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Sin foliar Giovanni Battista Lanzavecchia, nacido en Alexandría della Paglia (Italia) en 1564, entra en la Compañía en la Provincia de Andalucía en 1582. Hizo la profesión de cuatro votos el 8 de septiembre de 1595. Fue Profesor de Retórica. En Córdoba enseñó Filosofía durante dos años y luego teología durante veinte. Murió en el mismo Córdoba el 10 de febrero de 1616. Véase Sommervogel, C., Bibliothéque de la Compagnie de Jesús, Bruxelles-Paris 1890-1932, tom. 4, col. 1499. Son del mismo el 332-42, 332-43, 333-73, 333-103-IV A 332/004

Research found that those who believe sexual orientation is inborn have generally positive attitudes towards gay men and lesbians. However, other studies have also found that these beliefs could include negative eugenic ideas. This study aims to investigate the role of people’s beliefs about the aetiology of sexual orientation on attitudes towards adoption for both gay and lesbian couples. We hypothesized that this relationship would be mediated by sexual prejudice. To test the predictions, 256 Italian heterosexual participants were asked to answer to a scale about their beliefs regarding the aetiology of sexual orientation, sexual prejudice, and attitudes towards adoption by same-sex couples. Results confirmed that the relationship between aetiology beliefs and adoption support was fully mediated by sexual prejudice. These investigation results suggest that the belief that sexual orientation is controllable may serve to justify one’s prejudice and, in turn, result in a lower support for same-sex couples’ adoption.

Crohn’s disease (CD) and ulcerative colitis, two forms of inflammatory bowel disease (IBD), are chronic and relapsing conditions of the gastrointestinal tract both characterized by long lasting chronic inflammation and increased risk of dysplasia and colorectal cancer (CRC). The aim of our study was to evaluate the interobserver agreement about IBD-associated dysplasia among pathologists belonging to the Italian Group for Inflammatory Bowel Diseases (IG-IBD P). The present multicenter survey was performed using telepathology, supported by an open source E-learning platform. Biopsy specimens from 30 colonoscopies and from 20 patients were included. The glass slides of any case, including clinical and endoscopic data, were digitalized and uploaded on the E-learning platform. All the digital slides were grouped in 54 diagnostic “blocks”. Blinded histopathological evaluation on all the digital slides was performed by 20 gastrointestinal pathologists. Closed-ended questions about (1) the occurrence of IBD; (2) the classification of IBD (as UC or CD); (3) the presence of active versus quiescent disease; (4) the presence of dysplasia; (5) the possible association of dysplasia with the sites of disease (dysplasia-associated lesion or mass—DALM vs adenoma-like mass—ALM); (6) the grading of dysplasia according to the ECCO guidelines (negative, indefinite, low grade, high grade categories) and (7) the presence of associated serrated features, were proposed in each case. Inter-observer agreement was evaluated by mean agreement percentage and kappa statistic, when suitable. The diagnosis of IBD was confirmed in 19 of 20 patients, 17 of 19 being classified as UC, 2 as CD. The mean interobserver agreement percentages about (1) the evidence of IBD, (2) the presence of either UC or CD and (3) the activity grading resulted to be 80%, 69% and 86%, respectively. Dysplasia was detected in 8/20 patients, with moderate agreement between pathologists (mean 72%, k 0.48). Particularly, low grade dysplasia was found in 13 biopsies (combined k 0.38), whereas high grade dysplasia in 8 (combined k 0.47). When the endoscopic and histopathological data were combined, features consistent with DALM were found in 6 of 20 patients with low grade dysplasia and those consistent with ALM in 2 patients with low grade dysplasia in a single biopsy (mean agreement: 86%). An associated serrated pattern was discovered in 4 patients (7 biopsies). Our study showed moderate interobserver agreement about the histopathological detection and classification of IBD-associated dysplasia. Further efforts should be undertaken to integrate the histopathological data with both the ancillary tests and molecular investigations.

Foliac. I. 1-148 texto; 149-151 índice. II. 153-300v. III. 303-407.IV. 411-428v. Los restantes en blanco. Varias letras del siglo XVII. El segundo tratado muy incompleto (muchos folios en blanco) A 333/073

El descubrimiento de los microRNAs (miRNAs) ha demostrado que estos se comportan como una poderosa clase de reguladores de la expresión génica. Al actuar a nivel postranscripcional, los miRNAs son capaces de modular la expresión de al menos un tercio de los RNA mensajeros codificados por el genoma. Aquí resumimos las principales alteraciones en la expresión de los genes para miRNAs identificados en el carcinoma papilar de tiroides. Se discuten también los mecanismos por los cuales la desregulación de estos miRNAs podrían estar involucrados en la transformación de las células foliculares tiroideas MicroRNAs (miRNAs) small (~22 nt) single-stranded RNA molecules that are not further translated into proteins. They can act as negative regulators of the protein-coding gene expression and may impact cell differentiation, proliferation and survival. They have been implicated in carcinogenesis. The purpose of this review is to summarize the main alterations of miRNA expression identified in thyroid papillary carcinomas, and discuss the mechanisms by which miRNA deregulation might be involved in thyroid cell transformation. Fil: Pallante, P.. Università degli Studi di Napoli Federico II; Italia Fil: Battista, S.. Università degli Studi di Napoli Federico II; Italia Fil: Juvenal, Guillermo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina Fil: Fusco, A.. Università degli Studi di Napoli Federico II; Italia