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31 results on '"Bausys, Rimantas"'

1. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in combination with FOLFOX chemotherapy as a first-line treatment for gastric cancer patients with peritoneal metastases: single-arm phase II study

Author

Luksta, Martynas, Bausys, Augustinas, Bickaite, Klaudija, Rackauskas, Rokas, Paskonis, Marius, Luksaite-Lukste, Raminta, Ranceva, Anastasija, Stulpinas, Rokas, Brasiuniene, Birute, Baltruskeviciene, Edita, Lachej, Nadezda, Sabaliauskaite, Rasa, Bausys, Rimantas, Tulyte, Skaiste, and Strupas, Kestutis

Published
2023
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3. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Gastric Cancer Peritoneal Metastases: Results from the Lithuanian PIPAC Program.

Author

Luksta, Martynas, Bausys, Augustinas, Gendvilaite, Neda, Bickaite, Klaudija, Rackauskas, Rokas, Paskonis, Marius, Luksaite-Lukste, Raminta, Ranceva, Anastasija, Stulpinas, Rokas, Brasiuniene, Birute, Baltruskeviciene, Edita, Lachej, Nadezda, Bausiene, Juste, Poskus, Tomas, Bausys, Rimantas, Tulyte, Skaiste, and Strupas, Kestutis

Subjects
STOMACH tumors, INTRAPERITONEAL injections, PATIENT safety, ACADEMIC medical centers, AEROSOLS, EVALUATION of human services programs, IMMUNOTHERAPY, TREATMENT effectiveness, RETROSPECTIVE studies, CANCER patients, DESCRIPTIVE statistics, METASTASIS, CANCER chemotherapy, SURGICAL complications, DISEASES, DRUG efficacy, COMBINED modality therapy, PERITONEUM tumors, CANCER patient psychology, CONFIDENCE intervals, OVERALL survival
Abstract

Simple Summary: Peritoneal metastases from gastric cancer are linked to a poor prognosis, with median survival ranging from 2 to 9 months. Standard treatments, including systemic chemotherapy and targeted therapies, have demonstrated only limited effectiveness. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an experimental approach under investigation for treating these metastases, but its widespread clinical use is hindered by insufficient evidence regarding its safety and efficacy. This retrospective study presents outcomes from the first PIPAC program in Lithuania, where 32 patients underwent 71 PIPAC procedures between 2015 and 2022. Intraoperative and postoperative complications occurred in 4.2% of cases. Although reductions in peritoneal carcinomatosis index (PCI) and ascites volume were noted, they were not statistically significant. The median overall survival after PM diagnosis was 12.5 months. These findings suggest that PIPAC is a safe and feasible treatment, but further research is needed to establish its efficacy. Background: Peritoneal metastases (PM) of gastric cancer (GC) are considered a terminal condition, with reported median survival ranging from 2 to 9 months. Standard treatment typically involves systemic chemotherapy alone or combined with targeted therapy or immunotherapy, though efficacy is limited. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged as a novel technique for treating GC PM, although it remains an experimental treatment under investigation. This study aimed to summarize the outcomes of GC PM treatment with PIPAC from the Lithuanian PIPAC program. Methods: All patients who underwent PIPAC for GC PM at Vilnius University Hospital Santaros Klinikos between 2015 and 2022 were included in this retrospective study. The safety of PIPAC was assessed by postoperative complications according to the Clavien–Dindo classification. Efficacy was evaluated based on the peritoneal carcinomatosis index (PCI), ascites dynamics throughout the treatment, and long-term outcomes. Results: In total, 32 patients underwent 71 PIPAC procedures. Intraoperative and postoperative morbidity related to PIPAC occurred after three (4.2%) procedures. Following PIPAC, there was a tendency towards a decrease in median PCI from 10 (Q1 3; Q3 13) to 7 (Q1 2; Q3 12), p = 0.75, and a decrease in median ascites volume from 1300 mL (Q1 500; Q3 3600) at the first PIPAC to 700 mL (Q1 250; Q3 4750) at the last PIPAC, p = 0.56; however, these differences were not statistically significant. The median overall survival after PM diagnosis was 12.5 months (95% CI 10–17), and the median survival after the first PIPAC procedure was 5 months (95% CI 4–10). Conclusions: PIPAC is a safe and feasible treatment option for GC PM; however, well-designed prospective studies are needed to fully assess its efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Neoadjuvant Chemotherapy Followed by Gastrectomy for Cytology-Positive Gastric Cancer without Any Other Non-Curative Factors in a Western Setting: An International Eastern European Cohort Study

Author

Bausys, Augustinas, primary, Ümarik, Toomas, additional, Dobrzhanskyi, Oleksii, additional, Luksta, Martynas, additional, Kondratskyi, Yourii, additional, Reinsoo, Arvo, additional, Vassiljev, Mihhail, additional, Bausys, Bernardas, additional, Bickaite, Klaudija, additional, Rauduvyte, Kornelija, additional, Luksaite-Lukste, Raminta, additional, Bausys, Rimantas, additional, and Strupas, Kestutis, additional

Published
2023
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7. Effect of home-based prehabilitation on postoperative complications after surgery for gastric cancer: randomized clinical trial

Author

Bausys, Augustinas, primary, Luksta, Martynas, additional, Anglickiene, Giedre, additional, Maneikiene, Vyte V, additional, Kryzauskas, Marius, additional, Rybakovas, Andrius, additional, Dulskas, Audrius, additional, Kuliavas, Justas, additional, Stratilatovas, Eugenijus, additional, Macijauskiene, Lina, additional, Simbelyte, Toma, additional, Celutkiene, Jelena, additional, Jamontaite, Ieva E, additional, Cirtautas, Alma, additional, Lenickiene, Svetlana, additional, Petrauskiene, Dalia, additional, Cikanaviciute, Evelina, additional, Gaveliene, Edita, additional, Klimaviciute, Gertruda, additional, Rauduvyte, Kornelija, additional, Bausys, Rimantas, additional, and Strupas, Kestutis, additional

Published
2023
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9. Achieving Textbook Outcomes in Colorectal Cancer Surgery Is Associated with Improved Long-Term Survival: Results of the Multicenter Prospective Cohort Study.

Author

Kryzauskas, Marius, Bausys, Augustinas, Abeciunas, Vilius, Degutyte, Austeja Elzbieta, Bickaite, Klaudija, Bausys, Rimantas, and Poskus, Tomas

Subjects
COLORECTAL cancer, ONCOLOGIC surgery, PROCTOLOGY, HEALTH facilities, MINIMALLY invasive procedures
Abstract

Background: The outcomes of patients with colorectal cancer greatly depend on the quality of their surgical care. However, relying solely on a single quality indicator does not adequately capture the multifaceted nature of modern perioperative care. A new tool—"Textbook Outcome" (TO)—has been suggested to provide a comprehensive evaluation of surgical quality. This study aims to examine how TO affects the long-term outcomes of colorectal cancer patients who are scheduled for surgery. Methods: The data of all patients undergoing elective colorectal cancer resection with primary anastomosis at two major cancer treatment centers in Lithuania—Vilnius University Hospital Santaros Klinikos and National Cancer Institute—between 2014 and 2018 were entered into the prospectively maintained database. The study defined TO as a composite quality indicator that incorporated seven parameters: R0 resection, retrieval of ≥12 lymph nodes, absence of postoperative complications during the intrahospital period, hospital stay duration of fewer than 14 days, no readmission within 90 days after surgery, no reinterventions within 30 days after surgery, and no 30-day mortality. Long-term outcomes between patients who achieved TO and those who did not were compared. Factors associated with failure to achieve TO were identified. Results: Of the 1524 patients included in the study, TO was achieved by 795 (52.2%). Patients with a higher ASA score (III-IV) were identified to have higher odds of failure to achieve TO (OR 1.497, 95% CI 1.203–1.863), while those who underwent minimally invasive surgery had lower odds for similar failure (OR 0.570, 95% CI 0.460–0.706). TO resulted in improved 5-year overall—(80.2% vs. 65.5%, p = 0.001) and disease-free survival (76.6% vs. 62.6%; p = 0.001) rates. Conclusions: Elective colorectal resections result in successful TO for 52.5% of patients. The likelihood of failure to achieve TO is increased in patients with a high ASA score, while minimally invasive surgery is associated with higher TO rates. Patients who fail to achieve successful surgical outcomes experience reduced long-term outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Personalized trimodal prehabilitation for gastrectomy

Author

Bausys, Augustinas, Luksta, Martynas, Kuliavas, Justas, Anglickiene, Giedre, Maneikiene, Vyte, Gedvilaite, Lina, Celutkiene, Jelena, Jamontaite, Ieva, Cirtautas, Alma, Lenickiene, Svetlana, Vaitkeviciute, Dalia, Gaveliene, Edita, Klimaviciute, Gertruda, Bausys, Rimantas, and Strupas, Kestutis

Published
2020
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13. The problem of colorectal anastomosis safety

Author

Kryzauskas, Marius, Poskus, Eligijus, Dulskas, Audrius, Bausys, Augustinas, Jakubauskas, Matas, Imbrasaite, Ugne, Makunaite, Gabija, Kuliavas, Justas, Bausys, Rimantas, Stratilatovas, Eugenijus, Strupas, Kestutis, and Poskus, Tomas

Published
2020
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18. The optimal timing for gastrectomy after neoadjuvant chemotherapy

Author

Luksta, Martynas, primary, Ümarik, Toomas, additional, Bausys, Augustinas, additional, Reinsoo, Arvo, additional, Rackauskas, Rokas, additional, Anglickiene, Giedre, additional, Kryzauskas, Marius, additional, Tõnismäe, Kristina, additional, Senina, Veslava, additional, Seinin, Dmitrij, additional, Bausys, Rimantas, additional, and Strupas, Kestutis, additional

Published
2022
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23. Quality of Life and Bowel Function Following Early Closure of a Temporary Ileostomy in Patients with Rectal Cancer: A Report from a Single-Center Randomized Controlled Trial

Author

Dulskas, Audrius, primary, Petrauskas, Vidas, additional, Kuliavas, Justas, additional, Bickaite, Klaudija, additional, Kairys, Mikalojus, additional, Pauza, Kastytis, additional, Kilius, Alfredas, additional, Sangaila, Egidijus, additional, Bausys, Rimantas, additional, and Stratilatovas, Eugenijus, additional

Published
2021
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24. Histologic Lymph Nodes Regression after Preoperative Chemotherapy as Prognostic Factor in Non-metastatic Advanced Gastric Adenocarcinoma

Author

Bausys, Augustinas, primary, Senina, Veslava, additional, Luksta, Martynas, additional, Anglickiene, Giedre, additional, Molnikaite, Greta, additional, Bausys, Bernardas, additional, Rybakovas, Andrius, additional, Baltruskeviciene, Edita, additional, Laurinavicius, Arvydas, additional, Poskus, Tomas, additional, Bausys, Rimantas, additional, Seinin, Dmitrij, additional, and Strupas, Kestutis, additional

Published
2021
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26. Distal Gastrectomy with Billroth II Reconstruction is Associated with Oralization of Gut Microbiome and Intestinal Inflammation: A Proof-of-Concept Study

Author

Horvath, Angela, primary, Bausys, Augustinas, additional, Sabaliauskaite, Rasa, additional, Stratilatovas, Eugenijus, additional, Jarmalaite, Sonata, additional, Schuetz, Burkhard, additional, Stiegler, Philipp, additional, Bausys, Rimantas, additional, Stadlbauer, Vanessa, additional, and Strupas, Kestutis, additional

Published
2020
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27. Global variation in the long-term outcomes of ypT0 rectal cancers

Author

Lorenzon, Laura, primary, Evrard, Serge, additional, Beets, Geerard, additional, Gonzalez-Moreno, Santiago, additional, Kovacs, Tibor, additional, D’Ugo, Domenico, additional, Polom, Karol, additional, Terrenato, Irene, additional, Shinde, Rajesh S., additional, Saklani, Avanish, additional, Martins, Pedro, additional, Videira, José Flávio, additional, Bonci, Eduard-Alexandru, additional, Achimas-Cadariu, Patriciu, additional, Marinello, Franco, additional, Espin, Eloy, additional, Xenaki, Sofia, additional, Lasithiotakis, Konstantinos, additional, Rega, Daniela, additional, Delrio, Paolo, additional, Andrási, László, additional, Lázár, György, additional, Quattromani, Roberto, additional, Elmore, Ugo, additional, Branciforte, Martina Azzurra, additional, Piazza, Diego, additional, Sztipits, Tamás, additional, Mersich, Tamás, additional, Vigorita, Vincenzo, additional, Ildefonso, Alberto San, additional, Cianflocca, Desiree, additional, Giuffrida, Maria Carmela, additional, Biondi, Alberto, additional, Persiani, Roberto, additional, Košir, Jurij Aleš, additional, Grosek, Jan, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Dieninyte-Misiune, Egle, additional, Bausys, Rimantas, additional, Bausys, Augustinas, additional, Poskus, Tomas, additional, Dupré, Aurélien, additional, Muresan, Mihai-Stefan, additional, Ionescu, Călin, additional, Alyami, Mohammad, additional, Cotte, Eddy, additional, Candido, Francesca Di, additional, Spinelli, Antonino, additional, Lucarini, Alessio, additional, Balducci, Genoveffa, additional, Kisielewski, Michał, additional, Pędziwiatr, Michał, additional, Kroon, Hidde, additional, Sammour, Tarik, additional, Unger, Lukas, additional, Stift, Anton, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Uzunoglu, Mustafa Yener, additional, Altintoprak, Fatih, additional, Capponi, Michela Giulii, additional, Poiasina, Elia, additional, Brandl, Andreas, additional, Aigner, Felix, additional, Aparício, David, additional, Leichsenring, Carlos, additional, Corleone, Pio, additional, Manzini, Nicolò de, additional, Kabata, Paweł, additional, Świerblewski, Maciej, additional, Gallo, Gaetano, additional, Trompetto, Mario, additional, Negoi, Ionut, additional, Beuran, Mircea, additional, Souriti, Ahmad, additional, Taylor, Gregory, additional, De Luca, Raffaele, additional, Simone, Michele, additional, Bedford, Matthew, additional, Charalampakis, Vasileios, additional, Rajan, Shiv, additional, Chaturvedi, Arun, additional, Veltri, Marco, additional, Parini, Dario, additional, Turati, Luca, additional, Sgroi, Giovanni, additional, Bratu, Matei, additional, Diaconescu, Bogdan, additional, Slavchev, Mihail, additional, Belev, Nikolay, additional, Perfumo, Mariana Matzner, additional, Rotholtz, Nicolas, additional, Wajda, Justyna, additional, Wysocki, Wojciech, additional, Fernandez, Carmen Cagigas, additional, Ruiz, Marcos Gomez, additional, Marino, Serafino, additional, Resta, Giuseppe, additional, Ivanov, Tsvetomir, additional, Dimitrov, Dobromir, additional, Kaufmann, Claudia, additional, Kafka-Ritsch, Reinhold, additional, Yalkin, Omer, additional, Ünal, Ali Ekrem, additional, Loche, Giovanni Augusto, additional, Cillara, Nicola, additional, Colombo, Francesco, additional, Foschi, Diego, additional, Pollesel, Sara, additional, and Roviello, Franco, additional

Published
2020
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29. The clinical response to preoperative chemotherapy is associated with improved long-term outcomes of patients with non-metastatic gastric cancer

Author

Bausys, Augustinas, primary, Luksta, Martynas, additional, Kuliavas, Justas, additional, Anglickiene, Giedre, additional, Baltruskeviciene, Edita, additional, Molnikaite, Greta, additional, Sukyte, Gerda, additional, Sangaila, Egidijus, additional, Rackauskas, Rokas, additional, Stratilatovas, Eugenijus, additional, Bausys, Rimantas, additional, and Strupas, Kestutis, additional

Published
2020
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