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22 results on '"Bathon, Melanie"'

2. Adressen

Author

Eucker, Jan, primary, Scholz, Christian W., additional, Bathon, Melanie, additional, Busse, Antonia, additional, Dieing, Annette, additional, Eucker, Jan, additional, Flath, Bernd, additional, Folprecht, Gunnar, additional, Habbel, Jan-Piet, additional, Heidel, Florian, additional, Hochhaus, Andreas, additional, Hübel, Kai, additional, Jann, Henning, additional, Jehn, Christian, additional, Klinghammer, Konrad, additional, Knauf, Wolfgang, additional, Kolb, Hans-Jochem, additional, Kroenlein, Hannes, additional, Kubasch, Anne Sophie, additional, Lüftner, Diana, additional, Meyer, Oliver, additional, Möhlig, Matthias, additional, Naumann, Ralph, additional, Nogai, Axel, additional, Ochsenreither, Sebastian, additional, Oettle, Helmut, additional, Pape, Ulrich-Frank, additional, Platzbecker, Uwe, additional, Rank, Andreas, additional, Reichardt, Peter, additional, Rick, Oliver, additional, Rieke, Damian, additional, Riess, Hanno, additional, Ruhnke, Markus, additional, Schaich, Markus, additional, Schalhorn, Andreas, additional, Schmälter, Ann-Kristin, additional, Schmidt-Graf, Friederike, additional, Schmittel, Alexander, additional, Schrezenmeier, Hubert, additional, Schulz, Carsten-Oliver, additional, Speiser, Dorothee, additional, Vogel, Arndt, additional, Baumgarten, Louisa von, additional, and Welland, Dr. med. Sabrina, additional

Published
2024
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3. Malignome des Gastrointestinaltrakts

Author

Bathon, Melanie, primary, Folprecht, Gunnar, additional, Jehn, Christian, additional, Lüftner, Diana, additional, Oettle, Helmut, additional, Riess, Hanno, additional, Vogel, Arndt, additional, and Welland, Sabrina, additional

Published
2024
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5. Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma

Author

Haber, Philipp K., Castet, Florian, Torres-Martin, Miguel, Andreu-Oller, Carmen, Puigvehí, Marc, Miho, Maeda, Radu, Pompilia, Dufour, Jean-Francois, Verslype, Chris, Zimpel, Carolin, Marquardt, Jens U., Galle, Peter R., Vogel, Arndt, Bathon, Melanie, Meyer, Tim, Labgaa, Ismail, Digklia, Antonia, Roberts, Lewis R., Mohamed Ali, Mohamed A., Mínguez, Beatriz, Citterio, Davide, Mazzaferro, Vincenzo, Finkelmeier, Fabian, Trojan, Jörg, Özdirik, Burcin, Müller, Tobias, Schmelzle, Moritz, Bejjani, Anthony, Sung, Max W., Schwartz, Myron E., Finn, Richard S., Thung, Swan, Villanueva, Augusto, Sia, Daniela, and Llovet, Josep M.

Published
2023
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7. Malignome des Gastrointestinaltrakts (GIT)

Author

Bathon, Melanie, primary, Folprecht, Gunnar, additional, Jehn, Christian, additional, Lüftner, Diana, additional, Oettle, Helmut, additional, Riess, Hanno, additional, and Vogel, Arndt, additional

Published
2021
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9. Characterization and clinical correlation of the immune contexture in intrahepatic cholangiocarcinoma using multiplex immunohistochemistry

Author

Peter, Simon, primary, Volk, Valery, additional, Hoffmann, Charlotte, additional, Bathon, Melanie, additional, Goeppert, Benjamin, additional, Longerich, Thomas, additional, Albrecht, Thomas, additional, Reineke-Plaaß, Tanja, additional, Feuerhake, Friedrich, additional, Vogel, Arndt, additional, and Saborowski, Anna, additional

Published
2022
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10. sj-docx-2-tam-10.1177_17588359221080298 ��� Supplemental material for Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience

Author

de Castro, Tiago, Jochheim, Leonie S., Bathon, Melanie, Welland, Sabrina, Scheiner, Bernhard, Shmanko, Kateryna, Roessler, Daniel, Khaled, Najib Ben, Jeschke, Matthias, Ludwig, Johannes M., Marquardt, Jens U., Weinmann, Arndt, Pinter, Matthias, Lange, Christian M., Vogel, Arndt, and Saborowski, Anna

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-2-tam-10.1177_17588359221080298 for Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience by Tiago de Castro, Leonie S. Jochheim, Melanie Bathon, Sabrina Welland, Bernhard Scheiner, Kateryna Shmanko, Daniel Roessler, Najib Ben Khaled, Matthias Jeschke, Johannes M. Ludwig, Jens U. Marquardt, Arndt Weinmann, Matthias Pinter, Christian M. Lange, Arndt Vogel and Anna Saborowski in Therapeutic Advances in Medical Oncology

Published
2022
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11. sj-docx-1-tam-10.1177_17588359221080298 ��� Supplemental material for Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience

Author

de Castro, Tiago, Jochheim, Leonie S., Bathon, Melanie, Welland, Sabrina, Scheiner, Bernhard, Shmanko, Kateryna, Roessler, Daniel, Khaled, Najib Ben, Jeschke, Matthias, Ludwig, Johannes M., Marquardt, Jens U., Weinmann, Arndt, Pinter, Matthias, Lange, Christian M., Vogel, Arndt, and Saborowski, Anna

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tam-10.1177_17588359221080298 for Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience by Tiago de Castro, Leonie S. Jochheim, Melanie Bathon, Sabrina Welland, Bernhard Scheiner, Kateryna Shmanko, Daniel Roessler, Najib Ben Khaled, Matthias Jeschke, Johannes M. Ludwig, Jens U. Marquardt, Arndt Weinmann, Matthias Pinter, Christian M. Lange, Arndt Vogel and Anna Saborowski in Therapeutic Advances in Medical Oncology

Published
2022
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12. Atezolizumab and bevacizumab in patients with advanced hepatocellular carcinoma with impaired liver function and prior systemic therapy: a real-world experience

Author

de Castro, Tiago, primary, Jochheim, Leonie S., additional, Bathon, Melanie, additional, Welland, Sabrina, additional, Scheiner, Bernhard, additional, Shmanko, Kateryna, additional, Roessler, Daniel, additional, Ben Khaled, Najib, additional, Jeschke, Matthias, additional, Ludwig, Johannes M., additional, Marquardt, Jens U., additional, Weinmann, Arndt, additional, Pinter, Matthias, additional, Lange, Christian M., additional, Vogel, Arndt, additional, and Saborowski, Anna, additional

Published
2022
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18. The orphan response regulator HP1021 of Helicobacter priori regulates transcription of a gene cluster presumably involved in acetone metabolism

Author

Pflock, Michael, Bathon, Melanie, Schar, Jennifer, Muller, Stefanie, Mollenkopf, Hans, Meyer, Thomas F., and Beier, Dagmar

Subjects
Acetone -- Research, Helicobacter pylori -- Genetic aspects, Helicobacter pylori -- Research, Genetic regulation -- Research, Protein binding -- Research, Biological sciences
Abstract

Helicobacter pylori is a gastric pathogen for which no nonhuman reservoir is known. In accordance with thetight adaptation to its unique habitat, the human stomach, H. pylori is endowed with a very restricted repertoire of regulatory proteins. Nevertheless, the three complete two-component systems of H. pylori were shown to be involved in the regulation of important virulence traits like motility and acid resistance and in the control of metal homeostasis. HP1021 is an orphan response regulator with an atypical receiver domain whose inactivation has a considerable impact on the growth of H. pylori. Here we report the identification of HP1021regulated genes by whole-genome transcriptional profiling. We show that the transcription of the essential housekeeping genes nifS and nifU, which are required for the assembly of Fe-S clusters, is activated by HP1021. Furthermore, we demonstrate that the expression of a gene cluster comprising open reading frames hp0690 to hp0693 and hp0695 to hp0697 which is probably involved in acetone metabolism is strongly upregulated by HP1021. Evidence is provided for a direct regulation of the hp0695-to-hp0697 operon by the binding of HP1021 to its promoter region.

Published
2007

22. Immunotherapies in clinical development for biliary tract cancer

Author

Vogel, Arndt, Bathon, Melanie, and Saborowski, Anna

Abstract

ABSTRACTIntroduction: Cancers of the biliary tract (BTC) are aggressive malignancies with limited treatment options and an overall dismal prognosis. In recent years, two concepts, namely precision oncology and immune oncology (IO) have profoundly influenced and, in some cancers, even revolutionized tumor treatments. While positive data from randomized trials have led to the incorporation of targeted concepts for genetically select BTC patients, IO is not yet implemented in clinical practice.Areas covered: We discuss published results from completed, as well as from ongoing studies on IO in BTC, based on a literature search on Pubmed and information provided by clinicaltrials.gov in October 2020. Apart from monotherapy, we outline IO-based combination approaches and highlight pivotal studies whose results will likely influence the future development of relevant concepts in BTC.Expert opinion: Despite partially positive signals, IO thus far disappointed in unselected BTC populations and should currently not be considered as a preferred systemic treatment in patients with microsatellite stable disease outside of clinical trials. In the coming years, a better understanding of the molecular mechanisms underlying resistance to checkpoint inhibition, and the identification of positive predictive biomarkers will be important for the successful integration of IO into treatment concepts for BTC patients.

Published
2021
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