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1. Integrating artificial intelligence into lung cancer screening: a randomised controlled trial protocol

Author

Paul Hofman, Sylvie Leroy, Jonathan Benzaquen, Bernard Padovani, Charles Hugo Marquette, Fontas Eric, Eric Fontas, Stephanie Lopez, Nesrine Rouis, Jacques Boutros, Allegra Maryline, Amamou-Elhani Faten, ARFI Thierry, Baque Jean, Baque-Juston Marie, Barel Remy, Barrios Baretto Deisy, Baudin Guillaume, Beck Camille, Bellmann Laurent, Benchetrit Maxime, Benkirane Mohamed-Taib, Benyoussef Sid Ali, Benzaquen Jonathan, Berthet Jean Philippe, Bonnard Eric, Bordone Olivier, Boutros Jacques, Boyer Guy-René, Bulsei Julie, Caillon Cynthia, Castelnau Olivier, Chalmin Jérémy, Chebib Ralph, Cohen Charlotte, Cruzel Coralie, Degoutte Aurélien, Delin Margot, Diascorn Yann, Doux Nathalie, Durand Lorraine, Duval Yannick, El Hemweh Omar, Fayada Julien, Felderhoof Eric, Feliciello Stéphane:, Femenia Richard, Ferrari Victoria, Francisci Marc Paul, Ghalloussi Hannah, Gomez-Caro-Andres Abel, Gora Assia, Griffonnet Jennifer, Gubeno Marie Christine, Guigay Joël, Hamila Marame, Harrathi Mohamed-Ali, Henaut Quentin, Herin Edouard, Hofman Paul, Hofman Véronique, ILIE Marius, Korzeniewski Sylvia, Lalvee Salomé, Lassalle Sandra, Le Heron Charles, Leray Loïc, Leriche Julien, Lerousseau Lionel, Leroy Sylvie, Lespinet Fabre Virginie, Lestrez Roxane, Leyssalle Axelle, Long Mira Elodie, Lopez Stephanie, Mahler Valentin, Maniel Charlotte, Marcano Xavier, Marco Roucayrol Sabine, Marquette Charles-Hugo, Martin Nicolas, Mistri Aurélie, Nicolle Isabelle, Novellas Sébastien, Oddo Frédéric, Otto Josiane, Padovani Bernard, PERQUIS Marie Pierre, Philibert Lorène, Pop Daniel, Pottier Héloïse, Raguin Olivier, Rolland Fabien, Rouis Nesrine, Rousset Johanna, Ruitort Frédéric, Sanfiorenzo Céline, Selva Eric, Tanga Virginie, Tardy Magalie, Thomas Olivier, Varenio Sophie, Verdoire Paul, Vigny Isabelle, Washetine Kévin, Zurlinden Olivier, Tarhini Adam, and Perrotin Cédric

Subjects
Medicine
Abstract

Introduction Lung cancer (LC) is the most common cause of cancer-related deaths worldwide. Its early detection can be achieved with a CT scan. Two large randomised trials proved the efficacy of low-dose CT (LDCT)-based lung cancer screening (LCS) in high-risk populations. The decrease in specific mortality is 20%–25%.Nonetheless, implementing LCS on a large scale faces obstacles due to the low number of thoracic radiologists and CT scans available for the eligible population and the high frequency of false-positive screening results and the long period of indeterminacy of nodules that can reach up to 24 months, which is a source of prolonged anxiety and multiple costly examinations with possible side effects.Deep learning, an artificial intelligence solution has shown promising results in retrospective trials detecting lung nodules and characterising them. However, until now no prospective studies have demonstrated their importance in a real-life setting.Methods and analysis This open-label randomised controlled study focuses on LCS for patients aged 50–80 years, who smoked more than 20 pack-years, whether active or quit smoking less than 15 years ago. Its objective is to determine whether assisting a multidisciplinary team (MDT) with a 3D convolutional network-based analysis of screening chest CT scans accelerates the definitive classification of nodules into malignant or benign. 2722 patients will be included with the aim to demonstrate a 3-month reduction in the delay between lung nodule detection and its definitive classification into benign or malignant.Ethics and dissemination The sponsor of this study is the University Hospital of Nice. The study was approved for France by the ethical committee CPP (Comités de Protection des Personnes) Sud-Ouest et outre-mer III (No. 2022-A01543-40) and the Agence Nationale du Medicament et des produits de Santé (Ministry of Health) in December 2023. The findings of the trial will be disseminated through peer-reviewed journals and national and international conference presentations.Trial registration number NCT05704920.

Published
2024
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2. MRI restaging of rectal cancer: The RAC (Response–Anal canal–CRM) analysis joint consensus guidelines of the GRERCAR and GRECCAR groups

Author

Nougaret, Stephanie, Rousset, Pascal, Lambregts, Doenja M.J., Maas, Monique, Gormly, Kirsten, Lucidarme, Oliver, Brunelle, Serge, Milot, Laurent, Arrivé, Lionel, Salut, Celine, Pilleul, Franck, Hordonneau, Constance, Baudin, Guillaume, Soyer, Philippe, Brun, Vanessa, Laurent, Valérie, Savoye-Collet, Celine, Petkovska, Iva, Gerard, Jean-Pierre, Cotte, Eddy, Rouanet, Philippe, Catalano, Onofrio, Denost, Quentin, Tan, Regina Beets, Frulio, Nora, and Hoeffel, Christine

Published
2023
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3. Structured and shared MRI staging lexicon and report of rectal cancer: A consensus proposal by the French Radiology Group (GRERCAR) and Surgical Group (GRECCAR) for rectal cancer

Author

Nougaret, Stephanie, Rousset, Pascal, Gormly, Kirsten, Lucidarme, Oliver, Brunelle, Serge, Milot, Laurent, Salut, Cécile, Pilleul, Franck, Arrivé, Lionel, Hordonneau, Constance, Baudin, Guillaume, Soyer, Philippe, Brun, Vanessa, Laurent, Valérie, Savoye-Collet, Celine, Petkovska, Iva, Gerard, Jean Pierre, Rullier, Eric, Cotte, Eddy, Rouanet, Philippe, Beets-Tan, Regina G.H., Frulio, Nora, and Hoeffel, Christine

Published
2022
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5. Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial)

Author

Assenat, Eric, Delhom-Christol, Elisabeth, Fourcade, Marjolène, Guiu, Boris, Ilonca, Alina Diana, Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Allaham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Chor, Hélène, Devictor, Julie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Imbert, Laetitia, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Gallais, Christelle, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean Pierre, Borentain, Patrick, Farman, Bardia, Gerolami, René, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouchet, Francis, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Darreon, Julien, Raoul, Jean Luc, Sarran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Masset, Hélène, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Laffont, Sophie, Rolland, Yan, Archambeaud, Isabelle, Carlier, Thomas, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Tendero, Karine, Vergniol, Julien, Bachellier, Philippe, Détour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Enderlin, Elise, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Talbot, Antoine, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Maurel, Fabien, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Vrigneaud, Jean-Marc, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Rousset, Evelyne, Leroy, Vincent, Reboulet, Ghislaine, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Ganne-Carrie, Nathalie, Seror, Olivier, Costo, Sylvie, Dao, Thông, Desmonts, Cédric, Pelage, Jean-Pierre, Defez, Didier, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Bernardini, Michela, Ghazar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Heurgue-Berlot, Alexandra, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Forbes, Aurélie, Maitre, Sophie, Marthey, Lysiane, Pereira, Helena, Burgio, Marco D., Grégory, Jules, and Chatellier, Gilles

Published
2021
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6. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Assenat, Eric, Delhom-Christol, Elisabeth, Guiu, Boris, Ilonca, Alina D., Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Al-laham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean-Pierre, RenéGerolami, Patrick Borentain, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sar-ran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Rolland, Yan, Archambeaud, Isabelle, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Vergniol, Julien, Bachellier, Philippe, Detour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Leroy, Vincent, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Carrie, Nathalie Ganne, Seror, Olivier, Costo, Sylvie, Dao, Thông, Pelage, Jean-Pierre, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Ghazzar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Berlot, Alexandra Heurgue, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Maitre, Sophie, Marthey, Lysiane, Zarca, Kevin, Mimouni, Maroua, Pereira, Helena, Chatellier, Gilles, and Durand-Zaleski, Isabelle

Published
2021
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8. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

Author

Assenat, Eric, Delhom - Christol, Elisabeth, Guiu, Boris, Ilonca, Alina D, Lonjon, Julie, Pageaux, Georges-Philippe, Abdel-Rehim, Mohamed, Allaham, Wassim, Bouattour, Mohamed, Castera, Laurent, Dieudonné, Arnaud, Lebtahi, Rachida, Ronot, Maxime, Sibert, Annie, Vilgrain, Valérie, Barraud, Hélène, Bazin, Christophe, Bronowicki, Jean-Pierre, Laurent, Valérie, Mathias, Elodie, Chagneau-Derrode, Carine, Perdrisot, Rémy, Silvain, Christine, Tasu, Jean-Pierre, Borentain, Patrick, Gerolami, René, Mundler, Olivier, Seitz, Jean-Francois, Vidal, Vincent, Aubé, Christophe, Bouvier, Antoine, Couturier, Olivier, Oberti, Frédéric, Vervueren, Laurent, Brenot-Rossi, Isabelle, Raoul, Jean-Luc, Sarran, Anthony, Chalaye, Julia, Costentin, Charlotte, Itti, Emmanuel, Kobeiter, Hicham, Luciani, Alain, Adam, René, Lewin, Maïté, Samuel, Didier, Edeline, Julien, Garin, Etienne, Rolland, Yan, Archambeaud, Isabelle, Eugene, Thomas, Frampas, Eric, Cassinotto, Christophe, Guyot, Martine, Hiriart, Jean-Baptiste, Lapuyade, Bruno, Vergniol, Julien, Bachellier, Philippe, Detour, Julien, Duclos, Bernard, Greget, Michel, Habersetzer, Francois, Imperiale, Alessio, Merle, Philippe, Rode, Agnès, Morvan, Julie, Nguyen-Khac, Eric, Yzet, Thierry, Baudin, Guillaume, Chevallier, Patrick, Mahamat, Abakar, Piche, Thierry, Razzouk, Micheline, Hillon, Patrick, Loffroy, Romaric, Toubeau, Michel, Vincent, Julie, Barabino, Gabriele, Bouarioua, Nadia, Cuilleron, Muriel, Ecochard, Marie, Prevot-Bitot, Nathalie, Leroy, Vincent, Roux, Julie, Sengel, Christian, Bourcier, Valérie, Ganne-Carrie, Nathalie, Seror, Olivier, Costo, Sylvie, Dao, Thông, Pelage, Jean-Pierre, Dumortier, Jérôme, Giammarile, Francesco, Valette, Pierre-Jean, Ghazzar, Nadia, Pellerin, Olivier, Taieb, Julien, Weinmann, Pierre, Heurgue-Berlot, Alexandra, Marcus, Claude, Sommacale, Daniele, Castilla-Lièvre, Maria-Angéla, Maitre, Sophie, Marthey, Lysiane, Pereira, Helena, Ilonca, Alina Diana, Dinut, Aurelia, and Chatellier, Gilles

Published
2017
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11. Efficacy of adalimumab in patients with Crohnʼs disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study

Author

Bouhnik, Yoram, Carbonnel, Franck, Laharie, David, Stefanescu, Carmen, Hébuterne, Xavier, Abitbol, Vered, Nachury, Maria, Brixi, Hedia, Bourreille, Arnaud, Picon, Laurence, Bourrier, Anne, Allez, Matthieu, Peyrin-Biroulet, Laurent, Moreau, Jacques, Savoye, Guillaume, Fumery, Mathurin, Nancey, Stephane, Roblin, Xavier, Altwegg, Romain, Bouguen, Guillaume, Bommelaer, Gilles, Danese, Silvio, Louis, Edouard, Zappa, Magaly, Mary, Jean-Yves, Arrive, Lionel, Aubourg, Alexandre, Baillon, Audrey, Baudin, Guillaume, Beaugerie, Laurent, Bolivar, Julie, Brun, Vanessa, Buisson, Anthony, Cadiot, Guillaume, Chevalier, Patrick, Colombel, Jean Frédéric, Cuilleron, Muriel, Dupas, Jean Louis, Filippi, Jérôme, Flourié, Bernard, Frampas, Eric, Gayet, Mathilde, Gornet, Jean Marc, Hordonneau, Constance, Lapuyade, Bruno, Laurent, Valérie, Leroy, Christophe, Lewin, Maïté, Otal, Philippe, Oudjit, Ammar, Panis, Yves, Pariente, Benjamin, Scotto, Béatrice, Simon, Marion, Treton, Xavier, Valette, Pierre-Jean, Yzet, Thierry, and Zagdanski, Anne Marie

Published
2018
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12. EASL and AASLD recommendations for the diagnosis of HCC to the test of daily practice

Author

Aubé, Christophe, Oberti, Frédéric, Lonjon, Julie, Pageaux, Georges, Seror, Olivier, NʼKontchou, Giséle, Rode, Agnes, Radenne, Sylvie, Cassinotto, Christophe, Vergniol, Julien, Bricault, Ivan, Leroy, Vincent, Ronot, Maxime, Castera, Laurent, Michalak, Sophie, Esvan, Maxime, Vilgrain, Valérie, Tasu, Jean Pierre, Sylvain, Christine, Luciani, Alain, Duvoux, Christophe, Pilleul, Frank, Dumortier, Jérôme, Baudin, Guillaume, Anty, Rodolphe, Chevallier, Patrick, Le Pennec, Vincent, Hourmand, Isabelle Ollivier, Estivalet, Louis, Minello, Anne, Frampas, Eric, Archambeaud, Isabelle, Guillygomarc’h, Anne, Brun, Vanessa, Gandon, Yves, Cuilleron, Muriel, Patouillard, Brigitte, Guiu, Boris, Gallix, Benoit, and Lebigot, Jérôme

Published
2017
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13. Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography

Author

UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, Stéfanescu, Carmen, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de radiologie, Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, and Stéfanescu, Carmen

Abstract

Background The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). Methods Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. Results Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. Conclusions The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.

Published
2022

14. Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn’s Disease Using Magnetic Resonance Enterography

Author

Bouhnik, Yoram, Le Berre, Catherine, Zappa, Magaly, Lewin, Maïté, Boudiaf, Mourad, Zagdanski, Anne Marie, Frampas, Eric, Oudjit, Ammar, Scotto, Béatrice, Tissier, Muriel, Annet, Laurence, Aufort, Sophie, Yzet, Thierry, Cuilleron, Muriel, Baudin, Guillaume, Abitbol, Vered, Cosnes, Jacques, Bourreille, Arnaud, Mary, Jean Yves, Simon, Marion, Dupas, Jean Louis, Marteau, Philippe, Picon, Laurence, Pelletier, Anne Laure, Altwegg, Romain, Dewit, Olivier, Filippi, Jérome, Roblin, Xavier, Stéfanescu, Carmen, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - (SLuc) Centre du cancer, and UCL - (SLuc) Service de radiologie

Subjects
MRE, Gastroenterology, CDMRIS, macromolecular substances, crohn, Small bowel
Abstract

Background The severity of small bowel (SB) inflammation in Crohn’s disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). Methods Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. Results Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild–moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. Conclusions The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.

Published
2022

16. Health-related quality of life in locally advanced hepatocellular carcinoma treated by either radioembolisation or sorafenib (SARAH trial)

Author

Pereira, Helena, primary, Bouattour, Mohamed, additional, Burgio, Marco D., additional, Assenat, Eric, additional, Grégory, Jules, additional, Bronowicki, Jean-Pierre, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Delhom-Christol, Elisabeth, additional, Fourcade, Marjolène, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Allaham, Wassim, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Chor, Hélène, additional, Devictor, Julie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Imbert, Laetitia, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Gallais, Christelle, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean Pierre, additional, Borentain, Patrick, additional, Farman, Bardia, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouchet, Francis, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Darreon, Julien, additional, Raoul, Jean Luc, additional, Sarran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Masset, Hélène, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Laffont, Sophie, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Carlier, Thomas, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Tendero, Karine, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Détour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Enderlin, Elise, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Talbot, Antoine, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Maurel, Fabien, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Vrigneaud, Jean-Marc, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Rousset, Evelyne, additional, Leroy, Vincent, additional, Reboulet, Ghislaine, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Desmonts, Cédric, additional, Pelage, Jean-Pierre, additional, Defez, Didier, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Bernardini, Michela, additional, Ghazar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Forbes, Aurélie, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
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17. Cost-Utility Analysis of Transarterial Radioembolization With Yttrium-90 Resin Microspheres Compared With Sorafenib in Locally Advanced and Inoperable Hepatocellular Carcinoma

Author

Zarca, Kevin, primary, Mimouni, Maroua, additional, Pereira, Helena, additional, Chatellier, Gilles, additional, Vilgrain, Valérie, additional, Durand-Zaleski, Isabelle, additional, Assenat, Eric, additional, Delhom-Christol, Elisabeth, additional, Guiu, Boris, additional, Ilonca, Alina D., additional, Lonjon, Julie, additional, Pageaux, Georges-Philippe, additional, Abdel-Rehim, Mohamed, additional, Al-laham, Wassim, additional, Bouattour, Mohamed, additional, Castera, Laurent, additional, Dieudonné, Arnaud, additional, Lebtahi, Rachida, additional, Ronot, Maxime, additional, Sibert, Annie, additional, Barraud, Hélène, additional, Bazin, Christophe, additional, Bronowicki, Jean-Pierre, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Chagneau-Derrode, Carine, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Tasu, Jean-Pierre, additional, RenéGerolami, Patrick Borentain, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Bouvier, Antoine, additional, Couturier, Olivier, additional, Oberti, Frédéric, additional, Vervueren, Laurent, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sar-ran, Anthony, additional, Chalaye, Julia, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Kobeiter, Hicham, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Carrie, Nathalie Ganne-, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Berlot, Alexandra Heurgue-, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2021
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19. Early Toxicities After High Dose Rate Proton Therapy in Cancer Treatments

Author

Doyen, Jérôme, primary, Sunyach, Marie-Pierre, additional, Almairac, Fabien, additional, Bourg, Véronique, additional, Naghavi, Arash O., additional, Duhil de Bénazé, Gwenaëlle, additional, Claren, Audrey, additional, Padovani, Laetitia, additional, Benezery, Karen, additional, Noël, Georges, additional, Hannoun-Lévi, Jean-Michel, additional, Guedea, Ferran, additional, Giralt, Jordi, additional, Vidal, Marie, additional, Baudin, Guillaume, additional, Opitz, Lucas, additional, Claude, Line, additional, and Bondiau, Pierre-Yves, additional

Published
2021
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20. Le prétexte au désœuvrement

Author

Baudin, Guillaume

Subjects
poésie, informatique, LAN005000, Literature (General), CBV, littérature, Cultural studies, écriture
Abstract

Guillaume Baudin, co-auteur d’ACSOO, premier scénario interactif réalisé pour minitel, présente l’expérience d’écriture qu’il a vécue et les leçons qu’il en a tirées. A partir de l’exposition de cette réalisation particulière, il esquisse une réflexion sur l’interactivité appliquée au domaine du récit de fiction.

Published
2018

21. L'Imagination informatique de la Littérature

Author

Abeille, Anne, Balazard, Simone, Balpe, Jean-Pierre, Baudin, Guillaume, Cadet, Christiane, Demers, Jeanne, Goossens, Daniel, Laufer, Roger, Lesbros, Vincent, Lusson, Pierre, Magné, Bernard, and Oriol-Boyer, Claudette

Subjects
poésie, informatique, LAN005000, Literature (General), CBV, littérature, Cultural studies, écriture
Abstract

Recoupant certaines tentations de l'écriture, l'ordinateur a très vite été sollicité pour la création. Des œuvres existent, encore mal connues. Origine de cet ouvrage, un colloque de Cerisy s'est interrogé sur les modifications que ces essais introduisent dans le champ littéraire. Lorsqu'il est requis pour écrire, l'ordinateur n'intervient pas en outil neutre, simple pourvoyeur de facilités techniques. Il s'agit en fait d'un véritable média, soumettant la production des textes à des règles et à des fonctionnements originaux, qui en modifient l'allure et l'image. C'est cette imagination nouvelle de la littérature qu'on met ici en débat, à travers ses représentations, ses approches descriptives et analytiques, son insertion culturelle et ses modalités d'enseignement. L'enjeu concerne la définition même du fait littéraire : jusqu'où le recours informatique pourra-t-il en transformer l'idée ?

Published
2018

27. Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial

Author

Vilgrain, Valérie, primary, Pereira, Helena, additional, Assenat, Eric, additional, Guiu, Boris, additional, Ilonca, Alina Diana, additional, Pageaux, Georges-Philippe, additional, Sibert, Annie, additional, Bouattour, Mohamed, additional, Lebtahi, Rachida, additional, Allaham, Wassim, additional, Barraud, Hélène, additional, Laurent, Valérie, additional, Mathias, Elodie, additional, Bronowicki, Jean-Pierre, additional, Tasu, Jean-Pierre, additional, Perdrisot, Rémy, additional, Silvain, Christine, additional, Gerolami, René, additional, Mundler, Olivier, additional, Seitz, Jean-Francois, additional, Vidal, Vincent, additional, Aubé, Christophe, additional, Oberti, Frédéric, additional, Couturier, Olivier, additional, Brenot-Rossi, Isabelle, additional, Raoul, Jean-Luc, additional, Sarran, Anthony, additional, Costentin, Charlotte, additional, Itti, Emmanuel, additional, Luciani, Alain, additional, Adam, René, additional, Lewin, Maïté, additional, Samuel, Didier, additional, Ronot, Maxime, additional, Dinut, Aurelia, additional, Castera, Laurent, additional, Chatellier, Gilles, additional, Delhom - Christol, Elisabeth, additional, Ilonca, Alina D, additional, Lonjon, Julie, additional, Abdel-Rehim, Mohamed, additional, Dieudonné, Arnaud, additional, Vilgrain, Valérie, additional, Bazin, Christophe, additional, Chagneau-Derrode, Carine, additional, Borentain, Patrick, additional, Bouvier, Antoine, additional, Vervueren, Laurent, additional, Chalaye, Julia, additional, Kobeiter, Hicham, additional, Edeline, Julien, additional, Garin, Etienne, additional, Rolland, Yan, additional, Archambeaud, Isabelle, additional, Eugene, Thomas, additional, Frampas, Eric, additional, Cassinotto, Christophe, additional, Guyot, Martine, additional, Hiriart, Jean-Baptiste, additional, Lapuyade, Bruno, additional, Vergniol, Julien, additional, Bachellier, Philippe, additional, Detour, Julien, additional, Duclos, Bernard, additional, Greget, Michel, additional, Habersetzer, Francois, additional, Imperiale, Alessio, additional, Merle, Philippe, additional, Rode, Agnès, additional, Morvan, Julie, additional, Nguyen-Khac, Eric, additional, Yzet, Thierry, additional, Baudin, Guillaume, additional, Chevallier, Patrick, additional, Mahamat, Abakar, additional, Piche, Thierry, additional, Razzouk, Micheline, additional, Hillon, Patrick, additional, Loffroy, Romaric, additional, Toubeau, Michel, additional, Vincent, Julie, additional, Barabino, Gabriele, additional, Bouarioua, Nadia, additional, Cuilleron, Muriel, additional, Ecochard, Marie, additional, Prevot-Bitot, Nathalie, additional, Leroy, Vincent, additional, Roux, Julie, additional, Sengel, Christian, additional, Bourcier, Valérie, additional, Ganne-Carrie, Nathalie, additional, Seror, Olivier, additional, Costo, Sylvie, additional, Dao, Thông, additional, Pelage, Jean-Pierre, additional, Dumortier, Jérôme, additional, Giammarile, Francesco, additional, Valette, Pierre-Jean, additional, Ghazzar, Nadia, additional, Pellerin, Olivier, additional, Taieb, Julien, additional, Weinmann, Pierre, additional, Heurgue-Berlot, Alexandra, additional, Marcus, Claude, additional, Sommacale, Daniele, additional, Castilla-Lièvre, Maria-Angéla, additional, Maitre, Sophie, additional, and Marthey, Lysiane, additional

Published
2017
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33. Lumbar Discitis Caused by Clostridium perfringens

Author

Lotte, Romain, Popoff, M. R., Degand, Nicolas, Lotte, Laurene, Bouvet, Philippe, Baudin, Guillaume, Cua, Eric, Roger, Pierre-Marie, and Ruimy, Raymond

Abstract

ABSTRACTWe report here a rare case of chronic lumbar discitis caused by Clostridium perfringensin an elderly patient that was treated with a combination of ß-lactams and clindamycin. Molecular analysis performed on the strain revealed an unusual toxin gene pattern.

Published
2014
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34. Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn's Disease Using Magnetic Resonance Enterography.

Author

Bouhnik Y, Le Berre C, Zappa M, Lewin M, Boudiaf M, Zagdanski AM, Frampas E, Oudjit A, Scotto B, Tissier M, Annet L, Aufort S, Yzet T, Cuilleron M, Baudin G, Abitbol V, Cosnes J, Bourreille A, and Mary JY

Abstract

Background: The severity of small bowel (SB) inflammation in Crohn's disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS)., Methods: Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity., Results: Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild-moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76., Conclusions: The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps., (© The Author(s) 2022. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.)

Published
2022
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35. The value of pelvic MRI in the diagnosis of posterior cul-de-sac obliteration in cases of deep pelvic endometriosis.

Author

Macario S, Chassang M, Novellas S, Baudin G, Delotte J, Toullalan O, and Chevallier P

Subjects
Adult, Contrast Media, Endometriosis surgery, Female, Humans, Laparoscopy, Meglumine, Middle Aged, Organometallic Compounds, Peritoneal Diseases surgery, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Endometriosis diagnosis, Magnetic Resonance Imaging methods, Peritoneal Diseases diagnosis
Abstract

Objective: The objective of our study was to define relevant MRI signs allowing preoperative diagnosis of posterior cul-de-sac obliteration in patients with deep pelvic endometriosis., Materials and Methods: This retrospective study included patients who underwent pelvic MRI completed by a laparoscopic examination. Three radiologists performed the MRI review blinded and recorded the following signs: sign 1, retroflexed uterus; sign 2, retrouterine mass; sign 3, displacement of intraperitoneal fluid; sign 4, elevation of the fornix; and sign 5, adherence of bowel loops. Laparoscopic results provided the criterion standard for diagnosis of posterior cul-de-sac obliteration. The performance of MRI was evaluated by calculating the average sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of MRI results of the two more experienced radiologists for each sign and for combinations of signs. Interobserver agreement for each sign and impression for posterior cul-de-sac obliteration were calculated for all radiologists., Results: Sixty-three patients were included in the study. Posterior cul-de-sac obliteration was diagnosed in 43 patients at laparoscopy. The mean sensitivity, specificity, and accuracy of each sign and impression of posterior cul-de-sac obliteration were, respectively, as follows: sign 1, 24.4%, 77.5%, 41.3%; sign 2, 97.1%, 83.7%, 92.8%; sign 3, 95.0%, 88.7%, 93.1%; sign 4, 30.2%, 97.5%, 51.6%; sign 5, 83.7%, 91.2%, 86.1%; and impression of posterior cul-de-sac obliteration, 91.9%, 91.2%, 91.7%. Interobserver concordance varied from 0.26 to 0.81 with best results obtained with the combination of signs 2, 3, and 5. Best concordances for junior radiologist evaluations were obtained with assessment of sign 3., Conclusion: MRI allows posterior cul-de-sac obliteration diagnosis. Pelvic fluid displacement may be the sign with greatest utility when considering both diagnostic accuracy and interobserver agreement.

Published
2012
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36. CT-guided percutaneous catheter drainage of acute infectious necrotizing pancreatitis: assessment of effectiveness and safety.

Author

Baudin G, Chassang M, Gelsi E, Novellas S, Bernardin G, Hébuterne X, and Chevallier P

Subjects
Biopsy, Fine-Needle, C-Reactive Protein analysis, Catheterization adverse effects, Drainage adverse effects, Female, Hemorrhage etiology, Humans, Intestinal Fistula etiology, Length of Stay, Male, Middle Aged, Pancreas pathology, Pancreatic Fistula etiology, Pancreatitis, Acute Necrotizing blood, Pancreatitis, Acute Necrotizing mortality, Pancreatitis, Acute Necrotizing pathology, Predictive Value of Tests, Radiographic Image Enhancement, Retrospective Studies, Survival Rate, Treatment Outcome, Drainage methods, Pancreatitis, Acute Necrotizing diagnostic imaging, Pancreatitis, Acute Necrotizing therapy
Abstract

Objective: The purpose of this study is to assess retrospectively the effectiveness and safety of CT-guided percutaneous drainage and to determine the factors influencing clinical success and mortality in patients with infectious necrotizing pancreatitis., Materials and Methods: From April 1997 to December 2005, 48 consecutive patients (33 men and 15 women; median age, 58.5 years) with proven infectious necrotizing pancreatitis underwent percutaneous catheter drainage via CT guidance. Evaluated factors included clinical, biologic, and radiologic scores; drainage and catheter characteristics; and complications. Clinical success was defined as control of sepsis without requirement for surgery. Univariate analysis was performed to determine factors that could have affected the clinical success and the mortality rates., Results: Clinical success was achieved in 31 of 48 patients (64.6%) and was significantly associated with Ranson score (p = 0.01) and with the delay between admission and the beginning of the drainage (p = 0.005), with a calculated threshold delay of 18 days (p = 0.001). The global mortality rate (14/48 [29%]) was also influenced by the Ranson score (p = 01) and the delay of drainage (p = 0.04) with the same threshold delay (p = 0.01). Only two major nonlethal procedure-related complications were observed., Conclusion: Percutaneous catheter drainage is a safe and effective technique to treat acute infectious necrotizing pancreatitis.

Published
2012
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