1. A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
- Author
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Monasso, Giulietta S, Hoang, Thanh T, Mancano, Giulia, Fernández-Barrés, Sílvia, Dou, John, Jaddoe, Vincent WV, Page, Christian M, Johnson, Laura, Bustamante, Mariona, Bakulski, Kelly M, Håberg, Siri E, Ueland, Per M, Battram, Thomas, Merid, Simon K, Melén, Erik, Caramaschi, Doretta, Küpers, Leanne K, Sunyer, Jordi, Nystad, Wenche, Heil, Sandra G, Schmidt, Rebecca J, Vrijheid, Martine, Sharp, Gemma C, London, Stephanie J, and Felix, Janine F
- Subjects
Biological Sciences ,Genetics ,Pediatric ,Prevention ,Nutrition ,Perinatal Period - Conditions Originating in Perinatal Period ,Reproductive health and childbirth ,Good Health and Well Being ,Infant ,Newborn ,Pregnancy ,Child ,Female ,Humans ,DNA Methylation ,Epigenome ,Birth Weight ,Vitamin B 12 ,Epigenesis ,Genetic ,Fetal Blood ,Vitamin B12 ,DNA methylation ,epidemiology ,cohort study ,meta-analysis ,PACE consortium ,Biochemistry and Cell Biology ,Medical Biochemistry and Metabolomics ,Developmental Biology ,Biochemistry and cell biology - Abstract
Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide associations of circulating vitamin B12 concentrations in mothers during pregnancy (n = 2,420) or cord blood (n = 1,029), with cord blood DNA methylation. Maternal and newborn vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs, respectively (False Discovery Rate P-value
- Published
- 2023