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7. MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration

Author

Winkler, Iris, primary, Engler, Jan Broder, additional, Vieira, Vanessa, additional, Bauer, Simone, additional, Liu, Yi-Hsiang, additional, Di Liberto, Giovanni, additional, Grochowska, Katarzyna M., additional, Wagner, Ingrid, additional, Bier, Jasmina, additional, Bal, Lukas C., additional, Rothammer, Nicola, additional, Meurs, Nina, additional, Egervari, Kristof, additional, Schattling, Benjamin, additional, Salinas, Gabriela, additional, Kreutz, Michael R., additional, Huang, Yi-Shuian, additional, Pless, Ole, additional, Merkler, Doron, additional, and Friese, Manuel A., additional

Published
2023
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8. Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells

Author

Woo, Marcel S., primary, Ufer, Friederike, additional, Sonner, Jana K., additional, Belkacemi, Anouar, additional, Tintelnot, Joseph, additional, Sáez, Pablo J., additional, Krieg, Paula F., additional, Mayer, Christina, additional, Binkle-Ladisch, Lars, additional, Engler, Jan Broder, additional, Bauer, Simone, additional, Kursawe, Nina, additional, Vieira, Vanessa, additional, Mannebach, Stefanie, additional, Freichel, Marc, additional, Flockerzi, Veit, additional, Vargas, Pablo, additional, and Friese, Manuel A., additional

Published
2023
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10. G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis

Author

Rothammer, Nicola, primary, Woo, Marcel S., additional, Bauer, Simone, additional, Binkle-Ladisch, Lars, additional, Di Liberto, Giovanni, additional, Egervari, Kristof, additional, Wagner, Ingrid, additional, Haferkamp, Undine, additional, Pless, Ole, additional, Merkler, Doron, additional, Engler, Jan Broder, additional, and Friese, Manuel A., additional

Published
2022
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11. Evaluation of the decision-making process within the table-top exercise of the Terror and Disaster Surgical Care (TDSC®) course.

Author

Achatz, Gerhard, Reckziegel, Alexander, Friemert, Benedikt, Blätzinger, Markus, Hinz-Bauer, Simone, Franke, Axel, Bieler, Dan, Paffrath, Thomas, and Hoth, Patrick

Subjects
MEDICAL triage, TERRORISM, OPERATIVE surgery, TIME, DISASTERS, EMERGENCY management education, SIMULATION methods in education, PATIENTS, COMPARATIVE studies, EMERGENCY medical services, DECISION making, DESCRIPTIVE statistics, DECISION making in clinical medicine, MASS casualties, LONGITUDINAL method
Abstract

Purpose: The threat of terror is omnipresent in Europe and the number of attacks worldwide is increasing. The target of attacks in Europe is usually the civilian population. Incalculable dangerous situations at the scene of the event and severe injury patterns such as complex gunshot and explosion injuries with a high number of highly life-threatening people present rescue forces, emergency physicians and subsequently hospitals with medical, organizational as well as tactical and strategic challenges. The Terror and Disaster Surgical Care (TDSC®) course trains clinical decision-makers to meet these challenges of a TerrorMASCAL in the first 24–48 h. Methods: A table-top exercise was developed for the TDSC® course as a decision training tool, which was prospectively evaluated in six courses. The evaluation took place in 3 courses of the version 1.0, in 3 courses in the further developed version 2.0 to different target values like, e.g., the accuracy of the in-hospital triage. Furthermore, 16 TDSC® course instructors were evaluated. Results: For the evaluation, n = 360 patient charts for version 1.0 and n = 369 for version 2.0 could be evaluated. Overall, the table-top exercise was found to be suitable for training of internal clinical decision makers. Version 2.0 was also able to depict the action and decision-making paths in a stable and valid manner compared to the previous version 1.0. The evaluation of the instructors also confirmed the further value and improvement of version 2.0. Conclusion: With this prospective study, the table-top exercise of the TDSC® course was tested for decision stability and consistency of the participants' decision paths. This could be proven for the selected target variables, it further showed an improvement of the training situation. A further development of the table-top exercise, in particular also using digital modules, will allow a further optimization. http://www.bundeswehrkrankenhaus-ulm.de [ABSTRACT FROM AUTHOR]

Published
2023
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12. G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis

Author

Rothammer, Nicola, Woo, Marcel S., Bauer, Simone, Binkle-Ladisch, Lars, Di Liberto, Giovanni, Egervari, Kristof, Wagner, Ingrid, Haferkamp, Undine, Pless, Ole, Merkler, Doron, Engler, Jan Broder, Friese, Manuel A., and Publica

Subjects
Inflammation, Neurons, Mice, Multidisciplinary, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Gene Expression Regulation, Animals, Ferroptosis, Humans, Histone-Lysine N-Methyltransferase
Abstract

Neuroinflammation leads to neuronal stress responses that contribute to neuronal dysfunction and loss. However, treatments that stabilize neurons and prevent their destruction are still lacking. Here, we identify the histone methyltransferase G9a as a druggable epigenetic regulator of neuronal vulnerability to inflammation. In murine experimental autoimmune encephalomyelitis (EAE) and human multiple sclerosis (MS), we found that the G9a-catalyzed repressive epigenetic mark H3K9me2 was robustly induced by neuroinflammation. G9a activity repressed anti-ferroptotic genes, diminished intracellular glutathione levels, and triggered the iron-dependent programmed cell death pathway ferroptosis. Conversely, pharmacological treatment of EAE mice with a G9a inhibitor restored anti-ferroptotic gene expression, reduced inflammation-induced neuronal loss, and improved clinical outcome. Similarly, neuronal anti-ferroptotic gene expression was reduced in MS brain tissue and was boosted by G9a inhibition in human neuronal cultures. This study identifies G9a as a critical transcriptional enhancer of neuronal ferroptosis and potential therapeutic target to counteract inflammation-induced neurodegeneration.

Published
2022

15. miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells

Author

Bauer, Simone, Ratz, Leonie, Heckmann-Noetzel, Doreen, Kaczorowski, Adam, Hohenfellner, Markus, Kristiansen, Glen, Duensing, Stefan, Altevogt, Peter, Klauck, Sabine M., Sueltmann, Holger, Bauer, Simone, Ratz, Leonie, Heckmann-Noetzel, Doreen, Kaczorowski, Adam, Hohenfellner, Markus, Kristiansen, Glen, Duensing, Stefan, Altevogt, Peter, Klauck, Sabine M., and Sueltmann, Holger

Abstract

Simple Summary The reason for the frequent presence of the TMPRSS2:ERG (T2E) gene fusion in prostate cancer (PCa) is not fully understood. We were interested in investigating epigenomic alterations associated with the T2E gene fusion in PCa cells. Making use of publicly available genome-wide data and in vitro analyses using an LNCaP cell line model with inducible T2E expression, we uncovered a molecular network driving NOTCH signaling in T2E-positive PCa. We show that ERG directly activates NOTCH1 and HES1 expression by interacting with their promoter regions. Furthermore, NOTCH is activated by downregulation of miR-449a in ERG overexpressing cells. Experimental NOTCH pathway inhibition as well as HES1 knockdown reduced oncogenic capacities in vitro, suggesting that the NOTCH pathway triggers oncogenic processes in TMPRSS2:ERG-positive PCa. HES1 and ERG expression are correlated in tissue samples from PCa patients. Our data suggest a novel epigenomic network driving NOTCH signaling in T2E+ PCa cells. About 50% of prostate cancer (PCa) tumors are TMPRSS2:ERG (T2E) fusion-positive (T2E+), but the role of T2E in PCa progression is not fully understood. We were interested in investigating epigenomic alterations associated with T2E+ PCa. Using different sequencing cohorts, we found several transcripts of the miR-449 cluster to be repressed in T2E+ PCa. This repression correlated strongly with enhanced expression of NOTCH and several of its target genes in TCGA and ICGC PCa RNA-seq data. We corroborated these findings using a cellular model with inducible T2E expression. Overexpression of miR-449a in vitro led to silencing of genes associated with NOTCH signaling (NOTCH1, HES1) and HDAC1. Interestingly, HDAC1 overexpression led to the repression of HES6, a negative regulator of the transcription factor HES1, the primary effector of NOTCH signaling, and promoted cell proliferation by repressing the cell cycle inhibitor p21. Inhibition of NOTCH as well as knockdown of HES1

Published
2021

16. Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

Author

Woo, Marcel S., primary, Ufer, Friederike, additional, Rothammer, Nicola, additional, Di Liberto, Giovanni, additional, Binkle, Lars, additional, Haferkamp, Undine, additional, Sonner, Jana K., additional, Engler, Jan Broder, additional, Hornig, Sönke, additional, Bauer, Simone, additional, Wagner, Ingrid, additional, Egervari, Kristof, additional, Raber, Jacob, additional, Duvoisin, Robert M., additional, Pless, Ole, additional, Merkler, Doron, additional, and Friese, Manuel A., additional

Published
2021
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18. Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Author

Rosenkranz, Sina C, primary, Shaposhnykov, Artem A, additional, Träger, Simone, additional, Engler, Jan Broder, additional, Witte, Maarten E, additional, Roth, Vanessa, additional, Vieira, Vanessa, additional, Paauw, Nanne, additional, Bauer, Simone, additional, Schwencke-Westphal, Celina, additional, Schubert, Charlotte, additional, Bal, Lukas Can, additional, Schattling, Benjamin, additional, Pless, Ole, additional, van Horssen, Jack, additional, Freichel, Marc, additional, and Friese, Manuel A, additional

Published
2021
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19. Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma

Author

Zhang, Xin-Wen, primary, Huck, Katrin, additional, Jähne, Kristine, additional, Cichon, Frederik, additional, Sonner, Jana K., additional, Ufer, Friederike, additional, Bauer, Simone, additional, Woo, Marcel Seungsu, additional, Green, Ed, additional, Lu, Kevin, additional, Kilian, Michael, additional, Friese, Manuel A., additional, Platten, Michael, additional, and Sahm, Katharina, additional

Published
2021
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20. Author response: Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Author

Rosenkranz, Sina C, primary, Shaposhnykov, Artem A, additional, Träger, Simone, additional, Engler, Jan Broder, additional, Witte, Maarten E, additional, Roth, Vanessa, additional, Vieira, Vanessa, additional, Paauw, Nanne, additional, Bauer, Simone, additional, Schwencke-Westphal, Celina, additional, Schubert, Charlotte, additional, Bal, Lukas Can, additional, Schattling, Benjamin, additional, Pless, Ole, additional, van Horssen, Jack, additional, Freichel, Marc, additional, and Friese, Manuel A, additional

Published
2020
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22. Enhancing mitochondrial activity in neurons protects against neurodegeneration in CNS inflammation

Author

Rosenkranz, Sina C., primary, Shaposhnykov, Artem A., additional, Träger, Simone, additional, Engler, Jan Broder, additional, Witte, Maarten E., additional, Roth, Vanessa, additional, Vieira, Vanessa, additional, Paauw, Nanne, additional, Bauer, Simone, additional, Schwencke-Westphal, Celina, additional, Bal, Lukas, additional, Schattling, Benjamin, additional, Pless, Ole, additional, van Horssen, Jack, additional, Freichel, Marc, additional, and Friese, Manuel A., additional

Published
2020
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23. SIR-Tests – Sicherheit und Qualität nach strengster Norm.

Author

Bauer, Simone

Subjects
FLUX (Energy), SOLDER & soldering, ELECTRICAL conductors, AUTOMOBILE industry, MEDICAL technology
Abstract

The article presents the discussion on determining the electrical safety of fluxes in soldering technology. Topics include insulation resistance between adjacent conductors on the surface of a printed circuit board being determined; production or machine failures leading to defective end devices showing customers in the automotive industry, aerospace, and medical technology.

Published
2022

24. Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

Author

Schattling, Benjamin, primary, Engler, Jan Broder, additional, Volkmann, Constantin, additional, Rothammer, Nicola, additional, Woo, Marcel S., additional, Petersen, Meike, additional, Winkler, Iris, additional, Kaufmann, Max, additional, Rosenkranz, Sina C., additional, Fejtova, Anna, additional, Thomas, Ulrich, additional, Bose, Aparajita, additional, Bauer, Simone, additional, Träger, Simone, additional, Miller, Katharine K., additional, Brück, Wolfgang, additional, Duncan, Kent E., additional, Salinas, Gabriela, additional, Soba, Peter, additional, Gundelfinger, Eckart D., additional, Merkler, Doron, additional, and Friese, Manuel A., additional

Published
2019
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25. Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma.

Author

Xin-Wen Zhang, Huck, Katrin, Jähne, Kristine, Cichon, Frederik, Sonner, Jana K., Ufer, Friederike, Bauer, Simone, Woo, Marcel Seungsu, Green, Ed, Lu, Kevin, Kilian, Michael, Friese, Manuel A., Platten, Michael, and Sahm, Katharina

Subjects
DENDRITIC cells, MELANOMA, AUTOIMMUNE diseases, ANTIGEN presentation, CELLULAR immunity, TUMOR microenvironment, VACCINATION, CANCER vaccines, TUMOR suppressor genes
Abstract

Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within the tumor microenvironment promotes adaptive antitumor immunity, enhancement of DC migration toward the tumor microenvironment following DC vaccination might represent one possible approach to increase its therapeutic efficacy. While recent findings suggest the activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) as critical regulator of DC migration in the context of autoimmune diseases, we aimed to investigate the impact of Arc/Arg3.1 expression for DC-based cancer vaccines. To this end, DC migration capacity as well as the induction of T cell-mediated antitumor immunity was assessed in an experimental B16 melanoma model with Arc/Arg3A-/- and Arc/Arg3.1-expressing BMDCs applied as a subcutaneous vaccine. While antigen presentation on DCs was critical for unleashing effective T cell mediated antitumor immune responses, Arc/Arg3.1 expression enhanced DC migration toward the tumor and secondary lymphoid organs. Moreover, Arc/Arg3.1-expressing BMDCs shape the tumor immune microenvironment by facilitating tumor recruitment of antigen-specific effector T cells. Thus, Arc/Arg3.1 may represent a novel therapeutic target in DCs in order to increase the therapeutic efficacy of DC vaccination. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Terror and disaster surgical care: training experienced trauma surgeons in decision making for a MASCAL situation with a tabletop simulation game.

Author

Achatz, Gerhard, Friemert, Benedikt, Trentzsch, Heiko, Hofmann, Marzellus, Blätzinger, Markus, Hinz-Bauer, Simone, Paffrath, Thomas, Franke, Axel, and Bieler, Dan

Subjects
EDUCATION of surgeons, DISASTERS, EMERGENCY management, EMERGENCY management education, GAMES, LEARNING strategies, MASS casualties, TERRORISM, DECISION making in clinical medicine, TEACHING methods, PERIOPERATIVE care
Abstract

Background: Mass-casualty incidents, especially in connection with a terrorist attack, can quickly overwhelm the capacities of receiving hospitals. After a mass-casualty terrorist incident, patients often arrive at hospitals in an uncoordinated manner on account of the chaotic situation. Many patients leave the incident site and refer themselves to hospitals independently. Hospital decision makers must, therefore, be able to make quick decisions on diagnostic procedures and treatment for every individual patient and, at the same time, take into consideration available resources. They require decision criteria and aids to properly manage such scenarios. Materials and methods: As part of the preparation of the Terror and Disaster Surgical Care (TDSC®) course, we developed a tabletop simulation game based on a comprehensive and structured review of the literature, the opinions of renowned experts, and the results of specialised conferences. This tabletop simulation game is played four times during each TDSC® course. Results: Our analysis involved 264 of 465 course–participants from 2017 to 2019 and showed that the overall evaluation was very good and that participants grew more positive about the tabletop simulation game during the course. The tabletop simulation game received an average rating of 1.53 (1 = very good, 6 = insufficient). This rating remained consistently high over 19 courses. Discussion: Hospital decision makers must respond to mass-casualty terrorist situations in a defined tactical and strategic approach. Rapid decisions must be made that take into account the special situation and available capacities and resources to maximise the number of survivors even though individual patients may have a poorer functional outcome. As part of the TDSC® course, the tabletop simulation game teaches high-level decision-making algorithms and prepares key hospital personnel for such situations. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation

Author

Ufer, Friederike, primary, Vargas, Pablo, additional, Engler, Jan Broder, additional, Tintelnot, Joseph, additional, Schattling, Benjamin, additional, Winkler, Hana, additional, Bauer, Simone, additional, Kursawe, Nina, additional, Willing, Anne, additional, Keminer, Oliver, additional, Ohana, Ora, additional, Salinas-Riester, Gabriela, additional, Pless, Ole, additional, Kuhl, Dietmar, additional, and Friese, Manuel A., additional

Published
2016
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30. Multiple sclerosis associated genetic variants ofCD226impair regulatory T cell function

Author

Piédavent-Salomon, Melanie, primary, Willing, Anne, additional, Engler, Jan Broder, additional, Steinbach, Karin, additional, Bauer, Simone, additional, Eggert, Britta, additional, Ufer, Friederike, additional, Kursawe, Nina, additional, Wehrmann, Sabine, additional, Jäger, Jan, additional, Reinhardt, Stefanie, additional, and Friese, Manuel A., additional

Published
2015
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33. Recycling von Lotmaterial ohne Qualitätsverlust.

Author

Bauer, Simone

Subjects
GREENHOUSE gas mitigation, SOLDER pastes, RAW materials, BLOCKCHAINS, WASTE recycling
Abstract

Copyright of Productronic is the property of Dokumentations- und Informationszentrum (DIZ) Munchen GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

37. Das hat sich in der IPC geändert.

Author

Bauer, Simone

Subjects
ION exchange chromatography, MANUFACTURING processes, ROSES
Abstract

Copyright of Productronic is the property of Dokumentations- und Informationszentrum (DIZ) Munchen GmbH and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

38. Construction and In VitroTesting of a Novel Fab-Hirudin–Based Fusion Protein That Targets Fibrin and Inhibits Thrombin in a Factor Xa–Dependent Manner

Author

Peter, Karlheinz, Gupta, Amitabh, Nordt, Thomas, Bauer, Simone, Runge, Marschall S., and Bode, Christoph

Abstract

Fibrin targeting of the thrombin inhibitor hirudin via chemical coupling is effective in vitro and in vivo. However, since chemical coupling has limitations, a recombinant approach was taken to improve the fibrin-targeting ability of hirudin. Additionally, to activate hirudin selectively at the target area and thereby limit side effects in an in vivo setting, the authors aimed to construct an inactive precursor molecule that is converted into an active thrombin inhibitor only upon cleavage by factor Xa. Using PCR, the coding region for hirudin was fused to parts of the genomic DNA of the IgG heavy chain that was cloned from the antifibrin antibody–producing hybridoma cell line 59D8. Additionally, a factor Xa recognition site was introduced between the antibody and the hirudin sequence. The fusion construct was then transfected into a heavy-chain loss variant of the hybridoma cell line 59D8. After selection of stable hybridoma clones, the expressed fusion protein was evaluated for its molecular size (57 kd) and its binding ability to the fibrin-specific peptide B 15-22. The cleavage of the fusion protein by factor Xa was demonstrated by HPLC. The recombinant anticoagulant revealed antithrombin activity only after cleavage by factor Xa. Thus, the newly designed hirudin fusion protein revealed the anticipated functions in vitro. Further experiments are needed to prove whether this precursor anticoagulant allows a highly clot-specific and efficient thrombin inhibition in vivo.

Published
2003

39. Calcium channel ß3 subunit regulates ATP-dependent migration of dendritic cells.

Author

Woo, Marcel S., Ufer, Friederike, Sonner, Jana K., Belkacemi, Anouar, Tintelnot, Joseph, Sáez, Pablo J., Krieg, Paula F., Mayer, Christina, Binkle-Ladisch, Lars, Engler, Jan Broder, Bauer, Simone, Kursawe, Nina, Vieira, Vanessa, Mannebach, Stefanie, Freichel, Marc, Flockerzi, Veit, Vargas, Pablo, and Friese, Manuel A.

Subjects
*CALCIUM channels, *CELL migration, *DENDRITIC cells, *FIBRONECTINS, *ATMOSPHERIC carbon dioxide, *T cells, *CALCIUM ions, *GRANULOCYTE-macrophage colony-stimulating factor
Abstract

The article focuses on the role of the calcium channel β3 subunit (CACNB3) in regulating Adenosine Triphosphate (ATP) dependent migration of dendritic cells (DCs). Topics include the exclusive expression of CACNB3 in migratory DCs, its role in ATP-induced calcium release from the endoplasmic reticulum, and how CACNB3 regulates the suppression of adhesion molecules.

Published
2023
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