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2. Diisobutylaluminium hydride mediated efficient synthesis of Morita–Baylis–Hilman adducts through α‐functionalization of alkyl propiolates.

Author

Gogula, Sailam Sri, Konakalla, Ramakrishna, Kamireddy, Kamalaker Reddy, Puchakayala, Muralidar Reddy, Lincoln, Ch. Abraham, and Basireddy, Venkata Subba Reddy

Subjects
HYDRIDES, INDOLE derivatives, ORGANIC synthesis, LOW temperatures
Abstract

Generally, oxindole derivatives are biologically important molecules and valuable building blocks in organic synthesis. Herein, we report a diisobutylaluminium hydride mediated efficient one‐pot synthesis of oxindole derivatives using N‐substituted isatins with methyl or ethyl propiolates at lower temperature (−78°C) through Morita‐Baylis‐Hillman (MBH) reaction. Within a short reaction time, a wide range of N‐alkyl or N‐aryl 3‐hydroxy oxindole derivatives (MBH adducts) were easily accessed in excellent yields under mild reaction conditions. [ABSTRACT FROM AUTHOR]

Published
2023
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5. A Green Approach towards the Synthesis of Enantio Pure Diols Using Horse Radish Peroxidase Enzyme Immobilized on Magnetic Nanoparticles

Author

Adari Bhaskar Rao, Basireddy Venkata Subba Reddy, Seelam S. Deepthi, Bojja Sreedhar, and Ernala Prasad

Subjects
inorganic chemicals, biology, Chemistry, organic chemicals, technology, industry, and agriculture, Enantioselective synthesis, Nanoparticle, Horseradish peroxidase, Hydrolysis, Enantiopure drug, polycyclic compounds, biology.protein, Magnetic nanoparticles, Organic chemistry, Amine gas treating, Peroxidase
Abstract

Enantiopure epoxides and their corresponding chiral vicinal diols serve as valuable intermediates in the synthesis of biologically active pharma and agro-compounds and also value added fine chemicals. Biocatalysts are well known for their selective hydrolysis of racemic epoxides to give optically pure chiral diols. This study highlights an efficient process of synthesis of chiral vicinal diols in good yields and enantioselectiviy using horse radish peroxidase enzyme immobilized on the amine functionalized magnetic nano particles (Fe3O4 nanoparticles) as enzyme carriers. It also facilitates separation of MNP-immobilized enzymes by applying external magnetic field. The immobilization of magnetic nano particles was confirmed by transmission electron microscope (TEM) and scanning electron microscope (SEM). The MNP-immobilized peroxidase enzyme improved stability of the enzyme and has shown broader substrate specificity in enantioselective hydrolysis of racemic epoxides, under mild and environmentally friendly conditions. The methodology MNP-immobilized enzyme developed in the synthesis of chiral diols has a potential for use in large-scale applications.

Published
2014
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