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1. EchoDFKD: Data-Free Knowledge Distillation for Cardiac Ultrasound Segmentation using Synthetic Data

Author

Petit, Grégoire, Palluau, Nathan, Bauer, Axel, and Dlaska, Clemens

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

The application of machine learning to medical ultrasound videos of the heart, i.e., echocardiography, has recently gained traction with the availability of large public datasets. Traditional supervised tasks, such as ejection fraction regression, are now making way for approaches focusing more on the latent structure of data distributions, as well as generative methods. We propose a model trained exclusively by knowledge distillation, either on real or synthetical data, involving retrieving masks suggested by a teacher model. We achieve state-of-the-art (SOTA) values on the task of identifying end-diastolic and end-systolic frames. By training the model only on synthetic data, it reaches segmentation capabilities close to the performance when trained on real data with a significantly reduced number of weights. A comparison with the 5 main existing methods shows that our method outperforms the others in most cases. We also present a new evaluation method that does not require human annotation and instead relies on a large auxiliary model. We show that this method produces scores consistent with those obtained from human annotations. Relying on the integrated knowledge from a vast amount of records, this method overcomes certain inherent limitations of human annotator labeling. Code: https://github.com/GregoirePetit/EchoDFKD

Published
2024

2. Cardiomyocyte Injury Following Acute Ischemic Stroke: Protocol for a Prospective Observational Cohort Study

Author

Stengl, Helena, Ganeshan, Ramanan, Hellwig, Simon, Blaszczyk, Edyta, Fiebach, Jochen B, Nolte, Christian H, Bauer, Axel, Schulz-Menger, Jeanette, Endres, Matthias, and Scheitz, Jan F

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundElevated cardiac troponin, which indicates cardiomyocyte injury, is common after acute ischemic stroke and is associated with poor functional outcome. Myocardial injury is part of a broad spectrum of cardiac complications that may occur after acute ischemic stroke. Previous studies have shown that in most patients, the underlying mechanism of stroke-associated myocardial injury may not be a concomitant acute coronary syndrome. Evidence from animal research and clinical and neuroimaging studies suggest that functional and structural alterations in the central autonomic network leading to stress-mediated neurocardiogenic injury may be a key underlying mechanism (ie, stroke-heart syndrome). However, the exact pathophysiological cascade remains unclear, and the diagnostic and therapeutic implications are unknown. ObjectiveThe aim of this CORONA-IS (Cardiomyocyte injury following Acute Ischemic Stroke) study is to quantify autonomic dysfunction and to decipher downstream cardiac mechanisms leading to myocardial injury after acute ischemic stroke. MethodsIn this prospective, observational, single-center cohort study, 300 patients with acute ischemic stroke, confirmed via cerebral magnetic resonance imaging (MRI) and presenting within 48 hours of symptom onset, will be recruited during in-hospital stay. On the basis of high-sensitivity cardiac troponin levels and corresponding to the fourth universal definition of myocardial infarction, 3 groups are defined (ie, no myocardial injury [no cardiac troponin elevation], chronic myocardial injury [stable elevation], and acute myocardial injury [dynamic rise/fall pattern]). Each group will include approximately 100 patients. Study patients will receive routine diagnostic care. In addition, they will receive 3 Tesla cardiovascular MRI and transthoracic echocardiography within 5 days of symptom onset to provide myocardial tissue characterization and assess cardiac function, 20-min high-resolution electrocardiogram for analysis of cardiac autonomic function, and extensive biobanking. A follow-up for cardiovascular events will be conducted 3 and 12 months after inclusion. ResultsAfter a 4-month pilot phase, recruitment began in April 2019. We estimate a recruitment period of approximately 3 years to include 300 patients with a complete cardiovascular MRI protocol. ConclusionsStroke-associated myocardial injury is a common and relevant complication. Our study has the potential to provide a better mechanistic understanding of heart and brain interactions in the setting of acute stroke. Thus, it is essential to develop algorithms for recognizing patients at risk and to refine diagnostic and therapeutic procedures. Trial RegistrationClinicaltrials.gov NCT03892226; https://www.clinicaltrials.gov/ct2/show/NCT03892226. International Registered Report Identifier (IRRID)DERR1-10.2196/24186

Published
2021
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3. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Author

Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Gracey, Jay, López-Sobrino, Teresa, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Duerschmied, Daniel, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, John, Stefan, Ewen, Sebastian, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, Freund, Anne, Møller, Jacob E, Henriques, Jose P S, Bogerd, Margriet, Hochadel, Matthias, and Schulze, P Christian

Published
2024
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5. Festvortrag

Author

Bauer, Axel W.

Subjects
Bibliography. Library science. Information resources, Medicine (General), R5-920
Abstract

The German physician Rudolf Virchow (1821-1902) is world-famous not only due to the fact that he was the most distinguished chairman in Pathological Anatomy, a new discipline at the German Medical Schools in the second half of 19th century. Virchow became well-known also by his further activities, especially his endeavours for reforming medicine on a scientific basis and his political commitment to healthcare and social politics. As a member of the liberal party Deutsche Fortschrittspartei he became a representative of the Prussian State Parliament Landtag and of the German Federal Parliament Reichstag. As a gifted author and as an untiring editor he founded and ran two different journals: In 1848/49 he published the weekly paper The Medical Reform in which he gave his support to a scientific reform of medicine and to a democratic change in society, writing that politics were „nothing else but medicine in the broader perspective". In 1847 he founded the Archives for Pathological Anatomy and Physiology and for Clinical Medicine which is published yet today under the name of Virchow Archiv. In this journal many different schools of scientific medicine were invited to publish the results of their research. Occasionally, Virchow himself wrote articles on medical epistemology or on social politics. When he died in 1902, Rudolf Virchow had edited 169 volumes of his journal.

Published
2005

8. Infarct severity and outcomes in ST-elevation myocardial infarction patients without standard modifiable risk factors – A multicenter cardiac magnetic resonance study

Author

Reindl, Martin, Stiermaier, Thomas, Lechner, Ivan, Tiller, Christina, Holzknecht, Magdalena, Fink, Priscilla, Mayr, Agnes, Klug, Gert, Feistritzer, Hans-Josef, Delewi, Ronak, Hirsch, Alexander, Carberry, Jaclyn, Carrick, David, Bauer, Axel, Metzler, Bernhard, Nijveldt, Robin, Thiele, Holger, Berry, Colin, Eitel, Ingo, and Reinstadler, Sebastian J.

Published
2024
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10. Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery

Author

Pölzl, Leo, Engler, Clemens, Sterzinger, Philipp, Lohmann, Ronja, Nägele, Felix, Hirsch, Jakob, Graber, Michael, Eder, Jonas, Reinstadler, Sebastian, Sappler, Nikolay, Kilo, Juliane, Tancevski, Ivan, Bachmann, Sebastian, Abfalterer, Hannes, Ruttmann-Ulmer, Elfriede, Ulmer, Hanno, Griesmacher, Andrea, Heuts, Samuel, Thielmann, Matthias, Bauer, Axel, Grimm, Michael, Bonaros, Nikolaos, Holfeld, Johannes, and Gollmann-Tepeköylü, Can

Published
2023
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11. Cardiac Magnetic Resonance Imaging Versus Computed Tomography to Guide Transcatheter Aortic Valve Replacement: A Randomized, Open-Label, Noninferiority Trial

Author

Reindl, Martin, Lechner, Ivan, Holzknecht, Magdalena, Tiller, Christina, Fink, Priscilla, Oberhollenzer, Fritz, von der Emde, Sebastian, Pamminger, Mathias, Troger, Felix, Kremser, Christian, Laßnig, Elisabeth, Danninger, Kathrin, Binder, Ronald K., Ulmer, Hanno, Brenner, Christoph, Klug, Gert, Bauer, Axel, Metzler, Bernhard, Mayr, Agnes, and Reinstadler, Sebastian J.

Published
2023
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19. Electrocardiographic parameters of left ventricular hypertrophy and prediction of mortality in hemodialysis patients

Author

Braunisch, Matthias C., Gundel, Peter, Werfel, Stanislas, Mayer, Christopher C., Bauer, Axel, Haller, Bernhard, Günthner, Roman, Lorenz, Georg, Angermann, Susanne, Matschkal, Julia, Schaller, Carolin, Holzmann-Littig, Christopher, Kemmner, Stephan, Mann, Johannes, Krieter, Axel, Renders, Lutz, Wassertheurer, Siegfried, Schmidt, Georg, Heemann, Uwe, Malik, Marek, and Schmaderer, Christoph

Published
2022
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23. QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators

Author

Arts Assistenten Cardiologie, Medische Fysiologie, Circulatory Health, Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Vanderberk, Bert, Sprenkeler, David, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A, Friede, Tim, Bauer, Axel, Huikuri, Heikki V, Willems, Rik, Schmidt, Georg, Sticherling, Christian, Zabel, Markus, Malik, Marek, Arts Assistenten Cardiologie, Medische Fysiologie, Circulatory Health, Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Vanderberk, Bert, Sprenkeler, David, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A, Friede, Tim, Bauer, Axel, Huikuri, Heikki V, Willems, Rik, Schmidt, Georg, Sticherling, Christian, Zabel, Markus, and Malik, Marek

Published
2024

25. Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial

Author

May, Andreas, Seitzer, Peter, Schmidt, Roland, Keta, Dritan, Janke, Viktoria, Schläger, Christian, André, Elisabeth, Brandt, Niels, Schön, Alexandra, Zollner, Alfred, Freyer, Luisa, Hamm, Wolfgang, Beil, Johannes, Strüven, Anna Katharina, Loew, Anja, Fichtner, Stephanie, Lange, Philipp, Krasniqi, Aresa, Grabmeier, Ulrich, Estner, Heidi, Bengel, Philipp, Lüthje, Lars, Kirova, Aleksandra, Fischer, Thomas, Bergau, Leonard, Herting, Jonas, Schlögl, Simon, Haarmann, Helge, Schlögl (Illes), Klaudia, Uecer, Ekrem, Sag, Sabine, Tafelmeier, Maria, Jungbauer, Carsten, Fredersdorf-Hahn, Sabine, Strack, Christina, Seither, Benedikt, Seegers, Joachim, Millenaar, Dominic, Wintrich, Jan, Fischer, Patrick, Buob, Axel, Razouk, Amjad, Demming, Thomas, Frank, Johanne, Kühl, Constantin, Ellendt, Ulrike, Sandrock, Sarah, Gänsbacher, Julia, Cupa, Janosch, Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Steger, Alexander, Berkefeld, Anna, Schinke, Karin, Barthel, Petra, Dommasch, Michael, Amadei, Maiwand, Hindricks, Gerhard, Obradovic, Danilo, Döring, Michael, Bode, Kerstin, Hilbert, Sebastian, Löbe, Susanne, Knopp, Helge, König, Sebastian, John, Silke, Schöne, Katharina, Hartung, Philipp, Binner, Christian, Meyer-Zürn, Christine, Duckheim, Martin, Eick, Christian, Simpfle, Fabian, Schreieck, Jürgen, Mizera, Lars, Tscholl, Verena, Steinbeck, Lisa, Güc, Nadija, Schatz, Anne-Sophie, Attanasio, Philipp, Heuberger, Andrea, Roser, Mattias, Bellmann, Barbara, Nagel, Patrick, Biewener, Sebastian, Suhail, Saba, Juri, Benjamin, Meyer, Christian, Wiilems, Stephan, Jungen, Christiane, Schmitt, Susanne, Münkerer, Paula, Vogler, Julia, Kaiser, Lukas, Schäffer, Benjamin, Nies, Moritz, Tönnis, Tobias, Fluschnik, Nina, Grahn, Hanno, Waldeyer, Christoph, Kany, Shinwan, Sörensen, Nils Arne, Winkelmann, Simon, Akbulak, Özge, Gosau, Nils Arne, Würger, Tilman, Arnold, Natalie, Geßler, Nele, Jobs, Alexander, Münkler, Paula, Rausch, Stefan, Köster, Jelena, Brüggemann, Ben, Abdin, Amr, Wacker, Christian, Grotherr, Philipp, Fries, Bastian, Faust, Maximilian, Steuer, Stefanie, Swojanowsky, Patrick, Willems, Stephan, Portz, Nathaniel, Ujeyl, Amar, Krüger, Matthias, Gramlich, Robert, Köhler, Till, Sause, Armin, Nover, Ina, Ziakos, Athanasios-Panagiotis, Ciobanu, Veaceslav, Spelsberg, Norman, Siebermair, Johannes, Mahabadi, Amir-Abbas, Köhler, Miriam, Vonderlin, Nadine, Riesinger, Lisa, Abdiu, Edison, Bachmann, Anja, Frenzel, Marie, Hummel, Astrid, Lehnert, Kristin, Krüger, Anne, Busse, Franke, Napp, Andreas, Müller-Wieland, Dirk, Battermann, Simone, Lacour, Philipp, Trippel, Tobias, Beetz, Nick Lasse, Schleußner, Leonhard, Zach, Veronika, Rozados, Christina, Mudra, Harald, Staubach, Stephan, Illmann, Alexander, Joner, Michael, Bock, Matthias, Kolb, Christof, Koch, Tobias, Fröhlich, Rebecca, Lennerz, Carsten, Lenz, Tobias, Fuchs, Patrick, Freißmuth, Markus, Grebmer, Christian, Kuschyk, Jürgen, Kranert, Malte, Fastenrath, Fabian, Yücel, Gökhan, Rudic, Boris, Würfel, Sarah, Römer, Albrecht, Böhmer, Andreas, Honold, Jörg, Georgopoulos, Stamatis, Gleirscher, Lukas, Lederle, Susanne, Chaplygin, Artem, Pauschinger, Matthias, Brinker-Paschke, Andrea, Kropacek, Jana, Eckardt, Lars, Ellermann, Christian, Bode, Niklas, Reinke, Florian, Engelke, Hauke, Höllriegel, Robert, Woitek, Felix, Winzer, Ephraim, Ibrahim, Karim, Pflücke, Christian, Ende, Georg, Speiser, Uwe, Haußig, Stephan, Wachter, Rolf, Uhe, Tobias, Konrad, Torsten, Zitron, Edgar, Destani, Jeton, Fu, Fangyi, Al Said, Samer, Kaya, Ziya, Schgör, Wilfried, Senoner, Thomas, Bauer, Axel, Sappler, Nikolay, von Stülpnagel, Lukas, Klemm, Mathias, Schreinlechner, Michael, Wenner, Felix, Schier, Johannes, Al Tawil, Amani, Dolejsi, Theresa, Eiffener, Elodie, Bongarth, Christa, Stühlinger, Markus, Huemer, Martin, Gori, Tommaso, Wakili, Reza, Sahin, Riza, Schwinger, Robert, Lutz, Matthias, Luik, Armin, Gessler, Nele, Clemmensen, Peter, Linke, Axel, Maier, Lars S, Hinterseer, Martin, Busch, Mathias C, Blaschke, Florian, Sack, Stefan, Licka, Manuela, Tilz, Roland R, Ukena, Christian, Ehrlich, Joachim R, Zabel, Markus, Schmidt, Georg, Mansmann, Ulrich, Kääb, Stefan, Rizas, Konstantinos D, and Massberg, Steffen

Published
2022
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28. Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: the CAST-HF trial.

Author

Holfeld, Johannes, Nägele, Felix, Pölzl, Leo, Engler, Clemens, Graber, Michael, Hirsch, Jakob, Schmidt, Sophia, Mayr, Agnes, Troger, Felix, Pamminger, Mathias, Theurl, Markus, Schreinlechner, Michael, Sappler, Nikolay, Ruttmann-Ulmer, Elfriede, Schaden, Wolfgang, Cooke, John P, Ulmer, Hanno, Bauer, Axel, Gollmann-Tepeköylü, Can, and Grimm, Michael

Abstract

Background and Aims In chronic ischaemic heart failure, revascularisation strategies control symptoms but are less effective in improving left ventricular ejection fraction (LVEF). The aim of this trial is to investigate the safety of cardiac shockwave therapy (SWT) as a novel treatment option and its efficacy in increasing cardiac function by inducing angiogenesis and regeneration in hibernating myocardium. Methods In this single-blind, parallel-group, sham-controlled trial (cardiac shockwave therapy for ischemic heart failure, CAST-HF; NCT03859466) patients with LVEF ≤40% requiring surgical revascularisation were enrolled. Patients were randomly assigned to undergo direct cardiac SWT or sham treatment in addition to coronary bypass surgery. The primary efficacy endpoint was the improvement in LVEF measured by cardiac magnetic resonance imaging from baseline to 360 days. Results Overall, 63 patients were randomized, out of which 30 patients of the SWT group and 28 patients of the Sham group attained 1-year follow-up of the primary endpoint. Greater improvement in LVEF was observed in the SWT group (Δ from baseline to 360 days: SWT 11.3%, SD 8.8; Sham 6.3%, SD 7.4, P =.0146). Secondary endpoints included the 6-minute walking test, where patients randomized in the SWT group showed a greater Δ from baseline to 360 days (127.5 m, SD 110.6) than patients in the Sham group (43.6 m, SD 172.1) (P =.028) and Minnesota Living with Heart Failure Questionnaire score on day 360, which was 11.0 points (SD 19.1) for the SWT group and 17.3 points (SD 15.1) for the Sham group (P =.15). Two patients in the treatment group died for non-device-related reasons. Conclusions In conclusion, the CAST-HF trial indicates that direct cardiac SWT, in addition to coronary bypass surgery improves LVEF and physical capacity in patients with ischaemic heart failure. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice.

Author

Zaruba, Marc-Michael, Staggl, Simon, Ghadge, Santhosh Kumar, Maurer, Thomas, Gavranovic-Novakovic, Jasmina, Jeyakumar, Vivek, Schönherr, Patric, Wimmer, Andreas, Pölzl, Gerhard, Bauer, Axel, and Messner, Moritz

Subjects
ACUTE coronary syndrome, GENE expression, MYOCARDIAL infarction, CELL migration, ANEMIA treatment
Abstract

Activation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI) clinically approved by the European Medicines Agency 2021 for the treatment of renal anemia, with the purpose of improving LV function and attenuating ischemic cardiomyopathy. Methods: We evaluated roxadustat's impact on HIF-1 stimulation, cardiac remodeling, and function after MI. Therefore, we analyzed nuclear HIF-1 expression, the mRNA and protein expression of key HIF-1 target genes (RT-PCR, Western blot), inflammatory cell infiltration (immunohistochemistry), and apoptosis (TUNEL staining) 7 days after MI. Additionally, we performed echocardiography in male and female C57BL/6 mice 28 days post-MI. Results: We found a substantial increase in nuclear HIF-1, associated with an upregulation of HIF-1α target genes like CXCL12/CXCR4/ACKR3 at the mRNA and protein levels. Roxadustat increased the proportion of myocardial reparative M2 CD206+ cells, suggesting beneficial alterations in immune cell migration and a trend towards reduced apoptosis. Echocardiography showed that roxadustat treatment significantly preserved ejection fraction and attenuated subsequent ventricular dilatation, thereby reducing adverse remodeling. Conclusions: Our findings suggest that roxadustat is a promising clinically approved treatment option to preserve myocardial function by attenuating adverse remodeling. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Rationale and design of a digital trial using smartphones to detect subclinical atrial fibrillation in a population at risk: The eHealth-based bavarian alternative detection of Atrial Fibrillation (eBRAVE-AF) trial

Author

Freyer, Luisa, von Stülpnagel, Lukas, Spielbichler, Peter, Sappler, Nikolay, Wenner, Felix, Schreinlechner, Michael, Krasniqi, Aresa, Behroz, Amira, Eiffener, Elodie, Zens, Martin, Dolejsi, Theresa, Massberg, Steffen, Rizas, Konstantinos D, and Bauer, Axel

Published
2021
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36. Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial

Author

Bantkowiak, Marcin, Baur, Gabriele, Baylacher, Monika, Beaucamp, Marcel, Berger, Manuel, Besch, Lisa, Brunner, Stefan, Budweiser, Stephan, Bugger, Heiko, Coletti, Raffaele, Dorwarth, Uwe, Egresits, Jozsef, Eiffener, Elodie, Faul, Christian, Finkenstedt, Armin, Gatos, Konstantinos, Gauchel, Nadine, Gindele, Frank, Grander, Wilhelm, Gunschl, Markus, Hartig, Frank, Hecht, Moritz, Heer, Tobias, Heger, Lukas, Hentrich, Marcus, Horvath, Lena, Keta, Dritan, Kiechl, Stefan, Kirchmaier, Rudolf, Klein, Andreas, Klemm, Mathias, Kolesnik, Ewald, König, Andreas, Kossmann, Hans Christian, Kropacek, Jana, Lanser, Lukas, Lother, Achim, Löw, Anja, Mahabadi, Amir-Abbas, Malleier, Stefan, Mayer, Gert, Müller, Christoph, Müller-Wieland, Dirk, Nagel, Bernhard, Neuwirt, Hannes, Olivier, Christoph, Raunegger, Thomas, Reindl, Martin, Reinstadler, Sebastian, Riesinger, Lisa, Schäffner, Michael, Schier, Johannes, Schock, Julia, Schönherr, Peter, Schulz, Martina, Schütz, Thomas, Schwarz, Johannes, Siebermair, Johannes, Siry, Marcus, Spaur, Anna, Sturm, Wolfgang, Tessadri, Kristin, Theurl, Fabian, Theurl, Markus, Thommes, Liz, Tiller, Christina, Toifl, Michael, Totzeck, Matthias, von zur Mühlen, Hedda, Vonderlin, Nadine, Wakili, Reza, Wendtner, Clemens, Wenner, Felix, Wimmert-Roidl, Daniela, Zabernigg, August, Bauer, Axel, Schreinlechner, Michael, Sappler, Nikolay, Dolejsi, Theresa, Tilg, Herbert, Aulinger, Benedikt A, Weiss, Günter, Bellmann-Weiler, Rosa, Adolf, Christian, Wolf, Dominik, Pirklbauer, Markus, Graziadei, Ivo, Gänzer, Hannes, von Bary, Christian, May, Andreas E, Wöll, Ewald, von Scheidt, Wolfgang, Rassaf, Tienush, Duerschmied, Daniel, Brenner, Christoph, Kääb, Stefan, Metzler, Bernhard, Joannidis, Michael, Kain, Hans-Ulrich, Kaiser, Norbert, Schwinger, Robert, Witzenbichler, Bernhard, Alber, Hannes, Straube, Florian, Hartmann, Niels, Achenbach, Stephan, von Bergwelt-Baildon, Michael, von Stülpnagel, Lukas, Schoenherr, Sebastian, Forer, Lukas, Embacher-Aichhorn, Sabine, Mansmann, Ulrich, Rizas, Konstantinos D, and Massberg, Steffen

Published
2021
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37. Outcome of patients treated with extracorporeal life support in cardiogenic shock complicating acute myocardial infarction: 1-year result from the ECLS-Shock study

Author

Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, and Guenther, Sabina P. W.

Published
2021
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40. Central Sleep Apnea and Pacing-Induced Cardiomyopathy

Author

Barbieri, Fabian, Adukauskaite, Agne, Heidbreder, Anna, Brandauer, Elisabeth, Bergmann, Melanie, Stefani, Ambra, Holzknecht, Evi, Senoner, Thomas, Rubatscher, Andrea, Schgör, Wilfried, Stühlinger, Markus, Pfeifer, Bernhard Erich, Bauer, Axel, Hintringer, Florian, Högl, Birgit, and Dichtl, Wolfgang

Published
2021
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41. Nocturnal respiratory rate predicts ICD benefit: A prospective, controlled, multicentre cohort study

Author

Dommasch, Michael, Steger, Alexander, Barthel, Petra, Huster, Katharina M, Müller, Alexander, Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Penzel, Thomas, Lubinski, Andrzej, Flevari, Panagiota, Harden, Markus, Friede, Tim, Kääb, Stefan, Merkely, Bela, Sticherling, Christian, Willems, Rik, Huikuri, Heikki V., Bauer, Axel, Malik, Marek, Zabel, Markus, and Schmidt, Georg

Published
2021
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42. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Author

Thiele, Holger, Møller, Jacob E, Henriques, Jose P S, Bogerd, Margriet, Seyfarth, Melchior, Burkhoff, Daniel, Ostadal, Petr, Rokyta, Richard, Belohlavek, Jan, Massberg, Steffen, Flather, Marcus, Hochadel, Matthias, Schneider, Steffen, Desch, Steffen, Freund, Anne, Eiskjær, Hans, Mangner, Norman, Pöss, Janine, Polzin, Amin, Schulze, P Christian, Skurk, Carsten, Zeymer, Uwe, Hassager, Christian, Burkhoff, Daniel, Cohen, Howard, Brunckhorst, Corinna, O'Neill, William W., Thiele, Holger Thiele, Sick, Peter, Boudriot, Enno, Diederich, Klaus-Werner, Hambrecht, Rainer, Niebauer, Josef, Schuler, Gerhard, Seyfarth, Melchior, Sibbing, Dirk, Bauer, Iris, Fröhlich, Georg, Bott-Flügel, Lorenz, Byrne, Robert, Dirschinger, Josef, Kastrati, Adnan, Schömig, Albert, Ouweneel, Dagmar M., Eriksen, Erlend, Sjauw, Krischan D., van Dongen, Ivo M., Hirsch, Alexander, Packer, Erik J.S, Vis, M. Marie, Wykrzykowska, Joanna J., Koch, Karel T., Baan, Jan, De Winter, Robbert J, Piek, Jan J., Lagrand, Wim K, de Mol, Bas A.J.M, Tijssen, Jan G.P., Henriques, José P.S., Møller, Jacob E., Engstrøm, Thomas, Jensen, Lisette Okkels, Eiskjær, Hans, Mangner, Norman, Polzin, Amin, Schulze, P. Christian, Skurk, Carsten, Nordbeck, Peter, Clemmensen, Peter, Panoulas, Vasileios, Zimmer, Sebastian, Schäfer, Andreas, Werner, Nikos, Frydland, Martin, Holmvang, Lene, Kjærgaard, Jesper, Sørensen, Rikke, Lønborg, Jacob, Greve, Matias, Christiansen, Evald H., Linke, Axel, Woitek, Felix J., Westenfeld, Ralf, Moebius-Winkler, Sven, Wachtell, Kristian, Ravn, Hanne Berg, Lassen, Jens Flensted, Boesgaard, Søren, Gerke, Oke, Hassager, Christian, Lackermair, Korbinian, Brunner, Stefan, Orban, Mathias, Peterss, Sven, Orban, Martin, Theiss, Hans D., Huber, Bruno C., Juchem, Gerd, Born, Frank, Boulesteix, Anne-Laure, Bauer, Axel, Pichlmaier, Maximilian, Hausleiter, Jörg, Massberg, Steffen, Hagl, Christian, Guenther, Sabina P.W., Ostadal, Petr, Rokyta, Richard, Karasek, Jiri, Kruger, Andreas, Vondrakova, Dagmar, Janotka, Marek, Naar, Jan, Smalcova, Jana, Hubatova, Marketa, Hromadk, Milan, Volovar, Stefan, Seyfrydova, Miroslava, Jarkovsky, Jiri, Svoboda, Michal, Linhart, Ales, Belohlavek, Jan, Banning, Amerjeet S., Sabaté, Manel, Orban, Martin, Gracey, Jay, López-Sobrino, Teresa, Massberg, Steffen, Kastrati, Adnan, Bogaerts, Kris, Adriaenssens, Tom, Berry, Colin, Erglis, Andrejs, Haine, Steven, Myrmel, Truls, Patel, Sameer, Buera, Irene, Sionis, Alessandro, Vilalta, Victoria, Yusuff, Hakeem, Vrints, Christiaan, Adlam, David, Flather, Marcus, Gershlick, Anthony H., Thiele, Holger, Zeymer, Uwe, Akin, Ibrahim, Behnes, Michael, Rassaf, Tienush, Mahabadi, Amir-Abbas, Lehmann, Ralf, Eitel, Ingo, Graf, Tobias, Seidler, Tim, Schuster, Andreas, Skurk, Carsten, Duerschmied, Daniel, Clemmensen, Peter, Hennersdorf, Marcus, Fichtlscherer, Stephan, Voigt, Ingo, Seyfarth, Melchior, John, Stefan, Ewen, Sebastian, Linke, Axel, Tigges, Eike, Nordbeck, Peter Steffen, Bruch, Leonhard, Jung, Christian, Franz, Jutta, Lauten, Philipp, Goslar, Tomaz, Feistritzer, Hans-Josef, Pöss, Janine, Kirchhof, Eva, Ouarrak, Taoufik, Schneider, Steffen, Desch, Steffen, and Freund, Anne

Abstract

Percutaneous active mechanical circulatory support (MCS) devices are being increasingly used in the treatment of acute myocardial infarction-related cardiogenic shock (AMICS) despite conflicting evidence regarding their effect on mortality. We aimed to ascertain the effect of early routine active percutaneous MCS versus control treatment on 6-month all-cause mortality in patients with AMICS.

Published
2024
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47. Heart rate turbulence in acute ischemic stroke

Author

Stengl, Helena, primary, Ganeshan, Ramanan, additional, von Rennenberg, Regina, additional, Hellwig, Simon, additional, Herm, Juliane, additional, Krause, Thomas, additional, Bauer, Axel, additional, Endres, Matthias, additional, Georg Haeusler, Karl, additional, Scheitz, Jan F, additional, and Nolte, Christian H, additional

Published
2023
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50. Long-Term Prognostic Value of High-Sensitivity Troponin T Added to N-Terminal Pro Brain Natriuretic Peptide Plasma Levels Before Valve Replacement for Severe Aortic Stenosis

Author

Barbieri, Fabian, Senoner, Thomas, Adukauskaite, Agne, Dobner, Stephan, Holfeld, Johannes, Semsroth, Severin, Lambert, Thomas, Zweiker, David, Theurl, Thomas, Rainer, Peter Paul, Schmidt, Albrecht, Feuchtner, Gudrun Maria, Steinwender, Clemens, Hoppe, Uta Charlotte, Hintringer, Florian, Bauer, Axel, Müller, Silvana, Grimm, Michael, Pfeifer, Bernhard Erich, and Dichtl, Wolfgang

Published
2019
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