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20 results on '"Batista-Gonzalez, Ana"'

1. Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism

Author

Ávalos, Yenniffer, Hernández-Cáceres, María Paz, Lagos, Pablo, Pinto-Nuñez, Daniela, Rivera, Patricia, Burgos, Paulina, Díaz-Castro, Francisco, Joy-Immediato, Michelle, Venegas-Zamora, Leslye, Lopez-Gallardo, Erik, Kretschmar, Catalina, Batista-Gonzalez, Ana, Cifuentes-Araneda, Flavia, Toledo-Valenzuela, Lilian, Rodriguez-Peña, Marcelo, Espinoza-Caicedo, Jasson, Perez-Leighton, Claudio, Bertocchi, Cristina, Cerda, Mauricio, Troncoso, Rodrigo, Parra, Valentina, Budini, Mauricio, Burgos, Patricia V., Criollo, Alfredo, and Morselli, Eugenia

Published
2022
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9. Lipid Activates mTORC1 and mTORC2 in the Absorption of Dietary Triglycerides

Author

Batista-Gonzalez, Ana, primary, Tarabra, Elena, additional, Toledo, Miriam, additional, Barros, Jean-Paul Pais de, additional, Tam, Gillian, additional, Aoun, Marie Louise, additional, Picarda, Elodie, additional, Riascos-Bernal, Dario F., additional, Sibinga, Nicolas E.S., additional, Zang, XingXing, additional, Buhman, Kimberly K., additional, Masson, David, additional, and Singh, Rajat, additional

Published
2018
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12. Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

Author

Prados-Rosales, Rafael, primary, Carreño, Leandro, additional, Cheng, Tingting, additional, Blanc, Caroline, additional, Weinrick, Brian, additional, Malek, Adel, additional, Lowary, Todd L., additional, Baena, Andres, additional, Joe, Maju, additional, Bai, Yu, additional, Kalscheuer, Rainer, additional, Batista-Gonzalez, Ana, additional, Saavedra, Noemi A., additional, Sampedro, Leticia, additional, Tomás, Julen, additional, Anguita, Juan, additional, Hung, Shang-Cheng, additional, Tripathi, Ashish, additional, Xu, Jiayong, additional, Glatman-Freedman, Aharona, additional, Jacobs, Williams R., additional, Chan, John, additional, Porcelli, Steven A., additional, Achkar, Jacqueline M., additional, and Casadevall, Arturo, additional

Published
2017
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13. The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination AgainstMycobacterium tuberculosis

Author

Prados-Rosales, Rafael, primary, Carreño, Leandro J., additional, Weinrick, Brian, additional, Batista-Gonzalez, Ana, additional, Glatman-Freedman, Aarona, additional, Xu, Jiayong, additional, Chan, John, additional, Jacobs, William R., additional, Porcelli, Steven A., additional, and Casadevall, Arturo, additional

Published
2016
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16. Mycobacterial Membrane Vesicles Administered Systemically in Mice Induce a Protective Immune Response to Surface Compartments of Mycobacterium tuberculosis

Author

Prados-Rosales, Rafael, primary, Carreño, Leandro J., additional, Batista-Gonzalez, Ana, additional, Baena, Andres, additional, Venkataswamy, Manjunatha M., additional, Xu, Jiayong, additional, Yu, Xiaobo, additional, Wallstrom, Garrick, additional, Magee, D. Mitchell, additional, LaBaer, Joshua, additional, Achkar, Jacqueline M., additional, Jacobs, William R., additional, Chan, John, additional, Porcelli, Steven A., additional, and Casadevall, Arturo, additional

Published
2014
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17. Inhibition of LDL-oxidation and antioxidant properties related to polyphenol content of hydrophilic fractions from seaweed Halimeda Incrassata (Ellis) Lamouroux

Author

Costa-Mugica, Ariana, primary, Batista- Gonzalez, Ana Elsa, additional, Mondejar, Diadelis, additional, Soto-López, Yosdel, additional, Brito-Navarro, Victor, additional, Vázquez, Ana Maria, additional, Brömme, Dieter, additional, Zaldívar-Muñoz, Claudina, additional, Vidal-Novoa, Alexis, additional, Silva, Ana Mara de Oliveira e, additional, and Mancini-Filho, Jorge, additional

Published
2012
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19. ANALYSIS OF IN VITRO AND IN VIVO ANTIOXIDANT PROPERTIES OF HYDROPHILIC FRACTIONS FROM THE SEAWEED HALIMEDA MONILE L.

Author

BATISTA-GONZALEZ, ANA ELSA, SILVA, ANA MARA DE OLIVEIRA E, VIDAL-NOVOA, ALEXIS, PINTO, JOSE RICARDO, MANCINI, DALVA ASSUNÇÃO PORTARI, and MANCINI-FILHO, JORGE

Subjects
*ANTIOXIDANTS, *HYDROPHILIC compounds, *MARINE algae, *HALIMEDA, *TERPENES, *FLAVONOIDS, *FIRE assay
Abstract

ABSTRACT In this work, in vitro and in vivo antioxidant properties of the marine algae Halimeda monile were assessed and the levels of some of its compounds likely to be responsible for such properties were determined. The estimated contents of total polyphenols, chlorophylls a and b and carotenoids were 179.5, 356.3, 452.8 and 42.2 µg/g dry weight seaweed, respectively. The presence of terpenoids and flavonoids was also observed. The antioxidant activity of two polar fractions from H. monile (lyophilized aqueous extract and free phenolic acid fraction) was evaluated using three antioxidant assays: ferric reducing antioxidant power, 1,1-diphenyl-2-picrylhydrazyl and lipid peroxidation. Treatment of CCl4-induced liver damage in rats with extracts resulted in lower serum thiobarbituric acid-reactive substances levels and higher hepatic glutathione concentrations compared to those observed in the CCl4-treated group. Also, a significant increase in catalase activity was detected after treatment with the extracts. These results suggest that the seaweed H. monile could be a potential source for natural antioxidants. PRACTICAL APPLICATIONS Seaweeds have a broad chemical composition, consisting of bioactive molecules as chlorophyll, carotenoids, mycosporine-like amino acids, terpenoids, carbohydrates, vitamins and phenolic compounds. Different seaweed extracts have received increased attention, due to their pharmacological effects, particularly in vivo hypolipidemic, antioxidant, immunological and antitumoral activities. The phenolic compounds are powerful antioxidant molecules, and fractions rich in these compounds may be use as antioxidant complement in health states where oxidative state is damage. Results of this research with Halimeda monile L. fractions showed in experiments in vitro and in vivo the presence of different phenolic compounds and that the antioxidant activity is related to them. Therefore, the H. monile L. seaweed fractions have the potential to be developed into new health foods. [ABSTRACT FROM AUTHOR]

Published
2012
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20. The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis.

Author

Hazari Y, Urra H, Garcia Lopez VA, Diaz J, Tamburini G, Milani M, Pihan P, Durand S, Aprahamia F, Baxter R, Huang M, Dong XC, Vihinen H, Batista-Gonzalez A, Godoy P, Criollo A, Ratziu V, Foufelle F, Hengstler JG, Jokitalo E, Bailly-Maitre B, Maiers JL, Plate L, Kroemer G, and Hetz C

Abstract

Collagen is one the most abundant proteins and the main cargo of the secretory pathway, contributing to hepatic fibrosis and cirrhosis due to excessive deposition of extracellular matrix. Here we investigated the possible contribution of the unfolded protein response, the main adaptive pathway that monitors and adjusts the protein production capacity at the endoplasmic reticulum, to collagen biogenesis and liver disease. Genetic ablation of the ER stress sensor IRE1 reduced liver damage and diminished collagen deposition in models of liver fibrosis triggered by carbon tetrachloride (CCl 4 ) administration or by high fat diet. Proteomic and transcriptomic profiling identified the prolyl 4-hydroxylase (P4HB, also known as PDIA1), which is known to be critical for collagen maturation, as a major IRE1-induced gene. Cell culture studies demonstrated that IRE1 deficiency results in collagen retention at the ER and altered secretion, a phenotype rescued by P4HB overexpression. Taken together, our results collectively establish a role of the IRE1/P4HB axis in the regulation of collagen production and its significance in the pathogenesis of various disease states.

Published
2023
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