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The paper is devoted to the development of general methodological approaches to evaluate and identify the possibility for creating IT clusters in Kazakhstan regions. The present study considers the formation of IT clusters as growth poles. These poles are based on the establishing the groups of interconnected companies and institutions in IT industry linked by commonalities. The analysis of previous literature has shown that this approach is a novel approach to IT clusters formation. The study employs methods, which focus on analysing and identifying IT clusters in the interests of innovative development and the possibility of spreading information technology in Kazakhstan regions. We propose the methodological tools for presenting a standard form to assess innovative potential and industry specialization. This assessment allows to objectively and realistically define a potentially important region for creating IT cluster. The empirical analysis has identified certain trends in possibilities to create IT clusters in the cities of Almaty and Astana. Therefore, these regions play the role of specialized platforms for a new generation. This platform is to provide a multiplier effect on the development of the agglomeration and located in close territories or periphery. The results of this research can be used to elaborate important strategic documents in the field of the development of the IT industry, digital technology, knowledge-based and high-tech sectors in Kazakhstan on the way to Industry 4.0.