Bax, Matthijs, Marques, Koen M., Postema, Pieter G., Wilde, Arthur A.M., and Henriques, José P.S.

Published
2018
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5. TCT-417 10-Year Clinical Outcomes After Randomization to PCI of a Concurrent Chronic Total Coronary Occlusion or Optimal Medical Therapy Alone in Patients with STEMI: Extended Follow-Up of the EXPLORE Trial

Author

van Veelen, Anna, primary, Coerkamp, Casper, additional, Elias, Joëlle, additional, Somsen, Yvemarie, additional, Laanmets, Peep, additional, Van der Schaaf, René, additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley, additional, Barbato, Emanuele, additional, Meuwissen, Martijn, additional, Knaapen, Paul, additional, Hoebers, Loes, additional, Claessen, Bimmer, additional, and Henriques, Jose, additional

Published
2023
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6. Proning the extracorporeal membrane oxygenation plus Impella: a case report.

Author

Jongh, Marjolein C de, Bax, Matthijs, Ayan, Khalil, and Akin, Sakir

Subjects
EXTRACORPOREAL membrane oxygenation, CARDIOGENIC shock, CORONARY artery bypass, PATIENT positioning, ADULT respiratory distress syndrome, LEFT ventricular dysfunction
Abstract

Background The prone position is recommended as supportive therapy in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). However, little is known about prone position ventilation in patients with cardiogenic shock supported by extracorporeal membrane oxygenation (ECMO) plus Impella (ECPELLA) developing ARDS. Case summary A 66-year-old man with severe left ventricular dysfunction was admitted to a non-academic ECMO centre for a high-risk coronary artery bypass grafting. He developed post-cardiotomy shock needing ECMO support. To improve left ventricular unloading, an Impella was inserted 2 days later. One day later, he developed ARDS and needed prone position ventilation with ECPELLA in situ. After 4 weeks, he was discharged from the intensive care unit. Discussion Previous studies demonstrated that prone positioning could help avoid an additional venous cannula in veno-arterial ECMO patients, which is associated with mechanical complications. In this case, there was a promising role for unloading the left ventricle with Impella during veno-arterial ECMO and, for proning, the patient with cardiogenic shock developing ARDS during ECMO support without the need for an extra venous cannula. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Less bleeding by omitting aspirin in non-ST-segment elevation acute coronary syndrome patients: Rationale and design of the LEGACY study

Author

Team Medisch, van der Sangen, Niels M R, Küçük, I Tarik, Sivanesan, Shabiga, Appelman, Yolande, Ten Berg, Jurriën M, Verburg, Ashley, Azzahhafi, Jaouad, Arkenbout, E Karin, Kikkert, Wouter J, Pisters, Ron, Jukema, J Wouter, Arslan, Fatih, van 't Hof, Arnoud, Ilhan, Mustafa, Hoebers, Loes P, van der Schaaf, René J, Damman, Peter, Woudstra, Pier, van de Hoef, Tim P, Bax, Matthijs, Anthonio, Rutger L, Polad, Jawed, Adriaenssens, Tom, Dewilde, Willem, Zivelonghi, Carlo, Laanmets, Peep, Majas, Risko, Dijkgraaf, Marcel G W, Claessen, Bimmer E P M, Henriques, José P S, Team Medisch, van der Sangen, Niels M R, Küçük, I Tarik, Sivanesan, Shabiga, Appelman, Yolande, Ten Berg, Jurriën M, Verburg, Ashley, Azzahhafi, Jaouad, Arkenbout, E Karin, Kikkert, Wouter J, Pisters, Ron, Jukema, J Wouter, Arslan, Fatih, van 't Hof, Arnoud, Ilhan, Mustafa, Hoebers, Loes P, van der Schaaf, René J, Damman, Peter, Woudstra, Pier, van de Hoef, Tim P, Bax, Matthijs, Anthonio, Rutger L, Polad, Jawed, Adriaenssens, Tom, Dewilde, Willem, Zivelonghi, Carlo, Laanmets, Peep, Majas, Risko, Dijkgraaf, Marcel G W, Claessen, Bimmer E P M, and Henriques, José P S

Published
2023

9. Coronary hemodynamics in acute myocardial infarction

Author

Bax, Matthijs, Piek, J.J., de Winter, R.J., Koch, K.T., Henriques, J.P., Faculteit der Geneeskunde, Piek, Jan J., de Winter, Robbert J., Koch, Karel T., Simao Henriques, Jose P., ACS - Atherosclerosis & ischemic syndromes, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, ACS - Heart failure & arrhythmias, and Graduate School

Subjects
cardiovascular diseases
Abstract

Microvascular dysfunction in the setting of ST-segment elevation myocardial infarction (STEMI) plays an important role in long-term poor clinical outcome. Microvascular dysfunction in the heart may exist despite successful primary PCI of the epicardial coronary occlusion. Intracoronary derived coronary flow characteristics can be used to evaluate the coronary microcirculation. In our studies we evaluated the time course of the microvascular function as reflected by alterations in microcirculatory physiological parameters in the infarct-related and the noninfarct-related arteries immediately after reperfusion and during follow-up in STEMI patients. Our studies revealed the following results: • Coronary flow reserve and flow capacity in the infarct and noninfarct-related coronary artery were reduced following reperfusion therapy for STEMI; • Microvascular vasodilation, assessed by Doppler derived coronary flow velocity reserve immediately after primary PCI for anterior myocardial infarction, was associated with left ventricular function recovery; • The Doppler flow guidewire may identify patients with apparently restored epicardial flow but impaired microvascular reperfusion; • A low coronary flow reserve in the non-culprit reference vessel after reperfusion for anterior STEMI was associated with a 4-fold increase in cardiac mortality at 10 years follow-up; • Persistent impairment of coronary flow reserve in the non-infarct related coronary artery, due to enhanced baseline blood flow velocity at 6-month follow-up, was associated with a 10-fold increase in 10-year cardiac mortality hazard; furthermore, elevated admission glucose levels in the setting of STEMI were associated with impaired microvascular function in non-culprit vessels.

Published
2021

10. Impact of clinical and haemodynamic factors on coronary flow reserve and invasive coronary flow capacity in non-obstructed coronary arteries: a patient-level pooled analysis of the DEBATE and ILIAS studies

Author

Team Medisch, Circulatory Health, Stegehuis, Valérie Elise, Wijntjens, Gilbert W M, Bax, Matthijs, Meuwissen, Martijn, Chamuleau, Steven A J, Voskuil, Michiel, Koch, Karel T, Di Mario, Carlo, Vrints, Christiaan, Haude, Michael, Board, Ei Statistical, Serruys, Patrick W, Piek, Jan J, van de Hoef, Tim P, Team Medisch, Circulatory Health, Stegehuis, Valérie Elise, Wijntjens, Gilbert W M, Bax, Matthijs, Meuwissen, Martijn, Chamuleau, Steven A J, Voskuil, Michiel, Koch, Karel T, Di Mario, Carlo, Vrints, Christiaan, Haude, Michael, Board, Ei Statistical, Serruys, Patrick W, Piek, Jan J, and van de Hoef, Tim P

Published
2021

11. Impact of clinical and haemodynamic factors on coronary flow reserve and invasive coronary flow capacity in non-obstructed coronary arteries: a patient-level pooled analysis of the DEBATE and ILIAS studies

Author

Stegehuis, Valérie Elise, primary, Wijntjens, Gilbert W.M., additional, Bax, Matthijs, additional, Meuwissen, Martijn, additional, Chamuleau, Steven A.J., additional, Voskuil, Michiel, additional, Koch, Karel T., additional, Di Mario, Carlo, additional, Vrints, Christiaan, additional, Haude, Michael, additional, Boersma, Eric, additional, Serruys, Patrick W., additional, Piek, Jan J., additional, and van de Hoef, Tim P., additional

Published
2021
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14. Time course of coronary flow capacity impairment in ST-segment elevation myocardial infarction

Author

van Lavieren, Martijn A, primary, Stegehuis, Valérie E, additional, Bax, Matthijs, additional, Echavarría-Pinto, Mauro, additional, Wijntjens, Gilbert W M, additional, de Winter, Robbert J, additional, Koch, Karel T, additional, Henriques, José P, additional, Escaned, Javier, additional, Meuwissen, Martijn, additional, van de Hoef, Tim P, additional, and Piek, Jan J, additional

Published
2020
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15. Predictors and outcomes of procedural failure of percutaneous coronary intervention of a chronic total occlusion—A subanalysis of the EXPLORE trial

Author

Kolk, Maarten Z. H., primary, Veelen, Anna, additional, Agostoni, Pierfrancesco, additional, Houwelingen, Gert K., additional, Ouweneel, Dagmar M., additional, Hoebers, Loes P., additional, Råmunddal, Truls, additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten J., additional, Claessen, Bimmer E. P. M., additional, Schaaf, René J., additional, Elias, Joëlle, additional, Dongen, Ivo M., additional, and Henriques, José P. S., additional

Published
2020
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18. C-reactive protein and coronary events following percutaneous coronary angioplasty

Author

Winter, Robbert J. de, Koch, Karel T., Straalen, Jan P. van, Heyde, Gerlind, Bax, Matthijs, Schotborgh, Carl E., Mulder, Karla J., Sanders, Gerard T., Fischer, Johan, Tijssen, Jan G. P., and Piek, Jan J.

Subjects
Coronary artery bypass -- Prognosis, C-reactive protein -- Influence, Cohort analysis, Health, Health care industry
Published
2003

20. TCT-474 Impact of Clinical and Hemodynamic Factors on Coronary Flow Reserve and Invasive Coronary Flow Capacity in Nonobstructed Coronary Arteries: A Patient-Level Pooled Analysis of the DEBATE and ILIAS Studies

Author

Stegehuis, Valérie, primary, Wijntjens, Gilbert, additional, Bax, Matthijs, additional, Meuwissen, Martijn, additional, Chamuleau, Steven, additional, Voskuil, Michiel, additional, Di Mario, Carlo, additional, Vrints, Christiaan, additional, Haude, Michael, additional, Serruys, Patrick, additional, Piek, Jan, additional, and van de Hoef, Tim, additional

Published
2019
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21. Organization of outcome-based quality improvement in Dutch heart centres

Author

van Veghel, Dennis, primary, Daeter, Edgar J, additional, Bax, Matthijs, additional, Amoroso, Giovanni, additional, Blaauw, Yuri, additional, Camaro, Cyril, additional, Cummins, Paul, additional, Halfwerk, Frank R, additional, Wijdh-den Hamer, Inez J, additional, de Jong, Jonas S S G, additional, Stooker, Wim, additional, van der Wees, Philip J, additional, and van der Nat, Paul B, additional

Published
2019
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22. Rationale and design of EXPLORE: a randomized, prospective, multicenter trial investigating the impact of recanalization of a chronic total occlusion on left ventricular function in patients after primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

Author

Tuseth Vegard, Olivecrona Göran K, Strauss Bradley H, Bax Matthijs, Barbato Emanuele, Suttorp Maarten J, Koolen Jacques J, Verouden Niels J, Hoebers Loes P, Claessen Bimmer E, van der Schaaf René J, Glogar Dietmar, Råmunddal Truls, Tijssen Jan G, Piek Jan J, and Henriques José PS

Subjects
Medicine (General), R5-920
Abstract

Abstract Background In the setting of primary percutaneous coronary intervention, patients with a chronic total occlusion in a non-infarct related artery were recently identified as a high-risk subgroup. It is unclear whether ST-elevation myocardial infarction patients with a chronic total occlusion in a non-infarct related artery should undergo additional percutaneous coronary intervention of the chronic total occlusion on top of optimal medical therapy shortly after primary percutaneous coronary intervention. Possible beneficial effects include reduction in adverse left ventricular remodeling and preservation of global left ventricular function and improved clinical outcome during future coronary events. Methods/Design The Evaluating Xience V and left ventricular function in Percutaneous coronary intervention on occLusiOns afteR ST-Elevation myocardial infarction (EXPLORE) trial is a randomized, prospective, multicenter, two-arm trial with blinded evaluation of endpoints. Three hundred patients after primary percutaneous coronary intervention for ST-elevation myocardial infarction with a chronic total occlusion in a non-infarct related artery are randomized to either elective percutaneous coronary intervention of the chronic total occlusion within seven days or standard medical treatment. When assigned to the invasive arm, an everolimus-eluting coronary stent is used. Primary endpoints are left ventricular ejection fraction and left ventricular end-diastolic volume assessed by cardiac Magnetic Resonance Imaging at four months. Clinical follow-up will continue until five years. Discussion The ongoing EXPLORE trial is the first randomized clinical trial powered to investigate whether recanalization of a chronic total occlusion in a non-infarct related artery after primary percutaneous coronary intervention for ST-elevation myocardial infarction results in a better preserved residual left ventricular ejection fraction, reduced end-diastolic volume and enhanced clinical outcome. Trial registration trialregister.nl NTR1108.

Published
2010
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24. Impact of Clinical and Hemodynamic Factors on Coronary Flow Reserve and Invasive Coronary Flow Capacity in Nonobstructed Coronary Arteries: A Patient-Level Pooled Analysis of the DEBATE and ILIAS Studies

Author

Team Medisch, Cardiologie, Circulatory Health, Regenerative Medicine and Stem Cells, Stegehuis, Valerie, Wijntjens, Gilbert, Bax, Matthijs, Meuwissen, Martijn, Chamuleau, Steven, Voskuil, Michiel, Di Mario, Carlo, Vrints, Christiaan, Haude, Michael, Serruys, Patrick, Piek, Jan, van de Hoef, Tim, Team Medisch, Cardiologie, Circulatory Health, Regenerative Medicine and Stem Cells, Stegehuis, Valerie, Wijntjens, Gilbert, Bax, Matthijs, Meuwissen, Martijn, Chamuleau, Steven, Voskuil, Michiel, Di Mario, Carlo, Vrints, Christiaan, Haude, Michael, Serruys, Patrick, Piek, Jan, and van de Hoef, Tim

Published
2019

25. Predictors and outcomes of procedural failure of percutaneous coronary intervention of a chronic total occlusion—A subanalysis of the EXPLORE trial.

Author

Kolk, Maarten Z. H., Veelen, Anna, Agostoni, Pierfrancesco, Houwelingen, Gert K., Ouweneel, Dagmar M., Hoebers, Loes P., Råmunddal, Truls, Laanmets, Peep, Eriksen, Erlend, Bax, Matthijs, Suttorp, Maarten J., Claessen, Bimmer E. P. M., Schaaf, René J., Elias, Joëlle, Dongen, Ivo M., and Henriques, José P. S.

Published
2021
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27. Mid- and long-term outcome of the EXPLORE trial, a Global, Randomized, Prospective, Multicenter Trial Investigating the Impact of Recanalization of a Chronic Total Occlusion in Patients after Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction

Author

Elias, Joelle, van Dongen, Ivo M., Laanmets, Peep, Eriksen, Erlend, Meuwissen, Martijn, Bax, Matthijs, Ioanes, Dan, Suttorp, Maarten, Strauss, Bradley, Barbato, Emanuele, Marques, Koen, Claessen, Bimmer E. P. M., Hirsch, Alexander, van der Schaaf, Rene, Tijssen, Jan, Hoebers, Loes P., Henriques, Jose P. S., Cardiology, and ACS - Atherosclerosis & ischemic syndromes

Published
2017

28. Impact of collateralisation to a concomitant chronic total occlusion in patients with ST-elevation myocardial infarction: a subanalysis of the EXPLORE randomised controlled trial

Author

van Dongen, Ivo M, primary, Elias, Joëlle, additional, van Houwelingen, K Gert, additional, Agostoni, Pierfrancesco, additional, Claessen, Bimmer E P M, additional, Hoebers, Loes P, additional, Ouweneel, Dagmar M, additional, Scheunhage, Esther M, additional, Delewi, Ronak, additional, Piek, Jan J, additional, Råmunddal, Truls, additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Suttorp, Maarten J, additional, van der Schaaf, René J, additional, Tijssen, Jan G P, additional, and Henriques, José P S, additional

Published
2018
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29. Percutaneous Intervention for Concurrent Chronic Total Occlusions in Patients With STEMI The EXPLORE Trial

Author

Henriques, José P. S., Hoebers, Loes P., Råmunddal, Truls, Laanmets, Peep, Eriksen, Erlend, Bax, Matthijs, Ioanes, Dan, Suttorp, Maarten J., Strauss, Bradley H., Barbato, Emanuele, Nijveldt, Robin, van Rossum, Albert C., Marques, Koen M., Elias, Joëlle, van Dongen, Ivo M., Claessen, Bimmer E. P. M., Tijssen, Jan G., van der Schaaf, René J., Cardiology, ICaR - Ischemia and repair, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Radiology and Nuclear Medicine, and ACS - Amsterdam Cardiovascular Sciences

Subjects
surgical procedures, operative, cardiovascular diseases, therapeutics
Abstract

In 10% to 15% of patients with ST-segment elevation myocardial infarction (STEMI), concurrent coronary chronic total occlusion (CTO) in a non-infarct-related artery is present and is associated with increased morbidity and mortality. The EXPLORE (Evaluating Xience and Left Ventricular Function in Percutaneous Coronary Intervention on Occlusions After ST-Elevation Myocardial Infarction) trial evaluated whether patients with STEMI and concurrent CTO in a non-infarct-related artery benefit from additional percutaneous coronary intervention (PCI) of CTO shortly after primary PCI. From November 2007 through April 2015, we enrolled 304 patients with acute STEMI who underwent primary PCI and had concurrent CTO in 14 centers in Europe and Canada. A total of 150 patients were randomly assigned to early PCI of the CTO (CTO PCI), and 154 patients were assigned to conservative treatment without PCI of the CTO (no CTO PCI). Primary outcomes were left ventricular ejection fraction (LVEF) and left ventricular end diastolic volume (LVEDV) on cardiac magnetic resonance imaging after 4 months. The investigator-reported procedural success rate in the CTO PCI arm of the trial was 77%, and the adjudicated success rate was 73%. At 4 months, mean LVEF did not differ between the 2 groups (44.1 ± 12.2% vs. 44.8 ± 11.9%, respectively; p = 0.60). Mean LVEDV at 4 months was 215.6 ± 62.5 ml in the CTO PCI arm versus 212.8 ± 60.3 ml in the no-CTO PCI arm (p = 0.70). Subgroup analysis revealed that patients with CTO located in the left anterior descending coronary artery who were randomized to the CTO PCI strategy had significantly higher LVEF compared with patients randomized to the no-CTO PCI strategy (47.2 ± 12.3% vs. 40.4 ± 11.9%; p = 0.02). There were no differences in terms of 4-month major adverse coronary events (5.4% vs. 2.6%; p = 0.25). Additional CTO PCI within 1 week after primary PCI for STEMI was feasible and safe. In patients with STEMI and concurrent CTO, we did not find an overall benefit for CTO PCI in terms of LVEF or LVEDV. The finding that early CTO PCI in the left anterior descending coronary artery subgroup was beneficial warrants further investigation. (Evaluating Xience and Left Ventricular Function in Percutaneous Coronary Intervention on Occlusions After ST-Segment Elevation Myocardial Infarction; NTR1108)

Published
2016
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31. Long-term impact of chronic total occlusion recanalisation in patients with ST-elevation myocardial infarction

Author

Elias, Joëlle, primary, van Dongen, Ivo M, additional, Råmunddal, Truls, additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Meuwissen, Martijn, additional, Michels, H Rolf, additional, Bax, Matthijs, additional, Ioanes, Dan, additional, Suttorp, Maarten Jan, additional, Strauss, Bradley H, additional, Barbato, Emanuele, additional, Marques, Koen M, additional, Claessen, Bimmer E P M, additional, Hirsch, Alexander, additional, van der Schaaf, René J, additional, Tijssen, Jan G P, additional, Henriques, José P S, additional, and Hoebers, Loes P, additional

Published
2018
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32. Percutaneous Intervention for Concurrent Chronic Total Occlusions in Patients With STEMI: The EXPLORE Trial

Author

Henriques, José P. S, Hoebers, Loes P, Råmunddal, Truls, Laanmets, Peep, Eriksen, Erlend, Bax, Matthijs, Ioanes, Dan, Suttorp, Maarten J, Strauss, Bradley H, BARBATO, EMANUELE, Nijveldt, Robin, van Rossum, Albert C, Marques, Koen M, Elias, Joëlle, van Dongen, Ivo M, Claessen, Bimmer E. P. M, Tijssen, Jan G, van der Schaaf, René J., Henriques, José P. S, Hoebers, Loes P, Råmunddal, Trul, Laanmets, Peep, Eriksen, Erlend, Bax, Matthij, Ioanes, Dan, Suttorp, Maarten J, Strauss, Bradley H, Barbato, Emanuele, Nijveldt, Robin, van Rossum, Albert C, Marques, Koen M, Elias, Joëlle, van Dongen, Ivo M, Claessen, Bimmer E. P. M, Tijssen, Jan G, and van der Schaaf, René J.

Subjects
ST-segment elevation myocardial infarction, chronic total occlusion percutaneous coronary intervention
Abstract

In 10% to 15% of patients with ST-segment elevation myocardial infarction (STEMI), concurrent coronary chronic total occlusion (CTO) in a non-infarct-related artery is present and is associated with increased morbidity and mortality.

Published
2016

33. TCT-19 Mid- and long-term outcome of the EXPLORE trial, a Global, Randomized, Prospective, Multicenter Trial Investigating the Impact of Recanalization of a Chronic Total Occlusion in Patients after Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction

Author

Elias, Joelle, primary, van Dongen, Ivo M., additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Meuwissen, Martijn, additional, Bax, Matthijs, additional, Ioanes, Dan, additional, Suttorp, Maarten, additional, Strauss, Bradley, additional, Barbato, Emanuele, additional, Marques, Koen, additional, Claessen, Bimmer E.P.M., additional, Hirsch, Alexander, additional, van der Schaaf, Rene, additional, Tijssen, Jan, additional, Hoebers, Loes P., additional, and Henriques, Jose P.S., additional

Published
2017
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34. Microvascular dysfunction following ST-elevation myocardial infarction and its recovery over time

Author

Hassell, Mariëlla, primary, Bax, Matthijs, additional, van Lavieren, Martijn, additional, Nijveldt, Robin, additional, Hirsch, Alexander, additional, Robbers, Lourens, additional, Marques, Koen, additional, Tijssen, Jan, additional, Zijlstra, Felix, additional, van Rossum, Albert, additional, Delewi, Ronak, additional, and Piek, Jan, additional

Published
2017
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36. Organization of outcome-based quality improvement in Dutch heart centres.

Author

van Veghel, Dennis, Daeter, Edgar J, Bax, Matthijs, Amoroso, Giovanni, Blaauw, Yuri, Camaro, Cyril, Cummins, Paul, Halfwerk, Frank R, Wijdh-den Hamer, Inez J, de Jong, Jonas S S G, Stooker, Wim, van der Wees, Philip J, and van der Nat, Paul B

Abstract

Fourteen Dutch heart centres collected patient-relevant outcomes to support quality improvements in a value-based healthcare initiative that began in 2012. This study aimed to evaluate the current state of outcome-based quality improvement within six of these Dutch heart centres.

Published
2020
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37. Time course of coronary flow capacity impairment in ST-segment elevation myocardial infarction

Author

van Lavieren, Martijn A, Stegehuis, Valérie E, Bax, Matthijs, Echavarría-Pinto, Mauro, Wijntjens, Gilbert WM, de Winter, Robbert J, Koch, Karel T, Henriques, José P, Escaned, Javier, Meuwissen, Martijn, van de Hoef, Tim P, and Piek, Jan J

Abstract

Background Microvascular dysfunction in the setting of ST-elevated myocardial infarction (STEMI) plays an important role in long-term poor clinical outcome. Coronary flow reserve (CFR) is a well-established physiological parameter to interrogate the coronary microcirculation. Together with hyperaemic average peak flow velocity, CFR constitutes the coronary flow capacity (CFC), a validated risk stratification tool in ischaemic heart disease with significant prognostic value. This mechanistic study aims to elucidate the time course of the microcirculation as reflected by alterations in microcirculatory physiological parameters in the acute phase and during follow-up in STEMI patients.Methods We assessed CFR and CFC in the culprit and non-culprit vessel in consecutive STEMI patients at baseline (n= 98) and after one-week (n= 64) and six-month follow-up (n= 65).Results A significant trend for culprit CFC in infarct size as determined by peak troponin T (p= 0.004), time to reperfusion (p= 0.038), the incidence of final Thrombolysis In Myocardial Infarction 3 flow (p= 0.019) and systolic retrograde flow (p= 0.043) was observed. Non-culprit CFC linear contrast analysis revealed a significant trend in C-reactive protein (p= 0.027), peak troponin T (p< 0.001) and heart rate (p= 0.049). CFC improved both in the culprit and the non-culprit vessel at one-week (both p< 0.001) and six-month follow-up (p= 0.0013 and p< 0.001) compared with baseline.Conclusion This study demonstrates the importance of microcirculatory disturbances in the setting of STEMI, which is relevant for the interpretation of intracoronary diagnostic techniques which are influenced by both culprit and non-culprit vascular territories. Assessment of non-culprit vessel CFC in the setting of STEMI might improve risk stratification of these patients following coronary reperfusion of the culprit vessel.

Published
2024
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38. TCT-8 First results of the EXPLORE trial, a Global, Randomized, Prospective, Multicenter Trial Investigating the Impact of Recanalization of a Chronic Total Occlusion on Left Ventricular Function in Patients after Primary Percutaneous Coronary Intervention for Acute ST-Elevation Myocardial Infarction

Author

Henriques, Jose P., primary, Hoebers, Loes, additional, Råmunddal, Truls, additional, Laanmets, Peep, additional, Eriksen, Erlend, additional, Bax, Matthijs, additional, Ioanes, Dan, additional, Suttorp, Maarten J., additional, Strauss, Bradley, additional, Barbato, Emanuele, additional, Nijveldt, Robin, additional, van Rossum, Albert C., additional, Marques, Koen, additional, Tijssen, Jan G., additional, and van der Schaaf, Rene J., additional

Published
2015
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39. Rationale and design of EXPLORE: a randomized, prospective, multicenter trial investigating the impact of recanalization of a chronic total occlusion on left ventricular function in patients after primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

Author

van der Schaaf, Rene J., Claessen, Bimmer E., Hoebers, Loes P., Verouden, Niels J., Koolen, Jacques J., Suttorp, Maarten J., Barbato, Emanuele, Bax, Matthijs, Strauss, Bradley H., Olivecrona, Goran K., Tuseth, Vegard, Glogar, Dietmar, Ramunddal, Truls, Tijssen, Jan G., Piek, Jan J., Henriques, Jose P., Investigators, Explore, Faculteit der Geneeskunde, Cardiology, ACS - Amsterdam Cardiovascular Sciences, Graduate School, van der Schaaf, R. J., Claessen, B. E., Hoebers, L. P., Verouden, N. J., Koolen, J. J., Suttorp, M. J., Barbato, Emanuele, Bax, M., Strauss, B. H., Olivecrona, G. K., Tuseth, V., Glogar, D. j., Råmunddal, T., Tijssen, J. G., Piek, J. J., and Henriques, J. P. S.

Subjects
medicine.medical_treatment, Left, Myocardial Infarction, recanalization, Study Protocol, Clinical Protocols, heart contraction, dipeptidyl carboxypeptidase inhibitor, Drug-Eluting Stent, acetylsalicylic acid, antilipemic agent, beta adrenergic receptor blocking agent, clopidogrel, everolimus, prasugrel, cardiovascular agent, drug derivative, rapamycin, acute disease, artery occlusion, article, chronic total occlusion, clinical research, clinical trial, controlled clinical trial, controlled study, follow up, heart left ventricle enddiastolic volume, heart left ventricle function, heart ventricle remodeling, human, major clinical study, methodology, multicenter study, nuclear magnetic resonance imaging, percutaneous coronary intervention, randomized controlled trial, ST segment elevation myocardial infarction, Canada, chronic disease, clinical protocol, convalescence, drug eluting stent, Europe, heart infarction, heart stroke volume, instrumentation, pathophysiology, prospective study, prosthesis, time, transluminal coronary angioplasty, treatment outcome, Angioplasty, Balloon, Coronary, Cardiovascular Agents, Chronic Disease, Coronary Occlusion, Drug-Eluting Stents, Humans, Magnetic Resonance Imaging, Myocardial Contraction, Ontario, Prospective Studies, Prosthesis Design, Recovery of Function, Research Design, Sirolimus, Stroke Volume, Time Factors, Treatment Outcome, Ventricular Function, Sirolimu, Pharmacology (medical), Cardiac and Cardiovascular Systems, Myocardial infarction, Angioplasty, Balloon, Coronary, treatment outcome, Angioplasty, Balloon, Coronary, cardiovascular system, lcsh:Medicine (General), medicine.medical_specialty, Multicenter trial, Everolimus, medicine.disease, Prospective Studie, Myocardial infarction complications, rapamycin, acute disease, Medicine (miscellaneous), Ventricular Function, Left, lcsh:R5-920, prosthesi, Cardiology, Time Factor, Internal medicine, Coronary stent, medicine, cardiovascular diseases, Ventricular remodeling, business.industry, everolimu, Percutaneous coronary intervention, Surgery, Coronary occlusion, business
Abstract

Background In the setting of primary percutaneous coronary intervention, patients with a chronic total occlusion in a non-infarct related artery were recently identified as a high-risk subgroup. It is unclear whether ST-elevation myocardial infarction patients with a chronic total occlusion in a non-infarct related artery should undergo additional percutaneous coronary intervention of the chronic total occlusion on top of optimal medical therapy shortly after primary percutaneous coronary intervention. Possible beneficial effects include reduction in adverse left ventricular remodeling and preservation of global left ventricular function and improved clinical outcome during future coronary events. Methods/Design The Evaluating Xience V and left ventricular function in Percutaneous coronary intervention on occLusiOns afteR ST-Elevation myocardial infarction (EXPLORE) trial is a randomized, prospective, multicenter, two-arm trial with blinded evaluation of endpoints. Three hundred patients after primary percutaneous coronary intervention for ST-elevation myocardial infarction with a chronic total occlusion in a non-infarct related artery are randomized to either elective percutaneous coronary intervention of the chronic total occlusion within seven days or standard medical treatment. When assigned to the invasive arm, an everolimus-eluting coronary stent is used. Primary endpoints are left ventricular ejection fraction and left ventricular end-diastolic volume assessed by cardiac Magnetic Resonance Imaging at four months. Clinical follow-up will continue until five years. Discussion The ongoing EXPLORE trial is the first randomized clinical trial powered to investigate whether recanalization of a chronic total occlusion in a non-infarct related artery after primary percutaneous coronary intervention for ST-elevation myocardial infarction results in a better preserved residual left ventricular ejection fraction, reduced end-diastolic volume and enhanced clinical outcome. Trial registration trialregister.nl NTR1108.

Published
2010

40. Impaired Coronary Autoregulation Is Associated With Long-term Fatal Events in Patients With Stable Coronary Artery Disease

Author

van de Hoef, Tim P., primary, Bax, Matthijs, additional, Damman, Peter, additional, Delewi, Ronak, additional, Hassell, Mariëlla E.C.J., additional, Piek, Martijn A., additional, Chamuleau, Steven A.J., additional, Voskuil, Michiel, additional, van Eck-Smit, Berthe L.F., additional, Verberne, Hein J., additional, Henriques, José P.S., additional, Koch, Karel T., additional, de Winter, Robbert J., additional, Tijssen, Jan G.P., additional, Piek, Jan J., additional, and Meuwissen, Martijn, additional

Published
2013
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41. Impact of Coronary Microvascular Function on Long-term Cardiac Mortality in Patients With Acute ST-Segment–Elevation Myocardial Infarction

Author

van de Hoef, Tim P., primary, Bax, Matthijs, additional, Meuwissen, Martijn, additional, Damman, Peter, additional, Delewi, Ronak, additional, de Winter, Robbert J., additional, Koch, Karel T., additional, Schotborgh, Carl, additional, Henriques, José P.S., additional, Tijssen, Jan G.P., additional, and Piek, Jan J., additional

Published
2013
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43. Response to Michiels et al and Sen et al Regarding Article, “Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions: Adenosine-Free Assessment of Functional Coronary Lesion Severity”

Author

van de Hoef, Tim P., primary, Nolte, Froukje, additional, Siebes, Maria, additional, Spaan, Jos AE, additional, Damman, Peter, additional, Delewi, Ronak, additional, Tijssen, Jan GP, additional, Piek, Jan J., additional, Bax, Matthijs, additional, Chamuleau, Steven AJ, additional, Voskuil, Michiel, additional, and Meuwissen, Martijn, additional

Published
2012
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44. Abstract 18654: Impaired Coronary Microvascular Function is Independently Associated with Fatal Cardiac Events at Long-term Follow-Up in Patients with Stable Coronary Artery Disease

Author

van de Hoef, Tim P, primary, Bax, Matthijs, additional, Damman, Peter, additional, Delewi, Ronak, additional, Hassell, Mariëlla E, additional, Chamuleau, Steven A, additional, Voskuil, Michiel, additional, Tijssen, Jan G, additional, Piek, Jan J, additional, and Meuwissen, Martijn, additional

Published
2012
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45. Diagnostic Accuracy of Combined Intracoronary Pressure and Flow Velocity Information During Baseline Conditions

Author

van de Hoef, Tim P., primary, Nolte, Froukje, additional, Damman, Peter, additional, Delewi, Ronak, additional, Bax, Matthijs, additional, Chamuleau, Steven A.J., additional, Voskuil, Michiel, additional, Siebes, Maria, additional, Tijssen, Jan G.P., additional, Spaan, Jos A.E., additional, Piek, Jan J., additional, and Meuwissen, Martijn, additional

Published
2012
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46. REFERENCE CORONARY FLOW VELOCITY RESERVE DETERMINED AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR A FIRST ACUTE ANTERIOR MYOCARDIAL INFARCTION IS AN INDEPENDENT PREDICTOR OF CARDIAC MORTALITY AT LONG TERM FOLLOW UP

Author

van de Hoef, Tim P., primary, Bax, Matthijs, additional, Meuwissen, Martijn, additional, Damman, Peter, additional, Delewi, Ronak, additional, de Winter, Robbert, additional, Th Koch, Karel, additional, Schotborgh, Carl, additional, Henriques, José, additional, Tijssen, Jan, additional, and Piek, Jan, additional

Published
2012
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47. INCREASED REFERENCE AND ABSOLUTE CORONARY FLOW RESERVE AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR A FIRST ACUTE ANTERIOR MYOCARDIAL INFARCTION ARE ASSOCIATED WITH SURVIVAL AT 10 YEARS FOLLOW-UP

Author

Bax, Matthijs, primary, Meuwissen, Martijn, additional, van de Hoef, Tim, additional, de Winter, Robbert J., additional, Koch, Karel T., additional, Tijssen, Jan GP, additional, Delewi, Ronak, additional, Schotborgh, Carl E., additional, Henriques, Jose PS, additional, and Piek, Jan J., additional

Published
2011
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48. Relationship between In Vitro Lipopolysaccharide-Induced Cytokine Response in Whole Blood, Angiographic In-Stent Restenosis, and Toll-Like Receptor 4 Gene Polymorphisms

Author

Rittersma, Saskia ZH, primary, Kremer Hovinga, Johanna A, primary, Koch, Karel T, primary, Boekholdt, S Matthijs, primary, van Aken, Benien E, primary, Scheepmaker, Arko, primary, Bax, Matthijs, primary, Schotborgh, Carl E, primary, Piek, Jan J, primary, Tijssen, Jan GP, primary, Reitsma, Pieter H, primary, and de Winter, Robbert J, primary

Published
2005
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49. Preprocedural C-Reactive Protein Is Not Associated with Angiographic Restenosis or Target Lesion Revascularization after Coronary Artery Stent Placement

Author

Rittersma, Saskia Z H, primary, de Winter, Robbert J, primary, Koch, Karel T, primary, Schotborgh, Carl E, primary, Bax, Matthijs, primary, Heyde, Gerlind S, primary, van Straalen, Jan P, primary, Mulder, Karla J, primary, Tijssen, Jan G P, primary, Sanders, Gerard T, primary, and Piek, Jan J, primary

Published
2004
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50. Thrombospondin gene polymorphisms and the risk of angiographic coronary in-stent restenosis

Author

Rittersma, Saskia Z.H., primary, Boekholdt, S.Matthijs, additional, Koch, Karel T., additional, Geuzebroek, Reina, additional, Bax, Matthijs, additional, Schotborgh, Carl E., additional, Eckmann, Hetty, additional, Peters, Ron J.G., additional, Piek, Jan J., additional, Tijssen, Jan G., additional, Reitsma, Pieter H., additional, and de Winter, Robbert J., additional

Published
2004
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