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6. Everolimus-eluting stents or bypass surgery for left main coronary artery disease

Author

Stone, Gw, Sabik, Jf, Serruys, Pw, Simonton, Ca, Généreux, P, Puskas, J, Kandzari, De, Morice, Mc, Lembo, N, Brown WM 3rd, Taggart, Dp, Banning, A, Merkely, B, Horkay, F, Boonstra, Pw, van Boven AJ, Ungi, I, Bogáts, G, Mansour, S, Noiseux, N, Sabaté, M, Pomar, J, Hickey, M, Gershlick, A, Buszman, P, Bochenek, A, Schampaert, E, Pagé, P, Dressler, O, Kosmidou, I, Mehran, R, Pocock, Sj, Kappetein, Ap, van Es GA, Leon, Mb, Gersh, B, Chaturvedi, S, Kint, Pp, Valgimigli, M, Colombo, A, Costa, M, Di Mario, C, Ellis, S, Fajadet, J, Fearon, W, Kereiakes, D, Makkar, R, Mintz, Gs, Moses, Jw, Teirstein, P, Ruel, M, Sergeant, P, Mack, M, Fontana, G, Mohr, Fw, Nataf, P, Smith, C, Boden, B, Fox, K, Maron, D, Steg, G, Blackstone, E, Juni, P, Parise, H, Wallentin, L, Bertrand, M, Krucoff, M, Turina, M, Ståhle, E, Tijssen, J, Brill, D, Atkins, C, Applegate, B, Argenziano, M, Faly, Rc, Dauerman, H, Davidson, C, Griffith, B, Reisman, M, Rizik, D, Sakwa, M, Shemin, R, Romano, M, Hamm, C, Gummert, J, Tamburino, C, Alfieri, O, Savina, C, de Bruyne, B, Machado, Fp, Uva, S, Moccetti, T, Siclari, F, Hildick Smith, D, Szekely, L, Erglis, A, Stradins, P, Abizaid, A, Bento Sousa LC, Belardi, J, Navia, D, Park, Sj, Lee, Jw, Meredith, I, Smith, J, Yehuda, Ob, Schneijdenberg, R, Ronden, J, Jonk, J, Jonkman, A, van Remortel, E, de Zwart, I, Elshout, L, de Vries, T, Andreae, R, Tol van, J, Teurlings, E, Balachandran, S, Breazna, A, Jenkins, P, Mcandrew, T, Marx, So, Connolly, Mw, Hong, Mk, Weinberger, J, Wong, Sc, Dizon, J, Biviano, A, Morrow, J, Wang, D, Corral, M, Alfonso, M, Sanchez, R, Wright, D, Djurkovic, C, Lustre, M, Jankovic, I, Sanidas, E, Lasalle, L, Maehara, A, Matsumura, M, Sun, E, Iacono, S, Greenberg, T, Jacobson, J, Pullano, A, Gacki, M, Liu, S, Cohen, Dj, Magnuson, E, Baron, Sj, Wang, K, Traylor, K, Worthley, S, Stuklis, R, Barbato, E, Stockman, B, Dubois, C, Meuris, B, Vrolix, M, Dion, R, Bento de Souza LC, Costantini, C, Woitowicz, V, Hueb, W, Stolf, N, Beydoun, H, Baskett, R, Curtis, M, Kieser, T, Doucet, S, Pellerin, M, Hamburger, J, Cook, R, Kutryk, M, Peterson, M, Madan, M, Fremes, S, Mehta, S, Cybulsky, I, Prabhakar, M, Peniston, C, Welsh, R, Macarthur, R, Berland, J, Bessou, Jp, Carrié, D, Glock, Y, Darremont, O, Deville, C, Grimaud, Jp, Soula, P, Lefèvre, T, Maupas, E, Durrleman, N, Silvestri, M, Houel, R, Pratt, A, Francis, J, Van Belle, E, Vicentelli, A, Luchner, A, Hilker, M, Endemann, Dh, Felix, S, Wollert, Hg, Walther, T, Erbel, R, Jacob, H, Kahlert, P, Kupatt, C, Näbauer, M, Schmitz, C, Scholtz, W, Börgermann, J, Schuler, G, Borger, M, Davierwala, P, Fontos, G, Székely, L, Bedogni, F, Panisi, P, Berti, S, Glauber, M, Marzocchi, A, Di Bartolomeo, R, Merlo, M, Guagliumi, G, Fenili, F, Napodano, M, Gerosa, G, Ribichini, F, Faggian, Giuseppe, Saccà, S, Giacomin, A, Mignosa, C, Tumscitz, C, Savini, C, Van Mieghem, N, von Birgelen, C, Grandjean, J, Kubica, J, Anisimowicz, L, Zmudka, K, Sadowski, J, Hernández García, J, Such, M, Macaya, C, Rodríguez Hernández JE, Maroto, L, Serra, A, Padro, J, Tenas, Ms, De Souza, A, Egred, M, Clark, S, Trivedi, U, Jain, A, Uppal, R, Redwood, S, Young, C, Stables, Rh, Pullan, M, Uren, N, Pessotto, R, Abu Fadel, M, Peyton, M, Allaqaband, S, O’Hair, D, Bachinsky, W, Mumtaz, M, Blankenship, J, Casale, A, Brott, B, Davies, J, Brown, D, Cannon, L, Talbott, J, Chang, G, Macheers, S, Choi, J, Henry, C, Cutlip, D, Khabbaz, K, Das, G, Liao, K, Diver, D, Thayer, J, Dobies, D, Fliegner, K, Fischbein, M, Feldman, T, Pearson, P, Foster, M, Briggs, R, Giugliano, G, Engelman, D, Gordon, P, Ehsan, A, Grantham, J, Allen, K, Grodin, J, Jessen, M, Gruberg, L, Taylor JR Jr, Gupta, S, Hermiller J., Jr, Heimansohn, D, Iwaoka, R, Chan, B, Kander, Nh, Duff, S, Brown, W, Karmpaliotis, D, Kini, A, Filsoufi, F, Kong, D, Lin, S, Kutcher, M, Kincaid, E, Leya, F, Bakhos, M, Liberman, H, Halkos, M, Lips, D, Eales, F, Mahoney, P, Rich, J, Barreiro, C, Cheng, W, Metzger, C, Greenfield, T, Moses, J, Palacios, I, Macgillivray, T, Perin, E, Del Prete, J, Pompili, V, Kilic, A, Ragosta, M, Kron, I, Rashid, J, Mueller, D, Riley, R, Reimers, C, Patel, N, Resar, J, Shah, A, Schneider, J, Landvater, L, Reardon, M, Shavelle, D, Baker, C, Singh, J, Maniar, H, Wei, L, Strain, J, Zapolanski, A, Taheri, H, Ad, N, Tannenbaum, M, Prabhakar, G, Waksman, R, Corso, P, Wang, J, Fiocco, M, Wilson, Bh, Steigel, Rm, Chadwick, S, Zidar, F, Oswalt, J., Stone, Gregg W., Sabik, Joseph F., Serruys, Patrick W., Simonton, Charles A., Généreux, Philippe, Puskas, John, Kandzari, David E., Morice, Marie Claude, Lembo, Nichola, Brown, W. Morri, Taggart, David P., Banning, Adrian, Merkely, Béla, Horkay, Ferenc, Boonstra, Piet W., Van Boven, Ad J., Ungi, Imre, Bogáts, Gabor, Mansour, Samer, Noiseux, Nicola, Sabaté, Manel, Pomar, José, Hickey, Mark, Gershlick, Anthony, Buszman, Pawel, Bochenek, Andrzej, Schampaert, Erick, Pagé, Pierre, Dressler, Ovidiu, Kosmidou, Ioanna, Mehran, Roxana, Pocock, Stuart J., Kappetein, A. Pieter, for the EXCEL Trial Investigators:, [. . ., Antonio, Marzocchi, DI BARTOLOMEO, Roberto, ], . ., and Cardiothoracic Surgery

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, law.invention, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Randomized controlled trial, law, Internal medicine, medicine, Clinical endpoint, Drug-Eluting Stent, Humans, Everolimus, 030212 general & internal medicine, cardiovascular diseases, Coronary Artery Bypass, Aged, Female, Middle Aged, Drug-Eluting Stents, business.industry, Coronary Artery Bypa, Medicine (all), Percutaneous coronary intervention, General Medicine, medicine.disease, Surgery, Cardiac surgery, Everolimu, surgical procedures, operative, Bypass surgery, Conventional PCI, Cardiology, business, medicine.drug, Human
Abstract

BACKGROUND: Patients with obstructive left main coronary artery disease are usually treated with coronary-artery bypass grafting (CABG). Randomized trials have suggested that drug-eluting stents may be an acceptable alternative to CABG in selected patients with left main coronary disease. METHODS: We randomly assigned 1905 eligible patients with left main coronary artery disease of low or intermediate anatomical complexity to undergo either percutaneous coronary intervention (PCI) with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). Anatomic complexity was assessed at the sites and defined by a Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score of 32 or lower (the SYNTAX score reflects a comprehensive angiographic assessment of the coronary vasculature, with 0 as the lowest score and higher scores [no upper limit] indicating more complex coronary anatomy). The primary end point was the rate of a composite of death from any cause, stroke, or myocardial infarction at 3 years, and the trial was powered for noninferiority testing of the primary end point (noninferiority margin, 4.2 percentage points). Major secondary end points included the rate of a composite of death from any cause, stroke, or myocardial infarction at 30 days and the rate of a composite of death, stroke, myocardial infarction, or ischemia-driven revascularization at 3 years. Event rates were based on Kaplan-Meier estimates in time-to-first-event analyses. RESULTS: At 3 years, a primary end-point event had occurred in 15.4% of the patients in the PCI group and in 14.7% of the patients in the CABG group (difference, 0.7 percentage points; upper 97.5% confidence limit, 4.0 percentage points; P=0.02 for noninferiority; hazard ratio, 1.00; 95% confidence interval, 0.79 to 1.26; P=0.98 for superiority). The secondary end-point event of death, stroke, or myocardial infarction at 30 days occurred in 4.9% of the patients in the PCI group and in 7.9% in the CABG group (P

Published
2017

7. Supplemental parenteral nutrition versus usual care in critically ill adults: A pilot randomized controlled study

Author

Ridley, EJ, Davies, AR, Parke, R, Bailey, M, McArthur, C, Gillanders, L, Cooper, DJ, McGuinness, S, Gilder, E, McCarthy, L, Cowdrey, KA, Baskett, R, Newby, L, Asrani, V, Henderson, S, Mehrtens, J, Morris, A, Minto, E, Orford, Neil, Bone, A, Elderkin, T, Salerno, T, Hoevenaars, R, Roodenburg, O, Young, M, McCracken, P, Board, J, Vallance, S, Capel, E, Young, P, Navarra, L, Hunt, A, Hurford, S, Andrews, L, Mackle, D, Boulton, C, Deane, A, Hodgson, C, Ridley, EJ, Davies, AR, Parke, R, Bailey, M, McArthur, C, Gillanders, L, Cooper, DJ, McGuinness, S, Gilder, E, McCarthy, L, Cowdrey, KA, Baskett, R, Newby, L, Asrani, V, Henderson, S, Mehrtens, J, Morris, A, Minto, E, Orford, Neil, Bone, A, Elderkin, T, Salerno, T, Hoevenaars, R, Roodenburg, O, Young, M, McCracken, P, Board, J, Vallance, S, Capel, E, Young, P, Navarra, L, Hunt, A, Hurford, S, Andrews, L, Mackle, D, Boulton, C, Deane, A, and Hodgson, C

Published
2018

14. Supplemental parenteral nutrition in critically ill patients: A study protocol for a phase II randomised controlled trial

Author

Ridley, EJ, Davies, AR, Parke, R, Bailey, M, McArthur, C, Gillanders, L, Cooper, DJ, McGuinness, S, Gilder, E, McCarthy, L, Cowdrey, KA, Baskett, R, Newby, L, Asrani, V, Henderson, S, Mehrtens, J, Morris, A, Minto, E, Orford, Neil, Bone, A, Elderkin, T, Salerno, T, Hoevenaars, R, Roodenburg, O, Young, M, McCracken, P, Board, J, Vallance, S, Capel, EE, Young, P, Navarra, L, Hunt, A, Hurford, S, Andrews, L, Mackle, D, Boulton, C, Deane, A, Hodgson, C, Ridley, EJ, Davies, AR, Parke, R, Bailey, M, McArthur, C, Gillanders, L, Cooper, DJ, McGuinness, S, Gilder, E, McCarthy, L, Cowdrey, KA, Baskett, R, Newby, L, Asrani, V, Henderson, S, Mehrtens, J, Morris, A, Minto, E, Orford, Neil, Bone, A, Elderkin, T, Salerno, T, Hoevenaars, R, Roodenburg, O, Young, M, McCracken, P, Board, J, Vallance, S, Capel, EE, Young, P, Navarra, L, Hunt, A, Hurford, S, Andrews, L, Mackle, D, Boulton, C, Deane, A, and Hodgson, C

Published
2015

17. Multicenter Canadian Experience with the HeartWare HVAD

Author

Rao, V., primary, Legare, J.F., additional, Mac Arthur, R., additional, Bashir, J., additional, Freed, D., additional, Cheung, A., additional, Baskett, R., additional, Mullen, J., additional, Rebeyka, I., additional, Yau, T., additional, and Cusimano, R.J., additional

Published
2013
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18. Investigation of boundary-layer wind predictions during nocturnal low-level jet events using the Weather Research and Forecasting model.

Author

Mirocha, J. D., Simpson, M. D., Fast, J. D., Berg, L. K., and Baskett, R. L.

Subjects
WIND turbines & the environment, ATMOSPHERIC boundary layer, WEATHER forecasting, MESOSCALE convective complexes, STRATIGRAPHIC geology, CIRCADIAN rhythms, WIND speed
Abstract

The accuracy of boundary-layer wind profiles occurring during nocturnal low-level jet (LLJ) events, and their sensitivities to variations of user-specifiable model configuration parameters within the Weather Research and Forecasting model, was investigated. Simulations were compared against data from a wind-profiling lidar, deployed to the Northern Great Plains during the U.S. Department of Energy-supported Weather Forecast Improvement Project. Two periods during the autumn of 2011 featuring LLJs of similar magnitudes and durations occurring during several consecutive nights were selected for analysis. Simulated wind speed and direction at 80 and 180 m above the surface, the former a typical wind turbine hub height, bulk vertical gradients between 40 and 120 m, a typical rotor span, and the maximum wind speeds occurring at 80 and 180 m, and their times of occurrence, were compared with the observations. Sensitivities of these parameters to the horizontal and vertical grid spacing, planetary boundary layer and land surface model physics options, and atmospheric forcing dataset, were assessed using ensembles encompassing changes of each of these configuration parameters. Each simulation captured the diurnal cycle of wind speed and stratification, producing LLJs during each overnight period; however, large discrepancies in relation to the observations were frequently observed, with each ensemble producing a wide range of distributions, reflecting highly variable representations of stratification during the weakly stable overnight conditions. Root mean square error and bias values computed over the LLJ cycle (late evening through the following morning) revealed that, while some configurations performed better or worse in different aspects and at different times, none exhibited definitively superior performance. The considerable root mean square error and bias values, even among the 'best' performing simulations, underscore the need for improved simulation capabilities for the prediction of near-surface winds during LLJ conditions. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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