1. Spontaneous α‐C−H Carboxylation of Ketones by Gaseous CO2 at the Air‐water Interface of Aqueous Microdroplets.
- Author
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Basuri, Pallab, Mukhopadhyay, Sinchan, Reddy, K. S. S. V. Prasad, Unni, Keerthana, Spoorthi, B. K., Shantha Kumar, Jenifer, Yamijala, Sharma S. R. K. C., and Pradeep, Thalappil
- Subjects
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AIR-water interfaces , *MICRODROPLETS , *CARBON-carbon bonds , *KETONES , *ORGANIC products , *CARBON dioxide reduction , *CARBOXYLATION - Abstract
We present a catalyst‐free route for the reduction of carbon dioxide integrated with the formation of a carbon‐carbon bond at the air/water interface of negatively charged aqueous microdroplets, at ambient temperature. The reactions proceed through carbanion generation at the α‐carbon of a ketone followed by nucleophilic addition to CO2. Online mass spectrometry reveals that the product is an α‐ketoacid. Several factors, such as the concentration of the reagents, pressure of CO2 gas, and distance traveled by the droplets, control the kinetics of the reaction. Theoretical calculations suggest that water in the microdroplets facilitates this unusual chemistry. Furthermore, such a microdroplet strategy has been extended to seven different ketones. This work demonstrates a green pathway for the reduction of CO2 to useful carboxylated organic products. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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