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3. Sex-Specific Risk Factors and Health Disparity Among Hepatitis C Positive Patients Receiving Pharmacotherapy for Opioid Use Disorder: Findings From a Propensity Matched Analysis

Author

Dennis, Brittany B., Martin, Leslie J., Naji, Leen, Akhtar, Daud, Cholankeril, George, Kim, Donghee, Sanger, Nitika, Hillmer, Alannah, Chawar, Caroul, D’Elia, Alessia, Panesar, Balpreet, Worster, Andrew, Marsh, David C., O’Shea, Tim, Bawor, Monica, Thabane, Lehana, Samaan, Zainab, and Ahmed, Aijaz

Published
2022
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5. Sex differences in social risk factors for suicidal behaviour

Author

Eisen, Rebecca B., Perera, Stefan, Bawor, Monica, Dennis, Brittany B., Bhatt, Meha, Zielinski, Laura, El-Sheikh, Wala, DeJesus, Jane, Rangarajan, Sumathy, Sholer, Heather, Iordan, Elisabeth, Mackie, Pam, Islam, Shofiqul, Dehghan, Mahshid, Brasch, Jennifer, Anglin, Rebecca, Minuzzi, Luciano, Thabane, Lehana, and Samaan, Zainab

Published
2017
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6. Feasibility of behavioral activation group therapy in reducing depressive symptoms and improving quality of life in patients with depression: the BRAVE pilot trial

Author

D’Elia, Alessia, Bawor, Monica, Dennis, Brittany B., Bhatt, Meha, Litke, Kathryn, McCabe, Kathleen, Whattam, Jeff, Garrick, Laura, O’Neill, Laura, Simons, Scott, Chalmers, Sandra, Key, Brenda, Goyert, Stefanie, Laplante, Phillip, Vanstone, Meredith, Xie, Feng, Guyatt, Gordon, Thabane, Lehana, and Samaan, Zainab

Published
2020
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8. A call for consensus in defining efficacy in clinical trials for opioid addiction: combined results from a systematic review and qualitative study in patients receiving pharmacological assisted therapy for opioid use disorder

Author

Dennis, Brittany B., Sanger, Nitika, Bawor, Monica, Naji, Leen, Plater, Carolyn, Worster, Andrew, Woo, Julia, Bhalerao, Anuja, Baptist-Mohseni, Natasha, Hillmer, Alannah, Rice, Danielle, Corace, Kim, Hutton, Brian, Tugwell, Peter, Thabane, Lehana, and Samaan, Zainab

Published
2020
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9. Opioid Use Disorder

Author

Bawor, Monica, primary, Dennis, Brittany, additional, MacKillop, James, additional, and Samaan, Zainab, additional

Published
2017
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11. Sex-Specific Risk Factors and Health Disparity Among Hepatitis C Positive Patients Receiving Pharmacotherapy for Opioid Use Disorder: Findings From a Propensity Matched Analysis

Author

Dennis, Brittany B., primary, Martin, Leslie J., additional, Naji, Leen, additional, Akhtar, Daud, additional, Cholankeril, George, additional, Kim, Donghee, additional, Sanger, Nitika, additional, Hillmer, Alannah, additional, Chawar, Caroul, additional, D’Elia, Alessia, additional, Panesar, Balpreet, additional, Worster, Andrew, additional, Marsh, David C., additional, O’Shea, Tim, additional, Bawor, Monica, additional, Thabane, Lehana, additional, Samaan, Zainab, additional, and Ahmed, Aijaz, additional

Published
2021
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12. Age and frailty are independently associated with increased covid-19 mortality and increased care needs in survivors: results of an international multi-centre study

Author

Alsahab, Mustafa, Beishon, Lucy, Brown, Bryony, Burn, Elinor, Burton, Jenni K, Cox, Natalie, Dani, Melanie, Elhadi, Muhammed, Freshwater, Sarah, Gaunt, Victoria, Gordon, Adam, Goujon, Marie, Hale, Matthew, Hughes, Terry, Jackson, Thomas A, Jelley, Benjamin, Khan, Asma, Khiroya, Heena, Lal, Rajni, Madden, Katy, Magill, Laura, Masoli, Jane, Masud, Tahir, McCluskey, Lauren, McNeela, Natalie, Mohammedseid-Nurhussien, Awolkhier, Moorey, Hannah, Lochlainn, Mary Ni, Nirantharakumar, Krishnarajah, Okoth, Kelvin, Osuafor, Christopher N, Patterson, Katherine, Pearson, Grace M E, Perry, Rita, Pettitt, Michala, Pigott, Jennifer, Pinkney, Thomas, Quinn, Terence, Reynolds, Abigail, Richardson, Sarah, Sanyal, Nik, Seed, Adam, Sleeman, Isobel, Soo, Chee, Steves, Claire, Strain, W David, Taylor, Joanne, Torsney, Kelli, Welch, Carly, Wilson, Daisy, Witham, Miles, Elazeem, Hossam Aldein S Abd, Abdelhafez, Mohammed H, Abdelmalak, Amir, Abdelwahab, Omar A, Abdulhadi, Osama M A S, Adewole, Olubayode, Ahmad, Mohammed, Ahmed, Eltayeb A, Ahmed, Hazem, Ahmed, Islam A, Akcay, Mertcan, Akdeniz, Yeşim, Akın, Emrah, Akladious, Carolyn, Alessandri, Francesco, Ali, Ali, Aljafari, Abdulmalek, Aljafari, Abdulmoiz, Al-Sadawi, Mohammed, Al-Sodani, Lobna, Altintoprak, Fatih, Amaratungaz, Gitanjali, Amer, Jocelyn, Amini, Sylvia, Amir, Taha, Anandarajah, Cheran, Anders, Rachael, Ansari, Muhammed H, Appiah, Kingsley, Atia, Jolene, Atkin, Catherine, Aujayeb, Avinash, Awad, Elsayed M, Azab, Mohammed A, Azam, Mohammad T, Aziz, Sally, Azzam, Ahmed Y, Babar, Laxmi, Babb, Laura, Badh, Manpreet, Baguneid, Clare, Bailey, Emily, Baili, Efstratia, Baldwin, Sarah, Baloyiannis, Ioannis, Bannerjee, Moulinath, Barnard, Anna, Barra, Fabio, Bashir, Hannah, Bawor, Monica, Bayhan, Zülfü, Belcher, James, Belgamwar, Ravindra, Bentley, Corrina, Birchenough, Amy, Bo, Yen Nee J, Boden, Hayley R, Bouhuwaish, Ahmad, Brachini, Gioia, Bremner, Laura, Bridgwater, Hannah, Bryant, Catherine, Budd, Gabrielle, Budd, Sharon, Budzikoski, Adam, Bulla, Reem, Buondonno, Antonio, Burden, Nicole, Butt, Hejab, Capoglu, Recayi, Caracostea, Andra, Cardoso, Rifa, Carr, Alexis, Carrasco-Prats, Milagros, Cattel, Caterina, Ceccarelli, Giancarlo, Cecere, Giuseppe, Charalabopoulos, Alexandros, Charsley, Evelyn, Cheney-Lowe, Hannah, Chevallier, Theodore, Choudhry, Asad J, Ciccarone, Flavia, Cicerchia, Pierfranco M, Cirillo, Bruno, Collins, Fatma D, Comerford, Victoria, Cordie, Ahmed, Coulter, Siobhan, Coulthard, Nick, Cox, Catrin, Cox, Victoria, Crowe, Andrew, Cullen, Jack, Cummings, Jean, Cunningham, Niamh, Curley, Daniel, Currie, Hannah, Daly, Madeleine, Darley, Jay, Dattani, Nikhita, Davakis, Spyridon, Davies, Rowan, De Paola, Gilda, De Toma, Giorgio, Del Valle-Ruiz, Sergio, Deldar, Benyamin, Demir, Hakan, Desai, Arjun, Desai, Nirali, Devaney, Alice, Dew, Lindsey, Dhesi, Jugdeep, Dias, Maria, Dick, Gordon, Doddamani, Parveen, Dogra, Gurinder, Doll, Tina, Dooley, Hannah C, Dost, Samiullah, Dotchin, Catherine, Dowell, Hannah, Draghita, Ioan M, Dundas, James M, Duranti, Giulia, Dusara, Hiren, Dwivedi, Rajesh, Dyer, Adam H, Eastaugh, Alison, Edwards, Elinor, Elghazaly, Shrouk M, Elmehrath, Ahmed O, Elrick, Hope, El-Shazly, Mostafa, Emery, Alexander, Etchill, Eric W, Evans, Sarah, Evison, Felicity, Fairhead, Cassandra, Faulkner, Margherita, Felska, Agnieszka, Fernandez, Antia, Fernández-Fernández, Pedro V, Ferraiolo, Antonella, Ferrero, Simone, Fiori, Enrico, Firat, Necattin, Fisk, Gracie, Fleck, Anna, Fonsi, Giovanni B, Gabre-Kidan, Alodia, Gallo, Gaetano, Gandhi, Ratnam, Garner, Madeleine, Georgiou, Nikolaos, Gerretsen, Hannah, Ghannam, Nourhan A A, Ghobrial, Andrew, Ghobrial, Hedra, Ghufoor, Zaynub, Gibbon, Jake, Gilbert, Georgia F, Giles, Marie, Giménez-Francés, Clara, Gonullu, Emre, Gray, Amy, Gray, Joshua H, Green, Deirdre, Greene, Charlotte, Griffin, Ellanna, Griffith, Karla, Grubb, Anthony, Guan, Yue, Guerero, Daniel N, Gupta, Ayushi, Gustavino, Claudio, Guzman, Laurenny, Hadreiez, Ahmed K M, Hajiioannou, Jiannis, Hanji, Deevia, Madhavan, Deepthy Hari, Harmantepe, Tarık, Harrison, Patrick, Hart, Barbara, Haslam, Aidan, Haunton, Victoria, Haut, Elliott R, Heinsohn, Torben, Hennah, Lindsay, Hetta, Helal F, Hickman, Alexander, Hobill, Abigail, Hogan, Patrick C P, Hogan, Vesna, Holmes, Elizabeth, Honney, Katie, Hood, Katharine, Hopkinson, Katherine, Howells, Lara, Hrouda, Nicole, Hunsley, Danielle, Hurst, William, Hussein, Rand A, Ibrahim, Mohamed Eltaher A A, Ibtida, Ishmam, Ibukunoluwakitan, Aina, Ishlek, Irem, Iyer, Rishi, Jackson, Karl, Jackson, Rosie, James, Ellen, Jarvis, Hayley, Jeffs, Sophie, Jenko, Nathan, Jeyakumar, Sasha, Kabir, Shahriar, Kainth, Harjinder, Kalloo, Jason, Kanzaria, Akhil, Karapanou, Amalia, Kardaman, Nuha, Karthikeyan, Sandeep, Karunatilleke, Anne, Kelly, Mairead, Kelly, Nicola I, Khalid, Hesham, Khan, Haris, Khan, Muhammad S, King, Matthew, Kneen, Thomas, Kok, Li, Kratochwila, Chiara, Kuzeva, Aneliya, Lapolla, Pierfrancesco, Lau, Rebecca, Law, Kar Yee, Leadbetter, Aimee, Lee, Gabriel, Lee, Helena, Levinson, Gavriella, Lewis, Grace, Liakakos, Theodore, Lim, Stephen, Lis, Danielle, Livesey, Emma, López-Morales, Pedro, Lowes, Lily, Lunt, Eleanor, Lyon, Emily, Madan, Suvira, Majid, Zeinab, Malapati, Harsha, Man, Jade, Mandane, Baguiasri, Manning, Sarah H, Mantoglu, Baris, Martínez-Sanz, Nuria, Marx, William, Masood, Almontacer E B, Maughan, Tom, Mawhinney, Jamie, Maxfield, Dominic, Mayer, Jordan, Maynard, Henry, McDonald, Claire, McGovern, Aine, Mclachlan, Sophie, Medina-Manuel, Esther, Meneghini, Simona, Metcalf, Michelle, Millwood-Hargrave, John, Mingoli, Andrea, Miu, Kelvin, Mohamed, Fawsiya, Mohamed, Soha M, Hussein, Aliae A R Mohamed, Mohammad, Abdulkader, Mohammed, Aaliya, Momen, Ahmed A, Moomo, Farhana, Mora-Guzmán, Ismael, Moriarty, Lizzie, Morrin, Hamilton, Morris, Claire, Moss, Nicholas, Moustafa, Mohamed M, Mpoura, Maria, Mubin, Mohammed, Muhtaroglu, Ali, Muir, Georgina, Mulhern, Stephanie, Muller, Daniel, Murphy, Declan C, Muzammil, Bushra, Nadkarni, Varun, Nageh, Mariam Albatoul, NasrEldin, Yasmin K, Nawaz, Wasim, Nguyen, Hanna, Cheallaigh, Cliona Ni, Noar, Alexander, North, Samuel, Nwolu, Favour, O’Docherty, Alice, Odutola, Omoteniola, O’Dwyer, Sinead, Ogochukwu, Olebu, O’Mahony, Catherine, Orlando, Lia, Osterdahl, Marc, Page, Christina, Panayotidis, Ismini, Pancholi, Shivam, Parkin, Jessica, Passby, Lauren C, Pastor-Pérez, Patricia, Patel, Harnish, Patel, Shefali, Penfold, Rose, Perinpanathan, Rupini, Perivoliotis, Konstantinos, Perra, Teresa, Pinkney, Martha, Pinotti, Enrico, Porcu, Alberto, Price, Angeline, Pugliese, Francesco, Puri, Prabhleen, Pytraczyk, Sylvia, Qaiser, Yusra, Qurashi, Maria, Radenkovic, Dina, Rajeswaran, Thurkka, Rapaport, Sarah F, Razzak, Tahmina, Reilly, Lara, Reynolds, Paul, Richardson, Alexandra, Roberts, Amelia, Roberts-Rhodes, Charlotte, Robinson, Tanya, Rocca, Aldo, Ross-Skinner, Emily, Ruiz-Marín, Miguel, Ryall, Rebecca, Saad, Alshaimaa M, Saad, Mahmoud M, Sadiq, Ambreen, Sammarco, Giuseppe, Sampanis, Michail A, Sanghvi, Hazel, Sapienza, Paolo, Sayers, Ross, Scott, Luca, Sen, Michael, Shaban, Mosab A A, Shakespeare, Kathleen T, Shaw, Ellie, Shaw, Hannah, Sheldrake, Jonathan, Sim, Sing Yang, Simonelli, Luigi, Sipsas, Nikolaos V, Sivam, Jarita, Sivarajan, Sri, Smith, Jennifer, Speranza, Fabio, Spice, Claire, Stafford, Amanda, Stambollouian, Katharine, Stevens, Kent A, Stewart, Jack, Stratton, Emma, Street, Hannah, Surtees, Michael, Swinnerton, Emma, Taher, Ahmed S A, Tait, Caroline, Taylor, Amybel, Thake, Miriam, Thin, Katie, Thould, Hannah, Thyn, Thyn, To, Benjaman, Tobiss, Hannah, Toppley, Kathryn, Townsend, Liam, Tullo, Ellen, Tzovaras, George, Umeadi, Anthony, Vaidya, Hrisheekesh, Valero-Soriano, María, Varden, Rosanna, Vergani, Vittoria, Vervoort, Dominique, Vescio, Giuseppina, Vettasseri, Mark, Virk, Madiha, Vyas, Vaishali, Wagland, Joanne, Wallis, Stephanie, Warner, Chloe, Watkins, Eleanor, Watson, Hannah, Webb, Rachael, Welsh, Sarah H, West, Ruth, Whelan, Elisha, Whitney, Julie, Whitsey, Mark, Wilcock, Catherine, Wilkinson, Iain, Williams, David, Williamson, Megan, Willott, Ruth H, Wimalasundera, Mettha, Win, Yu Lelt, Winter, Laura, Worrall, Stephanie, Wright, Rebecca, Yeo, Natalie, Yeung, Eirene, Yigit, Merve, Yildiz, Yasin A, Yusuf, Humza, Zambon, Martina, Zaw, Hein, and Elabedeen, Omar Zein

Subjects
Male, Aging, medicine.medical_specialty, Frail Elderly, COVID-19, delirium, frailty, mortality, transitions of care, Cohort Studies, AcademicSubjects/MED00280, Interquartile range, Internal medicine, medicine, Dementia, Humans, Survivors, Aged, Proportional hazards model, business.industry, SARS-CoV-2, Hazard ratio, Odds ratio, General Medicine, medicine.disease, Confidence interval, frailty,COVID-19, Ageing, Delirium, Female, medicine.symptom, Geriatrics and Gerontology, business, Cohort study, Research Paper
Abstract

Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.

Published
2021

17. A Call for Consensus in Defining Efficacy in Clinical Trials for Opioid Addiction: Combined Results from a Systematic Review and Qualitative Study in Patients Receiving Pharmacological Assisted Therapy for Opioid Use Disorder

Author

Dennis, Brittany B., primary, Sanger, Nitika, additional, Bawor, Monica, additional, Naji, Leen, additional, Worster, Andrew, additional, Baptist-Mohseni, Natasha, additional, Hillmer, Alannah, additional, Rice, Danielle, additional, Corace, Kim, additional, Hutton, Brian, additional, Tugwell, Peter, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2019
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18. Full A Call for Consensus in Defining Efficacy in Clinical Trials for Opioid Addiction: Combined Results from a Systematic Review and Qualitative Study in Patients Receiving Pharmacological Assisted Therapy for Opioid Use Disorder

Author

Dennis, Brittany B., primary, Sanger, Nitika, additional, Bawor, Monica, additional, Naji, Leen, additional, Worster, Andrew, additional, Baptist-Mohseni, Natasha, additional, Hillmer, Alannah, additional, Rice, Danielle, additional, Corace, Kim, additional, Hutton, Brian, additional, Tugwell, Peter, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2019
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19. Feasibility of behavioral activation group therapy in reducing depressive symptoms and improving quality of life in patients with depression: the BRAVE pilot trial.

Author

D'Elia, Alessia, Bawor, Monica, Dennis, Brittany B., Bhatt, Meha, Litke, Kathryn, McCabe, Kathleen, Whattam, Jeff, Garrick, Laura, O'Neill, Laura, Simons, Scott, Chalmers, Sandra, Key, Brenda, Goyert, Stefanie, Laplante, Phillip, Vanstone, Meredith, Xie, Feng, Guyatt, Gordon, Thabane, Lehana, and Samaan, Zainab

Subjects
GROUP psychotherapy, COGNITIVE therapy, QUALITY of life, MENTAL depression, SUPPORT groups
Abstract

Background: Depression impacts the lives of millions of people worldwide. Behavioral activation (BA), derived from cognitive behavioral therapy, has the potential for improving depressive symptoms in patients with depression. Studies evaluating the effectiveness of BA specifically in the context of group therapy programs in a hospital setting for patients with depression are limited. In this study, we report findings from a pilot trial evaluating group BA for major depressive disorder. Objective: The objectives of this pilot trial are to assess the potential of a full trial of BA group therapy in a large-scale tertiary care setting and to provide preliminary information about possible results regarding mood symptoms and quality of life in adults with depression. Methods: Using a parallel single-cohort pragmatic pilot randomized controlled trial design, we evaluated the potential of conducting a large trial of BA effectiveness among adults with depression. Participants were randomized to the intervention (BA in addition to usual care) or control (support group in addition to usual care) groups and were assessed weekly for 18 consecutive weeks. Participants randomized to intervention underwent 28 2-h group BA therapy visits administered by trained therapists and completed assessments to examine treatment outcomes. Feasibility was measured in terms of enrollment rates (min. 20%), completion rates of study (min. 80%), and completion rates of weekly measurement scales (min. 80%). The reporting of this pilot trial is in accordance with the CONSORT extension for randomized pilot and feasibility trials. Results: We randomized 20 individuals of mean age of 48.8 years (standard deviation = 9.7) with a DSM-5 diagnosis of major depressive disorder to intervention (n = 10) or control (n = 10) groups. Based on our feasibility criteria, our recruitment rate was excellent (20/27; 74%), study completion was found to be a moderate (80% of the total participants in both arms completed the study; BA = 100%, control = 60%), and completeness of measurements on a weekly basis was adequate overall (82%; BA = 86%, control = 79%). Conclusions: The study has demonstrated the potential feasibility to perform a larger scale trial upon modifications to the control group to avoid the low rate of study completion (60%) in this group. Trial registration: ClinicalTrials NCT02045771, Registered January 22, 2014 [ABSTRACT FROM AUTHOR]

Published
2020
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20. 48 Trials and tribulations of establishing treatment effectiveness in addiction research

Author

Dennis, Brittany, primary, Bawor, Monica, additional, Naji, Leen, additional, Boner, Ashley, additional, Roshanov, Pavel, additional, Paul, James, additional, Worster, Andrew, additional, Marsh, David C, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Plater, Carolyn, additional, Desai, Dipika, additional, Pare, Guillaume, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2018
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24. Adverse outcomes associated with opioid prescription for acute low back pain: a systematic review protocol

Author

Mouravska, Natalia, primary, Zielinski, Laura, additional, Bhatt, Meha, additional, Sanger, Nitika, additional, Bawor, Monica, additional, Dennis, Brittany, additional, Banfield, Laura, additional, MacKillop, James, additional, Paul, James, additional, Worster, Andrew, additional, Laplante, Philip, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2017
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26. The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy

Author

Naji, Leen, primary, Dennis, Brittany Burns, additional, Bawor, Monica, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Marsh, David C., additional, Worster, Andrew, additional, Desai, Dipika, additional, MacKillop, James, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2017
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27. SEX AND GENDER DIFFERENCES IN THE MANAGEMENT AND TREATMENT OF OPIOID ADDICTION

Author

Bawor, Monica, Samaan, Zainab, and Neuroscience

Subjects
Opioids, Addiction, Sex Differences, Methadone
Abstract

Background and Objectives: Opioid addiction is a major contributor to the global burden of disease and carries a significant risk of morbidity and mortality. Individuals with opioid addiction are subject to numerous adverse consequences including infectious diseases, medical complications, psychiatric disorders, and social disintegration. Women especially experience a heightened vulnerability to the adverse medical and social consequences of opioid addiction as a result of biological sex characteristics and socially-defined gender roles, which increases their risk for poor treatment outcomes. The general objective of this thesis if to investigate sex and gender differences in the management and treatment of opioid addiction with a focus on hormonal influences, genetic variation, and sociobehavioral characteristics including substance use behavior, health status, and social functioning. Methods: Using various methodologies, we compared the biological and social characteristics of men and women with opioid addiction in the context of methadone treatment. We assessed sex and gender differences in methadone treatment outcomes using a systematic review of the literature and a meta-analysis, which was developed based on published protocol. Next, we used data from the multi-centre GENOA cross-sectional study including 250 patients with opioid addiction recruited from Ontario methadone clinics to measure testosterone levels among men and women compared to non-opioid using controls; total serum testosterone was assayed using ELISA and RIA techniques. Following this study, we conducted a systematic review and meta-analysis to test the effect of opioid use on testosterone levels, performing subgroup analyses by sex and type of opioid used. Using the previous GENOA sample, we then completed genotype analysis on variants of BDNF and DRD2 genes to test the genetic effect on continued opioid use, measured through urine drug screening. Finally, we recruited an additional 503 participants meeting criteria for opioid use disorder who were receiving treatment with methadone, from which we obtained information on drug use patterns and addiction severity using the Maudsley Addiction Profile (MAP) tool to evaluate sex and gender differences. Results: In our initial systematic review, we found 20 studies collectively showing that women were less likely than men to report alcohol use, employment, or legal involvement, but were more likely to misuse amphetamines. Using the GENOA dataset of methadone patients, we found a significant reduction in testosterone level among men but not women, which was associated with methadone dose. We also determined that testosterone did not fluctuate significantly between menstrual cycle phases. In line with these findings, our systematic review showed a significant suppression in mean testosterone level among men that use opioids compared to controls, but not in women. Our results also showed that methadone did not affect testosterone differently than other opioids. Among GENOA participants, BDNF rs6265 and DRD2 rs1799978 genetic variants were not significantly associated with continued opioid use while in methadone maintenance treatment. Our final study identified sex and gender differences in substance use, health status, and social functioning. Women were younger, had children, were current smokers, had higher rates of benzodiazepine use, more frequent physical and psychological health problems, family history of psychiatric disorders, more partner conflict, and began regular use of opioids through a physician prescription. In comparison, men were more likely to be employed and to report cannabis and amphetamine use. Conclusions: This thesis has demonstrated that men and women are differentially affected by opioid addiction and experience sex- and gender-specific challenges throughout the course of methadone treatment that are likely to impact treatment outcomes. The identification of clinically-relevant sex and gender differences is important to our understanding of the addiction profile, and can therefore be used to promote strategies for effective treatment and management of opioid addiction among men and women incorporating both biological and social perspectives. Thesis Doctor of Philosophy (PhD)

Published
2015

28. The impact of comorbid psychiatric disorders on methadone maintenance treatment in opioid use disorder: a prospective cohort study

Author

Rosic,Tea, Naji,Leen, Bawor,Monica, Dennis,Brittany, Plater,Carolyn, Marsh,David, Thabane,Lehana, Samaan,Zainab, Rosic,Tea, Naji,Leen, Bawor,Monica, Dennis,Brittany, Plater,Carolyn, Marsh,David, Thabane,Lehana, and Samaan,Zainab

Abstract

Tea Rosic,1 Leen Naji,2 Monica Bawor,3 Brittany B Dennis,3 Carolyn Plater,4 David C Marsh,5 Lehana Thabane,6–8 Zainab Samaan6–11 1St Joseph’s Healthcare, 2Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; 3St George’s University of London, London, UK; 4Canadian Addiction Treatment Centre, Richmond Hill, 5Northern Ontario School of Medicine, Sudbury, 6Biostatistics Unit, Research Institute, St Joseph’s Healthcare, 7Department of Clinical Epidemiology and Biostatistics, McMaster University, 8Peter Boris Centre for Addictions Research, 9Mood Disorders Research Unit, St Joseph’s Healthcare, 10Population Genomics Program, Chanchlani Research Centre, 11Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada Objective: There is a significant interindividual variability in treatment outcomes in methadone maintenance treatment (MMT) for opioid use disorder (OUD). This prospective cohort study examines the impact of comorbid psychiatric disorders on continued illicit opioid use in patients receiving MMT for OUD. Methods: Data were collected from 935 patients receiving MMT in outpatient clinics between June 2011 and June 2015. Using linear regression analysis, we evaluated the impact of having a comorbid psychiatric disorder on continued illicit opioid use during MMT, adjusting for important confounders. The main outcome measure was percentage of opioid-positive urine screens for 6 months. We conducted a subgroup analysis to determine the influence of specific comorbid psychiatric disorders, including substance use disorders, on continued illicit opioid use. Results: Approximately 80% of participants had at least one comorbid psychiatric disorder in addition to OUD, and 42% of participants had a comorbid substance use disorder. There was no significant association between having a psychiatric comorbidity and continuing opioid use (P=0.2

Published
2017

32. The Genetics of Opioid Addiction Risk Evaluation Tool (GREAT) for Treatment Response in Methadone Patients

Author

Dennis, Brittany B., primary, Bawor, Monica, additional, Paul, James, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Worster, Andrew, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Marsh, David C., additional, Desai, Dipika, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2016
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33. Behavioral activation group therapy for reducing depressive symptoms and improving quality of life: a feasibility study

Author

Samaan, Zainab, primary, Dennis, Brittany B., additional, Kalbfleisch, Lindsay, additional, Bami, Herman, additional, Zielinski, Laura, additional, Bawor, Monica, additional, Litke, Kathryn, additional, McCabe, Kathleen, additional, Whattam, Jeff, additional, Garrick, Laura, additional, O’Neill, Laura, additional, Tabak, Terri Ann, additional, Simons, Scott, additional, Chalmers, Sandra, additional, Key, Brenda, additional, Vanstone, Meredith, additional, Xie, Feng, additional, Guyatt, Gordon, additional, and Thabane, Lehana, additional

Published
2016
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34. Exploring the Association between Serum BDNF and Attempted Suicide

Author

Eisen, Rebecca B., primary, Perera, Stefan, additional, Bawor, Monica, additional, Dennis, Brittany B., additional, El-Sheikh, Wala, additional, DeJesus, Jane, additional, Rangarajan, Sumathy, additional, Vair, Judith, additional, Sholer, Heather, additional, Hutchinson, Nicole, additional, Iordan, Elizabeth, additional, Mackie, Pam, additional, Islam, Shofiqul, additional, Dehghan, Mahshid, additional, Brasch, Jennifer, additional, Anglin, Rebecca, additional, Minuzzi, Luciano, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2016
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36. A systematic scoping review of adherence to reporting guidelines in health care literature

Author

Thabane, Lehana, Samaan,Zainab, Mbuagbaw,Lawrence, Kosa,Sarah, Borg Debono, Dillenburg, Zhang, Fruci,Vincent, Dennis,Brittany, and Bawor,Monica

Subjects
Journal of Multidisciplinary Healthcare
Abstract

Zainab Samaan,1–3 Lawrence Mbuagbaw,2 Daisy Kosa,2,4 Victoria Borg Debono,2,5 Rejane Dillenburg,6 Shiyuan Zhang2, Vincent Fruci,7 Brittany Dennis,2 Monica Bawor,8 Lehana Thabane2,5,91Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, 3Population Genomics Program, McMaster University, Hamilton, 4Department of Nephrology, Toronto General Hospital, Toronto, 5Department of Anesthesia, McMaster University, Hamilton, 6Department of Pediatrics, McMaster University, Hamilton, 7Michael G DeGroote School of Medicine, McMaster University, Hamilton, 8McMaster Integrative Neuroscience Discovery and Study (MiNDS) Program, McMaster University, Hamilton, 9Centre for Evaluation of Medicines, Hamilton, ON, CanadaBackground: Reporting guidelines have been available for the past 17 years since the inception of the Consolidated Standards of Reporting Trials statement in 1996. These guidelines were developed to improve the quality of reporting of studies in medical literature. Despite the widespread availability of these guidelines, the quality of reporting of medical literature remained suboptimal. In this study, we assess the current adherence practice to reporting guidelines; determine key factors associated with better adherence to these guidelines; and provide recommendations to enhance adherence to reporting guidelines for future studies.Methods: We undertook a systematic scoping review of systematic reviews of adherence to reporting guidelines across different clinical areas and study designs. We searched four electronic databases (Cumulative Index to Nursing and Allied Health Literature, Web of Science, Embase, and Medline) from January 1996 to September 2012. Studies were included if they addressed adherence to one of the following guidelines: Consolidated Standards of Reporting Trials (CONSORT), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), Quality of Reporting of Meta-analysis (QUOROM), Transparent Reporting of Evaluations with Nonrandomized Designs (TREND), Meta-analysis Of Observational Studies in Epidemiology (MOOSE) and Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). A protocol for this study was devised. A literature search, data extraction, and quality assessment were performed independently by two authors in duplicate. This study reporting follows the PRISMA guidelines.Results: Our search retrieved 5159 titles, of which 50 were eligible. Overall, 86.0% of studies reported suboptimal levels of adherence to reporting guidelines. Factors associated with better adherence included journal impact factor and endorsement of guidelines, publication date, funding source, multisite studies, pharmacological interventions and larger studies.Conclusion: Reporting guidelines in the clinical literature are important to improve the standards of reporting of clinical studies; however, adherence to these guidelines remains suboptimal. Action is therefore needed to enhance the adherence to these standards. Strategies to enhance adherence include journal editorial policies endorsing these guidelines.Keywords: scoping, systematic, review, adherence, reporting, guidelines

Published
2013

37. A Prospective Study to Investigate Predictors of Relapse among Patients with Opioid Use Disorder Treated with Methadone

Author

Naji, Leen, primary, Dennis, Brittany B., additional, Bawor, Monica, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Worster, Andrew, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Marsh, David C., additional, Desai, Dipika, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2016
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38. Sex differences in substance use, health, and social functioning among opioid users receiving methadone treatment: a multicenter cohort study

Author

Bawor, Monica, primary, Dennis, Brittany B., additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Marsh, David C., additional, Plater, Carolyn, additional, Worster, Andrew, additional, Steiner, Meir, additional, Anglin, Rebecca, additional, Pare, Guillaume, additional, Desai, Dipika, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2015
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39. Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria

Author

Dennis, Brittany B., primary, Roshanov, Pavel S., additional, Naji, Leen, additional, Bawor, Monica, additional, Paul, James, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Worster, Andrew, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Marsh, David C., additional, Desai, Dipika, additional, Samaan, Zainab, additional, and Thabane, Lehana, additional

Published
2015
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40. Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study

Author

Bawor, Monica, primary, Dennis, Brittany B., additional, Tan, Charlie, additional, Pare, Guillaume, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Plater, Carolyn, additional, Worster, Andrew, additional, Marsh, David C., additional, Steiner, Meir, additional, Anglin, Rebecca, additional, Desai, Dipika, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2015
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41. Exploring the Determinants of Suicidal Behavior: Conventional and Emergent Risk (DISCOVER): a feasibility study

Author

Samaan, Zainab, primary, Bawor, Monica, additional, Dennis, Brittany B., additional, El-Sheikh, Wala, additional, DeJesus, Jane, additional, Rangarajan, Sumathy, additional, Vair, Judith, additional, Sholer, Heather, additional, Hutchinson, Nicole, additional, Iordan, Elizabeth, additional, Mackie, Pam, additional, Islam, Shofiqul, additional, Deghan, Mahshid, additional, Brasch, Jennifer, additional, and Thabane, Lehana, additional

Published
2015
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45. Testosterone suppression in opioid users: A systematic review and meta-analysis

Author

Bawor, Monica, primary, Bami, Herman, additional, Dennis, Brittany B., additional, Plater, Carolyn, additional, Worster, Andrew, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Marsh, David C., additional, Steiner, Meir, additional, Anglin, Rebecca, additional, Coote, Margaret, additional, Pare, Guillaume, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2015
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46. Impact of Chronic Pain on Treatment Prognosis for Patients with Opioid Use Disorder: A Systematic Review and Meta-analysis

Author

Dennis, Brittany B., primary, Bawor, Monica, additional, Naji, Leen, additional, Chan, Carol K., additional, Varenbut, Jaymie, additional, Paul, James, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Marsh, David C., additional, Worster, Andrew, additional, Desal, Dipika, additional, Thabane, Lehana, additional, and Samaan, Zainab, additional

Published
2015
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47. Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation

Author

Dennis,Brittany B, Samaan,M Constantine, Bawor,Monica, Paul,James, Plater,Carolyn, Pare,Guillaume, Worster,Andrew, Varenbut,Michael, Daiter,Jeff, Marsh,David C, Desai,Dipika, Thabane,Lehana, Samaan,Zainab, Dennis,Brittany B, Samaan,M Constantine, Bawor,Monica, Paul,James, Plater,Carolyn, Pare,Guillaume, Worster,Andrew, Varenbut,Michael, Daiter,Jeff, Marsh,David C, Desai,Dipika, Thabane,Lehana, and Samaan,Zainab

Abstract

Brittany B Dennis,1 M Constantine Samaan,2 Monica Bawor,3 James Paul,4 Carolyn Plater,5 Guillaume Pare,1 Andrew Worster,6 Michael Varenbut,5 Jeff Daiter,5 David C Marsh,5,7 Dipika Desai,8 Lehana Thabane,1,9,10 Zainab Samaan1,8,11 1Department of Clinical Epidemiology and Biostatistics, 2Department of Pediatrics, Division of Pediatric Endocrinology, 3McMaster Integrative Neuroscience Discovery and Study Program, 4Department of Anesthesia, McMaster University, Hamilton, 5Ontario Addiction Treatment Centres, Richmond Hill, 6Department of Medicine, Hamilton General Hospital, Hamilton, 7Northern Ontario School of Medicine, Sudbury, 8Population Genomics Program, Chanchlani Research Centre, McMaster University, Hamilton, 9Centre for Evaluation of Medicine, 10System Linked Research Unit, Hamilton, 11Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada Background: Chronic pain is the most commonly reported comorbidity among patients with opioid addiction receiving methadone maintenance treatment (MMT), with an estimated prevalence ranging between 30% and 55%. Evidence suggests that patients with comorbid pain are at high risk for poor treatment response, including continued illicit substance use. Due to the important relationship between the presence of pain and illicit substance abuse within the MMT setting, it is imperative that we target our efforts toward understanding the characteristics of this patient population.Methods: The primary objective of this study was to explore the clinical and inflammatory profile of MMT patients reporting comorbid pain. This multicenter study enrolled patients (n=235) on MMT for the treatment of opioid dependence. Clinical history and blood and urine data were collected. Blood samples were obtained for estimating the serum levels of inflammatory markers (tumor necrosis factor [TNF]-α, interleukin-1 receptor antagonist [IL-1ra], IL-6, IL-8, IL-10, interferon [IFN]-γ an

Published
2014

48. Genetic influence on methadone treatment outcomes in patients undergoing methadone maintenance treatment for opioid addiction: a pilot study

Author

Samaan,Zainab, Bawor,Monica, Dennis,Brittany B, Plater,Carolyn, Varenbut,Michael, Daiter,Jeffrey, Worster,Andrew, Marsh,David C, Tan,Charlie, Desai,Dipika, Thabane,Lehana, Pare,Guillaume, Samaan,Zainab, Bawor,Monica, Dennis,Brittany B, Plater,Carolyn, Varenbut,Michael, Daiter,Jeffrey, Worster,Andrew, Marsh,David C, Tan,Charlie, Desai,Dipika, Thabane,Lehana, and Pare,Guillaume

Abstract

Zainab Samaan,1–4 Monica Bawor,3,4 Brittany B Dennis,2,3 Carolyn Plater,5 Michael Varenbut,5 Jeffrey Daiter,5 Andrew Worster,5,6 David C Marsh,5,7 Charlie Tan,8 Dipika Desai,3 Lehana Thabane,2,9,10 Guillaume Pare11 1Department of Psychiatry and Behavioural Neurosciences, 2Department of Clinical Epidemiology and Biostatistics, 3Population Genomics Program, Chanchlani Research Centre, 4MiNDS Neuroscience Program, McMaster University, Hamilton, Ontario, Canada; 5Ontario Addiction Treatment Centres, Richmond Hill, Ontario, Canada; 6Department of Medicine, McMaster University, Hamilton, Ontario, Canada; 7Northern Ontario School of Medicine, Laurentian University, Sudbury, Ontario, Canada; 8Michael G. DeGroote School of Medicine, McMaster University, 9Biostatistics Unit, Centre for Evaluation of Medicine, 10System Linked Research Unit, 11Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Introduction: Treatment of opioid addiction with methadone is effective; however, it is known to produce interindividual variability. This may be influenced in part by genetic variants, which can increase the initial risk of developing opioid addiction as well as explain differences in response to treatment. This pilot study aimed to assess the feasibility of conducting a full-scale genetic analysis to identify genes that predict methadone treatment outcomes in this population. Methods: This was a cross-sectional observational study of patients admitted to a methadone maintenance treatment program for opioid addiction. We obtained demographic and clinical characteristics in addition to blood and urine samples, for the assessment of treatment outcomes. Results: The recruitment process yielded 252 patients, representing a 20% recruitment rate. We conducted genetic testing based on a 99.6% rate of provision of DNA samples. The average retention in treatment was 3.4 years, and >50% of the participants reported psychiatric and medica

Published
2014

50. Evaluation of clinical and inflammatory profile in opioid addiction patients with comorbid pain: results from a multicenter investigation

Author

Samaan, Zainab, primary, Samaan, M. Constantine, additional, Bawor, Monica, additional, Paul, James, additional, Plater, Carolyn, additional, Pare, Guillaume, additional, Worster, Andrew, additional, Varenbut, Michael, additional, Daiter, Jeff, additional, C. Marsh, David, additional, Desai, Dipika, additional, Thabane, Lehana, additional, and Burns Dennis, Brittany, additional

Published
2014
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