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30 results on '"Batsa, Linda"'

1. Estimating the number of breeders from helminth larvae with genomic data

Author

Dennis, Tristan. P. W., primary, Sands, William, additional, Opoku, Millicent, additional, Debrah, Alex, additional, Batsa, Linda, additional, Pfarr, Kenneth, additional, Klarmann-Schulz, Ute, additional, Hoerauf, Achim, additional, Specht, Sabine, additional, Scandale, Ivan, additional, Ranford-Cartwright, Lisa C., additional, and Lamberton, Poppy H. L., additional

Published
2023
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2. Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Author

Debrah, Alexander Yaw, Specht, Sabine, Klarmann-Schulz, Ute, Batsa, Linda, Mand, Sabine, Marfo-Debrekyei, Yeboah, Fimmers, Rolf, Dubben, Bettina, Kwarteng, Alexander, Osei-Atweneboana, Mike, Boakye, Daniel, Ricchiuto, Arcangelo, Büttner, Marcelle, Adjei, Ohene, Mackenzie, Charles D., and Hoerauf, Achim

Published
2015
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9. Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

Author

Klarmann-Schulz, Ute, primary, Specht, Sabine, additional, Debrah, Alexander Yaw, additional, Batsa, Linda, additional, Ayisi-Boateng, Nana Kwame, additional, Osei-Mensah, Jubin, additional, Mubarik, Yusif, additional, Konadu, Peter, additional, Ricchiuto, Arcangelo, additional, Fimmers, Rolf, additional, Arriens, Sandra, additional, Dubben, Bettina, additional, Ford, Louise, additional, Taylor, Mark, additional, and Hoerauf, Achim, additional

Published
2017
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10. Immunoepidemiological Profiling of Onchocerciasis Patients Reveals Associations with Microfilaria Loads and Ivermectin Intake on Both Individual and Community Levels

Author

Fischer, Peter U., Arndts, Kathrin, Specht, Sabine, Debrah, Alexander Y., Tamarozzi, Francesca, Klarmann Schulz, Ute, Mand, Sabine, Batsa, Linda, Kwarteng, Alexander, Taylor, Mark, Adjei, Ohene, Martin, Coralie, Layland, Laura E., and Hoerauf, Achim

Subjects
wa_105, qw_700, qx_301, qv_38, wc_885
Abstract

Mass drug administration (MDA) programmes against Onchocerca volvulus use ivermectin (IVM) which targets microfilariae (MF), the worm's offspring. Most infected individuals are hyporesponsive and present regulated immune responses despite high parasite burden. Recently, with MDA programmes, the existence of amicrofilaridermic (a-MF) individuals has become apparent but little is known about their immune responses. Within this immunoepidemiological study, we compared parasitology, pathology and immune profiles in infection-free volunteers and infected individuals that were MF+ or a-MF. The latter stemmed from villages in either Central or Ashanti regions of Ghana which, at the time of the study, had received up to eight or only one round of MDA respectively. Interestingly, a-MF patients had fewer nodules and decreased IL-10 responses to all tested stimuli. On the other hand, this patient group displayed contrary IL-5 profiles following in vitro stimulation or in plasma and the dampened response in the latter correlated to reduced eosinophils and associated factors but elevated neutrophils. Furthermore, multivariable regression analysis with covariates MF, IVM or the region (Central vs. Ashanti) revealed that immune responses were associated with different covariates: whereas O. volvulus-specific IL-5 responses were primarily associated with MF, IL-10 secretion had a negative correlation with times of individual IVM therapy (IIT). All plasma parameters (eosinophil cationic protein, IL-5, eosinophils and neutrophils) were highly associated with MF. With regards to IL-17 secretion, although no differences were observed between the groups to filarial-specific or bystander stimuli, these responses were highly associated with the region. These data indicate that immune responses are affected by both, IIT and the rounds of IVM MDA within the community. Consequently, it appears that a lowered infection pressure due to IVM MDA may affect the immune profile of community members even if they have not regularly participated in the programmes.

Published
2014

12. Developing a community-led SMS reporting tool for the rapid assessment of lymphatic filariasis morbidity burden: case studies from Malawi and Ghana

Author

Stanton, Michelle C., primary, Mkwanda, Square Z., additional, Debrah, Alexander Y., additional, Batsa, Linda, additional, Biritwum, Nana-Kwadwo, additional, Hoerauf, Achim, additional, Cliffe, Matthew, additional, Best, Abigail, additional, Molineux, Andrew, additional, and Kelly-Hope, Louise A., additional

Published
2015
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13. Doxycycline Leads to Sterility and Enhanced Killing of FemaleOnchocerca volvulusWorms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

Author

Debrah, Alexander Yaw, primary, Specht, Sabine, additional, Klarmann-Schulz, Ute, additional, Batsa, Linda, additional, Mand, Sabine, additional, Marfo-Debrekyei, Yeboah, additional, Fimmers, Rolf, additional, Dubben, Bettina, additional, Kwarteng, Alexander, additional, Osei-Atweneboana, Mike, additional, Boakye, Daniel, additional, Ricchiuto, Arcangelo, additional, Büttner, Marcelle, additional, Adjei, Ohene, additional, Mackenzie, Charles D., additional, and Hoerauf, Achim, additional

Published
2015
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15. Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells

Author

Katawa, Gnatoulma, primary, Layland, Laura E., additional, Debrah, Alex Y., additional, von Horn, Charlotte, additional, Batsa, Linda, additional, Kwarteng, Alexander, additional, Arriens, Sandra, additional, W. Taylor, David, additional, Specht, Sabine, additional, Hoerauf, Achim, additional, and Adjobimey, Tomabu, additional

Published
2015
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16. Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial.

Author

Ricchiuto, Arcangelo, Arriens, Sandra, Dubben, Bettina, Klarmann-Schulz, Ute, Hoerauf, Achim, Specht, Sabine, Fimmers, Rolf, Batsa, Linda, Osei-Mensah, Jubin, Mubarik, Yusif, Debrah, Alexander Yaw, Ayisi-Boateng, Nana Kwame, Konadu, Peter, Ford, Louise, and Taylor, Mark

Subjects
DOXYCYCLINE, ALBENDAZOLE, ONCHOCERCIASIS treatment, MINOCYCLINE, WOLBACHIA, HISTOLOGY, RANDOMIZED controlled trials, THERAPEUTICS
Abstract

The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given for 4–6 weeks), identified minocycline (MIN) with superior efficacy to DOX. Further reduction in the treatment regimen may be achieved with co-administration with standard anti-filarial drugs. Therefore a randomized, open-label, pilot trial was carried out in an area in Ghana endemic for onchocerciasis, comprising 5 different regimens: the standard regimen DOX 200mg/d for 4 weeks (DOX 4w, N = 33), the experimental regimens MIN 200mg/d for 3 weeks (MIN 3w; N = 30), DOX 200mg/d for 3 weeks plus albendazole (ALB) 800mg/d for 3 days (DOX 3w + ALB 3d, N = 32), DOX 200mg/d for 3 weeks (DOX 3w, N = 31) and ALB 800mg for 3 days (ALB 3d, N = 30). Out of 158 randomized participants, 116 (74.4%) were present for the follow-up at 6 months of whom 99 participants (63.5%) followed the treatment per protocol and underwent surgery. Histological analysis of the adult worms in the extirpated nodules revealed absence of Wolbachia in 98.8% (DOX 4w), 81.4% (DOX 3w + ALB 3d), 72.7% (MIN 3w), 64.1% (DOX 3w) and 35.2% (ALB 3d) of the female worms. All 4 treatment regimens showed superiority to ALB 3d (p < 0.001, p < 0.001, p = 0.002, p = 0.008, respectively), which was confirmed by real-time PCR. Additionally, DOX 4w showed superiority to all other treatment arms. Furthermore DOX 4w and DOX 3w + ALB 3d showed a higher amount of female worms with degenerated embryogenesis compared to ALB 3d (p = 0.028, p = 0.042, respectively). These results confirm earlier studies that DOX 4w is sufficient for Wolbachia depletion and the desired parasitological effects. The data further suggest that there is an additive effect of ALB (3 days) on top of that of DOX alone, and that MIN shows a trend for stronger potency than DOX. These latter two results are preliminary and need confirmation in a fully randomized controlled phase 2 trial. Trial Registration: ClinicalTrials.gov [ABSTRACT FROM AUTHOR]

Published
2017
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17. Immunoepidemiological Profiling of Onchocerciasis Patients Reveals Associations with Microfilaria Loads and Ivermectin Intake on Both Individual and Community Levels

Author

Arndts, Kathrin, primary, Specht, Sabine, additional, Debrah, Alexander Y., additional, Tamarozzi, Francesca, additional, Klarmann Schulz, Ute, additional, Mand, Sabine, additional, Batsa, Linda, additional, Kwarteng, Alexander, additional, Taylor, Mark, additional, Adjei, Ohene, additional, Martin, Coralie, additional, Layland, Laura E., additional, and Hoerauf, Achim, additional

Published
2014
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18. Elevated Adaptive Immune Responses Are Associated with Latent Infections of Wuchereria bancrofti

Author

Arndts, Kathrin, primary, Deininger, Susanne, additional, Specht, Sabine, additional, Klarmann, Ute, additional, Mand, Sabine, additional, Adjobimey, Tomabu, additional, Debrah, Alexander Y., additional, Batsa, Linda, additional, Kwarteng, Alexander, additional, Epp, Christian, additional, Taylor, Mark, additional, Adjei, Ohene, additional, Layland, Laura E., additional, and Hoerauf, Achim, additional

Published
2012
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19. Transforming growth factor–β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis

Author

Debrah, Alexander Yaw, primary, Batsa, Linda, additional, Albers, Anna, additional, Mand, Sabine, additional, Toliat, Mohammad Reza, additional, Nürnberg, Peter, additional, Adjei, Ohene, additional, Hoerauf, Achim, additional, and Pfarr, Kenneth, additional

Published
2011
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22. Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp. in Wuchereria bancrofti with Doxycycline

Author

Debrah, Alexander Y., primary, Taylor, Mark, additional, Adjei, Ohene, additional, Pfarr, Kenneth, additional, Lawson, Bernard, additional, Mand, Sabine, additional, Hoerauf, Achim, additional, Marfo-Debrekyei, Yeboah, additional, and Batsa, Linda, additional

Published
2009
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23. Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus

Author

Hoerauf, Achim, primary, Specht, Sabine, additional, Marfo-Debrekyei, Yeboah, additional, Büttner, Marcelle, additional, Debrah, Alexander Yaw, additional, Mand, Sabine, additional, Batsa, Linda, additional, Brattig, Norbert, additional, Konadu, Peter, additional, Bandi, Claudio, additional, Fimmers, Rolf, additional, Adjei, Ohene, additional, and Büttner, Dietrich W., additional

Published
2008
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24. Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

Author

Hoerauf, Achim, primary, Specht, Sabine, additional, Büttner, Marcelle, additional, Pfarr, Kenneth, additional, Mand, Sabine, additional, Fimmers, Rolf, additional, Marfo-Debrekyei, Yeboah, additional, Konadu, Peter, additional, Debrah, Alexander Yaw, additional, Bandi, Claudio, additional, Brattig, Norbert, additional, Albers, Anna, additional, Larbi, John, additional, Batsa, Linda, additional, Adjei, Ohene, additional, and Büttner, Dietrich W., additional

Published
2007
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25. Plasma Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-A Gene Polymorphism are Associated with Hydrocele Development in Lymphatic Filariasis

Author

Debrah, Alexander Yaw, primary, Toliat, Mohammad Reza, additional, Batsa, Linda, additional, Marfo-Debrekyei, Yeboah, additional, Mand, Sabine, additional, Lawson, Bernard, additional, Hoerauf, Achim, additional, Nürnberg, Peter, additional, Adjei, Ohene, additional, and Pfarr, Kenneth, additional

Published
2007
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27. Frequent detection of worm movements in onchocercal nodules by ultrasonography

Author

Mand, Sabine, Marfo-Debrekyei, Yeboah, Debrah, Alex, Buettner, Marcelle, Batsa, Linda, Pfarr, Kenneth, Adjei, Ohene, and Hoerauf, Achim

Subjects
Research, parasitic diseases
Abstract

BACKGROUND: Ultrasonography (USG) is known to be a suitable tool for diagnosis in lymphatic filariasis as the adult filarial nematode Wuchereria bancrofti in scrotal lymphatic vessels of infected men can be detected by the characteristic pattern of movement, the Filaria Dance Sign. In onchocerciasis, moving adult worms have not yet been demonstrated by USG. In addition the verification of drug effects on living adult Onchocerca volvulus filariae in trials is hampered by the lack of tools for longitudinal observation of alterations induced by potentially macrofilaricidal drugs in vivo. The present study was carried out to determine the frequency of detection of moving adult filariae of O. volvulus by USG. METHODS: In an endemic region for onchocerciasis in Ghana, 61 patients infected with onchocerciasis were recruited by palpation and onchocercomas examined by USG using an ultrasound system equipped with a 7.5 - 10 MHz linear transducer. Onchocercomas were recorded on videotape and evaluated with regard to location, number and size, as well as to movements of adult filariae. RESULTS: In the 61 patients 303 onchocercomas were found by palpation and 401 onchocercomas were detected by USG. In 18 out of 61 patients (29.5%), altogether 22 nodules with moving adult O. volvulus filariae were detected and are presented in animated ultrasound images as mp-4 videos. CONCLUSION: Ultrasonographical examinations of onchocercomas where living adult filariae can be displayed may serve as a new tool for the longitudinal observation in vivo of patients with onchocerciasis undergoing treatment and as an adjunct to histological evaluation.

Published
2005

28. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Author

Yaw Debrah, Alexander, Mand, Sabine, Marfo-Debrekyei, Yeboah, Batsa, Linda, Albers, Anna, Specht, Sabine, Klarmann, Ute, Pfarr, Kenneth, Adjei, Ohene, and Hoerauf, Achim

Subjects
TREATMENT of filariasis, RIFAMPIN, WOLBACHIA, LYMPHEDEMA, HYDROCELE, ELEPHANTIASIS, IVERMECTIN, ALBENDAZOLE
Abstract

Infection with the filarial nematodeWuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti. [ABSTRACT FROM AUTHOR]

Published
2011
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29. Reliable and frequent detection of adultWuchereria bancroftiin Ghanaian women by ultrasonography.

Author

Mand, Sabine, Debrah, Alex, Batsa, Linda, Adjei, Ohene, and Hoerauf, Achim

Subjects
FILARIASIS, ULTRASONIC imaging, DISEASES in women, WORMS, DIAGNOSIS
Abstract

Detection of adultWuchereria bancroftiby ultrasonography of the scrotal region in men is a suitable diagnostic tool for lymphatic filariasis, whereas there are only a few case reports of adult filariae observed by ultrasonography in women. We examined 35 microfilaraemic women ultrasonographically in sites of the body suspected as locations for worm nests. In 15 women the‘filaria dance sign’ (FDS) was detected in various locations, some being novel, such as adult worms within lymphatic vessels between muscular fibres of the thighs. The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected withW. bancrofti. [ABSTRACT FROM AUTHOR]

Published
2004
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30. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.

Author

Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, and Hoerauf A

Abstract

Infection with the filarial nematode Wuchereria bancrofti can lead to lymphedema, hydrocele, and elephantiasis. Since adult worms cause pathology in lymphatic filariasis (LF), it is imperative to discover macrofilaricidal drugs for the treatment of the infection. Endosymbiotic Wolbachia in filariae have emerged as a new target for antibiotics which can lead to macrofilaricidal effects. In Ghana, a pilot study was carried out with 39 LF-infected men; 12 were treated with 200 mg doxycycline/day for 4 weeks, 16 were treated with a combination of 200 mg doxycycline/day + 10 mg/kg/day rifampicin for 2 weeks, and 11 patients received placebo. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia, and filarial dance sign (FDS). Both 4-week doxycycline and the 2-week combination treatment reduced Wolbachia load significantly. At 18 months posttreatment, four-week doxycycline resulted in 100% adult worm loss, and the 2-week combination treatment resulted in a 50% adult worm loss. In conclusion, this pilot study with a combination of 2-week doxycycline and rifampicin demonstrates moderate macrofilaricidal activity against W. bancrofti.

Published
2011
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