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2. Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals

Author

Argote, Mathilde, Sescousse, Guillaume, Brunelin, Jérôme, Baudin, Grégoire, Schaub, Michael Patrick, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio, Martinotti, Giovanni, Knížková, Karolína, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente, Amoretti, Silvia, Huber, Christian, Thibeau, Heather, Kline, Emily, Fakra, Eric, Jardri, Renaud, Nourredine, Mikail, and Rolland, Benjamin

Published
2023
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4. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

Author

Amoretti, Silvia, Arrojo, Manuel, Baudin, Grégoire, Beards, Stephanie, Bernardo, Miquel, Bobes, Julio, Bonetto, Chiara, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Cuadrado, Pedro, Díaz-Caneja, Covadonga M, Ferchiou, Aziz, Franke, Nathalie, Frijda, Flora, García Bernardo, Enrique, Garcia-Portilla, Paz, González, Emiliano, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Lorente-Rovira, Esther, Marcelino Loureiro, Camila, Marrazzo, Giovanna, Martínez, Covadonga, Matteis, Mario, Messchaart, Elles, Moltó, Ma Dolores, Nacher, Juan, Olmeda, Ma Soledad, Parellada, Mara, González Peñas, Javier, Pignon, Baptiste, Rapado, Marta, Richard, Jean-Romain, Rodríguez Solano, José Juan, Roldán Díaz, Laura, Ruggeri, Mirella, Sáiz, Pilar A., Sánchez, Emilio, Sanjuán, Julio, Sartorio, Crocettarachele, Schürhoff, Franck, Seminerio, Fabio, Shuhama, Rosana, Sideli, Lucia, Stilo, Simona A, Termorshuizen, Fabian, Tosato, Sarah, Tronche, Anne-Marie, van Dam, Daniella, van der Ven, Elsje, Di Forti, Marta, Quattrone, Diego, Freeman, Tom P, Tripoli, Giada, Gayer-Anderson, Charlotte, Quigley, Harriet, Rodriguez, Victoria, Jongsma, Hannah E, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Velthorst, Eva, Bernardo, Miguel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, Rutten, Bart PF, de Haan, Lieuwe, Sham, Pak C, van Os, Jim, Lewis, Cathryn M, Lynskey, Michael, Morgan, Craig, and Murray, Robin M

Published
2019
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6. Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals

Author

Argote, Mathilde; https://orcid.org/0000-0002-9344-0376, Sescousse, Guillaume, Brunelin, Jérôme; https://orcid.org/0000-0001-5479-5628, Baudin, Grégoire, Schaub, Michael Patrick; https://orcid.org/0000-0002-8375-4005, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine; https://orcid.org/0000-0002-3720-7115, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio; https://orcid.org/0000-0003-1717-2530, Martinotti, Giovanni, Knížková, Karolína; https://orcid.org/0000-0003-3069-6750, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente; https://orcid.org/0000-0002-4855-1608, Amoretti, Silvia, et al, Argote, Mathilde; https://orcid.org/0000-0002-9344-0376, Sescousse, Guillaume, Brunelin, Jérôme; https://orcid.org/0000-0001-5479-5628, Baudin, Grégoire, Schaub, Michael Patrick; https://orcid.org/0000-0002-8375-4005, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine; https://orcid.org/0000-0002-3720-7115, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio; https://orcid.org/0000-0003-1717-2530, Martinotti, Giovanni, Knížková, Karolína; https://orcid.org/0000-0003-3069-6750, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente; https://orcid.org/0000-0002-4855-1608, Amoretti, Silvia, and et al

Abstract

Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important confounding variables which is a source of bias. Methods: PubMed, ScienceDirect and PsycINFO were used to search for publications from inception to September 27, 2022. We contacted the authors of relevant studies to extract raw datasets and perform an Individual Participant Data meta-analysis (IPDMA). Inclusion criteria were: psychopathology of individuals with schizophrenia spectrum disorders assessed by the Positive and Negative Syndrome Scale (PANSS); cannabis-users had to either have a diagnosis of cannabis use disorder or use cannabis at least twice a week. The main outcomes were the PANSS subscores extracted via the 3-factor (positive, negative and general) and 5-factor (positive, negative, disorganization, depression, excitement) structures. Preregistration is accessible via Prospero: ID CRD42022329172. Findings: Among the 1149 identified studies, 65 were eligible and 21 datasets were shared, totaling 3677 IPD and 3053 complete cases. The adjusted multivariate analysis revealed that relative to non-use, cannabis use was associated with higher severity of positive dimension (3-factor: Adjusted Mean Difference, aMD = 0.34, 95% Confidence Interval, CI = [0.03; 0.66]; 5-factor: aMD = 0.38, 95% CI = [0.08; 0.63]), lower severity of negative dimension (3-factor: aMD = -0.49, 95% CI [-0.90; -0.09]; 5-factor: aMD = -0.50, 95% CI = [-0.91; -0.08]), higher severity of excitement dimension (aMD = 0.16, 95% CI = [0.03; 0.28]). No association was found between cannabis use and disorganization (aMD = -0.13, 95% CI = [-0.42; 0.17]) or depression (aMD = -0.14, 95% CI = [-0.34; 0.06]). Interpre

Published
2023

10. Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study

Author

Pignon, Baptiste, primary, Peyre, Hugo, additional, Ayrolles, Anaël, additional, Kirkbride, James, additional, Jamain, Stéphane, additional, ferchiou, AZIZ, additional, Richard, Jean-Romain, additional, Baudin, Grégoire, additional, Tosato, Sarah, additional, Jongsma, Hannah, additional, De Haan, Lieuwe, additional, Tarricone, Ilaria, additional, Bernardo, Miquel, additional, Velthorst, Eva, additional, braca, mauro, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Del-Ben, Cristina, additional, Forti, Marta di, additional, Gayer-Anderson, Charlotte, additional, Jones, Peter, additional, Lasalvia, Antonio, additional, Menezes, Paulo, additional, Quattrone, Diego, additional, Sanjuan, Julio, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Llorca, Pierre Michel, additional, Os, Jim van, additional, Rutten, Bart, additional, Murray, Robin, additional, Morgan, Craig, additional, Leboyer, Marion, additional, Szoke, Andrei, additional, and Schurhof, Franck, additional

Published
2022
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11. The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)

Author

Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, De Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., Van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Hubbard, Kathryn, Beards, Stephanie, Reininghaus, Ulrich, Tripoli, Giada, Stilo, Simona A., Roldán, Laura, López, Gonzalo, Matteis, Mario, Rapado, Marta, González, Emiliano, Martínez, Covadonga, Cuadrado, Pedro, Solano, José Juan Rodríguez, Carracedo, Angel, Costas, Javier, Bernardo, Enrique García, Sánchez, Emilio, Olmeda, Ma Soledad, Cabrera, Bibiana, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Jamain, Stéphane, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Sideli, Lucia, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Loureiro, Camila Marcelino, Shuhama, Rosana, Tosato, Sarah, Bonetto, Chiara, Cristofalo, Doriana, Gayer-Anderson, Charlotte [0000-0003-1636-889X], Apollo - University of Cambridge Repository, Gayer-Anderson C., Jongsma H.E., Di Forti M., Quattrone D., Velthorst E., de Haan L., Selten J.-P., Szoke A., Llorca P.-M., Tortelli A., Arango C., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Parellada M., Tarricone I., Berardi D., Ruggeri M., Lasalvia A., Ferraro L., La Cascia C., La Barbera D., Menezes P.R., Del-Ben C.M., Hubbard K., Beards S., Reininghaus U., Tripoli G., Stilo S.A., Roldan L., Lopez G., Matteis M., Rapado M., Gonzalez E., Martinez C., Cuadrado P., Solano J.J.R., Carracedo A., Costas J., Bernardo E.G., Sanchez E., Olmeda M.S., Cabrera B., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Baudin G., Ferchiou A., Pignon B., Jamain S., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Sideli L., Seminerio F., Sartorio C., Marrazzo G., Loureiro C.M., Shuhama R., Tosato S., Bonetto C., Cristofalo D., Rutten B.P., van Os J., Jones P.B., Murray R.M., Kirkbride J.B., Morgan C., Gayer-Anderson, Charlotte, Jongsma, Hannah E., Di Forti, Marta, Quattrone, Diego, Velthorst, Eva, de Haan, Lieuwe, Selten, Jean-Paul, Szöke, Andrei, Llorca, Pierre-Michel, Tortelli, Andrea, Arango, Celso, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, José Lui, Arrojo, Manuel, Parellada, Mara, Tarricone, Ilaria, Berardi, Domenico, Ruggeri, Mirella, Lasalvia, Antonio, Ferraro, Laura, La Cascia, Caterina, La Barbera, Daniele, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Rutten, Bart P., van Os, Jim, Jones, Peter B., Murray, Robin M., Kirkbride, James B., Morgan, Craig, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, MUMC+: Hersen en Zenuw Centrum (3), ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Adult Psychiatry, and APH - Mental Health

Subjects
Male, Health (social science), Epidemiology, Ethnic group, Ethnic Group, Gene-environment interactions, Environment–environment interactions, 0302 clinical medicine, Ethnicity, 10. No inequality, First episode, RISK, biology, Incidence (epidemiology), Incidence, CANNABIS, Middle Aged, Case-control, First-episode psychosis, 3. Good health, Europe, Psychiatry and Mental health, Case–control Environment–environment interactions EU-GEI First-episode psychosis Gene–environment interactions Incidence, Case–control, EU-GEI, Gene–environment interactions, Schizophrenia, Cohort, Female, Psychology, Case-Control Studie, Brazil, Human, Adult, medicine.medical_specialty, Social Psychology, Adolescent, Study Protocols and Samples, DISORDERS, Environment–environment interaction, Representativeness heuristic, 03 medical and health sciences, Young Adult, PSYCHOSIS, AGE, First-episode psychosi, Environment-environment interactions, medicine, Humans, Gene–environment interaction, Settore MED/25 - Psichiatria, METAANALYSIS, biology.organism_classification, medicine.disease, 030227 psychiatry, Case-Control Studies, Gene-Environment Interaction, Cannabis, CHILDHOOD ADVERSITIES, 030217 neurology & neurosurgery, Demography
Abstract

Funder: FP7 Ideas: European Research Council; doi: http://dx.doi.org/10.13039/100011199; Grant(s): HEALTH-F2-2010-241909, Purpose: The EUropean Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods: Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case–control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions: This resource constitutes the largest and most extensive incidence and case–control study of psychosis ever conducted.

Published
2020
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12. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Author

Quattrone, Diego, Reininghaus, Ulrich, Richards, Alex L., Tripoli, Giada, Ferraro, Laura, Quattrone, Andrea, Marino, Paolo, Rodriguez, Victoria, Spinazzola, Edoardo, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Jones, Peter B., La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Bonora, Elena, Tosato, Sarah, Lasalvia, Antonio, Szöke, Andrei, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Del Ben, Cristina Marta, Menezes, Paulo Rossi, Llorca, Pierre-Michel, Santos, Jose Luis, Sanjuán, Julio, Arrojo, Manuel, Tortelli, Andrea, Velthorst, Eva, Berendsen, Steven, De Haan, Lieuwe, Rutten, Bart P. F., Lynskey, Michael T., Freeman, Tom P., Kirkbride, James B., Sham, Pak C., O’Donovan, Michael C., Cardno, Alastair G., Vassos, Evangelos, Van Os, Jim, Morgan, Craig, Murray, Robin M., Lewis, Cathryn M., Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Fraguas, David, Castro, Marta Rapado, Andreu-Bernabeu, Álvaro, López, Gonzalo, Matteis, Mario, González, Emiliano, Durán-Cutilla, Manuel, Díaz-Caneja, Covadonga M., Cuadrado, Pedro, Rodríguez Solano, José Juan, Carracedo, Angel, Costas, Javier, Sánchez, Emilio, Amoretti, Silvia, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Jamain, Stéphane, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Bonetto, Chiara, Cristofalo, Doriana, Berardi, Domenico, Seri, Marco, D’Andrea, Giuseppe, Quattrone, Diego [0000-0002-6051-8309], Richards, Alex L. [0000-0003-3218-7247], Marino, Paolo [0000-0003-3571-1753], Rodriguez, Victoria [0000-0003-0383-0846], Jones, Peter B. [0000-0002-0387-880X], Tosato, Sarah [0000-0002-9665-7538], Bernardo, Miquel [0000-0001-8748-6717], Bobes, Julio [0000-0003-2187-4033], Del Ben, Cristina Marta [0000-0003-0145-9975], Menezes, Paulo Rossi [0000-0001-6330-3314], Llorca, Pierre-Michel [0000-0001-7438-8990], Rutten, Bart P. F. [0000-0002-9834-6346], Kirkbride, James B. [0000-0003-3401-0824], O’Donovan, Michael C. [0000-0001-7073-2379], Vassos, Evangelos [0000-0001-6363-0438], Murray, Robin M. [0000-0003-0829-0519], Lewis, Cathryn M. [0000-0002-8249-8476], and Apollo - University of Cambridge Repository

Subjects
45, 692/699/476/1799, 692/53/2423, 45/43, article, 631/208/2489
Abstract

Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.

Published
2021
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13. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Author

Hersenen-Medisch 1, Brain, Pignon, Baptiste, Lajnef, Mohamed, Kirkbride, James B, Peyre, Hugo, Ferchiou, Aziz, Richard, Jean-Romain, Baudin, Grégoire, Tosato, Sarah, Jongsma, Hannah, de Haan, Lieuwe, Tarricone, Ilaria, Bernardo, Miguel, Velthorst, Eva, Braca, Mauro, Arango, Celso, Arrojo, Manuel, Bobes, Julio, Del-Ben, Cristina Marta, Di Forti, Marta, Gayer-Anderson, Charlotte, Jones, Peter B, La Cascia, Caterina, Lasalvia, Antonio, Menezes, Paulo Rossi, Quattrone, Diego, Sanjuán, Julio, Selten, Jean-Paul, Tortelli, Andrea, Llorca, Pierre-Michel, van Os, Jim, Rutten, Bart P F, Murray, Robin M, Morgan, Craig, Leboyer, Marion, Szöke, Andrei, Schürhoff, Franck, Hersenen-Medisch 1, Brain, Pignon, Baptiste, Lajnef, Mohamed, Kirkbride, James B, Peyre, Hugo, Ferchiou, Aziz, Richard, Jean-Romain, Baudin, Grégoire, Tosato, Sarah, Jongsma, Hannah, de Haan, Lieuwe, Tarricone, Ilaria, Bernardo, Miguel, Velthorst, Eva, Braca, Mauro, Arango, Celso, Arrojo, Manuel, Bobes, Julio, Del-Ben, Cristina Marta, Di Forti, Marta, Gayer-Anderson, Charlotte, Jones, Peter B, La Cascia, Caterina, Lasalvia, Antonio, Menezes, Paulo Rossi, Quattrone, Diego, Sanjuán, Julio, Selten, Jean-Paul, Tortelli, Andrea, Llorca, Pierre-Michel, van Os, Jim, Rutten, Bart P F, Murray, Robin M, Morgan, Craig, Leboyer, Marion, Szöke, Andrei, and Schürhoff, Franck

Published
2021

14. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Author

Pignon, Baptiste, primary, Lajnef, Mohamed, additional, Kirkbride, James B, additional, Peyre, Hugo, additional, Ferchiou, Aziz, additional, Richard, Jean-Romain, additional, Baudin, Grégoire, additional, Tosato, Sarah, additional, Jongsma, Hannah, additional, de Haan, Lieuwe, additional, Tarricone, Ilaria, additional, Bernardo, Miguel, additional, Velthorst, Eva, additional, Braca, Mauro, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bobes, Julio, additional, Del-Ben, Cristina Marta, additional, Di Forti, Marta, additional, Gayer-Anderson, Charlotte, additional, Jones, Peter B, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Menezes, Paulo Rossi, additional, Quattrone, Diego, additional, Sanjuán, Julio, additional, Selten, Jean-Paul, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, van Os, Jim, additional, Rutten, Bart P F, additional, Murray, Robin M, additional, Morgan, Craig, additional, Leboyer, Marion, additional, Szöke, Andrei, additional, and Schürhoff, Franck, additional

Published
2021
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16. Childhood Trauma Predicts Less Remission from PTSD among Patients with Co-Occurring Alcohol Use Disorder and PTSD

Author

Brunault, Paul, Lebigre, Kevin, Idbrik, Fatima, Maugé, Damien, Adam, Philippe, Barrault, Servane, Baudin, Grégoire, Courtois, Robert, El Ayoubi, Hussein, Grall-Bronnec, Marie, Hingray, Coraline, Ballon, Nicolas, El-Hage, Wissam, Qualité de vie et Santé psychologique [Tours] (QualiPsy - E.E. 1901), Université de Tours (UT), Clinique Psychiatrique Universitaire [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), and Université de Tours

Subjects
childhood trauma, lcsh:R, lcsh:Medicine, [SHS.PSY]Humanities and Social Sciences/Psychology, dual disorders, alcohol use disorder, rehabilitation centers, behavioral disciplines and activities, Article, substance-related disorders, psychiatric disorders, impulsive behavior, mental disorders, addictive disorders, post-traumatic stress disorder, Substance-use disorder, ComputingMilieux_MISCELLANEOUS
Abstract

Post-traumatic stress disorder (PTSD) is highly prevalent among patients hospitalized for an alcohol use disorder (AUD). Hospitalization can improve PTSD and AUD outcomes in some but not all patients, but we lack data on the baseline predictors of PTSD non-remission. This study aimed to determine the baseline risk factors for non-remitted PTSD in patients hospitalized for an AUD. Of 298 AUD inpatients recruited in a rehabilitation center (Le Courbat, France), we included 91 AUD inpatients with a co-occurring PTSD and a longitudinal assessment at baseline (T1) and before discharge (T2: 8 weeks later). Patients were assessed for PTSD diagnosis/severity (PCL-5=PTSD Checklist for DSM-5), different types of trauma including childhood trauma (LEC-5=Life Events Checklist for DSM-5/CTQ-SF=Childhood Trauma Questionnaire, Short-Form), and AUD diagnosis/severity (clinical interview/AUDIT=Alcohol Use Disorders Identification Test). Rate of PTSD remission between T1 and T2 was 74.1%. Non-remitted PTSD at T2 was associated with a history of childhood trauma (physical, emotional or sexual abuse, physical negligence), but not with other types of trauma experienced, nor baseline PTSD or AUD severity. Among patients hospitalized for an AUD with co-occurring PTSD, PTSD remission was more strongly related to the existence of childhood trauma than to AUD or PTSD severity at admission. These patients should be systematically screened for childhood trauma in order to tailor evidence-based interventions.

Published
2020
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21. Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study.

Author

Pignon, Baptiste, Lajnef, Mohamed, Kirkbride, James B, Peyre, Hugo, Ferchiou, Aziz, Richard, Jean-Romain, Baudin, Grégoire, Tosato, Sarah, Jongsma, Hannah, Haan, Lieuwe de, Tarricone, Ilaria, Bernardo, Miguel, Velthorst, Eva, Braca, Mauro, Arango, Celso, Arrojo, Manuel, Bobes, Julio, Del-Ben, Cristina Marta, Forti, Marta Di, and Gayer-Anderson, Charlotte

Subjects
ADVERSE childhood experiences, LIFE change events, PSYCHOSES, SELF-evaluation, DISCRIMINATION (Sociology), CHILD abuse, REGRESSION analysis, MENTAL depression, PSYCHOLOGICAL stress, MENTAL illness
Abstract

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment–environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (β for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E × E interactions. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Posttraumatic Stress Disorder Is Highly Comorbid With Adult ADHD in Alcohol Use Disorder Inpatients.

Author

El Ayoubi, Hussein, Brunault, Paul, Barrault, Servane, Maugé, Damien, Baudin, Grégoire, Ballon, Nicolas, and El-Hage, Wissam

Subjects
POST-traumatic stress disorder, ATTENTION-deficit hyperactivity disorder, ALCOHOLISM, MARITAL status, DUAL diagnosis
Abstract

Objective: Increasing number of studies show an association between adult ADHD (a-ADHD) and posttraumatic stress disorder (PTSD). We explored this association in alcohol use disorder (AUD) inpatients. Method: In total, 551 inpatients cross-sectionally completed self-administered questionnaires regarding sociodemographics, lifetime trauma exposure, PTSD Checklist for DSM-5, Adult ADHD Self-Report Scale (ASRS), and Wender Utah Rating Scale (WURS). We considered self-reported a-ADHD when ASRS and WURS had significant scores. Results: Prevalence for a-ADHD was 20%. PTSD prevalence was higher in a-ADHD patients (84% vs. 40%; p <.001). They also were younger (p <.001) and women (p =.015). Adult ADHD was associated with more traumatic events, and symptoms were correlated with PTSD severity. After adjusting for age, gender and marital status, PTSD severity was associated with a-ADHD. Conclusion: Our study confirms that a-ADHD is associated with PTSD in AUD inpatients, and thus, may represent a specific subpopulation. Future studies should explore implication of this dual diagnosis on AUD and treatment outcome. [ABSTRACT FROM AUTHOR]

Published
2021
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23. The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study

Author

Di Forti, Marta, primary, Quattrone, Diego, additional, Freeman, Tom P, additional, Tripoli, Giada, additional, Gayer-Anderson, Charlotte, additional, Quigley, Harriet, additional, Rodriguez, Victoria, additional, Jongsma, Hannah E, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, La Barbera, Daniele, additional, Tarricone, Ilaria, additional, Berardi, Domenico, additional, Szöke, Andrei, additional, Arango, Celso, additional, Tortelli, Andrea, additional, Velthorst, Eva, additional, Bernardo, Miguel, additional, Del-Ben, Cristina Marta, additional, Menezes, Paulo Rossi, additional, Selten, Jean-Paul, additional, Jones, Peter B, additional, Kirkbride, James B, additional, Rutten, Bart PF, additional, de Haan, Lieuwe, additional, Sham, Pak C, additional, van Os, Jim, additional, Lewis, Cathryn M, additional, Lynskey, Michael, additional, Morgan, Craig, additional, Murray, Robin M, additional, Amoretti, Silvia, additional, Arrojo, Manuel, additional, Baudin, Grégoire, additional, Beards, Stephanie, additional, Bernardo, Miquel, additional, Bobes, Julio, additional, Bonetto, Chiara, additional, Cabrera, Bibiana, additional, Carracedo, Angel, additional, Charpeaud, Thomas, additional, Costas, Javier, additional, Cristofalo, Doriana, additional, Cuadrado, Pedro, additional, Díaz-Caneja, Covadonga M, additional, Ferchiou, Aziz, additional, Franke, Nathalie, additional, Frijda, Flora, additional, García Bernardo, Enrique, additional, Garcia-Portilla, Paz, additional, González, Emiliano, additional, Hubbard, Kathryn, additional, Jamain, Stéphane, additional, Jiménez-López, Estela, additional, Leboyer, Marion, additional, López Montoya, Gonzalo, additional, Lorente-Rovira, Esther, additional, Marcelino Loureiro, Camila, additional, Marrazzo, Giovanna, additional, Martínez, Covadonga, additional, Matteis, Mario, additional, Messchaart, Elles, additional, Moltó, Ma Dolores, additional, Nacher, Juan, additional, Olmeda, Ma Soledad, additional, Parellada, Mara, additional, González Peñas, Javier, additional, Pignon, Baptiste, additional, Rapado, Marta, additional, Richard, Jean-Romain, additional, Rodríguez Solano, José Juan, additional, Roldán Díaz, Laura, additional, Ruggeri, Mirella, additional, Sáiz, Pilar A., additional, Sánchez, Emilio, additional, Sanjuán, Julio, additional, Sartorio, Crocettarachele, additional, Schürhoff, Franck, additional, Seminerio, Fabio, additional, Shuhama, Rosana, additional, Sideli, Lucia, additional, Stilo, Simona A, additional, Termorshuizen, Fabian, additional, Tosato, Sarah, additional, Tronche, Anne-Marie, additional, van Dam, Daniella, additional, and van der Ven, Elsje, additional

Published
2019
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26. Prevalence of psychotic disorders in an urban area of France

Author

Szöke, Andrei, Baudin, Grégoire, Saba, Ghassen, Pignon, Baptiste, Richard, Jean-Romain, Leboyer, Marion, Schürhoff, Franck, INSERM U955, équipe 15, Service de psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Hôpital Albert Chenevier-Réseau de coopération scientifique en santé mentale, Fondation FondaMental [Créteil]-Fondation FondaMental [Créteil]-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Pôle de Psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Psychologie des âges de la vie et adaptation (PAVeA), Université de Tours (UT), Service de Psychiatrie [CHRU Lille], Hôpital Michel Fontan 1-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This study was supported by a'PHRC'grant (Clinical Research Hospital Program,registered as P100134) from Assistance Publique - Hôpitaux de Paris (AP-HP)., Université de Tours, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Michel Fontan 1, BMC, BMC, and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)

Subjects
[SDV] Life Sciences [q-bio], Psychiatry and Mental health, [SDV]Life Sciences [q-bio]
Abstract

International audience; AbstractBackgroundMost data on the prevalence of psychotic disorders is limited to global estimates or restricted to schizophrenia. Consequently, there is limited information available about the prevalence of psychotic disorders more widely and outwith age and sex - specific prevalence values. The objective of this study is to provide period prevalence estimates, detailed by gender and age groups, for treated psychotic disorders in an adult population (aged 18 years and over) from an urban area in France.MethodsProspective reporting of cases treated over an 8-week period complemented by several methods estimating the number of potentially missed cases, including a leakage study. The study took place in an urban, well defined catchment area, with a population of 67 430 at risk subjects living in the east of a Paris suburb.ResultsThe observed prevalence was of 3.72 per 1000 subjects at risk; after adjustment for potentially lost cases the estimate was of 4.60 per 1000 subjects at risk. Observed prevalence was higher in men (4.71 per 1000, Relative Risk = 1.68) and in the 35–45 age-band (6.05 per 1000, Relative Risk = 1.93).ConclusionGlobal prevalence estimates of psychotic disorders in this study are in line with expected values based on studies conducted in other countries. Careful consideration of the causes of missed cases and gathering of complementary data are essential and could result in significant changes in prevalence estimates. Detailed estimates (by age) suggest that treated psychosis might not be a lifelong condition.

Published
2015
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28. Childhood Trauma Predicts Less Remission from PTSD among Patients with Co-Occurring Alcohol Use Disorder and PTSD.

Author

Brunault P, Lebigre K, Idbrik F, Maugé D, Adam P, Barrault S, Baudin G, Courtois R, El Ayoubi H, Grall-Bronnec M, Hingray C, Ballon N, and El-Hage W

Abstract

Post-traumatic stress disorder (PTSD) is highly prevalent among patients hospitalized for an alcohol use disorder (AUD). Hospitalization can improve PTSD and AUD outcomes in some but not all patients, but we lack data on the baseline predictors of PTSD non-remission. This study aimed to determine the baseline risk factors for non-remitted PTSD in patients hospitalized for an AUD. Of 298 AUD inpatients recruited in a rehabilitation center (Le Courbat, France), we included 91 AUD inpatients with a co-occurring PTSD and a longitudinal assessment at baseline (T1) and before discharge (T2: 8 weeks later). Patients were assessed for PTSD diagnosis/severity (PCL-5=PTSD Checklist for DSM-5), different types of trauma including childhood trauma (LEC-5=Life Events Checklist for DSM-5/CTQ-SF=Childhood Trauma Questionnaire, Short-Form), and AUD diagnosis/severity (clinical interview/AUDIT=Alcohol Use Disorders Identification Test). Rate of PTSD remission between T1 and T2 was 74.1%. Non-remitted PTSD at T2 was associated with a history of childhood trauma (physical, emotional or sexual abuse, physical negligence), but not with other types of trauma experienced, nor baseline PTSD or AUD severity. Among patients hospitalized for an AUD with co-occurring PTSD, PTSD remission was more strongly related to the existence of childhood trauma than to AUD or PTSD severity at admission. These patients should be systematically screened for childhood trauma in order to tailor evidence-based interventions.

Published
2020
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29. Prevalence of psychotic disorders in an urban area of France.

Author

Szöke A, Baudin G, Saba G, Pignon B, Richard JR, Leboyer M, and Schürhoff F

Subjects
Adult, Age Distribution, Female, France epidemiology, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Sex Factors, Young Adult, Psychotic Disorders epidemiology, Urban Population statistics & numerical data
Abstract

Background: Most data on the prevalence of psychotic disorders is limited to global estimates or restricted to schizophrenia. Consequently, there is limited information available about the prevalence of psychotic disorders more widely and outwith age and sex - specific prevalence values. The objective of this study is to provide period prevalence estimates, detailed by gender and age groups, for treated psychotic disorders in an adult population (aged 18 years and over) from an urban area in France., Methods: Prospective reporting of cases treated over an 8-week period complemented by several methods estimating the number of potentially missed cases, including a leakage study. The study took place in an urban, well defined catchment area, with a population of 67 430 at risk subjects living in the east of a Paris suburb., Results: The observed prevalence was of 3.72 per 1000 subjects at risk; after adjustment for potentially lost cases the estimate was of 4.60 per 1000 subjects at risk. Observed prevalence was higher in men (4.71 per 1000, Relative Risk = 1.68) and in the 35-45 age-band (6.05 per 1000, Relative Risk = 1.93)., Conclusion: Global prevalence estimates of psychotic disorders in this study are in line with expected values based on studies conducted in other countries. Careful consideration of the causes of missed cases and gathering of complementary data are essential and could result in significant changes in prevalence estimates. Detailed estimates (by age) suggest that treated psychosis might not be a lifelong condition.

Published
2015
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30. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

Author

van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O'Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz C, Rohleder C, Bumb JM, Schwarz E, Alptekin K, Üçok A, Saka MC, Atbaşoğlu EC, Gülöksüz S, Gumus-Akay G, Cihan B, Karadağ H, Soygür H, Cankurtaran EŞ, Ulusoy S, Akdede B, Binbay T, Ayer A, Noyan H, Karadayı G, Akturan E, Ulaş H, Arango C, Parellada M, Bernardo M, Sanjuán J, Bobes J, Arrojo M, Santos JL, Cuadrado P, Rodríguez Solano JJ, Carracedo A, García Bernardo E, Roldán L, López G, Cabrera B, Cruz S, Díaz Mesa EM, Pouso M, Jiménez E, Sánchez T, Rapado M, González E, Martínez C, Sánchez E, Olmeda MS, de Haan L, Velthorst E, van der Gaag M, Selten JP, van Dam D, van der Ven E, van der Meer F, Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S, Tortelli A, Frijda F, Vilain J, Galliot AM, Baudin G, Ferchiou A, Richard JR, Bulzacka E, Charpeaud T, Tronche AM, De Hert M, van Winkel R, Decoster J, Derom C, Thiery E, Stefanis NC, Sachs G, Aschauer H, Lasser I, Winklbaur B, Schlögelhofer M, Riecher-Rössler A, Borgwardt S, Walter A, Harrisberger F, Smieskova R, Rapp C, Ittig S, Soguel-dit-Piquard F, Studerus E, Klosterkötter J, Ruhrmann S, Paruch J, Julkowski D, Hilboll D, Sham PC, Cherny SS, Chen EY, Campbell DD, Li M, Romeo-Casabona CM, Emaldi Cirión A, Urruela Mora A, Jones P, Kirkbride J, Cannon M, Rujescu D, Tarricone I, Berardi D, Bonora E, Seri M, Marcacci T, Chiri L, Chierzi F, Storbini V, Braca M, Minenna MG, Donegani I, Fioritti A, La Barbera D, La Cascia CE, Mulè A, Sideli L, Sartorio R, Ferraro L, Tripoli G, Seminerio F, Marinaro AM, McGorry P, Nelson B, Amminger GP, Pantelis C, Menezes PR, Del-Ben CM, Gallo Tenan SH, Shuhama R, Ruggeri M, Tosato S, Lasalvia A, Bonetto C, Ira E, Nordentoft M, Krebs MO, Barrantes-Vidal N, Cristóbal P, Kwapil TR, Brietzke E, Bressan RA, Gadelha A, Maric NP, Andric S, Mihaljevic M, and Mirjanic T

Subjects
Genetic Predisposition to Disease, Humans, Schizophrenia epidemiology, Social Environment, Gene-Environment Interaction, Schizophrenia genetics, Schizophrenic Psychology
Abstract

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype., (© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2014
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