Search

Your search keyword '"Baskaran, Saradha"' showing total 158 results
Start Over Author "Baskaran, Saradha"
158 results on '"Baskaran, Saradha"'

11. A Scientometric Evaluation of COVID-19 and Male Reproductive Research.

Author

Panner Selvam, Manesh Kumar, Kapoor, Anika, Baskaran, Saradha, Moharana, Ajaya Kumar, and Sikka, Suresh C.

Subjects
SCIENTIFIC literature, MOLECULAR biology, COVID-19, COVID-19 pandemic, MALES
Abstract

The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA (n = 72), Italy (n = 55), and China (n = 51). Such research was mainly focused around medicine (57.1%), followed by biochemistry, genetics, and molecular biology (25.7%). Also, in the area of male reproduction, only 37.1% (n = 128) of the articles contributed towards original research, whereas 52.8% (n = 182) were review articles and editorials focusing more on sexual dysfunction than infertility. Such a small number of studies published on COVID-19-related effects on male reproduction warrants a significant increase in research, which is required to decipher the mechanism(s) underlying SARS-CoV-2 infection-associated impairment of male reproductive function. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

21. Male infertility

Author

Agarwal, Ashok, primary, Baskaran, Saradha, additional, Parekh, Neel, additional, Cho, Chak-Lam, additional, Henkel, Ralf, additional, Vij, Sarah, additional, Arafa, Mohamed, additional, Panner Selvam, Manesh Kumar, additional, and Shah, Rupin, additional

Published
2021
Full Text
View/download PDF

23. Highly Cited Articles in the Field of Male Infertility and Antioxidants: A Scientometric Analysis

Author

Agarwal, Ashok, primary, Selvam, Manesh Kumar Panner, additional, Baskaran, Saradha, additional, Finelli, Renata, additional, Leisegang, Kristian, additional, Barbăroșie, Cătălina, additional, Pushparaj, Peter Natesan, additional, Robert, Kathy Amy, additional, Ambar, Rafael F., additional, Iovine, Concetta, additional, Durairajanayagam, Damayanthi, additional, and Henkel, Ralf, additional

Published
2021
Full Text
View/download PDF

24. A scientometric analysis of research publications on male infertility and assisted reproductive technology

Author

Agarwal, Ashok, primary, Panner Selvam, Manesh Kumar, additional, Baskaran, Saradha, additional, Finelli, Renata, additional, Leisegang, Kristian, additional, Barbăroșie, Cătălina, additional, Pushparaj, Peter Natesan, additional, Robert, Kathy Amy, additional, Ambar, Rafael, additional, Iovine, Concetta, additional, Durairajanayagam, Damayanthi, additional, and Henkel, Ralf, additional

Published
2020
Full Text
View/download PDF

34. Aberrant Upregulation of Compensatory Redox Molecular Machines May Contribute to Sperm Dysfunction in Infertile Men with Unilateral Varicocele: A Proteomic Insight

Author

Swain, Nirlipta, primary, Samanta, Luna, additional, Agarwal, Ashok, additional, Kumar, Sugandh, additional, Dixit, Anshuman, additional, Gopalan, Banu, additional, Durairajanayagam, Damayanthi, additional, Sharma, Rakesh, additional, Pushparaj, Peter N., additional, and Baskaran, Saradha, additional

Published
2020
Full Text
View/download PDF

37. Sperm DNA Fragmentation: A New Guideline for Clinicians

Author

Agarwal, Ashok, primary, Majzoub, Ahmad, additional, Baskaran, Saradha, additional, Panner Selvam, Manesh Kumar, additional, Cho, Chak Lam, additional, Henkel, Ralf, additional, Finelli, Renata, additional, Leisegang, Kristian, additional, Sengupta, Pallav, additional, Barbarosie, Catalina, additional, Parekh, Neel, additional, Alves, Marco G., additional, Ko, Edmund, additional, Arafa, Mohamed, additional, Tadros, Nicholas, additional, Ramasamy, Ranjith, additional, Kavoussi, Parviz, additional, Ambar, Rafael, additional, Kuchakulla, Manish, additional, Robert, Kathy Amy, additional, Iovine, Concetta, additional, Durairajanayagam, Damayanthi, additional, Jindal, Sunil, additional, and Shah, Rupin, additional

Published
2020
Full Text
View/download PDF

39. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Author

Agarwal, Ashok, Parekh, Neel, Selvam, Manesh Kumar Panner, Henkel, Ralf, Shah, Rupin, Homa, Sheryl T., Ramasamy, Ranjith, Ko, Edmund, Tremellen, Kelton, Esteves, Sandro, Majzoub, Ahmad, Alvarez, Juan G., Gardner, David K., Jayasena, Channa N., Ramsay, Jonathan W., Cho, Chak-Lam, Saleh, Ramadan, Sakkas, Denny, Hotaling, James M., Lundy, Scott D., Vij, Sarah, Marmar, Joel, Gosalvez, Jaime, Sabanegh, Edmund, Park, Hyun Jun, Zini, Armand, Kavoussi, Parviz, Micic, Sava, Smith, Ryan, Busetto, Gian Maria, Bakircioglu, Mustafa Emre, Haidl, Gerhard, Balercia, Giancarlo, Garrido Puchalt, Nicols, Ben-Khalifa, Moncef, Tadros, Nicholas, Kirkman-Browne, Jackson, Moskovtsev, Sergey, Huang, Xuefeng, Borges, Edson, Jr., Franken, Daniel, Bar-Chama, Natan, Morimoto, Yoshiharu, Tomita, Kazuhisa, Srini, Vasan Satya, Ombelet, Willem, Baldi, Elisabetta, Muratori, Monica, Yumura, Yasushi, La Vignera, Sandro, Kosgi, Raghavender, Martinez, Marlon P., Evenson, Donald P., Zylbersztejn, Daniel Suslik, Roque, Matheus, Cocuzza, Marcello, Vieira, Marcelo, Ben-Meir, Assaf, Orvieto, Raoul, Levitas, Eliahu, Wiser, Amir, Arafa, Mohamed, Malhotra, Vineet, Parekattil, Sijo Joseph, Elbardisi, Haitham, Carvalho, Luiz, Dada, Rima, Sifer, Christophe, Talwar, Pankaj, Gudeloglu, Ahmet, Mahmoud, Ahmed M. A., Terras, Khaled, Yazbeck, Chadi, Nebojsa, Bojanic, Durairajanayagam, Damayanthi, Mounir, Ajina, Kahn, Linda G., Baskaran, Saradha, Pai, Rishma Dhillon, Paoli, Donatella, Leisegang, Kristian, Moein, Mohamed-Reza, Malik, Sonia, Yaman, Onder, Samanta, Luna, Bayane, Fouad, Jindal, Sunil K., Kendirci, Muammer, Altay, Baris, Perovic, Dragoljub, Harlev, Avi, and Ege Üniversitesi

Subjects
Oxidative stress, Semen, Oxidation reduction potential, MOSI, Infertility, male
Abstract

WOS: 000482196700006, PubMed ID: 31081299, Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging condition to diagnose and manage. Increasing evidence suggests that oxidative stress (OS) plays an independent role in the etiology of male infertility, with 30% to 80% of infertile men having elevated seminal reactive oxygen species levels. OS can negatively affect fertility via a number of pathways, including interference with capacitation and possible damage to sperm membrane and DNA, which may impair the sperm's potential to fertilize an egg and develop into a healthy embryo. Adequate evaluation of male reproductive potential should therefore include an assessment of sperm OS. We propose the term Male Oxidative Stress Infertility, or MOSI, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility. Oxidation-reduction potential (ORP) can be a useful clinical biomarker for the classification of MOSI, as it takes into account the levels of both oxidants and reductants (antioxidants). Current treatment protocols for OS, including the use of antioxidants, are not evidence-based and have the potential for complications and increased healthcare-related expenditures. Utilizing an easy, reproducible, and cost-effective test to measure ORP may provide a more targeted, reliable approach for administering antioxidant therapy while minimizing the risk of antioxidant overdose. With the increasing awareness and understanding of MOSI as a distinct male infertility diagnosis, future research endeavors can facilitate the development of evidence-based treatments that target its underlying cause., American Center for Reproductive Medicine, Financial support for this study was provided by the American Center for Reproductive Medicine.

Published
2019

44. Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Author

Agarwal, Ashok, primary, Parekh, Neel, additional, Panner Selvam, Manesh Kumar, additional, Henkel, Ralf, additional, Shah, Rupin, additional, Homa, Sheryl T., additional, Ramasamy, Ranjith, additional, Ko, Edmund, additional, Tremellen, Kelton, additional, Esteves, Sandro, additional, Majzoub, Ahmad, additional, Alvarez, Juan G., additional, Gardner, David K., additional, Jayasena, Channa N., additional, Ramsay, Jonathan W., additional, Cho, Chak-Lam, additional, Saleh, Ramadan, additional, Sakkas, Denny, additional, Hotaling, James M., additional, Lundy, Scott D., additional, Vij, Sarah, additional, Marmar, Joel, additional, Gosalvez, Jaime, additional, Sabanegh, Edmund, additional, Park, Hyun Jun, additional, Zini, Armand, additional, Kavoussi, Parviz, additional, Micic, Sava, additional, Smith, Ryan, additional, Busetto, Gian Maria, additional, Bakırcıoğlu, Mustafa Emre, additional, Haidl, Gerhard, additional, Balercia, Giancarlo, additional, Puchalt, Nicolás Garrido, additional, Ben-Khalifa, Moncef, additional, Tadros, Nicholas, additional, Kirkman-Browne, Jackson, additional, Moskovtsev, Sergey, additional, Huang, Xuefeng, additional, Borges, Edson, additional, Franken, Daniel, additional, Bar-Chama, Natan, additional, Morimoto, Yoshiharu, additional, Tomita, Kazuhisa, additional, Srini, Vasan Satya, additional, Ombelet, Willem, additional, Baldi, Elisabetta, additional, Muratori, Monica, additional, Yumura, Yasushi, additional, La Vignera, Sandro, additional, Kosgi, Raghavender, additional, Martinez, Marlon P., additional, Evenson, Donald P., additional, Zylbersztejn, Daniel Suslik, additional, Roque, Matheus, additional, Cocuzza, Marcello, additional, Vieira, Marcelo, additional, Ben-Meir, Assaf, additional, Orvieto, Raoul, additional, Levitas, Eliahu, additional, Wiser, Amir, additional, Arafa, Mohamed, additional, Malhotra, Vineet, additional, Parekattil, Sijo Joseph, additional, Elbardisi, Haitham, additional, Carvalho, Luiz, additional, Dada, Rima, additional, Sifer, Christophe, additional, Talwar, Pankaj, additional, Gudeloglu, Ahmet, additional, Mahmoud, Ahmed M.A., additional, Terras, Khaled, additional, Yazbeck, Chadi, additional, Nebojsa, Bojanic, additional, Durairajanayagam, Damayanthi, additional, Mounir, Ajina, additional, Kahn, Linda G., additional, Baskaran, Saradha, additional, Pai, Rishma Dhillon, additional, Paoli, Donatella, additional, Leisegang, Kristian, additional, Moein, Mohamed-Reza, additional, Malik, Sonia, additional, Yaman, Onder, additional, Samanta, Luna, additional, Bayane, Fouad, additional, Jindal, Sunil K., additional, Kendirci, Muammer, additional, Altay, Baris, additional, Perovic, Dragoljub, additional, and Harlev, Avi, additional

Published
2019
Full Text
View/download PDF

46. Diagnostic value of routine semen analysis in clinical andrology.

Author

Baskaran, Saradha, Finelli, Renata, Agarwal, Ashok, and Henkel, Ralf

Subjects
*SEMEN analysis, *ANDROLOGY, *SPERMATOZOA, *TESTIS, *INFERTILITY
Abstract

Infertility is a major health issue affecting over 48.5 million couples around the world, with the male factor accounting for about 50% of the cases. The conventional semen analysis recommended by the World Health Organization (WHO) is the cornerstone in the evaluation of male fertility status. It includes macroscopic and microscopic evaluation of the ejaculate, which reflects the production of spermatozoa in the testes, the patency of the duct system and the glandular secretory activity. Evaluation of seminal fructose, sperm vitality and leucocytes (Endtz test) are useful adjuncts to semen analysis that provide information on specific clinical conditions. Though several computer‐assisted sperm analysis (CASA) systems have been developed, conventional methods for semen analysis are still widely accepted in clinical practice. This review summarises the conventional techniques used in routine semen analysis and their diagnostic value in clinical andrology. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

47. Environmental contaminants and male infertility: Effects and mechanisms.

Author

Selvaraju, Vaithinathan, Baskaran, Saradha, Agarwal, Ashok, and Henkel, Ralf

Subjects
*POLLUTANTS, *MALE reproductive organs, *MALE infertility, *SERTOLI cells, *CELL physiology
Abstract

The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess the ability to intervene with the growth and function of male reproductive organs. Several epidemiological reports have correlated the blood and seminal levels of environmental contaminants with poor sperm quality. Numerous in vivo and in vitro studies have been conducted to investigate the effect of various environmental contaminants on spermatogenesis, steroidogenesis, Sertoli cells, blood–testis barrier, epididymis and sperm functions. The reported reprotoxic effects include alterations in the spermatogenic cycle, increased germ cell apoptosis, inhibition of steroidogenesis, decreased Leydig cell viability, impairment of Sertoli cell structure and function, altered expression of steroid receptors, increased permeability of blood–testis barrier, induction of peroxidative and epigenetic alterations in spermatozoa resulting in poor sperm quality and function. In light of recent scientific reports, this review discusses the effects of environmental contaminants on the male reproductive function and the possible mechanisms of action. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

48. Protein profiling in unlocking the basis of varicocele‐associated infertility.

Author

Panner Selvam, Manesh Kumar, Baskaran, Saradha, Agarwal, Ashok, and Henkel, Ralf

Subjects
*INFERTILITY, *SEMEN analysis, *MALE infertility, *SPERMATOZOA, *VARICOCELE
Abstract

Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Mitochondrial dysfunction has been identified as the main factor affecting normal physiological functions of spermatozoa. This article discusses the proteomic studies of spermatozoa and seminal plasma in varicocele patients. Proteomics can identify potential spermatozoa and seminal plasma biomarkers in varicocele‐mediated male infertility. In future, these protein biomarkers can be useful in the development of noninvasive diagnostic and therapeutic strategies for varicocele patients. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

49. Reactive oxygen species in male reproduction: A boon or a bane?

Author

Baskaran, Saradha, Finelli, Renata, Agarwal, Ashok, and Henkel, Ralf

Subjects
*REACTIVE oxygen species, *SPERMATOGENESIS, *MALE reproductive health, *DNA condensation, *REPRODUCTION, *ACROSOME reaction, *FREE radicals
Abstract

Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular metabolism. ROS play a crucial role in the physiological processes and signalling pathways associated with male fertility. At physiological concentrations, ROS act as molecular mediators of signal transduction pathways involved in the regulation of the hypothalamic–pituitary–gonadal axis, spermatogenesis and steroidogenesis. They also trigger the morphological changes required for sperm maturation, such as DNA compaction and flagellar modification. Furthermore, ROS modulate crucial processes involved in the attainment of sperm fertilising ability such as capacitation, hyperactivation, acrosome reaction and sperm–oocyte fusion. Conversely, oxidative stress prevails when the concentration of ROS overwhelms the body's antioxidant defence. Various endogenous and exogenous factors enhance the synthesis of ROS resulting in the disruption of structural and functional integrity of spermatozoa through the induction of apoptotic pathway and oxidation of molecules, such as lipids, proteins and DNA. Therefore, maintenance of a balanced redox state is critical for normal male reproductive functions. This article discusses the dual role of ROS in male reproduction, highlighting the physiological role as well as their pathological implications on male fertility. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

50. A scientometric analysis of research publications on male infertility and assisted reproductive technology.

Author

Agarwal, Ashok, Panner Selvam, Manesh Kumar, Baskaran, Saradha, Finelli, Renata, Leisegang, Kristian, Barbăroșie, Cătălina, Pushparaj, Peter Natesan, Robert, Kathy Amy, Ambar, Rafael, Iovine, Concetta, Durairajanayagam, Damayanthi, and Henkel, Ralf

Subjects
MALE infertility, REPRODUCTIVE technology, INTRACYTOPLASMIC sperm injection, DENSITY gradient centrifugation, HISTORY in art
Abstract

Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male infertility and ART over the past 20 years (2000‐2019) by analysing scientometric data (the number of publications per year, authors, author affiliations, journals, countries, type of documents, subject area and number of citations) retrieved using the Scopus database. We used VOS viewer software to generate a network map on international collaborations as well as a heat map of the top scientists in this field. Our results revealed a total of 2,148 publications during this period with Cleveland Clinic Foundation contributing the most (n = 69). The current scientometric analysis showed that the research trend on ART has been stable over the past two decades. Further in‐depth analysis revealed that density gradient centrifugation (46%) and intracytoplasmic sperm injection (59.2%) are the most reported techniques for sperm separation and ART, respectively. Additionally, azoospermia was the most studied clinical scenario (60.6%), with majority of articles reporting pregnancy rate (47.25%) as the primary reproductive outcome for ART. This study provides insight into the current focus of research in the area of male infertility and ART as well as the areas that require further research in future. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results