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Your search keyword '"Bathellier, Brice"' showing total 200 results
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200 results on '"Bathellier, Brice"'

1. Differential roles of auditory and visual cortex for sensory detection in mice

Author

Ceballo, Sebastian, Deneux, Thomas, Siliceo, Mariana, and Bathellier, Brice

Subjects
Auditory cortex, Visual cortex, Perception, Sensory detection, Inactivation studies, Biology (General), QH301-705.5
Abstract

Sensory cortex encompasses the regions of the cerebral cortex that receive primary sensory inputs and is crucial for conscious sensory perception in humans. Yet, some forms of perception are possible without sensory cortex. For example in animal models, the association of a sound detection to a simple behavior resists to the inactivation of auditory cortex. In contrast, post-training inactivation experiments conducted in visual or somatosensory cortex led to much stronger effects. Here we show that muscimol inactivation of visual or auditory cortex in the same detection protocol transiently abolishes visual but not auditory detection. We also observe that cortex-dependency correlates with longer reaction times. This suggests that auditory cortex is more easily bypassed by other circuits for stimulus detection than other primary sensory areas, which may be due to timing differences between auditory and visual associations.

Published
2022
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15. Spike timing prediction with active dendrites

Author

Naud, Richard, Bathellier, Brice, and Gerstner, Wulfram

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

A complete single-neuron model must correctly reproduce the firing of spikes and bursts. We present a study of a simplified model of deep pyramidal cells of the cortex with active dendrites. We hypothesized that we can model the soma and its apical tuft with only two compartments, without significant loss in the accuracy of spike-timing predictions. The model is based on experimentally measurable impulse-response functions, which transfer the effect of current injected in one compartment to current reaching the other. Each compartment was modeled with a pair of non-linear differential equations and a small number of parameters that approximate the Hodgkin-and-Huxley equations. The predictive power of this model was tested on electrophysiological experiments where noisy current was injected in both the soma and the apical dendrite simultaneously. We conclude that a simple two-compartment model can predict spike times of pyramidal cells stimulated in the soma and dendrites simultaneously. Our results support that regenerating activity in the dendritic tuft is required to properly account for the dynamics of layer 5 pyramidal cells under in-vivo-like conditions., Comment: 7 pages, 4 figures

Published
2013

26. A Spatial Code for Temporal Information is Necessary for Sensory Learning

Author

Bagur, Sophie, primary, Bourg, Jacques, additional, Kempf, Alexandre, additional, Tarpin, Thibault, additional, Bergaoui, Khalil, additional, Guo, Yin, additional, Ceballo, Sebastian, additional, Schwenkgrub, Joanna, additional, Verdier, Antonin, additional, Puel, Jean-Luc, additional, Bourien, Jérôme, additional, and Bathellier, Brice, additional

Published
2023
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27. A spatial code for temporal cues is necessary for sensory learning

Author

Bagur, Sophie, primary, Bourg, Jacques, additional, Kempf, Alexandre, additional, Tarpin, Thibault, additional, Bergaoui, Khalil, additional, Guo, Yin, additional, Ceballo, Sebastian, additional, Schwenkgrub, Joanna, additional, Verdier, Antonin, additional, Puel, Jean Luc, additional, Bourien, Jérôme, additional, and Bathellier, Brice, additional

Published
2022
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31. Fast cortical dynamics encode tactile grating orientation during active touch

Author

Harrell, Evan, Renard, Anthony, Bathellier, Brice, Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), This work was supported by the Paris-Saclay University (Lidex NeuroSaclay) and by the International Human Frontier Science Program Organization (CDA-0064-2015, to B.B.) and Fondation pour l’Audition (FPA IDA02). A.R. was supported by the Fondation pour la Recherche Médicale ECO20170637482. We acknowledge the support of the Fondation pour l’Audition to the Institut de l’Audition., Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Bathellier, Brice

Subjects
[SDV] Life Sciences [q-bio], genetic structures, [SDV]Life Sciences [q-bio]
Abstract

International audience; Touch-based object recognition relies on perception of compositional tactile features like roughness, shape, and surface orientation. However, besides roughness, it remains unclear how these different tactile features are encoded by neural activity that is linked with perception. Here, we establish a cortex-dependent perceptual task in which mice discriminate tactile gratings on the basis of orientation using only their whiskers. Multielectrode recordings in the barrel cortex reveal weak orientation tuning in average firing rates (500-ms time scale) during grating exploration despite high levels of cortical activity. Just before decision, orientation information extracted from fast cortical dynamics (100-ms time scale) more closely resembles concurrent psychophysical measurements than single neuron orientation tuning curves. This temporal code conveys both stimulus and choice/action-related information, suggesting that fast cortical dynamics during exploration of a tactile object both reflect the physical stimulus and affect the decision.

Published
2021

45. Reduction in sound discrimination in noise is related to envelope similarity and not to a decrease in envelope tracking abilities.

Author

Souffi, Samira, Varnet, Léo, Zaidi, Meryem, Bathellier, Brice, Huetz, Chloé, and Edeline, Jean‐Marc

Subjects
AUDITORY pathways, AUDITORY neurons, COCHLEAR nucleus, ACOUSTIC nerve, AUDITORY cortex
Abstract

Humans and animals constantly face challenging acoustic environments, such as various background noises, that impair the detection, discrimination and identification of behaviourally relevant sounds. Here, we disentangled the role of temporal envelope tracking in the reduction in neuronal and behavioural discrimination between communication sounds in situations of acoustic degradations. By collecting neuronal activity from six different levels of the auditory system, from the auditory nerve up to the secondary auditory cortex, in anaesthetized guinea‐pigs, we found that tracking of slow changes of the temporal envelope is a general functional property of auditory neurons for encoding communication sounds in quiet conditions and in adverse, challenging conditions. Results from a go/no‐go sound discrimination task in mice support the idea that the loss of distinct slow envelope cues in noisy conditions impacted the discrimination performance. Together, these results suggest that envelope tracking is potentially a universal mechanism operating in the central auditory system, which allows the detection of any between‐stimulus difference in the slow envelope and thus copes with degraded conditions. Key points: In quiet conditions, envelope tracking in the low amplitude modulation range (<20 Hz) is correlated with the neuronal discrimination between communication sounds as quantified by mutual information from the cochlear nucleus up to the auditory cortex.At each level of the auditory system, auditory neurons retain their abilities to track the communication sound envelopes in situations of acoustic degradation, such as vocoding and the addition of masking noises up to a signal‐to‐noise ratio of −10 dB.In noisy conditions, the increase in between‐stimulus envelope similarity explains the reduction in both behavioural and neuronal discrimination in the auditory system.Envelope tracking can be viewed as a universal mechanism that allows neural and behavioural discrimination as long as the temporal envelope of communication sounds displays some differences. [ABSTRACT FROM AUTHOR]

Published
2023
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