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2. Brain tumor epidemiology - A hub within multidisciplinary neuro-oncology. report on the 15th brain tumor epidemiology consortium (BTEC) annual meeting, Vienna, 2014

Author

Wrensch, Margaret, Wiemels, Joseph, Woehrer, A, Lau, CC, Prayer, D, Bauchet, L, Rosenfeld, M, Capper, D, Fisher, PG, Kool, M, Müller, M, and Kros, JM

Abstract

© 2015 Dustri-Verlag Dr. K. Feistle.The Brain Tumor Epidemiology Consortium (BTEC) is an open scientific forum, which fosters the development of multi-center, international and inter-disciplinary collaborations. BTEC aims to develop a better understanding

Published
2015

13. Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

Author

Relier, S., primary, Amalric, A., additional, Attina, A., additional, Koumare, I.B., additional, Rigau, V., additional, Burel Vandenbos, F., additional, Fontaine, D., additional, Baroncini, M., additional, Hugnot, J.P., additional, Duffau, H., additional, Bauchet, L., additional, Hirtz, C., additional, Rivals, E., additional, and David, A., additional

Published
2022
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15. Isolated tumefactive demyelinating lesions: diagnosis and long-term evolution of 16 patients in a multicentric study

Author

Siri, A., Carra-Dalliere, Clarisse, Ayrignac, X., Pelletier, J., Audoin, B., Pittion-Vouyovitch, S., Debouverie, M., Lionnet, C., Viala, F., Sablot, D., Brassat, D., Ouallet, J.-C., Ruet, A., Brochet, B., Taillandier, L., Bauchet, L., Derache, N., Defer, G., Cabre, P., de Seze, J., Lebrun Frenay, C., Cohen, M., and Labauge, P.

Published
2015
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17. Procedures performed during neurosurgery residency in Europe

Author

Stienen, M. N., Freyschlag, C. F., Schaller, K., Meling, T., Al-Amin, A., Al-Mahfoudh, R., Amelot, A., Arvidsson, L., Athanasiou, A., Avellan, C. I. A., Bauchet, L., Berilazic, L., Bolger, C., Bourdillon, P., Boviatsis, S., Bozinov, O., Branco, P., Braunsdorf, W., Cahill, J., Clusmann, H., Conrad, J., Cordier, D., Cristino, N., Djilvesi, D., Duerinck, J., Dumot, C., Durak, M. A., Eisenring, C. V., Esposito, G., Finiels, P. -J., Flaskas, T., Fuentes, S., Ganau, M., Georgiadis, I., Georgiopoulos, M., Giakoumettis, D., Gilis, N., Gradil, C., Grau, S. J., Grin, A., Hadjigeorgiou, G., Halatsch, M. -E., Hecht, N., Holling, M., Ilic, R., Iken, L., Santos, N. I., Jacquesson, T., Jalloh, I., Jelaca, B., Kaestner, S., Kalasauskas, D., Kaliyev, A., Kleiber, J. -C., Konczalla, J., Kothbauer, K. F., Kovacevic, V., Krajcinovic, N., Krieg, S. M., Kamarainen, O. -P., Lapcic, M., Lapras, C., Ljungqvist, J., W. B., Lo, Lubrano, V., Majovsky, M., Manet, R., Marchi, F., Medetov, Y., Meling, T. R., Melloni, I., Melot, A., Mertens, P., Metcalfe, S., Moerkve, S. H., Mora, A. R., Musabelliu, E., Naushahi, M. J., Nurzhan, A., Omerhodzic, I., Paldor, I., Pallud, J., Papanastassiou, V., Papic, V., Paschalis, T., Payer, M., Peerdeman, S. M., Peruzzi, P., Segerlind, J. P., Posti, J. P., Proust, F., Regli, L., Rinne, J., Roche, P. -H., Rocka, S., Rotermund, R., Rutherford, S. A., Ratsep, T., Ruter, A., Saarenpaa, I. M., Samanci, M. Y., Samardzic, M., Sampron, N., Sandvik, U., Scerrati, A., Schneider, M., Schul, D. B., Sengul, G., Simon, E., Sinha, S., Solheim, O., Spatola, G., Spektor, S., Sundblom, J., Syrmos, N. C., Teo, M., Thomson, S., Tonchev, N., Tosic, L., Vandertop, W. P., von der Brelie, C., Vuk, A., Walkden, J., Wendel, C., Yaqout, M., Yusupova, M., Zollino, G., University of Zurich, Surgical clinical sciences, Neuroprotection & Neuromodulation, Neurosurgery, IOO, and ANS - Systems & Network Neuroscience

Subjects
Adult, Male, Neurosurgery/education, medicine.medical_specialty, Certification, Caseload, Europe, Neurosurgery, Residency, Training program, Working hour restriction, 610 Medicine & health, Neurosurgical Procedures, NO, 03 medical and health sciences, 10180 Clinic for Neurosurgery, 0302 clinical medicine, Surveys and Questionnaires, Germany, Medicine, Humans, Child, Greece, business.industry, Female sex, Internship and Residency, Mean age, Surgical procedures, Middle Aged, Current analysis, United Kingdom, Original Article - Neurosurgery Training, ddc:616.8, 030220 oncology & carcinogenesis, Surgery, Female, Neurology (clinical), France, business, 030217 neurology & neurosurgery, Switzerland, Demography
Abstract

Background In a previous article (10.1007/s00701-019-03888-3), preliminary results of a survey, aiming to shed light on the number of surgical procedures performed and assisted during neurosurgery residency in Europe were reported. We here present the final results and extend the analyses. Methods Board-certified neurosurgeons of European Association of Neurosurgical Societies (EANS) member countries were asked to review their residency case logs and participate in a 31-question electronic survey (SurveyMonkey Inc., San Mateo, CA). The responses received between April 25, 2018, and April 25, 2020, were considered. We excluded responses that were incomplete, from non-EANS member countries, or from respondents that have not yet completed their residency. Results Of 430 responses, 168 were considered for analysis after checking in- and exclusion criteria. Survey responders had a mean age of 42.7 ± 8.8 years, and 88.8% were male. Responses mainly came from surgeons employed at university/teaching hospitals (85.1%) in Germany (22.0%), France (12.5%), the United Kingdom (UK; 8.3%), Switzerland (7.7%), and Greece (7.1%). Most responders graduated in the years between 2011 and 2019 (57.7%). Thirty-eight responders (22.6%) graduated before and 130 responders (77.4%) after the European WTD 2003/88/EC came into effect. The mean number of surgical procedures performed independently, supervised or assisted throughout residency was 540 (95% CI 424–657), 482 (95% CI 398–568), and 579 (95% CI 441–717), respectively. Detailed numbers for cranial, spinal, adult, and pediatric subgroups are presented in the article. There was an annual decrease of about 33 cases in total caseload between 1976 and 2019 (coeff. − 33, 95% CI − 62 to − 4, p = 0.025). Variables associated with lesser total caseload during residency were training abroad (1210 vs. 1747, p = 0.083) and female sex by trend (947 vs. 1671, p = 0.111), whereas case numbers were comparable across the EANS countries (p = 0.443). Conclusion The final results of this survey largely confirm the previously reported numbers. They provide an opportunity for current trainees to compare their own case logs with. Again, we confirm a significant decline in surgical exposure during training between 1976 and 2019. In addition, the current analysis reveals that female sex and training abroad may be variables associated with lesser case numbers during residency.

Published
2020

21. 281P Prognostic impact of immune interactions in HER2+ and triple-negative breast cancer brain metastases

Author

Griguolo, G., primary, Tosi, A., additional, Dieci, M.V., additional, Fineberg, S., additional, Ventura, A., additional, Bottosso, M., additional, Bauchet, L., additional, Miglietta, F., additional, Jacob, J., additional, Rossi, V., additional, Rigau, V., additional, Jacot, W., additional, Conte, P.F., additional, Rosato, A., additional, Darlix, A., additional, and Guarneri, V., additional

Published
2021
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26. Méningiomes, Ependymomes, Schwannomes et Astrocytomes Dans la Neoplasie Endocrinienne Multiple de Type 1. Une étude de la cohorte GTE (Groupe d’étude des Tumeurs Endocrines)

Author

Graillon, T., primary, Romanet, P., additional, Camilla, C., additional, Bauchet, L., additional, Roche, C., additional, Appay, R., additional, Le Bras, M., additional, Figarella-Branger, D., additional, Dufour, H., additional, Barlier, A., additional, and Goudet, P., additional

Published
2020
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30. [Adult intramedullary gliomas]

Author

Campello, C., Parker, F., Slimani, S., Le Floch, A., Herbrecht, A., Aghakhani, N., Lacroix, C., Loiseau, H., Lejeune, J. P., Perrin, Gilles, Honnorat, J., Dufour, H., Chinot, O., Figarella, D., Bauchet, L., Duffau, H., Lonjon, M., Labauge, Pierre, Messerer, M., Daures, J. P., Fabbro, P., Ducot, B., Neuro-Oncologie [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'Anatomo-Cyto-Pathologie et de NeuroPathologie [Hôpital de la Timone - APHM] (ACPNP), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Pasteur [Nice] (CHU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and Institut des Neurosciences de Montpellier (INM)

Subjects
Adult, Male, Gliomes intramédullaires, Radiotherapy, Intramedullary gliomas, [SDV]Life Sciences [q-bio], Évolution, Glioma, nervous system diseases, Chemotherapy, Humans, Surgery, Female, Spinal Cord Neoplasms, Chirurgie, neoplasms, Chimiothérapie, Outcome, Radiothérapie, Retrospective Studies
Abstract

International audience; Intramedullary gliomas are rare tumors accounting for less than 4% of all primary central nervous system tumors. The aims of this retrospective multicenter study were to assess their natural outcome as well as management. METHODS AND MATERIALS: We studied 332~patients from 1984~to 2011. Histopathological examination revealed 72% ependymomas (94% were low grade tumors), 24% astrocytomas (29% were high grade tumors), 2.4% mixed gliomas and 1.7% oligodendrogliomas. RESULTS: The mean age at diagnosis was 42.4~years for ependymomas, with male predominance, versus 39.6~years for astrocytomas. Pain was the most common initial presentation. In 20% of cases, astrocytomas were biopsied alone, but more than 80% of ependymomas had surgical resection. Radiotherapy and chemotherapy were reserved for malignant tumors, especially if they were ependymomas. The 5-year survival rate was 76.8% for astrocytomas and 94.5% for ependymomas. Histology, functional status prior to surgery, and tumor grade are among the prognostic factors. CONCLUSION: Our study showed that surgical treatment of gliomas is well codified, at least for ependymomas, but adjuvant treatment continues to play a marginal role in the management even in astrocytomas, which are infiltrative tumors.

Published
2016

33. TRM6/61 connects PKCα with translational control through tRNAiMet stabilization : impact on tumorigenesis

Author

Macari, F., El-houfi, Y., Boldina, G., Xu, Hao, Khoury-Hanna, S., Ollier, J., Yazdani, L., Zheng, G., Bieche, I., Legrand, N., Paulet, D., Durrieu, S., Byström, Anders S., Delbecq, S., Lapeyre, B., Bauchet, L., Pannequin, J., Hollande, F., Pan, T., Teichmann, M., Vagner, S., David, A., Choquet, A., Joubert, D., Macari, F., El-houfi, Y., Boldina, G., Xu, Hao, Khoury-Hanna, S., Ollier, J., Yazdani, L., Zheng, G., Bieche, I., Legrand, N., Paulet, D., Durrieu, S., Byström, Anders S., Delbecq, S., Lapeyre, B., Bauchet, L., Pannequin, J., Hollande, F., Pan, T., Teichmann, M., Vagner, S., David, A., Choquet, A., and Joubert, D.

Abstract

Accumulating evidence suggests that changes of the protein synthesis machinery alter translation of specific mRNAs and participate in malignant transformation. Here we show that protein kinase C [alpha] (PKC[alpha]) interacts with TRM61, the catalytic subunit of the TRM6/61 tRNA methyltransferase. The TRM6/61 complex is known to methylate the adenosine 58 of the initiator methionine tRNA (tRNAiMet), a nuclear post-transcriptional modification associated with the stabilization of this crucial component of the translation-initiation process. Depletion of TRM6/61 reduced proliferation and increased death of C6 glioma cells, effects that can be partially rescued by overexpression of tRNAiMet. In contrast, elevated TRM6/61 expression regulated the translation of a subset of mRNAs encoding proteins involved in the tumorigenic process and increased the ability of C6 cells to form colonies in soft agar or spheres when grown in suspension. In TRM6/61/tRNAiMet-overexpressing cells, PKC[alpha] overexpression decreased tRNAiMet expression and both colony- and sphere-forming potentials. A concomitant increase in TRM6/TRM61 mRNA and tRNAiMet expression with decreased expression of PKC[alpha] mRNA was detected in highly aggressive glioblastoma multiforme as compared with Grade II/III glioblastomas, highlighting the clinical relevance of our findings. Altogether, we suggest that PKC[alpha] tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development., Supplementary information available for this article at http://www.nature.com/onc/journal/vaop/ncurrent/suppinfo/onc2015244s1.html

Published
2016
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34. Exemples de données cliniques et radiologiques sur 2 000 tumeurs astrocytaires et/ou oligodendrocytaires sous l’égide de la société française de neurochirurgie, l’association des neuro-oncologues d’expression française, la société française de neuropathologie, le groupe de neuro-oncologie de la fédération des centres de lutte contre le cancer

Author

Bauchet, L., Rigau, V., Mathieu-Daude, H., Figarella-Branger, D., Hugues, D., Fabbro, M., Campello, C., and Segnarbieuxet, F.

Published
2005
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37. TRM6/61 connects PKCα with translational control through tRNAiMet stabilization: impact on tumorigenesis

Author

Macari, F, primary, El-houfi, Y, additional, Boldina, G, additional, Xu, H, additional, Khoury-Hanna, S, additional, Ollier, J, additional, Yazdani, L, additional, Zheng, G, additional, Bièche, I, additional, Legrand, N, additional, Paulet, D, additional, Durrieu, S, additional, Byström, A, additional, Delbecq, S, additional, Lapeyre, B, additional, Bauchet, L, additional, Pannequin, J, additional, Hollande, F, additional, Pan, T, additional, Teichmann, M, additional, Vagner, S, additional, David, A, additional, Choquet, A, additional, and Joubert, D, additional

Published
2015
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41. Long-term results of carmustine wafers implantation for newly-diagnosed glioblastomas in France: Controlled propensity matched multicenter cohort study

Author

Pallud, J., primary, Audureau, E., additional, Noel, G., additional, Lechapt-Zalcman, E., additional, Duntze, J., additional, Guyotat, J., additional, Dam-Hieu, P., additional, Le Reste, P.-J., additional, Faillot, T., additional, Litre, F., additional, Desse, N., additional, Petit, A., additional, Emery, E., additional, Voirin, J., additional, Peltier, J., additional, Caire, F., additional, Vignes, J.-R., additional, Barat, J.-L., additional, Langlois, O., additional, Dezamis, E., additional, Pavlov, V., additional, Lefranc, M., additional, Bauchet, L., additional, Devaux, B., additional, Menei, P., additional, and Metellus, P., additional

Published
2014
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43. Stereotactic coregistration of 201Tl SPECT and MRI applied to brain tumor biopsies

Author

Hemm, S., Rigau, V., Chevalier, Jérome, Picot, M.C., Bauchet, L., El Fertit, H., Rodriguez, M.A., Cif, Laura, Vayssière, Nathalie, Zanca, M., Baldet, P., Segnarbieux, F., Coubes, Philippe, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

The aim of the present study was to determine the clinical feasibility of integration of stereotactic SPECT (sSPECT) with 201Tl in the stereotactic MRI (sMRI)-based planning of brain tumor biopsy. Furthermore, the predictive value of the integrated techniques was analyzed by comparison with the corresponding histologically determined metabolic activity. METHODS: Ten patients underwent combined 201Tl SPECT- and MRI-guided stereotactic biopsy of intracranial lesions according to a previously described technique. An area of abnormal 201Tl uptake was used to guide the stereotactic biopsy trajectory. Several samples were taken along the trajectory above and beneath the target. An extensive histologic diagnosis (tumor grade, mitotic index [MI], and Ki67 index) and the 201Tl index were obtained for all samples and compared statistically. RESULTS: Combined 201Tl sSPECT- and sMRI-guided biopsy could be performed on all patients. Ki67 index, MI, and tumor grade correlated significantly. The correlations between MI or Ki67 index and 201Tl index were not significant (0.18 and 0.09, respectively). A trend to significance existed between tumor grade and 201Tl index (R = 0.31; P = 0.06). Mean 201Tl index for grade III tumors (3.27 +/- 1.89 [SD]) was significantly different from that for grade IV tumors (4.34 +/- 1.29). The sample position on the trajectory correlated with the MI (R = 0.39; P = 0.01). In 4 of the 10 patients, a variation in tumor grade could be observed along the trajectory. In all patients, the highest proliferative activity was within 5-10 mm of the target. CONCLUSION: These results support the view that 201Tl SPECT may contribute to the successful management of brain tumor patients requiring stereotactic biopsy, without causing a significant increase in discomfort or morbidity. The development of similar techniques integrating sSPECT data in the planning of stereotactic biopsy should be considered by centers performing stereotactic surgery and having access to SPECT technology. In the long term, this technique could become a support for focused gene therapy and cell transfer.

Published
2005

45. The epidemiology of glioma in adults: a "state of the science" review

Author

Ostrom, Q. T., primary, Bauchet, L., additional, Davis, F. G., additional, Deltour, I., additional, Fisher, J. L., additional, Langer, C. E., additional, Pekmezci, M., additional, Schwartzbaum, J. A., additional, Turner, M. C., additional, Walsh, K. M., additional, Wrensch, M. R., additional, and Barnholtz-Sloan, J. S., additional

Published
2014
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50. Traitements oncologiques et survie de 265 patients, âgés de 70 ans et plus, atteints d’un glioblastome diagnostiqué en France métropolitaine

Author

Bauchet, L., primary, Zouaoui, S., additional, Mathieu-Daudé, H., additional, Fabbro-Peray, P., additional, Darlix, A., additional, Rigau, V., additional, Figarella-Branger, D., additional, Pallusseau, L., additional, Fabbro, M., additional, Kerr, C., additional, Chinot, O., additional, Ducray, F., additional, Bauchet, F., additional, Wager, M., additional, Capelle, L., additional, Faillot, T., additional, Loiseau, H., additional, Campello, C., additional, Menei, P., additional, Frappaz, D., additional, Duffau, H., additional, Labrousse, F., additional, and Trétarre, B., additional

Published
2012
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