24 results on '"Bastian Kaiser"'
Search Results
2. High-speed processing with ultrafast lasers and resonant scanning systems
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Thomas Herrmann, Bastian Kaiser, and Johannes A. L'huillier
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- 2023
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3. Real-time holographic 3D beam manipulation for ultrashort pulse laser processing
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Bastian Kaiser, Mareike Schäfer, and Johannes A. L'huillier
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- 2023
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4. High spectral resolution LIDAR source at 1 kHz amplifying spectrally single mode ns-pulses with active ASE suppression
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Andrea Nagel, Bastian Kaiser, Bernhard Henrich, Peter Koch, Martin Nittmann, Jürgen Bartschke, and Johannes A. L'huillier
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- 2023
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5. Improved durable pulmonary vein isolation with shorter procedure times and lower energy levels using RF ablation with ablation index and a stringent lesion contiguity
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Bastian Kaiser, Cathrin Theis, Giancarlo Pirozzolo, Carola Huber, Felix Hui, Philipp Kaesemann, and Raffi Bekeredjian
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medicine.medical_specialty ,medicine.diagnostic_test ,Paroxysmal atrial fibrillation ,business.industry ,medicine.medical_treatment ,Ablation index ,Catheter ablation ,Ablation ,medicine.disease ,Pericardial effusion ,Group B ,Pulmonary vein ,Lesion ,Catheter ,Physiology (medical) ,Internal medicine ,medicine ,Cardiology ,Fluoroscopy ,Original Article ,Interlesion distance ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) varies between 80 and 90%. Ablation index, incorporating contact force, stability, time and power is a more profound parameter of significant lesion size and has been established. Equally important is a stringent contiguity of the lesion set. METHODS AND RESULTS A total number of 100 consecutive patients undergoing de-novo catheter ablation for paroxysmal atrial fibrillation (PAF) were analyzed between 2016 and 2019. In the first 50 patients (group A) PVI was performed using a surround flow, contact force catheter (Biosense Webster Thermocool STSF, Biosense Webster, USA) with a drag-and-ablate technique to encircle the PVs. In the following 50 patients (group B), PVI was performed using ablation index and a stringent lesion contiguity with an interlesion distance (ILD) of
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- 2021
6. Bin im Wald!
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Bastian Kaiser
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- 2022
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7. Rezension von: Kaiser, Bastian, Bin im Wald!
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Reinhard Wolf and Bastian Kaiser
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Bastian Kaiser: Bin im Wald! – Mit einem Forstexperten durchs grüne Dickicht Hirzel-Verlag Stuttgart 2022. 300 Seiten mit 24 farbigen Abbildungen. Hardcover 22,00 €. ISBN 978-3-7776-3040-3
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- 2023
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8. Pulmonary vein isolation using cryoballoon ablation versus RF ablation using ablation index following the CLOSE protocol: A prospective randomized trial
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Cathrin Theis, Bastian Kaiser, Philipp Kaesemann, Felix Hui, Giancarlo Pirozzolo, Raffi Bekeredjian, and Carola Huber
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Treatment Outcome ,Pulmonary Veins ,Recurrence ,Physiology (medical) ,Atrial Fibrillation ,Catheter Ablation ,Humans ,Prospective Studies ,Cardiology and Cardiovascular Medicine ,Cryosurgery - Abstract
The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) vary between 80% and 90%. This prospective, randomized study investigated the efficacy of cryoballoon PVI (CBA) versus PVI with radio-frequency (RF)-energy following the CLOSE protocol (ablation index [AI], interlesion distance ≤6 mm, surround flow catheter) in terms of single-procedure arrhythmia-free outcome and safety.A total number of 150 patients undergoing de novo catheter ablation for paroxysmal AF were randomized to two different treatment arms. In group A patients, PVI was performed with the 23 or 28 mm cryoballoon (Artic Front™ Balloon in conjunction with an Achieve Mapping Catheter, Medtronic Inc.). The ablation procedure in group B was performed with RF-energy, using AI and following the CLOSE protocol. PVI using AI incorporates stability, contact force (CF), time, and power. The CLOSE protocol combines AI and ≤6 mm interlesion distance using a surround flow catheter (Biosense Webster Thermocool STSF). A total of 75 patients were randomized into each group without significant differences in baseline characteristics. During a mean follow-up of 12 ± 4.5 months after a single procedure, 64 (85.33%) patients of group A were free of arrhythmia recurrence versus 65 (86.67%) patients in group B (p = ns). A total of 14 patients (group A: 7 [9.33%]; group B: 7 [9.33%]; p = ns) underwent a redo-procedure. No significant difference between both groups was observed in terms of PV recovery (group A: 4 [5.33%] vs. group B: 3 [4%]; p = ns). In two patients of group A and four patients of group B, the PVs were durably isolated, whereas the patients had AF recurrence caused by extra-PV AF sources. Two patients of each group had continued paroxysmal AF but did not undergo redo-procedure. Patients of group A showed significantly more AF recurrence during the blanking period of 3 months (group A: 14 [18.67%] vs. group B: 6 [8%]; p .05). With regard to the procedural data, the procedure time was significantly shorter in group A (70.53 ± 16.13 vs. 115.35 ± 15.38; p .01); the flouroscopy time and dose area product showed no significant differences (Table 2). Both procedures were performed with a low number of complications; no pericardial effusion was seen in either group; in group A two patients had a significant hematoma of the groin with the need for surgical repair.Cryoballoon PVI and PVI using ablation index following the CLOSE protocol are equally efficient in achieving durable PV isolation. In this study, cryoballoon ablation led to significantly more AF recurrence during the blanking period.
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- 2021
9. Evaluation of the hepatocyte-derived cell line BFH12 as an in vitro model for bovine biotransformation
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Axel Schoeniger, Walther Honscha, Alexander Gleich, Herbert Fuhrmann, and Bastian Kaiser
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0301 basic medicine ,medicine.drug_class ,Clinical Biochemistry ,Biomedical Engineering ,Bioengineering ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Biotransformation ,medicine ,Bile acid ,biology ,Chemistry ,Cytochrome P450 ,Cell Biology ,Taurocholic acid ,030104 developmental biology ,medicine.anatomical_structure ,Biochemistry ,Cell culture ,030220 oncology & carcinogenesis ,Hepatocyte ,biology.protein ,Original Article ,Taurolithocholic acid ,Taurodeoxycholic acid ,Biotechnology - Abstract
The knowledge of drug metabolising enzymes (DMEs) in cattle is rather limited. The capability of the bovine foetal hepatocyte-derived cell line BFH12 to serve as model for biotransformation was evaluated. Gene expression analysis of DMEs was performed by reverse transcription PCR (RT-PCR). The presence of efflux transporters was visualised by immunocytochemistry, and functional induction of cytochrome P450 (CYP) 1A was assessed by the ethoxyresorufin-O-deethylase (EROD) assay. The production of bile acids was measured by liquid chromatography-tandem mass spectrometry (LC–MS/MS). RT-PCR revealed the expression of cytochromes 1A1, 1A2, 3A4 and phase II enzymes UGT1A1, UGT1A6 and GSTM1. Immunofluorescence demonstrated efflux transporters ABCG2 and ABCC1. The EROD assay revealed a dose-dependent CYP1A induction after treatment with benzo[a]pyrene (BP). LC–MS/MS analysis of cell culture supernatants showed the production of bile acids including taurocholic acid, tauro-chenodeoxycholic acid, taurodeoxycholic acid and taurolithocholic acid. The results strongly suggest the applicability of the cell line BFH12 for subsequent experiments in the emerging field of bovine biotransformation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10616-018-0279-4) contains supplementary material, which is available to authorized users.
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- 2019
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10. Pulmonary vein isolation using Cryo Balloon ablation versus RF ablation using ablation index following the CLOSE protocol: a Prospective Randomized Trial
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G Pirozzolo, Raffi Bekeredjian, Carola Huber, Cathrin Theis, Philipp Kaesemann, and Bastian Kaiser
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Radiofrequency ablation ,business.industry ,Paroxysmal atrial fibrillation ,medicine.medical_treatment ,Cardiac Ablation ,Balloon ,Ablation ,Pulmonary vein ,law.invention ,Randomized controlled trial ,law ,Physiology (medical) ,medicine ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Rf ablation - Abstract
Funding Acknowledgements Type of funding sources: None. Background The single procedure success rates of durable pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) varies between 80 and 90 %. This prospective, randomized study investigated the efficacy of Cryo-Balloon PVI versus pulmonary vein isolation with RF-energy following the CLOSE protocol (ablation index (AI), interlesion distance ≤ 6 mm, surround flow catheter) in terms of single-procedure arrhythmia-free outcome, safety and procedural time. Methods and results A total number of 150 patients undergoing de-novo catheter ablation for paroxysmal AF were randomized to two different treatment arms in a 1:1 fashion. In group-A patients, PVI was performed with the 23 or 28 mm Cryo-Balloon (Articfront Balloon, Medtronic Inc). The ablation procedure in group B was performed with RF-energy, using AI and following the CLOSE protocol. During a mean follow-up of 15 ± 6 months after a single procedure, 69 (92%) patients of group A were free of arrhythmia recurrence versus 68 (90.67%) patients in group B (p = ns). A total of 10 patients (group A: 4, group B: 6; p = ns) underwent a redo-procedure. No difference between both groups was observed in terms of patients with PV recovery (group A: 2 (2,67%) vs. group B: 3 (4%); p = ns). In 2 patients of group A and 3 patients of group B the PVs were durably isolated. Two patients of each group had continued paroxysmal AF but did not undergo redo-procedure. Significantly more patients of group A experienced AF recurrence during blanking period, whereas the outcome after 6 month showed no significant differences (group A 11 (14,66%), group B: 6 (8%); p< 0.05). With regard to the procedural data, the procedure time was significantly shorter in group A (115.35 ± 15.38 versus 70.53 ± 16.13; p Conclusions Cryo-Balloon PVI and PVI using ablation index following the CLOSE protocol are equally efficient in achieving durable PV-isolation. Approximately 7 % of the patients with clinically paroxysmal AF are having extra-pulmonary vein AF sources. Cryo-Balloon ablation leads to significantly more AF recurrence during the blanking period. Procedural data Cryo-Balloon(group A) Ablation Index(group B) p-value Proc. Time (min) 70.53 ± 16.13 115.35 ± 15.38
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- 2021
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11. Tunable electrochromic filter for in situ Fourier spatial frequency filtering
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Bastian Kaiser, Egbert Oesterschulze, Carsten Kortz, and Alexander Hein
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Materials science ,Spatial filter ,business.industry ,Fourier optics ,Nanopartikel ,Filter (signal processing) ,Electrochromic devices ,Fourier filtering ,Fourieroptik ,Atomic and Molecular Physics, and Optics ,electrochromic device ,symbols.namesake ,Optics ,Fourier transform ,Band-pass filter ,Electrochromism ,spatial optical filtering ,symbols ,ddc:530 ,Spatial frequency ,pacs:70.00.00 ,business ,Elektrochromes Material - Abstract
Spatial optical Fourier filtering is a widespread technique for in situ image or light field processing. However, conventional fixed absorbing patterns or mechanical irises only allow an inflexible, very restricted control. Thus, we present two electrochromic spatial filters with ring-shaped or directional segments, which can be individually addressed and continuously tuned in transmission resulting in up to 512 different filtering states. For realization of the electrochromic devices, we overcome technical obstacles to realize seamless, gap-free electrochromic segments. We describe this novel fabrication process and demonstrate the successful application in an optical Fourier transform set-up.
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- 2021
12. Current influences in the development of future-oriented forestry programs
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Bastian Kaiser
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010302 applied physics ,media_common.quotation_subject ,020206 networking & telecommunications ,Forestry ,02 engineering and technology ,Competitor analysis ,Melting pot ,01 natural sciences ,Fiscal policy ,forestry education ,interdisciplinarity and intradisciplinarity ,history of forestry ,social responsibility and challenge ,institutional profile building ,individual profiling ,Excellence ,Strategic partnership ,Political science ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,lcsh:SD1-669.5 ,General Earth and Planetary Sciences ,Conviction ,lcsh:Forestry ,Competence (human resources) ,General Environmental Science ,media_common - Abstract
The survival of Rottenburg University of Applied Sciences (HFR) was repeatedly questioned politically in the mid-1990 s. This had nothing to do with the fact that well-trained forestry academics were no longer needed, but had been triggered by fiscal policy savings. The applied Universities with forestry programs (five) and forestry faculties (four) in Germany are rather small and had no strong lobby like the forestry itself. Unlike some competitors, in this precarious situation, the universities did not opt for a change in their clear forestry profile, but for a broader, future-oriented understanding of modern forestry. For this purpose, they are orientated on the experience from their own past and the discipline, analyse the developments in the industries and sectors that are close to forestry and specifically sought strategic partnerships in order to be able to expand their own field of competence. Thus, the conviction for their own development process originated, that the forestry science has come in its history from the practice, passing a period influenced by knowledge of the general sciences. After that, the universities joined a phase of the development of forestry disciplines, and now they must turn back to the practice again. In this sense, a circle seems to close here and the universities have an additional, important task to deal with: more than before, in addition to teaching and research, the transfer of research results must also be put into practice. At the same time, the process of teaching has to be designed in such a way that it also provides continuous offers for job oriented training. Therefore, the universities must be the melting pot for all relevant influences from other sciences, which are and will be important for the forestry practice. This does not create a new profile, but a broader one. As a result, we are no longer training largely equal graduates, but forestry graduates with very individual strengths, attains, and profiles who fit like different keys into the various locks of practical challenges. This path helped the HFR to safeguard its future, to meet high demand among young students and to be recognized as the "smallest university of excellence" in Germany.
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- 2019
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13. Bin im Wald! : Mit einem Forstexperten durchs grüne Dickicht
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Bastian Kaiser and Bastian Kaiser
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Die Deutschen und ihr Wald! Alle fühlen sich berufen mitzureden und wenige Bestseller-Autoren steuern die allgemeine Gefühlslage zum Wald. Bleiben Fakten dabei vielleicht manchmal auf der Strecke? Forst-Experte Bastian Kaiser räumt mit Legenden und Missverständnissen auf und liefert Fakten rund um die Relevanz der Wälder im Hinblick auf aktuelle Klima- und Nachhaltigkeitsdebatten. Er erzählt in diesem ungewöhnlichen Sachbuch die (Kultur-)Geschichte unserer Wälder von der Holzwirtschaft bis zu den Bereichen „Bäume im Brauchtum'und der „Wald im Märchen'. Dabei lässt er uns an seiner ganz persönlichen und beruflichen Lebensgeschichte teilhaben, die vom Wald durchdrungen ist. Ein Wald-Lesebuch für alle, die sich gerne eine eigene Meinung bilden möchten.
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- 2022
14. Possible influence of free fatty acid receptors on pH regulation in the ruminal epithelium of sheep
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Franziska Masur, Franziska Dengler, Helga Pfannkuche, Gotthold Gäbel, Reiko Rackwitz, Lisa Baaske, and Bastian Kaiser
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Male ,Monocarboxylic Acid Transporters ,medicine.medical_specialty ,Rumen ,Intracellular pH ,Butyrate ,Niacin ,Epithelium ,Receptors, G-Protein-Coupled ,chemistry.chemical_compound ,Serous Membrane ,Food Animals ,Internal medicine ,medicine ,Cyclic AMP ,Animals ,Cyclic adenosine monophosphate ,Receptor ,chemistry.chemical_classification ,Sheep ,biology ,Chemistry ,Colforsin ,Fatty acid ,Hydrogen-Ion Concentration ,Fatty Acids, Volatile ,Butyrates ,Protein Transport ,Endocrinology ,Monocarboxylate transporter 1 ,Gastric Mucosa ,biology.protein ,Animal Science and Zoology ,Female ,Energy source ,Homeostasis - Abstract
High amounts of short-chain fatty acids (SCFAs) occur in the ovine rumen and constitute the animal's main energy source. However, they lead to an acidification of the ruminal epithelium. Therefore, effective intracellular pH (pHi ) regulation by transport proteins like monocarboxylate transporter 1 (MCT1) and Na+ /H+ exchangers (NHEs) is pivotal to ruminants to avoid epithelial damage. SCFAs might function not only as nutrients but also as signalling molecules by activating free fatty acid receptors (FFARs) in the ruminal epithelium and thus influence pHi regulation. FFARs work as nutrient sensors, transducing their information by modulating cyclic adenosine monophosphate (cAMP) levels. We hypothesized that (FFAR-modulated) decreases in cAMP levels stimulate the activity of MCT1 and NHEs in the ruminal epithelium of sheep. We detected two FFARs (GPR109A and FFAR2) immunohistochemically in the ovine ruminal epithelium. Administration of 10 mM butyrate to Ussing chamber-mounted epithelia provoked a significant reduction in intraepithelial cAMP levels. However, application of the GPR109A agonist niacin did not affect cAMP levels. MCT1 activity was analysed by measuring transepithelial 14 C-acetate fluxes, which were not inhibited by forskolin-induced increased cAMP levels. The recovery of pHi after acidification was assessed as an indicator of NHE activity in primary cultured ruminal epithelial cells. Recovery was significantly reduced when cells with increased cAMP levels were subjected to the NHE inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (10 µM). Nonetheless, with augmented cAMP levels alone, NHE activity tended to decline. We hypothesize that modulation of cAMP levels by butyrate is accomplished by FFAR2 activation, regulating NHE activity for pHi homoeostasis at least in part.
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- 2019
15. Unternehmerisches Handeln in der Wald- und Holzwirtschaft. : Betriebswirtschaftliche Grundlagen und Managementprozesse.
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Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, Alfred Kammerhofer, Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, and Alfred Kammerhofer
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Die Anforderungen an das ökonomische Wissen von Führungskräften in der Wald- und Holzwirtschaft sind enorm gestiegen. Daher erhält die 2. Auflage des vorliegenden Buches gerade jetzt ihre besondere Bedeutung. Die Unternehmen der Wald- und Holzwirtschaft agieren heute in einem dynamischen und in vielen Aspekten nur schwer einschätzbaren gesamtwirtschaftlichen Umfeld. Eine sich ständig verändernde Nachfrage nach Gütern und Dienstleistungen, technologische Innovationen und der Wertewandel in unseren modernen Gesellschaften sind wichtige Einflussfaktoren. Sie wirken sich auf die Geschäftstätigkeit von Unternehmen aus und bringen Chancen und Risiken für deren Zukunft mit sich. Gleiches gilt für eine hohe Aufmerksamkeit der Öffentlichkeit gegenüber dem Umgang mit unseren natürlichen Lebensgrundlagen, für Maßnahmen der Steuer-, Abgaben- und Subventionspolitik, für die wachsende Bedeutung politischer Institutionen z.B. in der Europäischen Union sowie für die Auswirkungen kurz- und langfristig zu erwartender Veränderungen des Klimas und der Weltwirtschaft. Im vorliegenden Lehr- und Fachbuch für Hochschulen und Praxis werden die Grundlagen und methodischen Hilfsmittel unternehmerischen Handelns in ihrer Vielfalt anwendungsorientiert dargestellt. Ausgangspunkt ist ein prozess- und akteurbezogener Ansatz, der die gesamte Kette und Netzwerke der Wertschöpfung in der Wald- und Holzwirtschaft umfasst. Die einzelnen Kapitel stehen in einem klaren Bezug zueinander und werden durch detaillierte Teilgliederungen erschlossen. Aufbau und Struktur des Textes sowie ein umfangreiches Schlagwortregister ermöglichen eine gezielte, selektive Lektüre zu spezifischen Themen. Zu den in der 2. Auflage neu behandelten Themen gehören die stoffliche und energetische Wertschöpfungskette Holz und ihre Bedeutung für eine moderne Logistik, die Mitbestimmung in Unternehmen und Betrieben, die Organisationsgestaltung aus Sicht der Institutionenökonomie sowie die Erstellung von Businessplänen. Das Lehr- und Fachbuch bereitet das betriebswirtschaftliche Wissen für alle auf, die in der Wald- und Holzwirtschaft kaufmännisch tätig sind, und stellt den Stand der weltweiten und europäischen Holznutzung und Anforderungen, die an die nachhaltige Bewirtschaftung von Wäldern zu stellen sind, dar. Es zeigt anhand von Beispielen die Bedeutung der modernen Managementlehre für die Unternehmens- und Betriebsführung und ist ein unentbehrliches Nachschlagewerk für die Branche. Für kommunale und staatliche Entscheidungsträger oder auch für Führungskräfte in NGO's, die sich mit konkreten wald- und holzwirtschaftlichen Problemen befassen, und für Leser, die ganz allgemein am Wald und der Holzverwendung interessiert sind, bietet das Buch einen Überblick zu grundlegenden Fragen der Walderhaltung und Holznutzung. Inzwischen wurde es in mehrere Sprachen übersetzt.
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- 2019
16. The Assembly Specific Force Atlas
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Jurij Wakula, Karlheinz Schaub, Rolf-Peter Ellegast, Bastian Kaiser, Knut Berg, Ralph Bruder, and Ulrich Glitsch
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Truck ,Engineering ,Specific force ,business.industry ,Kneeling ,Automotive industry ,Mechanical engineering ,Human Factors and Ergonomics ,Sample (statistics) ,Workload ,Industrial engineering ,Industrial and Manufacturing Engineering ,Task (project management) ,Static forces and virtual-particle exchange ,business - Abstract
Even in hi-tech industries, physical workload is partly considerable and cannot be avoided because of product and process requirements. Especially in automotive, aviation, and marine industries, the assembly of the product geometry requires force exertions in ergonomically unfavorable conditions. Unfortunately, internationally accepted methods for the evaluation of those types of force exertions are rare. Besides some traditional German methods and EN 1005-3 hardly any evaluation methods exist. Even those methods refer to force exertions in primarily upright symmetric working postures. To overcome these problems the Assembly Specific Fore Atlas was created during the recent years. From a sample of automotive workers n = 273, a set of 54 whole-body forces 6 main force directions while standing, sitting, kneeling; in an upward, bent, and overhead posture and a set of 38 types of finger-hand forces all at maximum voluntary contractions [MVC] levels were measured in the field. The inputs for the types of force exertions required in practice were sampled from a consortium of major European car and truck companies. In addition, evaluation methods were developed that allow "calculating" maximum recommended force limits from the measured maximum static forces i.e., MVC and task and user group relevant parameters. This contribution gives a short overview on the data collected and focuses on the evaluation methods that had been realized. First, qualitative results are presented from the first field tests.
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- 2014
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17. Unternehmerisches Handeln in der Wald- und Holzwirtschaft - Kapitel 1 : Wald- und Holzwirtschaft
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Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, Alfred W. Kammerhofer, Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, and Alfred W. Kammerhofer
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Die Anforderungen an das ökonomische und betriebswirtschaftliche Wissen der Führungskräfte in der Wald- und Holzwirtschaft sind enorm gestiegen. Das vorliegende Lehr- und Fachbuch greift diese Herausforderungen auf. Es wendet sich an Studierende und Dozenten forst- und holzwirtschaftlicher Studiengänge, an Unternehmer und Führungskräfte in der Praxis sowie an Lehrkräfte in der betrieblichen Aus- und Weiterbildung. Besonders angesprochen werden kommunale und staatliche Entscheidungsträger wie auch Umweltorganisationen. Leser, die ganz allgemein am Wald interessiert sind, finden hier einen umfassenden Überblick über den Stand der weltweiten und europäischen Holzverwendung und über die Chancen der nachhaltigen Waldwirtschaft und Ressourcennutzung. Zu den in der 2. Auflage neu behandelten Themen gehören die stoffliche und energetische Wertschöpfungskette Holz und ihre Bedeutung für eine moderne Logistik, die Mitbestimmung in Unternehmen und Betrieben sowie die Erstellung von Businessplänen.
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- 2015
18. Analysis and Evaluation of Physical Workload During Long-Cyclic Tasks as a Prerequisite for Ergonomic Work Design
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Peter Kuhlang, Bastian Kaiser, Andrea Sinn-Behrendt, Lukas Bier, Katharina Rönick, Steffen Rast, Dorothee Müglich, Karlheinz Schaub, and Ralph Bruder
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Engineering ,Data collection ,business.product_category ,business.industry ,Human factors and ergonomics ,Job design ,Workload ,Reliability engineering ,Transport engineering ,Work (electrical) ,Manufacturing ,Screening tool ,business ,Worksheet - Abstract
Evaluation of physical workload such as the screening tool Ergonomic Assessment Worksheet (EAWS) were developed and validated for use in industrial manufacturing with short cycles (up to 3 min). If this tool is used for work stations that have significantly longer cycles or no cycle at all, its use is limited. On the one hand, measuring the workload intensity becomes increasingly expensive. On the other hand, the workload intensity for these scenarios has to be examined as well. The following contribution presents an instance of how the EAWS can be used for long-cycle tasks on the example of a maintenance workplace at Deutsche Bahn. This work is focused on methods for adapted data collection from which indicators for possible adjustments to the evaluation procedure can be concluded.
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- 2016
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19. Establishment and Characterization of an SV40 Large T Antigen-Transduced Porcine Colonic Epithelial Cell Line
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Bastian Kaiser, Gotthold Gäbel, Ronald M. Brunner, Thilo Wedel, Helga Pfannkuche, Martina Böttner, Alexander Gleich, Szilvia Lesko, and Tom Goldammer
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0301 basic medicine ,Male ,Histology ,SV40 large T antigen ,Cell Survival ,Colon ,Swine ,medicine.medical_treatment ,Genetic Vectors ,Karyotype ,Cell Culture Techniques ,Cell Separation ,Biology ,Occludin ,Keratin 18 ,Viral vector ,Proinflammatory cytokine ,Cell Line ,03 medical and health sciences ,Transduction, Genetic ,medicine ,Animals ,Antigens, Viral, Tumor ,Cells, Cultured ,Cryopreservation ,Epithelial Cells ,Epithelium ,Cell biology ,030104 developmental biology ,Cytokine ,medicine.anatomical_structure ,Cell culture ,Anatomy - Abstract
Continuous cell lines have become indispensable tools that have enabled investigations into cellular mechanisms by increasing experimental reproducibility and sample availability, and decreasing the use of experimental animals. To facilitate studies of epithelial barrier function of the porcine colon, we aimed to establish an epithelial cell line with an extended replicative capacity. Cells were isolated from the proximal colon of a 3-week-old piglet and transduced using a recombinant retroviral vector construct containing the simian virus 40 large T antigen (SV40 TAg). We established a clonal epithelial cell line, referred to as PoCo83-3, that stably expressed the SV40 TAg, verified at mRNA and protein levels. PoCo83-3 showed epithelial cell-specific features, such as cobblestone-like morphology, dome structure formation, the presence of apical microvilli, and the expression of keratin 18, E-cadherin and the tight junction-associated proteins zonula occludens-1, occludin, and claudin-1. To validate PoCo83-3 as an in vitro model in epithelial barrier research, proinflammatory cytokine-inducible alterations in barrier integrity were demonstrated by incubating the cells with TNF-α and IFN-γ for 48 h. These cytokine treatments promoted a decreased transepithelial electrical resistance. In summary, PoCo83-3 exhibited an extended life span and a differentiated phenotype while maintaining epithelial characteristics. Based on these results, we present this cell line as a valuable in vitro model for investigations of epithelial barrier function in the porcine colon.
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- 2016
20. Entrepreneurship and Management in Forestry and Wood Processing : Principles of Business Economics and Management Processes
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Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, Karoline Perchthaler, Alfred Kammerhofer, Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, Karoline Perchthaler, and Alfred Kammerhofer
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- Forest products industry, Forest management
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Forestry has long been in a rather favourable position in offering a valuable raw material source in high demand. However, with rapidly changing end-user demands and cost competitiveness within the forest and wood chain as a whole, the industry is needing to adapt. Explaining entrepreneurial action as part of a chain of comprehensive value-added processes leads to a new perception of forest production and wood processing.This book applies the main concepts of modern managerial science to the world of forestry and is the perfect book for students studying forestry and wood processing, as well as entrepreneurs and managers within the sector.Topics are covered from an entrepreneurial perspective and include perspectives from accounting, finance, economics, supply chain management, marketing and strategy.
- Published
- 2014
21. Establishment and characterisation of a novel bovine SV40 large T-antigen-transduced foetal hepatocyte-derived cell line
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Bastian Kaiser, Julia Schumann, Alexander Gleich, and Herbert Fuhrmann
- Subjects
0301 basic medicine ,Antigens, Polyomavirus Transforming ,Fluorescent Antibody Technique ,Biology ,Fetal Research ,Polymerase Chain Reaction ,Cell Line ,03 medical and health sciences ,chemistry.chemical_compound ,Fetus ,Transduction, Genetic ,Gene expression ,Claudin-1 ,medicine ,Oil Red O ,Animals ,Urea ,Microscopy, Phase-Contrast ,ATP Binding Cassette Transporter, Subfamily B, Member 1 ,Triglycerides ,Glucose Transporter Type 2 ,Glycogen ,Gene Expression Profiling ,Cell Biology ,General Medicine ,Molecular biology ,In vitro ,Phosphoenolpyruvate Carboxylase ,Reverse transcription polymerase chain reaction ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Cell culture ,Hepatocyte ,Hepatocytes ,Zonula Occludens-1 Protein ,Keratins ,Cattle ,Phosphoenolpyruvate carboxykinase ,Developmental Biology - Abstract
Due to lack of in vitro models for bovine hepatocytes apart from primary cells, there is demand for a bovine hepatocyte-derived cell line. Transduction of bovine foetal hepatocytes with SV40 large T-antigen was performed using the vector pRetro-E2 SV40. Phase contrast microscopy was carried out to evaluate morphology. Immunofluorescence staining was conducted to study expression of keratins, tight junction proteins zona occludens-1 and claudin-1, glucose transporter-2 and P-glycoprotein as well as phosphoenolpyruvate carboxykinase. Urea and triglyceride production was quantified photometrically. Histochemical staining of glycogen by Periodic acid-Schiff stain and of lipids with Oil red O was performed after 24 h incubation with 20 mM glucose and 85 μM palmitic acid, respectively. Gene expression analysis of hepatocyte-typical genes was conducted by reverse transcription PCR. We obtained a SV40LTAg-transduced extended passage cell line, referred to as BFH12. Polygonal growth, keratins, tight junction proteins zona occludens-1 and claudin-1 and glucose transporter-2 as well as P-glycoprotein and phosphoenolpyruvate carboxykinase were attested positively. Urea production calculated as cell-specific rate was 14.2 ± 2.0 fmol/h (early passage) and 17.6 ± 3.7 fmol/h (late passage). Cell-specific triglyceride production was 1.6 ± 0.5 fmol/h (early passage) and 2.1 ± 0.3 fmol/h (late passage). Additionally, cells were positive for glycogen and lipid storage and showed a gene expression pattern resembling foetal hepatocytes. With the properties described here, the novel cell line BFH12 is a hepatocyte-derived cell line which can be used as an in vitro whole cell model.
- Published
- 2015
22. Entrepreneurship and Management in Forestry and Wood Processing
- Author
-
Franz Schmithüsen, Bastian Kaiser, Albin Schmidhauser, Stephan Mellinghoff, Karoline Perchthaler, and Alfred Kammerhofer
- Published
- 2015
- Full Text
- View/download PDF
23. Vom Push zum Pull – Der Perspektivewechsel in der Wertschöpfungskette von Forst- und Holzwirtschaft | From push to pull: a shift in the perspective of the value chain of forestry and wood management
- Author
-
Bastian Kaiser
- Subjects
Market forces ,Value (economics) ,Perspective (graphical) ,Forest management ,Price elasticity of supply ,Forestry ,Business ,Value chain ,Chain (unit) ,Public awareness - Abstract
Forestry management – contrary to general public awareness of the matter – is a branch in the process of undergoing dynamic changes. Impulses for these changes come in part from actors and others involved in the «timber value chain» and in part from outside influences. Today, in addition to numerous other effects, these dynamics have led to a situation where«timber chain» supply flows are no longer initiated and mobilised exclusively by what the forest owner fells and offers to customers, but above all by more specialised wood customers with an increasing appetite for wood who articulate their increasing impatience by the means of market forces. Over the years the traditional push effect has thus given way to a pull effect. Forest owners are obliged to react to this development and to seek, together with others-for instance with universities and their faculties-out suitable future strategies. In turn and without a doubt this will impact on the education and training of forest academics, as well as on the self-understanding of forestry employers.
- Published
- 2005
- Full Text
- View/download PDF
24. Unternehmerisches Handeln in der Wald- und Holzwirtschaft
- Author
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Stephan Mellinghoff, Alfred W. Kammerhofer, Franz Schmithüsen, Albin Schmidhauser, and Bastian Kaiser
- Subjects
Political science - Published
- 2009
- Full Text
- View/download PDF
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