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180 results on '"Bautsch, W."'

4. Anaphylatoxins in the pathogenesis of asthma

Author

Heinzmann Andrea, Bautsch W, Hoymann HG, Zhang Q, Meier-Wiedenbach I, Raschke U, Ames RS, Sohns B, Flemme N, Meyer zu Vilsendorf A, Grove M, Klos A, and Kohl J

Subjects
Anaphylatoxin C3a, asthma, C3a-receptor, guinea pig model of asthma, Diseases of the respiratory system, RC705-779
Published
2000
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8. Erfolgsfaktoren für Gesundheitsnetzwerke am Beispiel eHealth.Braunschweig

Author

Plischke, M, Bartkiewicz, T, Bautsch, W, Gerlach, A, Gusew, N, Goldapp, M, Haux, R, Heller, U, Kierdorf, H, Kleinschmidt, T, Ludwig, W, Markurth, U, Pfingsten-Würzburg, S, Reilmann, H, Schubert, R, Plischke, M, Bartkiewicz, T, Bautsch, W, Gerlach, A, Gusew, N, Goldapp, M, Haux, R, Heller, U, Kierdorf, H, Kleinschmidt, T, Ludwig, W, Markurth, U, Pfingsten-Würzburg, S, Reilmann, H, and Schubert, R

Published
2011

9. Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury

Author

Heller, T., Hennecke, M., Baumann, U., Gessner, J. E., Meyer Zu Vilsendorf, A., Baensch, M., Boulay, F., Kola, A., Klos, A., Bautsch, W., and Köhl, J.

Subjects
Neutrophils, Immunology, Complement C5a, Peritonitis, Binding, Competitive, Cell Degranulation, Mice, Antigens, CD, Cell Movement, Peptide Library, Arthus Reaction, Immunology and Allergy, Animals, Humans, Immune Complex Diseases, Lung, Receptor, Anaphylatoxin C5a, Skin, Mice, Inbred BALB C, Cell Differentiation, U937 Cells, Receptors, Complement, Chemotaxis, Leukocyte, Amino Acid Substitution, Reperfusion Injury, Cell Migration Inhibition, Macrophages, Peritoneal, Mutagenesis, Site-Directed, Female, Bacteriophage M13
Abstract

A C5a-receptor antagonist was selected from human C5a phage display libraries in which the C terminus of des-Arg74-hC5a was mutated. The selected molecule is a competitive C5a receptor antagonist in vitro and in vivo. Signal transduction is interrupted at the level of G-protein activation. In addition, the antagonist does not cause any C5a receptor phosphorylation. Proinflammatory properties such as chemotaxis or lysosomal enzyme release of differentiated U937 cells, as well as C5a-induced changes in intracellular Ca2+ concentration of murine peritoneal macrophages, are inhibited. The in vivo efficacy was evaluated in three different animal models of immune complex diseases in mice, i.e., the reverse passive Arthus reaction in the peritoneum, skin, and lung. The i.v. application of the C5a receptor antagonist abrogated polymorphonuclear neutrophil accumulation in peritoneum and markedly attenuated polymorphonuclear neutrophil migration into the skin and the lung. In a model of intestinal ischemia/reperfusion injury, i.v. administration of the C5a receptor antagonist decreased local and remote tissue injury: bowel wall edema and hemorrhage as well as pulmonary microvascular dysfunction. These data give evidence that C5a is an important mediator triggering the inflammatory sequelae seen in immune complex diseases and ischemia/reperfusion injury. The selected C5a receptor antagonist may prove useful to attenuate the inflammatory response in these disorders.

Published
1999

10. A Regional health care network: eHealth.Braunschweig. Domain fields and architectural challenges.

Author

Gusew N, Bartkiewicz T, Bautsch W, Gerlach A, Goldapp M, Haux R, Heller U, Kierdorf HP, Kleinschmidt T, Ludwig W, Markurth U, Pfingsten-Würzburg S, Plischke M, Reilmann H, Schubert R, Seidel C, Warnke R, Gusew, N, Bartkiewicz, T, and Bautsch, W

Abstract

Background: Health care network eHealth.Braunschweig has been started in the South-East region of Lower Saxony in Germany in 2009. It composes major health care players, participants from research institutions and important local industry partners.Objectives: The objective of this paper is firstly to describe the relevant regional characteristics and distinctions of the eHealth.Braunschweig health care network and to inform about the goals and structure of eHealth.Braunschweig; secondly to picture and discuss the main concepts and domain fields which are addressed in the health care network; and finally to discuss the architectural challenges of eHealth.Braunschweig regarding the addressed domain fields and defined requirements.Methods: Based on respective literature and former conducted projects we discuss the project structure and goals of eHealth.Braunschweig, depict major domain fields and requirements gained in workshops with participants and discuss the architectural challenges as well as the architectural approach of eHealth.Braunschweig network.Results: The regional healthcare network eHealth.Braunschweig has been established in April 2009. Since then the network has grown constantly and a sufficient progress in network activities has been achieved. The main domain fields have been specified in different workshops with network participants and an architectural realization approach for the transinstitutional information system architecture in the healthcare network has been developed. However, the effects on quality of information processing and quality of patient care have not been proved yet. Systematic evaluation studies have to be done in future in order to investigate the impact of information and communication technology on the quality of information processing and the quality of patient care.Conclusions: In general, the aspects described in this paper are expected to contribute to a systematic approach for the establishment of regional health care networks with lasting and sustainable effects on patient-centered health care in a regional context. [ABSTRACT FROM AUTHOR]

Published
2012
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11. A Regional Health Care Network: eHealth.Braunschweig

Author

Bartkiewicz, T., primary, Bautsch, W., primary, Gerlach, A., primary, Goldapp, M., primary, Haux, R., primary, Heller, U., primary, Kierdorf, H. P., primary, Kleinschmidt, T., primary, Ludwig, W., primary, Markurth, U., primary, Pfingsten-Würzburg, S., primary, Plischke, M., primary, Reilmann, H., primary, Schubert, R., primary, Seidel, C., primary, Warnke, R., primary, and Gusew, N., additional

Published
2012
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44. Requirements and assessment of laboratory tests: part 5 of a series on evaluation of scientific publications.

Author

Bautsch W

Abstract

BACKGROUND: Current laboratory tests exhibit high sensitivity and specificity combined with comparatively low costs thus favoring broad and uncritical ordering habits. METHODS: Introduction of Bayes' theorem and discussion of its implications for laboratory test results in a mostly non-technical form, accompanied by a selective literature review. RESULTS AND CONCLUSIONS: According to Bayes' theorem the positive predictive value of laboratory test results is directly dependent on the prevalence of the disease in a given patient cohort. Thus, the clinical value of a given test result is critically dependent on a precise indication. Ordering of tests that are not indicated in a given patient is clinically useless and undesirable, where detailed information on disease prevalence is missing. These considerations are valid irrespective of ethical or economic considerations. [ABSTRACT FROM AUTHOR]

Published
2009
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46. Successful treatment of a Trichosporon beigelii septicemia in a granulocytopenic patient with amphotericin B and granulocyte colony-stimulating factor.

Author

Grauer, M., Bokemeyer, C., Bautsch, W., Freund, M., and Link, H.

Abstract

Copyright of Infection is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1994
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47. Macrorestriction analysis of Pseudomonas aeruginosa in colonized burn patients.

Author

Pradella, S., Pletschette, M., Mantey-Stiers, F., and Bautsch, W.

Abstract

The colonization of hospitalized patients by Pseudomonas aeruginosa at an intensive care unit for burn victims was studied over a one-year period. A total of 231 isolates from 12 patients were analyzed by macrorestriction analysis. The results revealed that most patients were infected with only one to three different strains. In several patients Pseudomonas aeruginosa isolates of the same clonal lineage exhibited considerable differences in their macrorestriction fragment pattern. Digestion with further restriction enzymes, however, allowed differentiation between clonal variants due to a high genetic drift and superinfection with a different Pseudomonas aeruginosa strain. Isolates of the same clonal lineage could be isolated from several patients as well as from the patients' environment. Notably, Pseudomonas aeruginosa could be isolated from sedimentation plates. Thus, patients may have been extensively cross-infected on the ward. These data underline the importance of strict infection control measures and of regular surveillance for Pseudomonas aeruginosa by an appropriate typing method, i.e. one that can differentiate strains with high genomic variability. [ABSTRACT FROM AUTHOR]

Published
1994
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50. Chimeric receptors of the human C3a receptor and C5a receptor (CD88).

Author

Crass, T, Ames, R S, Sarau, H M, Tornetta, M A, Foley, J J, Köhl, J, Klos, A, and Bautsch, W

Abstract

Chimeras were generated between the human anaphylatoxin C3a and C5a receptors (C3aR and C5aR, respectively) to define the structural requirements for ligand binding and discrimination. Chimeric receptors were generated by systematically exchanging between the two receptors four receptor modules (the N terminus, transmembrane regions 1 to 4, the second extracellular loop, and transmembrane region 5 to the C terminus). The mutants were transiently expressed in HEK-293 cells (with or without Galpha-16) and analyzed for cell surface expression, binding of C3a and C5a, and functional responsiveness (calcium mobilization) toward C3a, C5a, and a C3a as well as a C5a analogue peptide. The data indicate that in both anaphylatoxin receptors the transmembrane regions and the second extracellular loop act as a functional unit that is disrupted by any reciprocal exchange. N-terminal substitution confirmed the two-binding site model for the human C5aR, in which the receptor N terminus is required for high affinity binding of the native ligand but not a C5a analogue peptide. In contrast, the human C3a receptor did not require the original N terminus for high affinity binding of and activation by C3a, a result that was confirmed by N-terminal deletion mutants. This indicates a completely different binding mode of the anaphylatoxins to their corresponding receptors. The C5a analogue peptide, but not C5a, was an agonist of the C3aR. Replacement of the C3aR N terminus by the C5aR sequence, however, lead to the generation of a true hybrid C3a/C5a receptor, which bound and functionally responded to both ligands, C3a and C5a.

Published
1999

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