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138 results on '"Battaglini, Matteo"'

4. Piezoelectric Barium Titanate Nanostimulators for the Treatment of Glioblastoma Multiforme

Author

Marino, Attilio, Almici, Enrico, Migliorin, Simone, Tapeinos, Christos, Battaglini, Matteo, Cappello, Valentina, Marchetti, Marco, de Vito, Giuseppe, Cicchi, Riccardo, Pavone, Francesco Saverio, and Ciofani, Gianni

Subjects
Physics - Biological Physics, Quantitative Biology - Tissues and Organs
Abstract

Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca2+ and K+ homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. In this work, we propose a nanotechnological approach based on ultrasound-sensitive piezoelectric nanoparticles to remotely deliver electric stimulations to glioblastoma cells. Barium titanate nanoparticles (BTNPs) have been functionalized with an antibody against the transferrin receptor (TfR) in order to obtain the dual targeting of blood-brain barrier and of glioblastoma cells. The remote ultrasound-mediated piezo-stimulation allowed to significantly reduce in vitro the proliferation of glioblastoma cells and, when combined with a sub-toxic concentration of temozolomide, induced an increased sensitivity to the chemotherapy treatment and remarkable anti-proliferative and pro-apoptotic effects.

Published
2018
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9. ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis

Author

Charmsaz, Sara, Doherty, Ben, Cocchiglia, Sinéad, Varešlija, Damir, Marino, Attilio, Cosgrove, Nicola, Marques, Ricardo, Priedigkeit, Nolan, Purcell, Siobhan, Bane, Fiona, Bolger, Jarlath, Byrne, Christopher, O’Halloran, Philip J., Brett, Francesca, Sheehan, Katherine, Brennan, Kieran, Hopkins, Ann M., Keelan, Stephen, Jagust, Petra, Madden, Stephen, Martinelli, Chiara, Battaglini, Matteo, Oesterreich, Steffi, Lee, Adrian V., Ciofani, Gianni, Hill, Arnold D. K., and Young, Leonie S.

Published
2020
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11. Magnetic self-assembly of 3D multicellular microscaffolds: A biomimetic brain tumor-on-a-chip for drug delivery and selectivity testing

Author

Marino, Attilio, Battaglini, Matteo, Carmignani, Alessio, Pignatelli, Francesca, De Pasquale, Daniele, Tricinci, Omar, and Ciofani, Gianni

Subjects
brain cancer model, tumor brainon-a-chip, self-assembed organoids, blood-brain barrier (BBB)
Abstract

In the last years, the need for highly predictive brain cancer models to test new anticancer compounds and experimental therapeutic approaches is significantly increased. Realistic in vitro tumor brain-on-a-chip platforms would allow a more accurate selection of valid candidate drugs and nanomedicines, therefore alleviating the economical and ethical costs of unsuccessful studies in vivo. Here, we present a multi-functional self-assembled brain tumor-on-a-chip model characterized by 3D glioma cultures interfaced both to brain non-malignant cells of the peritumoral niche and to a 3D-real-scale blood-brain barrier (BBB) microfluidic system. This platform allowed us to screen multiple features of a promising anticancer drug, nutlin-3a, that are fundamental for the treatment of brain cancer, such as the BBB crossing capabilities, apoptotic efficacy against GBM cells, and side effects on non-malignant brain cells.

Published
2023
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13. Contributors

Author

Albertazzi, Lorenzo, primary, Ancona, Andrea, additional, Arai, Satoshi, additional, Battaglini, Matteo, additional, Bayer, Ilker S., additional, Brachi, Giulia, additional, Burns, Austin, additional, Canavese, Giancarlo, additional, Canta, Marta, additional, Cao, Yiqi, additional, Capeletti, Larissa B., additional, Cardoso, Mateus B., additional, Cauda, Valentina, additional, Ciardelli, Gianluca, additional, Ciofani, Gianni, additional, d’Amora, Marta, additional, da Silva Liberato, Michelle, additional, Delcanale, Pietro, additional, Desai, Tejal A., additional, Diaconeasa, Zoriţa, additional, Dumontel, Bianca, additional, Feiner-Gracia, Natalia, additional, Garino, Nadia, additional, Genchi, Giada G., additional, Giordani, Silvia, additional, Laurenti, Marco, additional, Li, Tianshu, additional, Limongi, Tania, additional, Loiola, Lívia M.D., additional, Marino, Attilio, additional, Mattu, Clara, additional, Mele, Elisa, additional, Ménard-Moyon, Cécilia, additional, Pezzini, Ilaria, additional, Picco, Agustin S., additional, Pintea, Adela, additional, Pujals, Sílvia, additional, Racca, Luisa, additional, Rugină, Dumitriţa, additional, Self, William T., additional, Suzuki, Madoka, additional, Takeoka, Shinji, additional, and Tapeinos, Christos, additional

Published
2018
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14. Effects of Simulated Microgravity on the Internalization of Cerium Oxide Nanoparticles by Proliferating Human Skeletal Myoblasts.

Author

Genchi, Giada Graziana, Mollo, Valentina, Battaglini, Matteo, Belenli Gümüş, Melike, Marino, Attilio, Prato, Mirko, Marras, Sergio, Drago, Filippo, Pugliese, Giammarino, Santoro, Francesca, and Ciofani, Gianni

Abstract

Spaceflight typically exerts detrimental effects on living organisms by promoting/accelerating some degenerative processes associated with aging and pathology onset on Earth, like muscle degeneration. As possible countermeasures to spaceflight effects, a few recent studies successfully tested the administration of nanomaterials for tuning of cellular activities and for promotion of certain cell phenotypes in microgravity, but largely missed investigation of early interactions of these nanomaterials with their cellular targets under altered gravity conditions. This study aims at filling this gap by elucidation of early interactions of a selected typology of redox-active nanoparticles (cerium oxide nanoparticles, also termed nanoceria, NC) with proliferating human skeletal myoblasts (HSkM) by concomitant exposure to simulated microgravity (achieved by a random positioning machine, RPM). To this purpose, NC were synthesized by a direct precipitation method and were chemically, structurally, and functionally characterized by several independent techniques prior to administration to skeletal muscle cell cultures and loading on the RPM. Confocal and electron microscopy evidence of nanoparticle internalization by several mechanisms (mostly involving macropinocytosis) in HSkM is provided, along with evidence of transcriptional regulation of key antioxidant response markers (Nos1, Sod2, and Sod3), promising oxidative stress alleviation and muscle protection under mechanical unloading conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Innovative nanotechnology tools for the functional control and tracking of human stem cells

Author

Ingeniería Minera y Metalúrgica y Ciencia de los Materiales, Meatze eta metalurgia ingeniaritza materialen zientzia, Marino, Attilio, Battaglini, Matteo, Tapeinos, Christos, Larrañaga Espartero, Aitor, Ciofani, Gianni, Ingeniería Minera y Metalúrgica y Ciencia de los Materiales, Meatze eta metalurgia ingeniaritza materialen zientzia, Marino, Attilio, Battaglini, Matteo, Tapeinos, Christos, Larrañaga Espartero, Aitor, and Ciofani, Gianni

Abstract

The precise control of stem cell behavior, including differentiation, transdifferentiation, and reprog-ramming, is fundamental for safely and efficiently using human stem cells in regenerative medicine. Thanks to recent innovations and developments in the field of nanomedicine, as well as its integration with advanced molecular biology approaches, the possibility of engineering and restoring functions of complex tissues become reality. Multifunctional nanotechnological tools allow to finely control the release of growth factors, mRNA, and other molecules, to promote cell fate conversion, and to perform long-term tracking in vivo. Furthermore, stimulation approaches based on smart and biocompatible nanotransducers promise to remotely modulate the stem cell activity, paving the way for the actual exploitation of these technologies in the internal tissues of large-sized animals. In this review, the most innovative nanotechnology tools applied to stem cell-based regenerative medicine are presented, and their implications for future research and clinics are discussed.

Published
2022

17. Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood-brain barrier crossing

Author

Battaglini, Matteo, Feiner, Natalia, Tapeinos, Christos, De Pasquale, Daniele, Pucci, Carlotta, Marino, Attilio, Bartolucci, Martina, Petretto, Andrea, Albertazzi, Lorenzo, Ciofani, Gianni, Battaglini, Matteo, Feiner, Natalia, Tapeinos, Christos, De Pasquale, Daniele, Pucci, Carlotta, Marino, Attilio, Bartolucci, Martina, Petretto, Andrea, Albertazzi, Lorenzo, and Ciofani, Gianni

Abstract

Upon coming into contact with the biological environment, nanostructures are immediately covered by biomolecules, particularly by proteins forming the so-called "protein corona" (PC). The phenomenon of PC formation has gained great attention in recent years due to its implication in the use of nanostructures in biomedicine. In fact, it has been shown that the formation of the PC can impact the performance of nanostructures by reducing their stability, causing aggregation, increasing their toxicity, and providing unexpected and undesired nanostructure-cell interactions. In this work, we decided to study for the first time the formation and the evolution of PC on the surface of nanostructured lipid carriers loaded with superparamagnetic iron oxide nanoparticles, before and after the crossing of an in vitro model of the blood-brain barrier (BBB). Combining confocal microscopy, direct STochastic Optical Reconstruction Microscopy (dSTORM), and proteomic analysis, we were able to carry out a complete analysis of the PC formation and evolution. In particular, we highlighted that PC formation is a fast process, being formed around particles even after just 1 min of exposure to fetal bovine serum. Moreover, PC formed around particles is extremely heterogeneous: while some particles have no associated PC at all, others are completely covered by proteins. Lastly, the interaction with an in vitro BBB model strongly affects the PC composition: in particular, a large amount of the proteins forming the initial PC is lost after the BBB passage and they are partially replaced by new proteins derived from both the brain endothelial cells and the cell culture medium. Altogether, the obtained data could potentially provide new insights into the design and fabrication of lipid nanostructures for the treatment of central nervous system disorders.

Published
2022

18. Cerium oxide nanoparticles administration during machine perfusion of discarded human livers: A pilot study

Author

Del Turco, Serena, primary, Cappello, Valentina, additional, Tapeinos, Christos, additional, Moscardini, Aldo, additional, Sabatino, Laura, additional, Battaglini, Matteo, additional, Melandro, Fabio, additional, Torri, Francesco, additional, Martinelli, Caterina, additional, Babboni, Serena, additional, Silvestrini, Beatrice, additional, Morganti, Riccardo, additional, Gemmi, Mauro, additional, De Simone, Paolo, additional, Martins, Paulo N., additional, Crocetti, Laura, additional, Peris, Adriano, additional, Campani, Daniela, additional, Basta, Giuseppina, additional, Ciofani, Gianni, additional, and Ghinolfi, Davide, additional

Published
2022
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21. In vitro study of polydopamine nanoparticles as protective antioxidant agents in fibroblasts derived from ARSACS patients

Author

Battaglini, Matteo, primary, Carmignani, Alessio, additional, Martinelli, Chiara, additional, Colica, Jamila, additional, Marino, Attilio, additional, Doccini, Stefano, additional, Mollo, Valentina, additional, Santoro, Francesca, additional, Bartolucci, Martina, additional, Petretto, Andrea, additional, Santorelli, Filippo Maria, additional, and Ciofani, Gianni, additional

Published
2022
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22. Combining confocal microscopy, dSTORM, and mass spectroscopy to unveil the evolution of the protein corona associated with nanostructured lipid carriers during blood–brain barrier crossing

Author

Battaglini, Matteo, primary, Feiner, Natalia, additional, Tapeinos, Christos, additional, De Pasquale, Daniele, additional, Pucci, Carlotta, additional, Marino, Attilio, additional, Bartolucci, Martina, additional, Petretto, Andrea, additional, Albertazzi, Lorenzo, additional, and Ciofani, Gianni, additional

Published
2022
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24. Cerium Oxide Nanoparticle Administration to Skeletal Muscle Cells under Different Gravity and Radiation Conditions

Author

Genchi, Giada Graziana, primary, Degl’Innocenti, Andrea, additional, Martinelli, Chiara, additional, Battaglini, Matteo, additional, De Pasquale, Daniele, additional, Prato, Mirko, additional, Marras, Sergio, additional, Pugliese, Giammarino, additional, Drago, Filippo, additional, Mariani, Alessandro, additional, Balsamo, Michele, additional, Zolesi, Valfredo, additional, and Ciofani, Gianni, additional

Published
2021
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25. Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study

Author

di Leo, Nicoletta, primary, Moscato, Stefania, additional, Borso', Marco, additional, Sestito, Simona, additional, Polini, Beatrice, additional, Bandini, Lavinia, additional, Grillone, Agostina, additional, Battaglini, Matteo, additional, Saba, Alessandro, additional, Mattii, Letizia, additional, Ciofani, Gianni, additional, and Chiellini, Grazia, additional

Published
2021
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30. Polydopamine Nanoparticles as an Organic and Biodegradable Multitasking Tool for Neuroprotection and Remote Neuronal Stimulation

Author

Battaglini, Matteo, primary, Marino, Attilio, additional, Carmignani, Alessio, additional, Tapeinos, Christos, additional, Cauda, Valentina, additional, Ancona, Andrea, additional, Garino, Nadia, additional, Vighetto, Veronica, additional, La Rosa, Gabriele, additional, Sinibaldi, Edoardo, additional, and Ciofani, Gianni, additional

Published
2020
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36. Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme

Author

Tapeinos, Christos, primary, Tomatis, Francesca, additional, Battaglini, Matteo, additional, Larrañaga, Aitor, additional, Marino, Attilio, additional, Telleria, Iker Aguirrezabal, additional, Angelakeris, Makis, additional, Debellis, Doriana, additional, Drago, Filippo, additional, Brero, Francesca, additional, Arosio, Paolo, additional, Lascialfari, Alessandro, additional, Petretto, Andrea, additional, Sinibaldi, Edoardo, additional, and Ciofani, Gianni, additional

Published
2019
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39. Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy

Author

Tapeinos, Christos, primary, Marino, Attilio, additional, Battaglini, Matteo, additional, Migliorin, Simone, additional, Brescia, Rosaria, additional, Scarpellini, Alice, additional, De Julián Fernández, César, additional, Prato, Mirko, additional, Drago, Filippo, additional, and Ciofani, Gianni, additional

Published
2019
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40. In vitrostudy of polydopamine nanoparticles as protective antioxidant agents in fibroblasts derived from ARSACS patientsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2bm00729k

Author

Battaglini, Matteo, Carmignani, Alessio, Martinelli, Chiara, Colica, Jamila, Marino, Attilio, Doccini, Stefano, Mollo, Valentina, Santoro, Francesca, Bartolucci, Martina, Petretto, Andrea, Santorelli, Filippo Maria, and Ciofani, Gianni

Abstract

Reactive oxygen species (ROS) are active molecules involved in several biological functions. When the production of ROS is not counterbalanced by the action of protective antioxidant mechanisms present in living organisms, a condition of oxidative stress can arise with consequent damage to biological structures. The brain is one of the main ROS-generating organs in the human body, with the consequence that most of the neurological disorders are associated with an overproduction of ROS. Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease associated with mutations in the sacsin gene (SACS). At cellular level, ARSACS is characterized by mitochondrial impairments, a reduction in bioenergetic processes, and by both an over-production of and an over-sensitivity to ROS. Several antioxidant molecules have been proposed as a potential treatment for ARSACS, such as idebenone and resveratrol. Polydopamine nanoparticles (PDNPs) gained significant attention in recent years owing to their peculiar physical/chemical properties, and especially because of their antioxidant activity. PDNPs have shown a great ROS scavenging capacity that, combined with their completely organic nature that grants them the ability to be degraded and excreted by living organisms, make them a promising candidate in the treatment of oxidative stress-related disorders. In this work, we assessed the effect of PDNPs on human fibroblasts derived from ARSACS patients in terms of antioxidant properties and protein expression. PDNP interaction with fibroblasts was analyzed in terms of biocompatibility, internalization and uptake pathway, reduction of ROS levels, prevention of ROS-induced apoptosis/necrosis, and protective action upon ROS-induced mitochondrial dysfunctions. Moreover, a complete proteomic analysis was performed. Altogether, our data showed that PDNPs can partially counteract ROS-induced damages in ARSACS patient-derived fibroblasts, making them a potential therapeutic candidate to treat – or at least to ameliorate – the condition of oxidative stress associated with ARSACS.

Published
2022
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47. Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based in vitromodel of Parkinson's diseaseElectronic supplementary information (ESI) available: Five figures and one table. Fig. S1 shows the calibration curves of resveratrol for the Folin–Ciocalteu phenol quantification and of trolox for TEAC assessment. Fig. S2 shows the fluorescence calibration curve of different concentrations of DiO-stained ext-LSs. Fig. S3 reports the representative SEM scan, TEM image and the hydrodynamic size of empty liposomes. Fig. S4 shows the WST-1 viability assay of hCMEC/D3 cells and SH-SY5Y-derived neurons treated at different concentrations of LSs and ext-LSs. Fig. S5 shows the WST-1 cell viability assay of the SH-SY5Y-derived neurons co-treated for 72 h with rot and ext-LSs. Fig. S6 shows the volcano plot of gene expression in different experimental conditions. Fig. S7 reports the BBB crossing investigations. Table S1 reports the forward and revers

Author

Marino, Attilio, Battaglini, Matteo, Desii, Andrea, Lavarello, Chiara, Genchi, Giada, Petretto, Andrea, and Ciofani, Gianni

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease with no satisfactory therapy options. Similar to other neurodegenerative conditions, such as Alzheimer's and Huntington's diseases, oxidative stress plays a key factor in the neurodegeneration process. To counteract the uncontrolled increase of reactive oxygen species (ROS) and oxidative stress-dependent cell death, several preclinical and clinical tests exploit natural-derived organic antioxidants, such as polyphenols. Despite some promising results, free antioxidants show scarce brain accumulation and may exhaust their scavenging activity before reaching the brain. In this work, we developed an antioxidant therapeutic nanoplatform consisting of nano-sized functionalized liposomes loaded with selected polyphenol-rich vegetal extracts with high blood–brain barrier crossing capabilities. The antioxidant extracts were obtained from the grape seeds and skins as a byproduct of wine production (i.e., pomace), following a sustainable circular approach with reduced environmental impact. The antioxidant nanoplatform was successfully tested in a relevant in vitromodel of PD, where it completely rescued the ROS levels, prevented the aggregation of α-synuclein fibrils, and restored cell viability, paving the way for preclinical translation of the approach.

Published
2021
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