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21. Regosarc: regorafenib versus placebo in doxorubicin-refractory soft-tissue sarcoma-a quality-adjusted time without symptoms of progression or toxicity analysis

Author

Berry, V. (Vincent), Basson, L. (Laurent), Bogart, E. (Emilie), Mir, O. (Olivier), Blay, J-Y. (Jean-Yves), Italiano, A. (Antoine), Bertucci, F. (François), Chevreau, C. (Christine), Clisant-Delaine, S. (Stephanie), Liegl-Atzwanger, B. (Bernadette), Tresch-Bruneel, E. (Emmanuelle), Wallet, J. (Jennifer), Taieb, S. (Sophie), Decoupigny, E. (Emilie), Le Cesne, A. (Axel), Brodowicz, T. (Thomas), Penel, N. (Nicolas), Site de Recherche Intégrée en Cancérologie (SIRIC-ONCOLille), Université de Lille, Sciences et Technologies-Université de Lille, Sciences Humaines et Sociales-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER-Cancéropole Nord-Ouest-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Institut Gustave Roussy (IGR), Centre Léon Bérard [Lyon], Institut Bergonié [Bordeaux], UNICANCER, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut Claudius Regaud, Karl-Franzens-Universität Graz, University of Vienna [Vienna], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Cancéropole Nord-Ouest-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Lille Nord de France (COMUE)-UNICANCER, Karl-Franzens-Universität [Graz, Autriche], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, CHU Lille, Université de Lille, Site de Recherche Intégrée en Cancérologie [SIRIC-ONCOLille], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Institut Gustave Roussy [IGR], and Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Subjects
[SDV]Life Sciences [q-bio], Mesh:Diarrhea/chemically induced, Mesh:Alopecia/chemically induced, Mesh:Phenylurea Compounds/therapeutic use, Mesh:Aged, Mesh:Synovial/drug therapy, Mesh:Treatment Outcome, Mesh:Anorexia/chemically induced, Mesh:Quality of Life, Mesh:Proportional Hazards Models, Mesh:Severity of Illness Index, Mesh:Female, quality-adjusted survival, Mesh:Fecal Incontinence/chemically induced, Mesh:Male, Mesh:Sarcoma, Mesh:Middle Aged, quality-adjusted time without symptoms of progression or toxicity (Q-TWiST), Mesh:Asthenia/chemically induced, Mesh:Liposarcoma/drug therapy, metastatic soft-tissue sarcoma, placebo, regorafenib, Mesh:Mucositis/chemically induced, Mesh:Hospitalization, Mesh:Sarcoma/drug therapy, Mesh:Hand-Foot Syndrome/etiology, Mesh:Pyridines/therapeutic use, Mesh:Antineoplastic Agents/therapeutic use, Mesh:Leiomyosarcoma/drug therapy, Mesh:Humans, Mesh:Hypertension/chemically induced, Mesh:Double-Blind Method
Abstract

International audience; BACKGROUND: In a placebo-controlled, randomized phase 2 trial (ClinicalTrials.gov identifier NCT01900743), regorafenib improved progression-free survival (PFS) for patients with doxorubicin-pretreated advanced nonadipocytic sarcoma. A quality-adjusted time without symptoms of progression or toxicity (Q-TWiST) post hoc exploratory analysis was applied to provide an integrated measure of its clinical benefit.METHODS: In the base-case analysis, each patient's overall survival (OS) was partitioned into 3 mutually exclusive health states: the time with a grade 3 or 4 adverse event (TOX), the time without symptoms of disease or grade 3 or 4 toxicity from treatment, and the time after tumor progression or relapse. The time spent in each state was weighted with a health-state utility associated with that state and was summed to calculate the Q-TWiST. The stability of the base-case analysis was explored with several sensitivity analyses.RESULTS: In nonadipocytic sarcoma, the PFS was (4.0 months [2.6-5.5 months] with regorafenib vs 1.0 month [0.9-1.8 months] with a placebo; hazard ratio, 0.36 [0.25-0.53]; P < .0001); the OS was 13.4 months (8.6-17.3 months) with regorafenib and 9.0 months (6.8-12.5 months) with a placebo (hazard ratio, 0.67 [0.44-1.02]). With the classic definition of TOX (including all grade 3 and 4 clinical adverse events), the Q-TWiSTs were 8.0 months (7.0-9.0 months) with regorafenib and 5.7 months (4.9-6.4 months) with a placebo (P

Published
2017
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25. Taxonomic status of trichodina heterodentata Duncan, 1977 (Ciliophora: Peritrichia) using standard morphology, as well as molecular techniques

Author

De Jager, Gerhard P., Basson, L., Van As, J. G., De Jager, Gerhard P., Basson, L., and Van As, J. G.

Abstract

English: The family Trichodinidae Raabe, 1959 (Ciliophora, Peritrichia) consists of 11 genera, of which the cosmopolitan genus Trichodina Ehrenberg, 1838 has the largest number of species. A substantial majority of trichodinid species are associated with marine and freshwater fish hosts, while some are also found associated with amphibians, as well as a variety of invertebrate hosts. Some trichodinid species show high levels of host specificity, whilst others occur on a range of hosts. Trichodina heterodentata Duncan, 1977 was first described from fish breeding farms in the Philippines as ectoparasites of imported cichlids, more specifically the Mozambique tilapia from southern Africa, Oreochromis mossambicus (Peters 1885), from the Limpopo River System. Trichodina heterodentata has subsequently been described from Europe, Australia, India, China, South America and Africa, however, it has not yet been found in North America. This cosmopolitan species, with a seeming preference for cichlid hosts, has unambiguous morphological features, but with distinct variances between and within populations. Most fish species harbouring T. heterodentata display multi-trichodinid infestations, however, on its amphibian host, T. heterodentata occurs as a single infestation, which makes it perfect for using it as a model species. After reviewing previous descriptions from North American trichodinids, analysing the morphological data (both from literature along with type material obtained from the Smithsonian Museum) and investigating the distribution patterns of the southern African introduced O. mossambicus throughout North American water systems, it seems likely that Trichodina hypsilepis Wellborn, 1967, is a synonym of T. heterodentata. This not only delegates several North American trichodinid species into synonymy, but also probably indicate an insidious African alien introduction sneaking it way into this continent. Morphological analysis of T. heterodentata, shows that this sp, Afrikaans: Die familie Trichodinidae Raabe, 1959 (Ciliophora, Peritrichia) bestaan uit 11 genera, waarvan die mees kosmopolitiese genus, Trichodina Ehrenberg, 1838 die meeste spesies huisves. Die oorgrote meerderheid trigodina-spesies word met mariene en varswater visgashere geassosieër, terwyl ander op amfibiërs en ‘n verskeidenheid ander invertebrate gevind word. Sommige trigodinas is baie gasheerspesifiek en sommige word by talle verskillende tipe gashere aangetref. Trichodina heterodentata Duncan, 1977 was die eerste keer vanaf visteëlplase in die Filippyne op ingevoerde vis beskryf, meer spesifiek vanaf die ingevoerde bloukurpers,Oreochromis mossambicus (Peters 1885) uit die suider-Afrikaanse Limpopo Rivierstelsel. Trichodina heterodentata is sedertdien vanuit Europa, Australië, Indië, Sjina, Suid-Amerika en Afrika beskryf, maar nog nooit in Noord-Amerika nie. Hierdie kosmopolitiese spesie, met ‘n blykbare voorkeur vir Cichlidae gashere, het unieke morfologiese eienskappe, maar daar heers ook baie duidelike variasies tussen en binne verskillende bevolkings. Trichodina heterodentata word op meeste visspesies aangetref as deel van ‘n multi-spesie infestasie, alhoewel, op ‘n amfibiese gasheer blyk dit om ‘n enkel spesie infestasie te wees, wat hierdie gasheer ‘n ideale modelgasheer vir die studie van T. heterodentata maak. Na ‘n ondersoek van Noord-Amerikaanse trigodinas (vanaf literatuur en tiepmateriaal verkry vanaf die Smithsonianmuseum) en die verspreidingspatrone van O. mossambicus, blyk dit moontlik dat T. hypsilepis Wellborn, 1967 ‘n sinoniem van T. heterodentata kan wees. Laasgenoemde bevindings sink nie net sommige Noord-Amerikaanse trigodina spesies nie, maar verklaar ook hoe ‘n indringerspesie vannaf Afrika die pad na die Noord-Amerikaanse kontinent kon meemaak. As gevolg van die groot variasie wat T. heterodentata se tandringstrukture vertoon, word die vraag, of hierdie ‘n spesieskompleks of inderdaad ‘n enkel spesie is, gevra. Tot op hede het meeste v

Published
2017

27. Defining Relevance and Finding Rules: An Agent-Based Model of Biomass Use in the Humber Area

Author

Schiller, F, Skeldon, A, Balke, T, Grant, M, Penn, AS, Basson, L, Jensen, P, Gilbert, N, Kalkan, OD, Woodward, A, Kaminski, B, and Koloch, G

Subjects
Consumption (economics), Agent-based model, Engineering, Toy model, business.industry, Process (engineering), Field (Bourdieu), Industrial production, Environmental resource management, Operations management, Relevance (information retrieval), Industrial ecology, business
Abstract

The field of industrial ecology applies ecosystem theory to industrial production, human consumption and societies. This article presents a case study of the development of the bio-based economy in the area surrounding the Humber estuary in the North-East of England. The study developed an agent-based model to simulate the evolution of the industrial system. We explain how the qualitative research process led to the development of a toy model that has successively been specified.

Published
2014
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28. Electricity supply industry modeling for multiple objectives under demand growth uncertainty

Author

Heinrich, G, Howells, M I, Basson, L, Petrie, J G, Energy Research Centre, and Faculty of Engineering and the Built Environment

Subjects
Sustainability, Uncertainty, Multi-objective optimisation, Electricity supply industry modelling
Abstract

Appropriate energy–environment–economic (E3) modelling provides key information for policy makers in the electricity supply industry (ESI) faced with navigating a sustainable development path. Key challenges include engaging with stakeholder values and preferences, and exploring trade-offs between competing objectives in the face of underlying uncertainty. As a case study we represent the South African ESI using a partial equilibrium E3 modelling approach, and extend the approach to include multiple objectives under selected future uncertainties. This extension is achieved by assigning cost penalties to non-cost attributes to force the model's least-cost objective function to better satisfy non-cost criteria. This paper incorporates aspects of flexibility to demand growth uncertainty into each future expansion alternative by introducing stochastic programming with recourse into the model. Technology lead times are taken into account by the inclusion of a decision node along the time horizon where aspects of real options theory are considered within the planning process. Hedging in the recourse programming is automatically translated from being purely financial, to include the other attributes that the cost penalties represent. From a retrospective analysis of the cost penalties, the correct market signals, can be derived to meet policy goal, with due regard to demand uncertainty.

Published
2007

29. Ranking power expansion alternatives for multiple objectives under certainty

Author

Heinrich, G, Basson, L, Cohen, B, Petrie, J, Howells, M, Energy Research Centre, and Faculty of Engineering and the Built Environment

Abstract

Strategic planning in the electricity supply industry is a complex task due to the multiple and often conflicting objectives of the decision makers, as well as the inherent technical and valuation uncertainties involved. As such, a transparent decision support framework is needed, for guiding information management throughout the decision process, in a way which shapes decision outcomes, and enables confident choices to be made. This paper outlines a methodology for the ranking of power expansion alternatives given multiple objectives and uncertainty, and demonstrates this using the South African electricity supply industry. This methodology uses a value function MCDA approach that is augmented with scenario analysis to yield information relating to both the relative performance and credibility of power expansion alternatives. A portfolio of preferred alternatives is then identified based on performance and confidence criteria. Finally a more detailed analysis of the reduced solution set examines short-term technology investment details alongside attribute performance information, so as to gain insight into the decision problem and relate it back to real life actions.

Published
2007

30. Morphological evaluation of Trichodina heterodentata Duncan, 1977 (Ciliophora: Peritricha) from tadpoles and fish

Author

Groenewald, Hanlie, Basson, L., Van As, J. G., Groenewald, Hanlie, Basson, L., and Van As, J. G.

Abstract

English: Mobiline ciliophorans belonging to the family Trichodinidae Claus, 1874 are amongst the most common and widely distributed symbionts of fishes. Most of the 260 trichodinid species described from fishes are exclusively associated with fish hosts. A few are also associated with salamanders, crustaceans or coelenterates such as in the case of Trichodina pediculus Ehrenberg, 1831 that are hosted by fish or hydras. Juvenile and adult anurans also play host to some trichodinid species. Endotrichodinids such as T. xenopodos Fantham, 1924 infect the bladder of adult frogs during amplexus and feed on the debris within the bladder of the host. Ectotrichodinids are hosted on the skin and / or gills of various tadpole species worldwide. Tadpole trichodinids are typically not host specific and occur on fishes in the same water medium and are thus using tadpoles as facultative hosts. Only a few studies concentrated on the collection and / or identification of tadpole trichodinids in southern Africa.The objective of the present study was to determine if trichodinids hosted by tadpoles in southern Africa are fish trichodinids that are temporarily hosted by tadpoles or a different species that are not commonly found on fishes. Cross-transmission experiments indicated that trichodinids from naturally infested tadpoles could form a viable population on naturally uninfested fishes. This indicated that the tadpole trichodinids could be found on fishes in natural conditions. Trichodinids that were collected from various fish and tadpole species in South Africa and Botswana over the past 30 years, were examined. Morphological analysis of the examined trichodinids was undertaken by means of three known methods. These methods aided in describing all examined trichodinids as belonging to T. heterodentata Duncan, 1977. Trichodina heterodentata is globally distributed and has an apparent affinity for cichlids as fish hosts, but seems to be equally widely distributed on a variety of ta, Afrikaans: Mobiliene siliofore vorm deel van die familie Trichodinidae Claus, 1874 en is van die mees algemene en wyd verspreide vissimbionte. Die meeste van die 260 trigodinas wat vanaf visse beskryf is, word uitsluitlik met visse geassosieer. Sommiges word ook geassosieer met salamanders, skaaldiere of holtediere soos in die geval van Trichodina pediculus Ehrenberg, 1831 wat op visse sowel as hidras voorkom. Jong en volwasse verteenwoordigers van Anura word ook deur verskeie trigodinas as gashere gebruik. Endotrigodinas soos T. xenopodos Fantham, 1924 besmet die blaas van volwasse paddas tydens ampleksus en voed op die dooie selle binne die gasheer se blaas. Ektotrigodinas word wêreldwyd op die vel en / of kieue van verskeie paddavisse aangetref. Paddavistrigodinas is gewoonlik nie gasheerspesifiek nie en word ook op visse aangetref wat in die selfde waterbronne as die besmette paddavisse voorkom. Paddavisse word dus as fakultatiewe gashere vir trigodinas beskou. Slegs ‘n paar studies het voorheen op die versameling en / of bestudering van paddavistrigodinas in suider Afrika gekonsentreer. Die doelwit van die huidige studie was om vas te stel of paddavistrigodinas in suider Afrika vistrigodinas is wat slegs tydelik deur paddavisse gehuisves word, of ‘n ander spesie is wat nie op visse voorkom nie. Kruis-besmettingseksperimente het aangedui dat trigodinas wat natuurlik op paddavisse voorkom, ‘n lewensvatbare bevolking op visse kon vorm wat nie natuurlik besmet was nie. Hierdie bevinding dui aan dat die paddavistrigodinas moontlik onder natuurlike toestande op die visse kan voorkom. Trigodinas wat vanaf verskeie vis en paddavis spesies in Suid-Afrika en Botswana oor die laaste 30 jaar versamel is, is bestudeer. Morfologiese ondersoeke van hierdie trigodinas is uitgevoer deur van drie bekende metodes, soos voorgestel deur Lom (1958), Gong et al. (2005) en Van As en Basson (1992), gebruik te maak. Deur hierdie metodes te gebruik, is daar vasgestel dat die paddavistrig

Published
2013

31. Participatory Development and Analysis of a Fuzzy Cognitive Map of the Establishment of a Bio-Based Economy in the Humber Region.

Author

Penn, A.S., Knight, C.J.K., Lloyd, D.J.B., Avitabile, D., Kok, K., Schiller, F., Woodward, A., Druckman, A., Basson, L., Penn, A.S., Knight, C.J.K., Lloyd, D.J.B., Avitabile, D., Kok, K., Schiller, F., Woodward, A., Druckman, A., and Basson, L.

Abstract

Fuzzy Cognitive Mapping (FCM) is a widely used participatory modelling methodology in which stakeholders collaboratively develop a ‘cognitive map’ (a weighted, directed graph), representing the perceived causal structure of their system. This can be directly transformed by a workshop facilitator into simple mathematical models to be interrogated by participants by the end of the session. Such simple models provide thinking tools which can be used for discussion and exploration of complex issues, as well as sense checking the implications of suggested causal links. They increase stakeholder motivation and understanding of whole systems approaches, but cannot be separated from an intersubjective participatory context. Standard FCM methodologies make simplifying assumptions, which may strongly influence results, presenting particular challenges and opportunities. We report on a participatory process, involving local companies and organisations, focussing on the development of a bio-based economy in the Humber region. The initial cognitive map generated consisted of factors considered key for the development of the regional bio-based economy and their directional, weighted, causal interconnections. A verification and scenario generation procedure, to check the structure of the map and suggest modifications, was carried out with a second session. Participants agreed on updates to the original map and described two alternate potential causal structures. In a novel analysis all map structures were tested using two standard methodologies usually used independently: linear and sigmoidal FCMs, demonstrating some significantly different results alongside some broad similarities. We suggest a development of FCM methodology involving a sensitivity analysis with different mappings and discuss the use of this technique in the context of our case study. Using the results and analysis of our process, we discuss the limitations and benefits of the FCM methodology in this case and in

Published
2013

32. Reinterpreting Industrial Ecology

Author

Jensen, P D, Basson, L, Leach, M, Jensen, P D, Basson, L, and Leach, M

Abstract

This article argues that industrial ecology has, to date, largely engaged with the ecological sciences at a superficial level, which has both attracted criticism of the field and limited its practical application for sustainable industrial development. On the basis of an analysis of the principle of succession, the role of waste, and the concept of diversity, the article highlights some of the key misconceptions that have resulted from the superficial engagement with the science of ecology. It is argued that industrial ecology should not be seen as a metaphor for industrial development; industrial ecology is the ecology of industry and should be studied as such. There are manifold general principles of ecology that underpin our understanding of the world; however, the physical manifestation and causal effects of these principles are particular to the system and its constituent elements under analysis. It is thus proposed that context-specific observation and analysis of industry are required before theoretical and practical advancement of the field can be achieved.

Published
2011

33. Quantifying ‘geographic proximity’: Experiences from the United Kingdom's National Industrial Symbiosis Programme

Author

Jensen, PD, Basson, L, Hellawell, E, Bailey, MR, Leach, M, Jensen, PD, Basson, L, Hellawell, E, Bailey, MR, and Leach, M

Abstract

Geographic proximity is said to be a key characteristic of the resource reuse and recycling practice known as industrial symbiosis. To date, however, proximity of symbiont companies has remained an abstract characteristic. By conducting a statistical analysis of synergies facilitated by the United Kingdom's National Industrial Symbiosis Programme during their first five years of operation, this article attempts to quantify geographic proximity and in the process provide practitioners with an insight into the movement trends of different waste streams. Among other it was found that the median distance materials travelled within a symbiotic relationship is 20.4 miles. It is argued that quantitative information of this form is of practical value for the effective deployment of industrial symbiosis practitioners and wider resource efficiency planning. The results and discussion presented within this article are specific to industrial symbiosis opportunities facilitated within the United Kingdom; the methodology and assessment of resource movement influences are, however, expected to be relevant to all countries in which industrial activity is similarly mature and diversified.

Published
2011

34. Taxonomic review of the genus Histotylenchus Siddiqi, 1971 (Nematoda: Belonolaimidae) in South Africa

Author

Landman, Henda, Jansen van Rensburg, C., Basson, L., Marais, M., Landman, Henda, Jansen van Rensburg, C., Basson, L., and Marais, M.

Abstract

English: A diverse and abundant nematode fauna is known to exist in South Africa with plant parasitic nematodes being the most representative. Seven genera belonging to the family Belonolaimidae Whitehead, 1960 are known to occur in South Africa, including Histotylenchus Siddiqi, 1971, a small genus only found in Africa and India. Nematodes belonging to the family Belonolaimidae are obligatory, primarily migratory ectoparasites of roots. These nematodes are found in cultivated soils and natural veld and are usually seen as mild plant parasites. Histotylenchus is represented by three species from South Africa, namely Histotylenchus hedys Kleynhans, 1975, Histotylenchus histoides Siddiqi, 1971 and Histotylenchus mohalei Kleynhans, 1992. Diagnostic characters of Histotylenchus include a lip region confluent with body contour or offset, asymmetrical stylet conus with an angular lumen, a large metacorpus valve, genital tracts about equal, lateral fields with four lines usually areolated, spicules tapering distally with distinct vela and gubernaculum proximally recurved with titillae. The aim of this study was to review all existing literature concerning the genus Histotylenchus in Africa, and to examine and describe the species from this genus collected in South Africa, which are deposited in the National Collection of Nematodes, Biosystematics Programme, Agricultural Research Council, Plant Protection Research Institute, Pretoria, South Africa. Results showed that a total of 44% of the fixed material examined was not suitable for this morphological study as a result of the separation of the cuticle from the body. This phenomenon is reported from this genus for the first time. Histotylenchus hedys and Histotylenchus mohalei were re-described from material of the National Collection of Nematodes, while Histotylenchus histoides was re-described from type material of the Rothamsted Nematode Collection housed at the Food and Environment Research Agency (Fera), York, United K, Afrikaans: Die Suid-Afrikaanse nematood-fauna is uiteenlopend van aard en kom algemeen voor, met plantparasitiese nematode die mees verteenwoordigende groep. Sewe genera, wat aan die familie Belonolaimidae Whitehead, 1960 behoort, kom in Suid-Afrika voor. Een van hierdie genera is die klein genus Histotylenchus Siddiqi, 1971 wat slegs in Afrika en Indië aangetref word. Aalwurms wat tot hierdie genus behoort is verpligte, hoofsaaklik migratoriese ektoparasiete van plantwortels, maar word tans nie as gevaarlike plantparasiete beskou nie. Histotylenchus kan in beide bewerkte grond en onversteurde veld voorkom. Die drie spesies van die genus Histotylenchus wat tans in Suid Afrika aangemeld word, is Histotylenchus hedys Kleynhans, 1975, Histotylenchus histoides Siddiqi, 1971 en Histotylenchus mohalei Kleynhans, 1992. Diagnostiese kenmerke van Histotylenchus sluit ondermeer lipvorm wat aaneenlopend met die ligaam of afgesnoer kan wees, ‘n asimmetriese stekelkonus met ‘n hoekige lumen, ‘n groot metakorpusklep, reproduktiewe buise van naastenby dieselfde lengte, laterale velde met vier laterale met aërolasies, spikulas distaal gebuig met velum en gubernakulum proksimaal omgebuig met titilla. Die doel van hierdie studie was om alle bestaande literatuur met betrekking tot die genus te analiseer en om die materiaal van die genus in die Nasionale Versameling van Nematodes, Biosystematiek Program, Navorsingsinstituut vir Plantbeskerming, Landbounavorsingsraad, Pretoria, Suid-Afrika, te ondersoek. Vier-en-veertig persent van hierdie materiaal was ongeskik vir taksonomiese studies, as gevolg van die skeiding van die kutikula vanaf die liggaam. Hierdie verskynsel word vir die eerste keer in hierdie genus aangemeld. Histotylenchus hedys en Histotylenchus mohalei word vanaf materiaal van die Nasionale Versameling van Nematode herbeskryf, terwyl Histotylenchus histoides vanaf van die Rothamsted Nematode Collection gehuisves ter Food and Environment Research Agency (Fera), York, Vereen, National Research Foundation (NRF)

Published
2011

36. Systems analysis tools for promoting effective energy/minerals partnerships.

Author

Cohen B., Green processing 2004 Fremantle, Western Australia 10-May-0412-May-04, Basson L., Petrie J., Stewart M., Cohen B., Green processing 2004 Fremantle, Western Australia 10-May-0412-May-04, Basson L., Petrie J., and Stewart M.

Abstract

A review is presented of traditional energy utility planning tools along with those of network analysis. The existing approaches need to be adapted to allow for the analysis of partnerships within a network, taking into account considerations associated with sustainability. A basic set of indicators has been compiled that can be used for both the identification of suitable partnerships and the optimisation of existing electricity networks towards economic, environmental and social sustainability. The link between energy and minerals is briefly considered and pyrometallurgical processes are identified as having significant potential for recovery of energy to the transmission grid, whereas hydrometallurgical processes are energy sinks., A review is presented of traditional energy utility planning tools along with those of network analysis. The existing approaches need to be adapted to allow for the analysis of partnerships within a network, taking into account considerations associated with sustainability. A basic set of indicators has been compiled that can be used for both the identification of suitable partnerships and the optimisation of existing electricity networks towards economic, environmental and social sustainability. The link between energy and minerals is briefly considered and pyrometallurgical processes are identified as having significant potential for recovery of energy to the transmission grid, whereas hydrometallurgical processes are energy sinks.

Published
2004

41. Ranking and selection of power expansion alternatives for multiple objectives under uncertainty

Author

Heinrich, G., Basson, L., Cohen, B., Howells, M., and Petrie, J.

Subjects
*ELECTRICITY, *STRATEGIC planning
Abstract

Abstract: Strategic planning in the electricity supply industry is a complex task due to the multiple and often conflicting objectives of the decision makers, as well as the inherent technical and valuation uncertainties involved. As such, a transparent decision support framework is needed, for guiding information management throughout the decision process, in a way which shapes decision outcomes, and enables confident choices to be made. This paper outlines a methodology for the ranking of power expansion alternatives given multiple objectives and uncertainty, and demonstrates this using the South African electricity supply industry. This methodology uses a value function MCDA approach that is augmented with scenario analysis to yield information relating to both the relative performance and credibility of power expansion alternatives. A portfolio of preferred alternatives is then identified based on performance and confidence criteria. Finally a more detailed analysis of the reduced solution set examines short-term technology investment details alongside attribute performance information, so as to gain insight into the decision problem and relate it back to real life actions. [Copyright &y& Elsevier]

Published
2007
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45. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Astrid Lièvre, Anthony Turpin, Isabelle Ray-Coquard, Karine Le Malicot, Juliette Thariat, Guido Ahle, Cindy Neuzillet, Xavier Paoletti, Olivier Bouché, Kais Aldabbagh, Pierre Michel, Didier Debieuvre, Anthony Canellas, Marie Wislez, Lucie Laurent, May Mabro, Raphael Colle, Anne-Claire Hardy-Bessard, Laura Mansi, Emeline Colomba, Jean Bourhis, Philippe Gorphe, Yoann Pointreau, Ahmed Idbaih, Renata Ursu, Anna Luisa Di Stefano, Gérard Zalcman, Thomas Aparicio, Solenne Moulin, Olivier Leleu, Sylvie Leparree, Henri Goasdoue, Christine Piprot, Gerald Tourneur, Vincent Bayart, Delphine Lignier, Emma Lachaier, Marwa Khamari, Alexandre Coutte, Nicolas Siembida, Aline Houessinon, Jean Marc Regimbeau, Bruno Chauffert, Aurélie Moreira, Vincent Hautefeuille, Christine Hee, Mathieu Boone, Céline Bihan, Emilie Chive, Stéphane Poulet-Potriquier, Rachida Fahem, Dominique Luet, Guillaume Roquin, Carole Vitellius, Nathanaëlle Cornet-Trichereau, François-Xavier Caroli-Bosc, Anne Thirot-Bidault, Stanislas Ropert, Julie Gachet - Masson, Mélanie Dehais, Gwen-Ael L'helgoualc'h, Ibrahim Ali-Mahamadou, Safia Talfi, Laure Belmont, Dieudonné Kilendo, Nasro Benrezzak, Emeline Dubief, Guillaume Conroy, Laurence Delique, Maud Basso, Isabelle Pons, Karine Salignon, Anne-Laure Villing, Emmanuelle Mougenot, Cassandra Porebski, Asma Guiatni, Nicolas Cloarec, Laurent Mineur, Marie Bouchaud, Céleste David, Annie Peytier, Thomas Greletty, Franck Audemar, Emanuelle Vignes, Floriane Minne, Guillaume Goldzak, Fabienne Huysman, Fayçal Hocine, Zaher Lakkis, Guillaume Meynard, Hamadi Almotlak, Elodie Klajer, Xu-Shan Sun, Julie Wasselin, Pascale Catala, Claire Mazuy, Hélène Vandamme, Jean-Briac Prevost, Aurélie Fadin, Laurent Basson, Jean-Baptiste Huguet, Emmanuelle Dos Santos, Bérangère Jany, Alain Saad, Frédéric Goutorbe, Eric Oziol, Mohamed Ramdani, Ouafae Kadiri, Delphine Garbay, Clotilde Huet, Etienne Giroux Leprieur, Wen Teng, Justine Monvoisin, Patrick Arnaud Coffin, Sylvie Roux, Hubert Orfeuvre, Mélanie Chagros, Didier Pillon, Agathe Rassoul, Pierre Guillaume Poureau, Cécile Novello, François Ducray, Cécile Trouba, Vianney Bastit, Emmanuel Babin, Vincent Leon, Anne-Catherine Courtecuisse, Julie Vambre, Vincent Tack, Christophe Desauw, Fatima Meniai, Christina Peres, Aurélie Esparcieux, Hervé Perrier, Nathalie Doux, Régis Kaphan, Bertrand Roques, Christine Rebischung, Dominique Mille, Gaëlle Fernandes, Naceur Abdelli, Natacha Jousset, Pierre Combe, Eric Jonveaux, Patrick Dumont, Marc Kanaan, Corinne Berthelot Gras, Valérie Panis, Laure Kaluzinski, Marjolène Venant-Valery, You-Heng Lam, Laura Vallee, Frédéric Riviere, Muriel Durand, Dihya Benghadid, Emilie Villeneuve, Olivia Hentic Dhome, Zedjiga Bounouar, Louis De Mestier, Jacqueline Dubois, Magali Eyriey, Lionel Moreau, Dib Baihas, Kaïs Aldabbagh, Dominique Degriffolet, Virginie Sebbagh, Jean-Christophe Seghezzi, Marion Lozach-Brugirard, Julie Mandrou, Loubna Mavier, Florence Hennetier, Jean-Philippe Wagner, Elisabeth Carola, Karthiga Chandirakumaran, Sandrine Loutski, Isabelle Cojean-Zelek, Amina Bouras, Sandrine Lacour, Fahem Froura, Hadjer Ben Nadji, Sophie Cattelain, Franck Darloy, Geneviève Jolimoy Boilleau, Cyrielle Maissiat, Ariane Darut-Jouve, Véronique Lorgis, Ikram Charifi-Alaoui, François Ghiringhelli, Antoine Drouillard, Marie Chaix, Sylvain Manfredi, Côme Lepage, Alice Gagnaire, Marianne Latournerie, Sofia jourdan, Nora Perrot, Mireille folia, Anne Minello, Jean-Louis Jouve, Marielle Fery, Alain Landau, Diane Evrard, Bruno Valenza, Jean-François Paitel, Laetitia Chablais, Thomas Kreitmann, Laurence Lancry-Lecomte, Adrien Monard, Eve Faugeras, Paul Boucheret, Cécile Glommeau, Christine Tchikladze, Claire Garnier Tixidre, Jérôme Long, Manel Zaidi, Véronique Delabarre, Juliette Meyzenc, Loïc Ferrand, Denis Moro-Sibilot, Paul Bouheret, Cécile Leyronnas, Camille Herve, Audrey Thoor, Emanuelle Jacquet, Gaël Roth, Videsheka Madapathage-Senanyake, Peggy Chupeau, Elsa Bieber, Maud Rosso, Isabelle Lepage, Frank Priou, Margot Laly, Sylvie Aprelon, Natacha Sobolak, Helen Homokos, Fabienne Watelle, Alice Pham-Becker, Géraldine Lauridant, Charlotte Dujardin, Etienne Lenglin, Aimée Nienguet Tsota, Sophie Dominguez, Alexandra Forestier, Franck Nouvel, Justine Lerooy, Céline Ratajczak, Olivier Romano, Dorothéee Brzyski, Aurélien Barriere, Dominique Genet, Julien Tisse, Xavier Zasadny, Adeline Grelet, Amélie Hennion-Imbault, Eglantine Haustraete, Samy Louafi, Manal Awad, Younes Zekri, Caroline Cheneau, Nolwen Leissen, Joëlle Egreteau, Alexandra Breant, Matthieu Sarabi, Stéphanie Labonne, Julien Forestier, Céline Leclercq, Florence Prunier-Bossion, Isabelle Ray Coquard, Marielle Guillet, Aurélie Theillaumas, Emilie Prome, Thomas Walter, Pierre Philouze, Melody Lawo, Solène De Talhouet, Johanne Beuvelot, Yann Molin, Marie Bellecoste Martin, Maud Saussereau, Lauren Agnelli, Nicolas Fakhry, Christophe Laplace, Emmanuelle Norguet Monnereau, Céline Boucard, Kahina Djenad, Catherine Fontaine, Jean-François Seitz, Laétitia Dahan, Julie Sigrand, Muriel Duluc, Christophe Locher, Marjory Fleury, Ange Brou Marie, Ramdane Berkane, Séverine Poupblanc, Dominique Auby, Daniela Petran, Patrick Texereau, Elodie Guerineau, Morgan Andre, Linda Mahjoubi, Fanny Sarrazin, Sonia Jeanson, Anthony Gschwend, Virginie Birr, Mathieu Fore, Monique Noirclerc, Sihem Dahou, Dominique Spaeth, Mélanie Lambotin, Thomas Lelu, Benjamin Linot, Nathalie Hugon, Dominique Rousseau, Hélène Castanie, Carole Lenne, Alain Lortholary, Anatole Cessot, Messaouda Merzoug, Cécile Naudin, Jean-Michel Vannetzel, Ghina Aziz, Yacine Hadj Arab, Stéphanie Pernes, Isabelle Roche-Lachaise, Frédéric Fiteni, Hadjer Yahiaoui, Gwendoline Marel Lopez, Jeanne Oddoz, Fabienne Peira, Olivier Michel, Jérôme Meunier, Brahim Ouahrani, Antoine Roger, Sonia Branco, Van Nguyen, Mathilde Gisselbrecht, Ghania Hammad, Pierre Mordant, Magda Stroksztejn, Marc Pocard, Luc Nlo Meyengue, Emmanuelle Sacco, Sophie Simon Anne, Elizabeth Fabre-Guillevin, Marine Slim, Aziz Zaanan, Jacques Cadranel, Johan Pluvy, Rénata Ursu, Amyrath Geraldo, Rime Lihi, Maryline Vo, Zohra Brouk, Raphaël Colle, Mostefa Bennamoun, Fabrice Lacan, Christophe Louvet, Soraya Mebarki, Marianne Veyri, Elena Paillaud, Christelle Lucas, Olivier Dubreuil, Jamila Lyamani, Hanane Agguini, Emilie Soularue, Clément Jourdaine, Benjamin Verillaud, Hakima Herzine, Eric Raymond, Nathalie Mathiot, Lola Jade Palmieri, Christian Epanya, Julien Taieb, Eliane Bertrand, Gaël Goujon, Céline Namour, Benoit Gazeau, Biljana Zafirova, Haitham Mirghani, Catherine Belin, Kahina Belkhir, Myriam Gharib, Aurore Vozy, Karim Amrane, Jean-Philippe Spano, Johanna Wassermann, Loic Feuvret, Jean-Baptiste Bachet, Sara Philonenko, Laetitia Guillot, Marion Zabbe, Stéphanie Gibiat, Camille Baylot, Aude Jouinot, Nicolas Leduc, Sabine Vieillot, Laurie James, Camille Ducerf, Jean-Frédéric Blanc, Claire Falandry Leger, Virginie Wautot, Marion Chauvenet, Aude Vincent, David Tougeron, Sandrine Goulvent, Etienne Suc, Anne-Pascale Laurenty, Eric Marquis, Margaux Bonnaire, Maxime Dewolf, Esteban Brenet, Delphine Billard, Claude-Fabien Litre, Antoine Dumazet, Damien Botsen, Marion Vazel, Claire Carlier, David Bonnerave, Charles Marchand-Crety, Olivier Bouche, Patricia Fosse, David Sefrioui, Sarah Watson, Fatah Torche, Thierry Muron, Stéphane Natur, Romain Desgrippes, Véronique Bihel, François-Régis Ferrand, Caroline Leiterer, Julie Lavole, Claire Moquet, Nathalie Pressoir, Catherine Dziukala, Catherine Ligeza Poisson, Abdelhalim Naji, Nicolas Williet, Jean-Marc Phelip, Fabrice Di Palma, Amina Kherrour Mehdi, Julien Langrand-Escure, Pierre Fournel, Grégoire Pigne, Léa Saban-Roche, Nicolas Magne, Cécile Vassal, Jean-Philippe Jacquin, Carole Ramirez, Alexis Vallard, Olivier Collard, Romain Rivoirard, Ivan Graber, Stéphanie Trager Maury, Elodie Duboisset, Jorge Ayllon Ugarte, Dalilia Rami, Christine Saler, Manon Reinbolt, Clara Le Fevre, Meher Ben Abdelghani, Louis-Marie Dourthe, Joffrey Perruisseau-Carrier, Marlène Nguimpi-Tambou, Flavie Barret, Luisa Di Stefano Anna, Annie Balthazard, Camille Vassord-Dang, Mathilde Le Marchand, Julien Vergniol, Iulia Pripon, Axelle Daemaegdt, Vanessa Latry, Muna Larrieu, Gaëlle Landry, Laetitia Touihri Maximin, Francesco Del Piano, Agnès Barlet, Mylène Vernisse, Sophie Lafond, Charline Genin, Camille Sibertin-Blanc, Emilien Chabrillac, Caroline Gregoire, Sébastien Vergez, Quentin Panouille, Rosine Guimbaud, Floriane Richa, Loïc Lebellec, Sophie Gounin, Guillaume Buiret, Marine Baudin, Hervé Hamon, Anne-Claire Deshorgue, Eduardo Barrascout, Stéphanie Legrand, Morgane Houlze, Linda Cambula, Anthony Lopez, Guillaume Fouquet, Kahina Touabi, Adeline GermaIn, Benoit Godbert, Florence Voivret, Julie Perrin, Rosa Da Silva, Emilie Bernichon, GCO-002 CACOVID-19 collaborators/investigators, Moulin, S., Leleu, O., Leparree, S., Goasdoue, H., Piprot, C., Tourneur, G., Bayart, V., Lignier, D., Lachaier, E., Khamari, M., Coutte, A., Siembida, N., Houessinon, A., Regimbeau, J.M., Chauffert, B., Moreira, A., Hautefeuille, V., Hee, C., Boone, M., Bihan, C., Chive, E., Poulet-Potriquier, S., Fahem, R., Luet, D., Roquin, G., Vitellius, C., Cornet-Trichereau, N., Caroli-Bosc, F.X., Thirot-Bidault, A., Ropert, S., Gachet-Masson, J., Dehais, M., L'helgoualc'h, G.A., Ali-Mahamadou, I., Talfi, S., Belmont, L., Kilendo, D., Benrezzak, N., Dubief, E., Conroy, G., Delique, L., Basso, M., Pons, I., Salignon, K., Villing, A.L., Mougenot, E., Porebski, C., Guiatni, A., Cloarec, N., Mineur, L., Bouchaud, M., David, C., Peytier, A., Greletty, T., Audemar, F., Vignes, E., Minne, F., Goldzak, G., Huysman, F., Hocine, F., Lakkis, Z., Mansi, L., Meynard, G., Almotlak, H., Klajer, E., Sun, X.S., Wasselin, J., Catala, P., Mazuy, C., Vandamme, H., Prevost, J.B., Fadin, A., Basson, L., Huguet, J.B., Dos Santos, E., Jany, B., Saad, A., Goutorbe, F., Oziol, E., Ramdani, M., Kadiri, O., Garbay, D., Huet, C., Giroux Leprieur, E., Teng, W., Monvoisin, J., Arnaud Coffin, P., Roux, S., Orfeuvre, H., Chagros, M., Pillon, D., Rassoul, A., Poureau, P.G., Novello, C., Ducray, F., Trouba, C., Bastit, V., Babin, E., Thariat, J., Leon, V., Courtecuisse, A.C., Vambre, J., Tack, V., Desauw, C., Meniai, F., Peres, C., Esparcieux, A., Perrier, H., Doux, N., Kaphan, R., Roques, B., Rebischung, C., Mille, D., Fernandes, G., Abdelli, N., Jousset, N., Combe, P., Jonveaux, E., Dumont, P., Kanaan, M., Berthelot Gras, C., Panis, V., Kaluzinski, L., Venant-Valery, M., Lam, Y.H., Vallee, L., Riviere, F., Durand, M., Benghadid, D., Villeneuve, E., Hentic Dhome, O., Laurent, L., Bounouar, Z., De Mestier, L., Dubois, J., Eyriey, M., Moreau, L., Ahle, G., Baihas, D., Aldabbagh, K., Degriffolet, D., Sebbagh, V., Seghezzi, J.C., Lozach-Brugirard, M., Mandrou, J., Mavier, L., Hennetier, F., Wagner, J.P., Carola, E., Chandirakumaran, K., Loutski, S., Cojean-Zelek, I., Bouras, A., Lacour, S., Froura, F., Ben Nadji, H., Cattelain, S., Darloy, F., Jolimoy Boilleau, G., Maissiat, C., Darut-Jouve, A., Lorgis, V., Charifi-Alaoui, I., Ghiringhelli, F., Drouillard, A., Chaix, M., Manfredi, S., Lepage, C., Gagnaire, A., Latournerie, M., Jourdan, S., Perrot, N., Folia, M., Minello, A., Jouve, J.L., Fery, M., Landau, A., Evrard, D., Valenza, B., Paitel, J.F., Chablais, L., Kreitmann, T., Lancry-Lecomte, L., Monard, A., Faugeras, E., Boucheret, P., Glommeau, C., Tchikladze, C., Garnier Tixidre, C., Long, J., Zaidi, M., Delabarre, V., Meyzenc, J., Ferrand, L., Moro-Sibilot, D., Bouheret, P., Leyronnas, C., Herve, C., Thoor, A., Jacquet, E., Roth, G., Madapathage-Senanyake, V., Chupeau, P., Bieber, E., Rosso, M., Lepage, I., Priou, F., Laly, M., Aprelon, S., Sobolak, N., Homokos, H., Pointreau, Y., Watelle, F., Pham-Becker, A., Lauridant, G., Turpin, A., Dujardin, C., Lenglin, E., Nienguet Tsota, A., Dominguez, S., Forestier, A., Nouvel, F., Lerooy, J., Ratajczak, C., Romano, O., Brzyski, D., Barriere, A., Genet, D., Tisse, J., Zasadny, X., Grelet, A., Hennion-Imbault, A., Haustraete, E., Louafi, S., Awad, M., Zekri, Y., Cheneau, C., Leissen, N., Egreteau, J., Breant, A., Sarabi, M., Labonne, S., Forestier, J., Leclercq, C., Prunier-Bossion, F., Ray Coquard, I., Guillet, M., Theillaumas, A., Prome, E., Walter, T., Philouze, P., Lawo, M., De Talhouet, S., Beuvelot, J., Molin, Y., Bellecoste Martin, M., Saussereau, M., Agnelli, L., Fakhry, N., Laplace, C., Norguet Monnereau, E., Boucard, C., Djenad, K., Fontaine, C., Seitz, J.F., Dahan, L., Sigrand, J., Duluc, M., Locher, C., Fleury, M., Brou Marie, A., Berkane, R., Poupblanc, S., Auby, D., Petran, D., Texereau, P., Guerineau, E., Andre, M., Mahjoubi, L., Sarrazin, F., Jeanson, S., Gschwend, A., Birr, V., Debieuvre, D., Fore, M., Noirclerc, M., Dahou, S., Spaeth, D., Lambotin, M., Lelu, T., Linot, B., Hugon, N., Rousseau, D., Castanie, H., Lenne, C., Lortholary, A., Cessot, A., Merzoug, M., Naudin, C., Vannetzel, J.M., Aziz, G., Hadj Arab, Y., Pernes, S., Roche-Lachaise, I., Fiteni, F., Yahiaoui, H., Marel Lopez, G., Oddoz, J., Peira, F., Michel, O., Meunier, J., Ouahrani, B., Roger, A., Branco, S., Nguyen, V., Gisselbrecht, M., Hammad, G., Mordant, P., Stroksztejn, M., Pocard, M., Nlo Meyengue, L., Aparicio, T., Sacco, E., Simon Anne, S., Fabre-Guillevin, E., Wislez, M., Slim, M., Zaanan, A., Cadranel, J., Pluvy, J., Ursu, R., Geraldo, A., Lihi, R., Vo, M., Brouk, Z., Colle, R., Bennamoun, M., Lacan, F., Louvet, C., Mebarki, S., Veyri, M., Paillaud, E., Lucas, C., Dubreuil, O., Lyamani, J., Idbaih, A., Agguini, H., Soularue, E., Canellas, A., Zalcman, G., Jourdaine, C., Verillaud, B., Herzine, H., Raymond, E., Mathiot, N., Palmieri, L.J., Epanya, C., Taieb, J., Bertrand, E., Goujon, G., Namour, C., Gazeau, B., Zafirova, B., Mirghani, H., Belin, C., Belkhir, K., Gharib, M., Vozy, A., Amrane, K., Spano, J.P., Wassermann, J., Feuvret, L., Bachet, J.B., Philonenko, S., Guillot, L., Zabbe, M., Gibiat, S., Baylot, C., Jouinot, A., Leduc, N., Vieillot, S., James, L., Ducerf, C., Blanc, J.F., Falandry Leger, C., Wautot, V., Chauvenet, M., Vincent, A., Tougeron, D., Goulvent, S., Suc, E., Laurenty, A.P., Marquis, E., Bonnaire, M., Dewolf, M., Brenet, E., Billard, D., Litre, C.F., Dumazet, A., Botsen, D., Vazel, M., Carlier, C., Bonnerave, D., Marchand-Crety, C., Bouche, O., Fosse, P., Sefrioui, D., Michel, P., Watson, S., Neuzillet, C., Torche, F., Muron, T., Natur, S., Desgrippes, R., Bihel, V., Ferrand, F.R., Leiterer, C., Lavole, J., Moquet, C., Pressoir, N., Dziukala, C., Ligeza Poisson, C., Naji, A., Williet, N., Phelip, J.M., Di Palma, F., Kherrour Mehdi, A., Langrand-Escure, J., Fournel, P., Pigne, G., Saban-Roche, L., Magne, N., Vassal, C., Jacquin, J.P., Ramirez, C., Vallard, A., Collard, O., Rivoirard, R., Graber, I., Trager Maury, S., Duboisset, E., Ayllon Ugarte, J., Rami, D., Saler, C., Reinbolt, M., Le Fevre, C., Ben Abdelghani, M., Dourthe, L.M., Perruisseau-Carrier, J., Nguimpi-Tambou, M., Barret, F., Di Stefano Anna, L., Balthazard, A., Mabro, M., Vassord-Dang, C., Le Marchand, M., Vergniol, J., Pripon, I., Daemaegdt, A., Latry, V., Larrieu, M., Landry, G., Touihri Maximin, L., Del Piano, F., Barlet, A., Vernisse, M., Lafond, S., Genin, C., Sibertin-Blanc, C., Chabrillac, E., Gregoire, C., Vergez, S., Panouille, Q., Guimbaud, R., Richa, F., Lebellec, L., Gounin, S., Buiret, G., Baudin, M., Hamon, H., Deshorgue, A.C., Barrascout, E., Legrand, S., Houlze, M., Cambula, L., Lopez, A., Fouquet, G., Touabi, K., GermaIn, A., Godbert, B., Voivret, F., Perrin, J., Da Silva, R., Bernichon, E., Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), CH Colmar, Institut Curie [Paris], Centre Hospitalier Universitaire de Reims (CHU Reims), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Beaujon, Hôpital Foch [Suresnes], CHU Saint-Antoine [AP-HP], ARCAGY-GINECO, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut Gustave Roussy (IGR), Département de médecine nucléaire [Rennes], CRLCC Eugène Marquis (CRLCC), Département de médecine oncologique [Gustave Roussy], Département de cancérologie cervico-faciale [Gustave Roussy] (CCF), Centre Jean Bernard [Institut Inter-régional de Cancérologie - Le Mans], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hopital Saint-Louis [AP-HP] (AP-HP), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), AbbVie, Merck, Carthera, Transgene, Nutritheragene, Roche, Air Liquide, Eli Lilly Japan, LEO Pharma Research Foundation, Bayer, Novartis, Sanofi, Biogen, Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, 0301 basic medicine, Cancer Research, medicine.medical_treatment, Disease, law.invention, Cohort Studies, 0302 clinical medicine, Mechanical ventilation, Risk Factors, law, Neoplasms, Medicine, Prospective Studies, Prospective cohort study, Original Research, Cancer, Intensive care unit, 3. Good health, Death, Oncology, 030220 oncology & carcinogenesis, Female, France, Immunotherapy, Cohort study, medicine.medical_specialty, chemotherapy. radiotherapy, Antineoplastic Agents, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Internal medicine, Humans, Chemotherapy, Mortality, Pandemics, Aged, Retrospective Studies, Radiotherapy, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, Odds ratio, medicine.disease, Antineoplastic Agents/adverse effects, Antineoplastic Agents/therapeutic use, COVID-19/mortality, France/epidemiology, Neoplasms/mortality, Neoplasms/therapy, Neoplasms/virology, SARS-CoV-2/isolation & purification, 030104 developmental biology, business
Abstract

Background Cancer patients are thought to have an increased risk of developing severe Coronavirus Disease 2019 (COVID-19) infection and of dying from the disease. In this work, predictive factors for COVID-19 severity and mortality in cancer patients were investigated. Patients and Methods In this large nationwide retro-prospective cohort study, we collected data on patients with solid tumours and COVID-19 diagnosed between March 1 and June 11, 2020. The primary endpoint was all-cause mortality and COVID-19 severity, defined as admission to an intensive care unit (ICU) and/or mechanical ventilation and/or death, was one of the secondary endpoints. Results From April 4 to June 11, 2020, 1289 patients were analysed. The most frequent cancers were digestive and thoracic. Altogether, 424 (33%) patients had a severe form of COVID-19 and 370 (29%) patients died. In multivariate analysis, independent factors associated with death were male sex (odds ratio 1.73, 95%CI: 1.18-2.52), ECOG PS ≥ 2 (OR 3.23, 95%CI: 2.27-4.61), updated Charlson comorbidity index (OR 1.08, 95%CI: 1.01-1.16) and admission to ICU (OR 3.62, 95%CI 2.14-6.11). The same factors, age along with corticosteroids before COVID-19 diagnosis, and thoracic primary tumour site were independently associated with COVID-19 severity. None of the anticancer treatments administered within the previous 3 months had any effect on mortality or COVID-19 severity, except cytotoxic chemotherapy in the subgroup of patients with detectable SARS-CoV-2 by RT-PCR, which was associated with a slight increase of the risk of death (OR 1.53; 95%CI: 1.00-2.34; p = 0.05). A total of 431 (39%) patients had their systemic anticancer treatment interrupted or stopped following diagnosis of COVID-19. Conclusions Mortality and COVID-19 severity in cancer patients are high and are associated with general characteristics of patients. We found no deleterious effects of recent anticancer treatments, except for cytotoxic chemotherapy in the RT-PCR-confirmed subgroup of patients. In almost 40% of patients, the systemic anticancer therapy was interrupted or stopped after COVID-19 diagnosis., Highlights • A total of 1289 patients with solid tumours and COVID-19 were analysed. • Mortality and COVID-19 severity were mainly driven by patient general characteristics. • Overall, we found no deleterious effects of recent anticancer treatments on mortality. . • Systemic anticancer treatment was interrupted or stopped in 39% of patients.

Published
2020
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46. Comparative exploration of the morphological plasticity of Trichodina centrostrigeata (Peritrichia: Mobilida), ectoparasite from the gills of two tilapia species (Oreochromis niloticus and O. mossambicus) in a global context.

Author

Islas-Ortega AG, Marcotegui PS, Basson L, de Jager GP, and Aguilar-Aguilar R

Subjects
Humans, Animals, Gills parasitology, Ecosystem, Argentina epidemiology, Cichlids parasitology, Tilapia genetics
Abstract

Trichodina centrostrigeata Basson, Van As et Paperna, 1983 from Oreochromis mossambicus (Peters) and O. niloticus (Linnaeus) from different host populations from Argentina, Mexico and South Africa was reviewed. Although T. centrostrigeata has a distinct denticle structure that makes morphological taxonomic inferences uncomplicated, variation of the denticles within and among individuals and populations were still observed. While traditional taxonomy of mobilines is heavily reliant on morphometrics, and recently even more so on molecular analysis, this paper proposes the use of geometric morphometry, specifically elliptical Fourier analysis, to address morphological conflicts that arise when comparing different populations. By applying this technique, combined with traditional taxonomy, it was found that T. centrostrigeata in this study can be grouped into two separate morphotypes, the first (type a) from aquaculture farms in Argentina and Mexico and the second (type b) from a natural habitat in Glen Alpine Dam, South Africa. This study supports the validity of geometric morphometry as an additional technique to distinguish not only between species but also evolutionary plasticity of the same species from different localities and habitats.

Published
2022
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47. A checklist of trichodinid species (Ciliophora: Trichodinidae) on tilapia fishes (Cichlidae), with new records from Mexico and the first data from Argentina.

Author

Islas-Ortega AG, Marcotegui PS, Basson L, and Aguilar-Aguilar R

Subjects
Animals, Argentina, Fishes, Mexico, Cichlids, Ciliophora, Fish Diseases, Tilapia
Abstract

Tilapia is the common name for a wide spectrum of cichlid fishes usually selected for aquaculture activities. However, some aspects of the natural history of these fishes, such as the diversity of certain ectoparasitic protistan groups remain understudied. In order to understand the diversity of ciliates of the family Trichodinidae parasitizing tilapia around the world, a database with all available accounts was assembled. This information, along with records derived from our own recent research, allowed us to generate a checklist containing all the records for tilapia-Trichodinidae associations. The checklist is presented as a host-parasite list containing 44 nominal taxa from 29 countries on four continents, and it also presents the first data from Argentina, where tilapia culture is still an incipient, but growing activity. The observed high species richness of trichodinids is probably derived from a set of specific taxa for tilapia, along with an important component of species acquired from the new environments where tilapia have been introduced. Data presented here could be used along with existing information of metazoan parasites to build a general view about diseases that affect tilapia.

Published
2020
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48. Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer.

Author

Bataille B, Raoudha B, Le Tinier F, Basson L, Escande A, Langin H, Tresch E, Crop F, Darloy F, Carlier D, Lartigau E, and Pasquier D

Abstract

The objective of this study was to evaluate the acute and medium-term toxicities, the quality of life, and aesthetic results of patients with breast cancer (BC) treated with tomotherapy. This was a prospective study, including patients with BC treated by tomotherapy. Radiation therapy delivered 50 Gy in 25 fractions to the breast or chest wall and to lymph node areas, with a simultaneous integrated boost at a dose of 60 Gy at the tumor bed in cases of breast conservative surgery. We included 288 patients, 168 and 120 treated with breast-conserving surgery and mastectomy respectively. Two hundred sixty patients (90.3%) received lymph node irradiation. Median follow-up was 25 months (6-48). Acute dermatitis was observed in 278 patients (96.5%), mostly grade 1 (59.7%). The aesthetic aspect of the breast at one year was reported as "good" or "excellent" in 84.6% of patients. The patients' quality of life improved over time, especially those treated with chemotherapy. The two-year overall survival and disease-free survival were 97.8% (95% confidence interval (CI): 94.1-99.2%), and 93.4% (95% CI: 89.2-96.0%) respectively. Tomotherapy for locally advanced BC has acceptable toxicity, supporting its use in this indication; however, longer follow-up is needed to assess long-term outcomes.

Published
2020
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49. Chest Magnetic Resonance Imaging Decreases Inter-observer Variability of Gross Target Volume for Lung Tumors.

Author

Basson L, Jarraya H, Escande A, Cordoba A, Daghistani R, Pasquier D, Lacornerie T, Lartigau E, and Mirabel X

Abstract

Purpose: PET/CT is a standard medical imaging used in the delineation of gross tumor volume (GTV) in case of radiation therapy for lung tumors. However, PET/CT could present some limitations such as resolution and standardized uptake value threshold. Moreover, chest MRI has shown good potential in diagnosis for thoracic oncology. Therefore, we investigated the influence of chest MRI on inter-observer variability of GTV delineation. Methods and Materials: Five observers contoured the GTV on CT for 14 poorly defined lung tumors during three contouring phases based on true daily clinical routine and acquisition: CT phase, with only CT images; PET phase, with PET/CT; and MRI phase, with both PET/CT and MRI. Observers waited at least 1 week between each phases to decrease memory bias. Contours were compared using descriptive statistics of volume, coefficient of variation (COV), and Dice similarity coefficient (DSC). Results: MRI phase volumes (median 4.8 cm 3 ) were significantly smaller than PET phase volumes (median 6.4 cm 3 , p = 0.015), but not different from CT phase volumes (median 5.7 cm 3 , p = 0.30). The mean COV was improved for the MRI phase (0.38) compared to the CT (0.58, p = 0.024) and PET (0.53, p = 0.060) phases. The mean DSC of the MRI phase (0.67) was superior to those of the CT and PET phases (0.56 and 0.60, respectively; p < 0.001 for both). Conclusions: The addition of chest MRI seems to decrease inter-observer variability of GTV delineation for poorly defined lung tumors compared to PET/CT alone and should be explored in further prospective studies.

Published
2019
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50. Trichodinid infections in internal organs of shorthorn sculpin (Myoxocephalus scorpius) collected around an industrial harbour in Nuuk, Greenland.

Author

Dang M, Basson L, Bach L, Sonne C, Nørregaard R, and Nowak B

Subjects
Animals, Ciliophora Infections epidemiology, Ciliophora Infections parasitology, Female, Fish Diseases parasitology, Greenland epidemiology, Kidney parasitology, Liver parasitology, Male, Prevalence, Sex Factors, Spleen parasitology, Ciliophora Infections veterinary, Fish Diseases epidemiology, Fishes, Oligohymenophorea isolation & purification
Abstract

Trichodinids are parasites generally found on gills and skin of a broad number of aquatic animals. Only a small number of endozoic species has been reported from the urinary tract, intestine and urogenital system in some fish, amphibians and molluscs. This is the first report on the presence of endozoic trichodinids in the spleen, kidney and liver of shorthorn sculpin (Myoxocephalus scorpius). In the present study, trichodinids displayed some of the typical morphological characteristics of endozoic trichodinids with narrow blades and straight rays of adhesive disc denticles. The parasites were observed at a relatively high prevalence (23.9%). There was a positive correlation between intensity of endozoic trichodinids in the internal organs and ectozoic trichodinids on the gills (R = 0.5, n = 46, P &lt; 0.001) whereas there was no correlation between intensity of endozoic trichodinids and the host's body length, body weight or liver weight. Infection levels of endozoic trichodinids were not dependent upon sculpin sex and there was no effect of sampling locations on prevalence and intensity of endozoic trichodinids.

Published
2019
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