14 results on '"Baucom, Zachary H."'
Search Results
2. Late contributions of repetitive head impacts and TBI to depression symptoms and cognition.
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Alosco, Michael L, Tripodis, Yorghos, Baucom, Zachary H, Mez, Jesse, Stein, Thor D, Martin, Brett, Haller, Olivia, Conneely, Shannon, McClean, Michael, Nosheny, Rachel, Mackin, Scott, McKee, Ann C, Weiner, Michael W, and Stern, Robert A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Physical Injury - Accidents and Adverse Effects ,Neurosciences ,Clinical Trials and Supportive Activities ,Traumatic Brain Injury (TBI) ,Mental Health ,Clinical Research ,Traumatic Head and Spine Injury ,Depression ,Behavioral and Social Science ,Mental health ,Injuries and accidents ,Aged ,Brain Injuries ,Brain Injuries ,Traumatic ,Cognition ,Cross-Sectional Studies ,Female ,Humans ,Male ,Middle Aged ,Unconsciousness ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
ObjectiveTo test the hypothesis that repetitive head impacts (RHIs), like those from contact sport play and traumatic brain injury (TBI) have long-term neuropsychiatric and cognitive consequences, we compared middle-age and older adult participants who reported a history of RHI and/or TBI with those without this history on measures of depression and cognition.MethodsThis cross-sectional study included 13,323 individuals (mean age, 61.95; 72.5% female) from the Brain Health Registry who completed online assessments, including the Ohio State University TBI Identification Method, the Geriatric Depression Scale (GDS-15), and the CogState Brief Battery and Lumos Labs NeuroCognitive Performance Tests. Inverse propensity-weighted linear regressions accounting for age, sex, race/ethnicity, and education tested the effects of RHI and TBI compared to a non-RHI/TBI group.ResultsA total of 725 participants reported RHI exposure (mostly contact sport play and abuse) and 7,277 reported TBI (n = 2,604 with loss of consciousness [LOC]). RHI (β, 1.24; 95% CI, 0.36-2.12), TBI without LOC (β, 0.43; 95% CI, 0.31-0.54), and TBI with LOC (β, 0.75; 95% CI, 0.59-0.91) corresponded to higher GDS-15 scores. While TBI with LOC had the most neuropsychological associations, TBI without LOC had a negative effect on CogState Identification (β, 0.004; 95% CI, 0.001-0.01) and CogState One Back Test (β, 0.004; 95% CI, 0.0002-0.01). RHI predicted worse CogState One Back Test scores (β, 0.02; 95% CI, -0.01 to 0.05). There were RHI × TBI interaction effects on several neuropsychological subtests, and participants who had a history of both RHI and TBI with LOC had the greatest depression symptoms and worse cognition.ConclusionsRHI and TBI independently contributed to worse mid- to later-life neuropsychiatric and cognitive functioning.
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- 2020
3. Brain morphometry in former American football players: Findings from the DIAGNOSE CTE research project
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Arciniega, Hector, primary, Baucom, Zachary H, additional, Tuz-Zahra, Fatima, additional, Tripodis, Yorghos, additional, John, Omar, additional, Carrington, Holly, additional, Kim, Nicholas, additional, Knyazhanskaya, Evdokiya E, additional, Jung, Leonard B, additional, Breedlove, Katherine, additional, Wiegand, Tim L T, additional, Daneshvar, Daniel H, additional, Rushmore, R Jarrett, additional, Billah, Tashrif, additional, Pasternak, Ofer, additional, Coleman, Michael J, additional, Adler, Charles H, additional, Bernick, Charles, additional, Balcer, Laura J, additional, Alosco, Michael L, additional, Koerte, Inga K, additional, Lin, Alexander P, additional, Cummings, Jeffrey L, additional, Reiman, Eric M, additional, Stern, Robert A, additional, Shenton, Martha E, additional, and Bouix, Sylvain, additional
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- 2024
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4. Neuroimmune proteins can differentiate between distinct neurodegenerative diseases
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Cherry, Jonathan D, primary, Baucom, Zachary H., additional, Eppich, Kaleb G, additional, Kirsch, Daniel A, additional, Dixon, Erin R, additional, Tripodis, Yorghos, additional, Bieniek, Kevin F, additional, Farrell, Kurt W., additional, Whitney, Kristen R., additional, Uretsky, Madeline, additional, Crary, John F., additional, Dickson, Dennis W., additional, and McKee, Ann C., additional
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- 2023
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5. Cognitive, functional, and neuropsychiatric correlates of regional tau in autopsy‐confirmed chronic traumatic encephalopathy
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Faheem, Farwa, primary, Alosco, Michael L, additional, White, Micaela, additional, Bell, Carter, additional, Tripodis, Yorghos, additional, Yhang, Eukyung, additional, Baucom, Zachary H., additional, Martin, Brett M, additional, Palmisano, Joseph N, additional, Goldstein, Lee E, additional, Katz, Douglas I, additional, Dwyer, Brigid, additional, Daneshvar, Daniel H, additional, Nowinski, Christopher, additional, Cantu, Robert, additional, Kowall, Neil W, additional, Stern, Robert A, additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Stein, Thor D., additional, McKee, Ann C., additional, and Mez, Jesse B., additional
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- 2023
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6. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease
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Cherry, Jonathan D., Esnault, Camille D., Baucom, Zachary H., Tripodis, Yorghos, Huber, Bertrand R., Alvarez, Victor E., Stein, Thor D., Dickson, Dennis W., and McKee, Ann C.
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- 2021
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7. Leveraging American football helmet accelerometer data to estimate associations between cumulative repetitive head impact exposure and chronic traumatic encephalopathy
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Nair, Evan S, primary, Daneshvar, Daniel H, additional, Rasch, Abigail, additional, Abdolmohammadi, Bobak, additional, Saltiel, Nicole, additional, Uretsky, Madeline, additional, Shah, Arsal, additional, Baucom, Zachary H., additional, Martin, Brett M, additional, Palmisano, Joseph, additional, Cherry, Jonathan D, additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Alosco, Michael L, additional, Tripodis, Yorghos, additional, Crary, John F., additional, Stein, Thor D., additional, McKee, Ann C., additional, and Mez, Jesse B., additional
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- 2022
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8. Florbetapir amyloid PET in cognitively impaired former professional and college American football players.
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Stern, Robert A, Trujillo‐Rodriguez, Diana, Tripodis, Yorghos, Pulukuri, Surya V, Alosco, Michael L, Adler, Charles, Balcer, Laura, Bernick, Charles B., Baucom, Zachary H., Marek, Kenneth, McClean, Michael D, Johnson, Keith A., McKee, Ann C., Stein, Thor D., Mez, Jesse B., Palmisano, Joseph N, Cummings, Jeffrey L., Shenton, Martha E, and Reiman, Eric M.
- Abstract
Background: Repetitive head impact (RHI) exposure from the routine play of American football increases the risk of later‐life cognitive impairment and dementia from the neurodegenerative disease, chronic traumatic encephalopathy (CTE). Although neuropathological studies of CTE have found comorbid neurodegenerative and other pathologies, neuritic Aβ plaques are infrequent, particularly in early stages. However, amyloid PET imaging has not been fully characterized in cognitively impaired former American football players. Method: In this cross‐sectional, observational cohort study from the DIAGNOSE CTE Research Project, florbetapir PET mean cortical standard uptake value ratios (SUVR) and positivity (defined by average SUVR >1.10, indicative of moderate‐to‐frequent neuritic Aβ plaques), were analyzed in 119 former professional (PRO) National Football League players, 60 former college football players (COL), and 58 men unexposed (UE) to RHI who were cognitively asymptomatic. Former players were categorized into one of four diagnostic groups: cognitively normal (CN), subjective memory complaints (SMC), mild cognitive impairment (MCI), and dementia (DEM). All participants were 45‐74 yo. Multivariable linear and logistic regressions were conducted, with race, education, age, and APOE4 genotype included as covariates. A priori power calculations demonstrated adequate power to detect significant findings Result: No differences between the three exposure groups in average florbetapir SUVR or proportion of elevated florbetapir uptake were found. Pairwise group comparisons resulted in no differences in average SUVR between PRO and COL (‐0.01, 95% CI [‐0.033, 0.025], p = 0.95), PRO and UE (0.02, 95% CI [‐0.010, 0.029], p = 0.41), and COL and UE (0.02, 95% CI [0.0004, 0.039], p = 0.36). Analysis of covariance resulted in no differences among diagnostic groups (F = 0.94, p = 0.43). Neither years of playing football nor measures of cognition and daily functioning showed significant associations with florbetapir SUVR. Conclusion: Former professional and college American football players with cognitive impairment and dementia did not have elevated florbetapir amyloid PET compared to a group of men without RHI exposure. Their rates of florbetapir positivity in the football players were lower than expected for a group of men this age. These findings suggest that cognitive impairment in former elite football players may not be due to Alzheimer's disease pathology. [ABSTRACT FROM AUTHOR]
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- 2023
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9. White matter hyperintensities in former American football players.
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Alosco, Michael L., Tripodis, Yorghos, Baucom, Zachary H., Adler, Charles H., Balcer, Laura J., Bernick, Charles, Mariani, Megan L., Au, Rhoda, Banks, Sarah J., Barr, William B., Wethe, Jennifer V., Cantu, Robert C., Coleman, Michael J., Dodick, David W., McClean, Michael D., McKee, Ann C., Mez, Jesse, Palmisano, Joseph N., Martin, Brett, and Hartlage, Kaitlin
- Abstract
Introduction: The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players. Methods: A total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45–74 years) completed fluid‐attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self‐report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60. Results: In older but not younger participants, former football players had greater total, frontal, temporal, and parietal log‐WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log‐WMH was associated with younger age of first exposure to football and worse executive function. Discussion: In older former football players, WMH may have unique presentations, risk factors, and etiologies. Highlights: Older but not younger former football players had greater total, frontal, temporal, and parietal lobe white matter hyperintensities (WMH) compared to same‐age asymptomatic unexposed men.Younger age of first exposure to football was associated with greater WMH in older but not younger former American football players.In former football players, greater WMH was associated with worse executive function and verbal memory. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes
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Daneshvar, Daniel H., primary, Mez, Jesse, additional, Alosco, Michael L., additional, Baucom, Zachary H., additional, Mahar, Ian, additional, Baugh, Christine M., additional, Valle, Jhaqueline P., additional, Weuve, Jennifer, additional, Paganoni, Sabrina, additional, Cantu, Robert C., additional, Zafonte, Ross D., additional, Stern, Robert A., additional, Stein, Thor D., additional, Tripodis, Yorghos, additional, Nowinski, Christopher J., additional, and McKee, Ann C., additional
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- 2021
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11. Genome wide association study of chronic traumatic encephalopathy
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Atherton, Kathryn, primary, Khan, Mohammed Muzamil, additional, Shea, Conor, additional, Chung, Jaeyoon, additional, Nair, Evan, additional, Baucom, Zachary H., additional, Abdolmohammadi, Bobak, additional, Uretsky, Madeline, additional, Martin, Brett M., additional, Palmisano, Joseph, additional, Farrell, Kurt W., additional, Cherry, Jonathan D., additional, Alvarez, Victor E., additional, Huber, Bertrand R., additional, Alosco, Michael L., additional, Lunetta, Kathryn L., additional, Tripodis, Yorghos, additional, Stein, Thor D., additional, Farrer, Lindsay A., additional, Crary, John F., additional, McKee, Ann C., additional, and Mez, Jesse, additional
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- 2020
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12. Thorough understanding of neuropsychological data using state space modelling
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Baucom, Zachary H.
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- Biostatistics
- Abstract
Alzheimer's disease, and other related dementia diseases, are a worsening issue with an acceleration in today's aging population. Longitudinal cognitive assessment of those suffering from dementia offers vital insight into disease progression and allows for assessment of possible disease interventions. Difficulty in modeling such data arises as there are often non-linear and heterogenous patterns of decline from patient to patient. We propose the use of state space models (SSM), specifically a Local Linear Trend (LLT) model, as an alternative to the commonly used linear mixed effect models (LMEM) for longitudinal assessments. The proposed model includes the estimation of interpretable population linear effects on the outcome, while also allowing for subject-specific non-linearities in cognitive trajectories. To fit the LLT model, we utilize the traditional full likelihood estimation using the Kalman Filter and Kalman Smoother. We also compare the use of a partitioned LLT and a Bayesian LLT for computational efficiency. In two separate simulation analyses, we show the advantages of the LLT models over the predominant techniques. We go on to show that of the LLT methods, the Bayesian LLT excels. The LLT models are then used to estimate the effect of the APOE e4 allele on cognitive trajectory. Running the LLT on a single outcome provides accurate estimation of linear effects, but multiple tests are often offered for better understanding of different cognitive domains. To gain a more thorough understanding of cognition and how it relates to Alzheimer's disease we propose the use of a multivariate local linear trend model (MLLT), which simultaneously models linear effects for multiple tests, while also measuring inter-correlation of the underlying cognitive state between tests. Lastly, we propose a factor MLLT (FMLLT) to clarify underlying factors of cognition. The FMLLT can be utilized in both a structured and unstructured approach. These tools are shown to provide a flexible and accurate framework for analyzing longitudinal neuropsychological data.
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- 2023
13. The relationship between first‐degree family history of dementia, tau pathology and functional impairment among brain donors at risk for chronic traumatic encephalopathy.
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Nair, Evan S, Burton, Rebecca, Abdolmohammadi, Bobak, Saltiel, Nicole, Uretsky, Madeline, Shah, Arsal, Baucom, Zachary H., Martin, Brett M, Palmisano, Joseph, Huber, Bertrand R., Cherry, Jonathan D, Alvarez, Victor E., Alosco, Michael L, Tripodis, Yorghos, Crary, John F, Stein, Thor D., McKee, Ann C., and Mez, Jesse
- Abstract
Background: Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. The clinical presentation of CTE can be progressive, leading to cognitive and functional impairment. CTE presence and severity varies among those with similar RHI exposure, suggesting a role for other factors, genetics among them. Family history (FH) of dementia is a proxy of genetic risk of neurodegenerative disease, but its relationship with CTE is unknown. This study aimed to analyze the relationships between FH of dementia, quantitative tau pathology and functional impairment in brain donors at risk for CTE. Method: 558 brain donors from the Veterans Affairs‐Boston University‐Concussion Legacy Foundation Brain Bank with known RHI exposure through contact sports or military service were examined for CTE pathology. We performed digital quantification of AT8 immunostaining for tau pathology in the CA4 hippocampal subfield, a region disproportionately affected in CTE. First‐degree FH of dementia and the Functional Assessment Questionnaire (FAQ; 30 point scale), a validated measure of instrumental activities of daily living, were collected through telephone interviews with brain donors' next‐of‐kin. Using a regression framework, we examined the direct and indirect relationships between FH of dementia, CA4 quantitative tau burden and FAQ score, adjusting for age and race. Result: The mean (SD) age at death was 59.9 (20.4) and 362 (65%) had CTE pathology. In separate models, first‐degree FH of dementia was significantly associated with increased CA4 tau burden (β=0.27, p=0.01) and with increased FAQ score (β=2.11, p=0.02). Additionally, CA4 tau burden was associated with increased FAQ score (β=2.58, p=0.001). After adjusting for CA4 tau burden, the effect of first‐degree FH of dementia was reduced and no longer significant (β=.598, p=.663). Conclusion: Among brain donors with RHI exposure, hippocampal CA4 tau burden may mediate the relationship between first‐degree FH of dementia and functional impairment. The findings suggest that the risk of CTE may be heritable and share etiologic mechanisms with other dementing illnesses. [ABSTRACT FROM AUTHOR]
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- 2021
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14. White matter hyperintensities in former American football players.
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Alosco ML, Tripodis Y, Baucom ZH, Adler CH, Balcer LJ, Bernick C, Mariani ML, Au R, Banks SJ, Barr WB, Wethe JV, Cantu RC, Coleman MJ, Dodick DW, McClean MD, McKee AC, Mez J, Palmisano JN, Martin B, Hartlage K, Lin AP, Koerte IK, Cummings JL, Reiman EM, Stern RA, Shenton ME, and Bouix S
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- Male, Humans, Aged, Middle Aged, Magnetic Resonance Imaging methods, Neuropsychological Tests, Executive Function, Football, White Matter diagnostic imaging, White Matter pathology
- Abstract
Introduction: The presentation, risk factors, and etiologies of white matter hyperintensities (WMH) in people exposed to repetitive head impacts are unknown. We examined the burden and distribution of WMH, and their association with years of play, age of first exposure, and clinical function in former American football players., Methods: A total of 149 former football players and 53 asymptomatic unexposed participants (all men, 45-74 years) completed fluid-attenuated inversion recovery magnetic resonance imaging, neuropsychological testing, and self-report neuropsychiatric measures. Lesion Segmentation Toolbox estimated WMH. Analyses were performed in the total sample and stratified by age 60., Results: In older but not younger participants, former football players had greater total, frontal, temporal, and parietal log-WMH compared to asymptomatic unexposed men. In older but not younger former football players, greater log-WMH was associated with younger age of first exposure to football and worse executive function., Discussion: In older former football players, WMH may have unique presentations, risk factors, and etiologies., Highlights: Older but not younger former football players had greater total, frontal, temporal, and parietal lobe white matter hyperintensities (WMH) compared to same-age asymptomatic unexposed men. Younger age of first exposure to football was associated with greater WMH in older but not younger former American football players. In former football players, greater WMH was associated with worse executive function and verbal memory., (© 2022 the Alzheimer's Association.)
- Published
- 2023
- Full Text
- View/download PDF
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